Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Porphyrin and chlorophyll metabolism (mmu00860)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Alad
KLA  ATP  ATP+KLA
 AK044938 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130014K12 product:unclassifiable, full insert sequence [AK044938] KLA .98 .94 .97 .84 .90 .92 1.00
ATP 1.04 .93 .94 .91 .95 .93 .99
KLA/ATP .95 .95 .98 .94 .97 .87 .96
Alad
KLA  ATP  ATP+KLA
 NM_008525 aminolevulinate, delta-, dehydratase (Alad), mRNA [NM_008525] KLA .64 .69 .59 .51 .45 .49 .77
ATP 1.05 1.11 1.09 1.25 .89 .70 .94
KLA/ATP .74 .66 .63 .72 .53 .48 .64
Alas1
KLA  ATP  ATP+KLA
 NM_020559 aminolevulinic acid synthase 1 (Alas1), mRNA [NM_020559] KLA 1.90 2.05 1.99 2.15 2.41 2.00 1.62
ATP .96 1.03 .87 .98 2.70 9.15 6.49
KLA/ATP 1.88 2.04 1.63 1.99 3.06 7.03 8.41
Alas2
KLA  ATP  ATP+KLA
 NM_009653 aminolevulinic acid synthase 2, erythroid (Alas2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_009653] KLA .94 1.05 1.03 .98 .93 .99 1.00
ATP 1.00 1.03 1.02 1.05 .95 .96 1.04
KLA/ATP 1.07 1.08 1.03 .94 .97 .98 .98
Blvra
KLA  ATP  ATP+KLA
 AK045022 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130020C21 product:hypothetical protein, full insert sequence. [AK045022] KLA .86 .76 .75 .88 .96 .86 .88
ATP 1.20 1.42 1.01 .87 .87 .87 .90
KLA/ATP .81 .82 .76 .87 .81 .79 .79
Blvra
KLA  ATP  ATP+KLA
 NM_026678 biliverdin reductase A (Blvra), mRNA [NM_026678] KLA .55 .58 .52 .46 .51 .71 .77
ATP .98 1.02 1.00 1.08 .82 .48 .75
KLA/ATP .61 .57 .51 .54 .44 .49 .67
Blvrb
KLA  ATP  ATP+KLA
 NM_144923 biliverdin reductase B (flavin reductase (NADPH)) (Blvrb), mRNA [NM_144923] KLA .92 .92 .90 .97 1.03 1.08 1.45
ATP 1.08 1.10 1.14 1.22 1.28 2.18 1.75
KLA/ATP .97 .92 .94 1.10 1.24 1.96 2.58
Cox10
KLA  ATP  ATP+KLA
 NM_178379 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (Cox10), nuclear gene encoding mitochondrial protein, mRNA [NM_178379] KLA 1.17 1.20 1.24 1.24 1.14 1.13 1.35
ATP 1.16 1.18 .99 1.15 .83 .98 1.06
KLA/ATP 1.24 1.39 1.07 1.11 .85 .95 .91
Cox15
KLA  ATP  ATP+KLA
 NM_144874 COX15 homolog, cytochrome c oxidase assembly protein (yeast) (Cox15), nuclear gene encoding mitochondrial protein, mRNA [NM_144874] KLA 1.93 1.96 2.10 2.26 1.93 1.90 1.24
ATP .98 .84 1.17 .86 .65 1.34 1.12
KLA/ATP 1.85 2.05 2.30 2.09 1.97 2.46 1.74
Cp
KLA  ATP  ATP+KLA
