Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Vitamin B6 metabolism (mmu00750)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aox1
KLA  ATP  ATP+KLA
 NM_009676 aldehyde oxidase 1 (Aox1), mRNA [NM_009676] KLA .87 .83 .82 .82 .71 .98 1.65
ATP 1.01 1.02 1.05 .84 .72 .86 .80
KLA/ATP .82 .84 .90 .73 .72 .82 1.06
Aox3
KLA  ATP  ATP+KLA
 NM_023617 aldehyde oxidase 3 (Aox3), mRNA [NM_023617] KLA .95 1.02 1.01 1.00 .99 1.01 1.04
ATP 1.04 1.03 1.01 .94 1.03 .92 .96
KLA/ATP 1.09 1.11 1.00 .97 .95 1.01 .94
Aox4
KLA  ATP  ATP+KLA
 NM_023631 aldehyde oxidase 4 (Aox4), mRNA [NM_023631] KLA .95 .97 .98 1.00 .98 .91 1.06
ATP .93 .99 .95 .99 .94 .95 1.00
KLA/ATP 1.05 1.00 .94 .98 .89 1.00 .93
Mm.45742
4
KLA  ATP  ATP+KLA
 85838507 Unknown KLA .42 .38 .47 .72 1.01 1.27 .84
ATP 1.10 1.14 1.55 1.12 .55 .71 .55
KLA/ATP .50 .42 .72 .55 1.18 .69 .68
Pdxk
KLA  ATP  ATP+KLA
 NM_172134 pyridoxal (pyridoxine, vitamin B6) kinase (Pdxk), mRNA [NM_172134] KLA .40 .38 .31 .27 .21 .31 .50
ATP 1.01 .97 .93 1.01 1.12 .64 2.00
KLA/ATP .41 .38 .32 .38 .74 .80 .80
Pdxp
KLA  ATP  ATP+KLA
 NM_020271 pyridoxal (pyridoxine, vitamin B6) phosphatase (Pdxp), mRNA [NM_020271] KLA .59 .51 .55 .70 1.07 .99 .86
ATP 1.07 1.21 1.26 1.10 .57 .70 .58
KLA/ATP .58 .56 .69 .61 .89 .62 .66
Phospho2
KLA  ATP  ATP+KLA
 AK010147 adult male tongue cDNA, RIKEN full-length enriched library, clone:2310074E15 product:unclassifiable, full insert sequence. [AK010147] KLA 1.03 1.02 1.06 .98 .98 1.00 1.04
ATP 1.08 .99 .96 1.05 1.02 1.03 1.03
KLA/ATP 1.01 .97 .97 .97 1.04 1.02 .93
Phospho2
KLA  ATP  ATP+KLA
 NM_028521 phosphatase, orphan 2 (Phospho2), mRNA [NM_028521] KLA 1.87 2.00 2.27 1.79 1.77 1.97 1.43
ATP 1.03 1.03 1.11 .97 1.82 2.55 1.88
KLA/ATP 1.95 2.13 1.70 1.94 2.10 3.72 2.83
Pnpo
KLA  ATP  ATP+KLA
 NM_134021 pyridoxine 5-phosphate oxidase (Pnpo), mRNA [NM_134021] KLA .64 .66 .64 .60 .58 .62 .81
ATP 1.07 1.06 1.02 1.08 .78 .55 1.18
KLA/ATP .73 .76 .60 .78 .54 .65 .78
Psat1
KLA  ATP  ATP+KLA
 NM_177420 phosphoserine aminotransferase 1 (Psat1), mRNA [NM_177420] KLA 1.02 1.21 1.24 1.27 1.64 1.59 .38
ATP 1.02 1.01 1.04 1.17 1.27 1.09 .43
KLA/ATP 1.16 1.11 1.04 1.37 1.04 .70 .24