Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Biotin metabolism (mmu00780)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Btd
KLA  ATP  ATP+KLA
NM_025295 biotinidase (Btd), mRNA [NM_025295] KLA .89 .88 .87 .74 .90 1.07 1.06
ATP .97 1.05 1.26 1.39 1.39 2.45 2.08
KLA/ATP .86 .89 1.01 1.14 1.11 1.74 2.61
Hlcs
KLA  ATP  ATP+KLA
NM_139145 holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs), mRNA [NM_139145] KLA .60 .62 .54 .59 .71 1.01 1.28
ATP 1.07 1.06 .91 .85 .54 .41 .51
KLA/ATP .65 .64 .48 .58 .48 .56 .86
Oxsm
KLA  ATP  ATP+KLA
NM_027695 3-oxoacyl-ACP synthase, mitochondrial (Oxsm), nuclear gene encoding mitochondrial protein, mRNA [NM_027695] KLA 1.05 1.03 1.11 1.27 1.24 1.26 1.18
ATP .94 .81 .79 .56 .47 1.05 1.43
KLA/ATP .99 .98 .95 .76 .59 .84 1.27