 NM_007752 ceruloplasmin (Cp), transcript variant 2, mRNA [NM_007752] KLA 31.57 28.40 28.46 33.05 30.23 27.47 18.96
ATP 1.05 1.12 1.42 1.53 2.19 3.53 1.34
KLA/ATP 27.08 32.57 39.76 26.53 20.02 18.72 14.54
Cpox
KLA  ATP  ATP+KLA
 NM_007757 coproporphyrinogen oxidase (Cpox), mRNA [NM_007757] KLA .92 .75 .68 .69 .53 .37 .61
ATP 1.07 1.05 .90 .59 .39 .65 .95
KLA/ATP .68 .71 .78 .57 .35 .38 .40
Ears2
KLA  ATP  ATP+KLA
 AK129469 mRNA for mKIAA1970 protein [AK129469] KLA .84 .88 .83 .81 .86 .92 .97
ATP .98 .97 .85 .85 .90 .92 .86
KLA/ATP .85 .84 .85 .97 .90 .95 .90
Ears2
KLA  ATP  ATP+KLA
 NM_026140 glutamyl-tRNA synthetase 2 (mitochondrial)(putative) (Ears2), nuclear gene encoding mitochondrial protein, mRNA [NM_026140] KLA .75 .73 .71 .69 .75 .84 1.22
ATP 1.12 1.02 .87 .70 .41 .53 .83
KLA/ATP .79 .84 .72 .56 .42 .38 .44
Eprs
KLA  ATP  ATP+KLA
 NM_029735 glutamyl-prolyl-tRNA synthetase (Eprs), mRNA [NM_029735] KLA .91 .97 .84 .80 .73 .74 1.32
ATP .97 1.13 1.17 1.10 1.19 .83 1.03
KLA/ATP .95 .98 .91 .76 .72 .61 .70
Fech
KLA  ATP  ATP+KLA
 NM_007998 ferrochelatase (Fech), nuclear gene encoding mitochondrial protein, mRNA [NM_007998] KLA .93 .80 .68 .81 .65 .59 .57
ATP .97 .91 1.31 .95 .74 .97 .77
KLA/ATP .65 .77 .98 .70 .62 .64 .52
Fth1
KLA  ATP  ATP+KLA
 NM_010239 ferritin heavy chain 1 (Fth1), mRNA [NM_010239] KLA .89 .88 .91 1.07 1.36 2.06 4.05
ATP .94 .88 .94 .85 1.27 2.56 3.84
KLA/ATP .80 .82 .97 .96 1.34 2.15 3.53
Ftl1
KLA  ATP  ATP+KLA
 NM_010240 ferritin light chain 1 (Ftl1), mRNA [NM_010240] KLA .63 .64 .56 .49 .54 .57 1.21
ATP 1.02 1.11 .77 1.09 1.00 1.01 1.89
KLA/ATP .65 .62 .41 .60 .60 .77 1.88
Ftmt
KLA  ATP  ATP+KLA
 NM_026286 ferritin mitochondrial (Ftmt), nuclear gene encoding mitochondrial protein, mRNA [NM_026286] KLA 1.03 1.07 1.10 1.07 1.10 1.04 1.04
ATP 1.07 1.02 1.03 1.04 1.00 .99 1.02
KLA/ATP 1.07 1.09 1.14 1.04 1.04 1.08 1.05
Gusb
KLA  ATP  ATP+KLA
 NM_010368 glucuronidase, beta (Gusb), mRNA [NM_010368] KLA .65 .67 .62 .52 .52 .47 .52
ATP 1.07 1.11 .95 1.00 .80 .57 .58
KLA/ATP .72 .71 .56 .62 .52 .48 .38
Hccs
KLA  ATP  ATP+KLA
 NM_008222 holocytochrome c synthetase (Hccs), mRNA [NM_008222] KLA 1.04 1.04 .92 .70 .63 .78 1.07
ATP 1.09 1.38 1.54 1.56 1.73 1.15 1.12
KLA/ATP 1.05 1.15 .96 1.11 .88 .91 .74
Hmbs
KLA  ATP  ATP+KLA
