Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Riboflavin metabolism (mmu00740)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acp1
KLA  ATP  ATP+KLA
 NM_001110239 acid phosphatase 1, soluble (Acp1), transcript variant 1, mRNA [NM_001110239] KLA 1.15 1.18 1.12 1.18 1.14 1.10 1.18
ATP .94 1.01 1.12 1.23 .90 .68 .98
KLA/ATP 1.10 1.24 1.20 1.33 .94 .82 .99
Acp2
KLA  ATP  ATP+KLA
 AK170658 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630113A07 product:acid phosphatase 2, lysosomal, full insert sequence [AK170658] KLA 1.17 1.24 1.33 1.51 2.46 3.34 3.43
ATP .95 .99 .76 1.07 .73 .56 .97
KLA/ATP 1.23 1.23 .78 1.06 .72 .78 2.19
Acp2
KLA  ATP  ATP+KLA
 NM_007387 acid phosphatase 2, lysosomal (Acp2), mRNA [NM_007387] KLA 1.52 1.61 1.73 1.82 2.82 4.19 5.68
ATP 1.12 1.21 .95 1.29 .87 .76 2.68
KLA/ATP 1.81 1.80 1.24 1.72 1.04 1.16 5.43
Acp5
KLA  ATP  ATP+KLA
 NM_007388 acid phosphatase 5, tartrate resistant (Acp5), transcript variant 3, mRNA [NM_007388] KLA 3.62 3.55 3.27 3.26 3.31 3.93 5.79
ATP .96 1.00 1.29 1.96 2.30 3.05 3.81
KLA/ATP 3.61 3.85 4.05 5.38 4.56 5.15 6.77
Acp6
KLA  ATP  ATP+KLA
 NM_019800 acid phosphatase 6, lysophosphatidic (Acp6), mRNA [NM_019800] KLA .56 .47 .41 .37 .24 .32 .79
ATP .88 .80 1.06 .84 .62 .51 .67
KLA/ATP .49 .44 .49 .36 .34 .37 .39
Acpp
KLA  ATP  ATP+KLA
 NM_019807 acid phosphatase, prostate (Acpp), transcript variant 2, mRNA [NM_019807] KLA 1.09 1.07 1.11 1.23 1.20 1.08 1.14
ATP 1.00 1.02 1.07 1.03 1.00 2.39 3.55
KLA/ATP 1.02 1.12 1.04 1.10 1.05 1.69 4.36
Acpp
KLA  ATP  ATP+KLA
 NM_207668 acid phosphatase, prostate (Acpp), transcript variant 1, mRNA [NM_207668] KLA 1.15 1.01 1.13 1.13 1.12 1.06 1.12
ATP .96 1.02 1.04 1.02 .96 2.62 2.40
KLA/ATP 1.00 1.04 1.09 1.08 1.15 1.91 2.69
AK134499
KLA  ATP  ATP+KLA
 AK134499 11 days embryo head cDNA, RIKEN full-length enriched library, clone:6230419C23 product:unclassifiable, full insert sequence [AK134499] KLA .97 1.04 .99 1.01 .93 1.08 1.21
ATP .97 1.02 .97 1.13 1.01 .98 1.06
KLA/ATP .95 .98 1.00 .95 1.00 .98 1.02
Blvrb
KLA  ATP  ATP+KLA
 NM_144923 biliverdin reductase B (flavin reductase (NADPH)) (Blvrb), mRNA [NM_144923] KLA .92 .92 .90 .97 1.03 1.08 1.45
ATP 1.08 1.10 1.14 1.22 1.28 2.18 1.75
KLA/ATP .97 .92 .94 1.10 1.24 1.96 2.58
Enpp1
KLA  ATP  ATP+KLA
 ENSMUST00000105520 ens|Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E- NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Lymphocyte antigen 41) (Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1 KLA .71 .79 .64 .61 .55 .51 .32
ATP .85 .97 .85 .72 .62 .45 .28
KLA/ATP .72 .73 .61 .66 .60 .55 .27
Enpp1
KLA  ATP  ATP+KLA
 NM_008813 ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), mRNA [NM_008813] KLA .82 .83 .77 .83 .65 .64 .51
ATP .89 .90 1.21 1.00 .98 .87 .64
KLA/ATP .72 .76 .96 .87 1.00 .94 .51
Enpp3
KLA  ATP  ATP+KLA
 BC005527 ectonucleotide pyrophosphatase [BC005527] KLA 1.06 .99 .98 1.01 .97 .99 .96
ATP .93 1.08 .99 1.05 .94 1.05 1.10
KLA/ATP .95 .96 1.10 .99 .95 .94 1.03
Enpp3
KLA  ATP  ATP+KLA
 BC006944 ectonucleotide pyrophosphatase/phosphodiesterase 3, mRNA (cDNA clone IMAGE:2655671), complete cds. [BC006944] KLA 1.02 1.01 1.03 1.08 1.04 1.01 1.01
ATP .97 1.01 .96 1.00 .98 1.07 .99
KLA/ATP 1.01 .99 1.07 1.02 .97 .98 .92
Enpp3
KLA  ATP  ATP+KLA
 NM_134005 ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA [NM_134005] KLA 1.01 .95 .99 .98 1.05 1.04 .98
ATP .98 .98 1.03 .98 .96 1.00 .98
KLA/ATP .97 1.03 1.04 .93 1.02 .99 1.04
Flad1
KLA  ATP  ATP+KLA
 NM_177041 RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) (Flad1), mRNA [NM_177041] KLA .86 .91 .90 1.00 1.13 1.42 1.85
ATP .94 .96 .95 .99 .68 1.02 2.24
KLA/ATP .84 .82 .78 .87 .70 1.08 2.77
Mm.23812
7
KLA  ATP  ATP+KLA
 168823498 Unknown KLA 1.07 .97 1.04 1.05 1.02 .98 1.02
ATP .95 1.00 .98 1.01 .95 .93 .92
KLA/ATP .93 .98 .98 1.04 1.01 1.02 .98
Mm.35983
1
KLA  ATP  ATP+KLA
 159032061 Unknown KLA 1.02 .93 .95 .94 1.01 .97 1.11
ATP .97 1.01 1.07 1.03 .93 1.03 1.02
KLA/ATP .94 .91 .99 .97 .97 .98 .91
Rfk
KLA  ATP  ATP+KLA
 NM_019437 riboflavin kinase (Rfk), mRNA [NM_019437] KLA 1.03 1.05 .97 .96 .86 .77 .86
ATP 1.05 1.20 1.16 1.43 1.21 1.23 1.24
KLA/ATP 1.04 1.09 .95 1.20 .91 .93 1.03
Tyr
KLA  ATP  ATP+KLA
 NM_011661 tyrosinase (Tyr), mRNA [NM_011661] KLA .99 1.02 .99 1.01 1.00 1.01 1.03
ATP 1.01 .98 .99 1.03 1.00 1.01 1.00
KLA/ATP 1.01 1.00 1.00 1.01 1.00 1.03 .98