Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Pantothenate and CoA biosynthesis (mmu00770)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aasdhppt
KLA  ATP  ATP+KLA
 AK144671 lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730021M24 product:aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, full insert sequence [AK144671] KLA .84 .86 .76 .67 .55 .59 .71
ATP .91 .84 1.14 .94 .65 .66 .53
KLA/ATP .77 .80 .84 .70 .57 .54 .39
Aasdhppt
KLA  ATP  ATP+KLA
 NM_026276 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (Aasdhppt), mRNA [NM_026276] KLA .90 .88 .76 .76 .58 .60 .91
ATP .89 .91 1.19 1.08 .74 .98 .97
KLA/ATP .79 .85 .93 .87 .69 .71 .66
Bcat1
KLA  ATP  ATP+KLA
 NM_001024468 branched chain aminotransferase 1, cytosolic (Bcat1), transcript variant 1, mRNA [NM_001024468] KLA 1.04 1.03 .98 1.04 .99 1.02 1.03
ATP 1.00 1.01 1.02 1.01 1.12 1.25 1.09
KLA/ATP .99 1.00 1.04 1.04 1.01 1.08 1.15
Bcat2
KLA  ATP  ATP+KLA
 NM_009737 branched chain aminotransferase 2, mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA [NM_009737] KLA 1.06 1.05 1.08 .97 1.08 .96 1.61
ATP 1.07 1.42 .96 1.55 .87 .66 .96
KLA/ATP 1.27 1.29 .84 1.36 .81 .76 .92
Coasy
KLA  ATP  ATP+KLA
 NM_027896 Coenzyme A synthase (Coasy), mRNA [NM_027896] KLA .50 .51 .45 .46 .58 .74 .99
ATP .98 .99 .91 .94 .55 .52 1.08
KLA/ATP .50 .48 .44 .45 .39 .39 .72
Dpyd
KLA  ATP  ATP+KLA
 NM_170778 dihydropyrimidine dehydrogenase (Dpyd), mRNA [NM_170778] KLA .94 .95 1.00 .98 .99 .98 .97
ATP 1.04 .95 1.02 1.01 1.02 1.02 .98
KLA/ATP 1.03 .98 .98 1.02 1.02 1.05 .93
Enpp1
KLA  ATP  ATP+KLA
 ENSMUST00000105520 ens|Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E- NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Lymphocyte antigen 41) (Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1 KLA .71 .79 .64 .61 .55 .51 .32
ATP .85 .97 .85 .72 .62 .45 .28
KLA/ATP .72 .73 .61 .66 .60 .55 .27
Enpp1
KLA  ATP  ATP+KLA
 NM_008813 ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), mRNA [NM_008813] KLA .82 .83 .77 .83 .65 .64 .51
ATP .89 .90 1.21 1.00 .98 .87 .64
KLA/ATP .72 .76 .96 .87 1.00 .94 .51
Enpp3
KLA  ATP  ATP+KLA
 BC005527 ectonucleotide pyrophosphatase [BC005527] KLA 1.06 .99 .98 1.01 .97 .99 .96
ATP .93 1.08 .99 1.05 .94 1.05 1.10
KLA/ATP .95 .96 1.10 .99 .95 .94 1.03
Enpp3
KLA  ATP  ATP+KLA
 BC006944 ectonucleotide pyrophosphatase/phosphodiesterase 3, mRNA (cDNA clone IMAGE:2655671), complete cds. [BC006944] KLA 1.02 1.01 1.03 1.08 1.04 1.01 1.01
ATP .97 1.01 .96 1.00 .98 1.07 .99
KLA/ATP 1.01 .99 1.07 1.02 .97 .98 .92
Enpp3
KLA  ATP  ATP+KLA
 NM_134005 ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA [NM_134005] KLA 1.01 .95 .99 .98 1.05 1.04 .98
ATP .98 .98 1.03 .98 .96 1.00 .98
KLA/ATP .97 1.03 1.04 .93 1.02 .99 1.04
Mm.15164
0
KLA  ATP  ATP+KLA
 23943833 Unknown KLA .99 1.01 1.02 .89 .85 .86 .83
ATP 1.05 1.26 .92 1.38 1.01 .90 1.15
KLA/ATP 1.08 1.15 .90 1.23 .78 .92 1.20
Pank1
KLA  ATP  ATP+KLA
 AK019493 0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4632412I06 product:hypothetical protein, full insert sequence. [AK019493] KLA .98 .91 .95 .97 .98 .95 .91
ATP .96 1.04 1.05 .96 1.01 1.01 1.04
KLA/ATP .95 1.05 .96 .97 .96 .96 .96
Pank1
KLA  ATP  ATP+KLA
 NM_023792 pantothenate kinase 1 (Pank1), transcript variant 2, mRNA [NM_023792] KLA .47 .50 .46 .55 .39 .35 .42
ATP 1.02 1.06 1.11 1.02 .57 .50 .58
KLA/ATP .48 .44 .56 .59 .48 .38 .34
Pank2
KLA  ATP  ATP+KLA
 NM_153501 pantothenate kinase 2 (Hallervorden-Spatz syndrome) (Pank2), nuclear gene encoding mitochondrial protein, mRNA [NM_153501] KLA 1.16 1.22 1.28 1.19 1.14 1.16 1.25
ATP .97 1.03 1.01 1.01 .73 1.08 1.92
KLA/ATP 1.14 1.16 1.14 1.36 1.03 1.19 2.04
Pank3
KLA  ATP  ATP+KLA
 NM_145962 pantothenate kinase 3 (Pank3), mRNA [NM_145962] KLA 1.08 1.11 .96 .82 .72 .58 .67
ATP 1.10 1.15 1.34 1.53 1.31 .98 .94
KLA/ATP 1.13 1.23 1.10 1.19 1.11 .73 .60
Pank4
KLA  ATP  ATP+KLA
 NM_172990 pantothenate kinase 4 (Pank4), mRNA [NM_172990] KLA .86 .90 .86 .79 .95 .87 1.14
ATP 1.01 1.02 1.07 1.06 1.17 .94 .86
KLA/ATP .83 .85 .99 .92 1.15 .90 .75
Ppcdc
KLA  ATP  ATP+KLA
 NM_176831 phosphopantothenoylcysteine decarboxylase (Ppcdc), mRNA [NM_176831] KLA .52 .50 .46 .57 .63 .84 .95
ATP .95 .81 .76 .61 .46 .55 .89
KLA/ATP .47 .46 .47 .46 .46 .56 .99
Ppcs
KLA  ATP  ATP+KLA
 NM_026494 phosphopantothenoylcysteine synthetase (Ppcs), mRNA [NM_026494] KLA .71 .66 .63 .72 .73 .93 1.01
ATP .93 .81 .72 .49 .43 .94 1.07
KLA/ATP .68 .67 .61 .47 .50 .97 .73
Upb1
KLA  ATP  ATP+KLA
 NM_133995 ureidopropionase, beta (Upb1), mRNA [NM_133995] KLA 1.22 1.30 1.23 1.20 1.25 1.21 1.15
ATP 1.06 1.13 1.16 1.14 1.01 1.57 1.24
KLA/ATP 1.23 1.24 1.29 1.26 1.18 1.91 2.90
Vnn1
KLA  ATP  ATP+KLA
 NM_011704 vanin 1 (Vnn1), mRNA [NM_011704] KLA 1.01 1.05 1.09 .91 1.00 1.00 1.03
ATP .94 .97 1.01 1.01 1.05 1.04 .97
KLA/ATP 1.05 1.04 1.05 1.00 1.01 .94 .99