 AK158160 adult inner ear cDNA, RIKEN full-length enriched library, clone:F930036J03 product:unclassifiable, full insert sequence. [AK158160] KLA .95 1.03 .98 .98 .94 1.01 1.06
ATP .98 1.02 1.04 .98 .87 .97 .95
KLA/ATP .99 .98 .97 .97 .94 .98 1.02
Hmbs
KLA  ATP  ATP+KLA
 NM_013551 hydroxymethylbilane synthase (Hmbs), transcript variant 1, mRNA [NM_013551] KLA .51 .49 .44 .43 .43 .57 .76
ATP .94 .95 .98 .88 .61 .35 .72
KLA/ATP .50 .46 .41 .37 .32 .31 .37
Hmox1
KLA  ATP  ATP+KLA
 NM_010442 heme oxygenase (decycling) 1 (Hmox1), mRNA [NM_010442] KLA .30 .31 .32 .45 1.00 2.36 3.22
ATP .91 .98 .96 1.24 2.53 5.47 2.27
KLA/ATP .31 .30 .40 .87 2.26 4.40 3.94
Hmox2
KLA  ATP  ATP+KLA
 NM_010443 heme oxygenase (decycling) 2 (Hmox2), mRNA [NM_010443] KLA .75 .83 .93 1.06 1.45 1.79 1.39
ATP 1.14 1.17 .88 .88 .55 .72 1.76
KLA/ATP .90 .84 .71 .93 1.00 1.22 2.44
Mm.1070
KLA  ATP  ATP+KLA
 158508616 Unknown KLA .89 .89 .78 .84 .68 .70 .71
ATP .97 .94 1.17 1.00 .76 .86 .78
KLA/ATP .86 .84 .86 .80 .67 .68 .60
Mm.28403
3
KLA  ATP  ATP+KLA
 142346469 Unknown KLA 1.00 1.00 .99 .70 .65 .78 1.02
ATP 1.01 1.31 1.54 1.67 1.61 1.02 1.08
KLA/ATP .99 1.07 .98 1.17 .84 .89 .76
Mm.30009
5
KLA  ATP  ATP+KLA
 145699117 Unknown KLA .70 .74 .85 .84 .90 .85 .90
ATP .83 .77 .93 .98 1.05 1.04 .86
KLA/ATP .72 .70 .86 .97 1.13 .80 .83
Mm.46685
9
KLA  ATP  ATP+KLA
 145699102 Unknown KLA .65 .64 .75 .87 .83 .79 .82
ATP .80 .77 .97 .86 1.13 1.05 .85
KLA/ATP .64 .65 .85 .86 1.16 .69 .72
Mmab
KLA  ATP  ATP+KLA
 NM_029956 methylmalonic aciduria (cobalamin deficiency) type B homolog (human) (Mmab), nuclear gene encoding mitochondrial protein, mRNA [NM_029956] KLA .85 .89 .82 .94 1.03 1.15 1.23
ATP 1.02 1.05 .91 .89 .60 .64 1.73
KLA/ATP .82 .87 1.15 .83 .70 .66 1.02
Ppox
KLA  ATP  ATP+KLA
 NM_008911 protoporphyrinogen oxidase (Ppox), nuclear gene encoding mitochondrial protein, mRNA [NM_008911] KLA 1.12 1.19 1.12 1.10 1.21 1.14 1.07
ATP 1.01 .86 .65 .67 .45 .71 1.09
KLA/ATP 1.28 1.00 .69 .77 .56 .69 1.08
Ugt1a1
KLA  ATP  ATP+KLA
 NM_201645 UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), mRNA [NM_201645] KLA .95 1.07 1.00 .99 .97 .98 1.02
ATP 1.08 .95 1.02 1.04 1.08 1.03 1.01
KLA/ATP 1.02 .95 .93 1.01 1.01 1.11 1.06
Ugt1a6b
KLA  ATP  ATP+KLA
 NM_201410 UDP glucuronosyltransferase 1 family, polypeptide A6B (Ugt1a6b), mRNA [NM_201410] KLA .89 .86 .93 .93 .89 .86 .89
ATP 1.10 1.05 1.15 1.07 1.01 .99 1.24
KLA/ATP .90 .94 1.02 .89 .87 .81 .92
Ugt1a9
KLA  ATP  ATP+KLA
 NM_201644 UDP glucuronosyltransferase 1 family, polypeptide A9 (Ugt1a9), mRNA [NM_201644] KLA 1.07 .96 .98 1.09 1.03 1.06 1.08
ATP 1.04 .94 1.01 1.07 1.05 1.02 1.06
KLA/ATP 1.05 1.00 .94 1.01 1.03 1.04 1.00
Ugt2a1
KLA  ATP  ATP+KLA
 NM_053184 UDP glucuronosyltransferase 2 family, polypeptide A1 (Ugt2a1), mRNA [NM_053184] KLA 1.01 1.03 .99 .99 .99 1.01 1.02
ATP 1.01 .93 1.04 1.03 1.02 1.01 1.03
KLA/ATP 1.04 1.01 1.01 1.02 1.01 1.02 1.00
Ugt2a3
KLA  ATP  ATP+KLA
 NM_028094 UDP glucuronosyltransferase 2 family, polypeptide A3 (Ugt2a3), mRNA [NM_028094] KLA 1.07 1.01 .97 1.05 1.01 .98 .99
ATP .98 .96 1.04 1.06 .95 .94 1.01
KLA/ATP 1.02 1.00 .94 1.02 1.02 1.01 1.06
Ugt2b1
KLA  ATP  ATP+KLA
 NM_152811 UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA [NM_152811] KLA 1.08 1.01 .95 1.08 1.00 1.04 .97
ATP 1.03 1.14 1.01 1.00 1.01 1.05 1.13
KLA/ATP 1.05 .99 1.06 .98 1.03 .96 .98
Ugt2b34
KLA  ATP  ATP+KLA
 NM_153598 UDP glucuronosyltransferase 2 family, polypeptide B34 (Ugt2b34), mRNA [NM_153598] KLA .98 1.08 .99 1.06 .97 1.05 1.03
ATP 1.06 1.04 .96 1.01 1.03 1.01 .99
KLA/ATP 1.09 .94 1.00 1.07 1.01 1.03 .97
Ugt2b35
KLA  ATP  ATP+KLA
 NM_172881 UDP glucuronosyltransferase 2 family, polypeptide B35 (Ugt2b35), mRNA [NM_172881] KLA .99 1.02 .99 1.01 1.00 .96 1.01
ATP .96 1.02 1.02 .96 .93 1.00 1.02
KLA/ATP 1.01 .99 1.04 1.00 .97 .93 .97
Ugt2b36
KLA  ATP  ATP+KLA
 NM_001029867 UDP glucuronosyltransferase 2 family, polypeptide B36 (Ugt2b36), mRNA [NM_001029867] KLA .95 .95 1.00 1.00 1.03 1.02 .92
ATP 1.02 1.07 1.03 .95 1.01 .93 1.00
KLA/ATP .99 1.05 .98 1.04 1.02 .98 .99
Ugt2b37
KLA  ATP  ATP+KLA
 NM_053215 UDP glucuronosyltransferase 2 family, polypeptide B37 (Ugt2b37), mRNA [NM_053215] KLA 1.02 1.06 1.04 1.05 1.00 1.05 1.03
ATP 1.01 1.03 1.08 1.01 1.05 1.02 1.05
KLA/ATP 1.01 .99 1.11 1.14 1.04 1.08 1.05
Ugt2b38
KLA  ATP  ATP+KLA
 NM_133894 UDP glucuronosyltransferase 2 family, polypeptide B38 (Ugt2b38), mRNA [NM_133894] KLA 1.00 .96 1.04 .99 1.10 .97 .99
ATP 1.02 1.04 1.03 .94 .96 .93 .99
KLA/ATP .98 .97 1.00 .97 .98 1.04 1.02
Ugt2b5
KLA  ATP  ATP+KLA
 NM_009467 UDP glucuronosyltransferase 2 family, polypeptide B5 (Ugt2b5), mRNA [NM_009467] KLA 1.01 .99 1.09 .96 .97 .99 1.01
ATP 1.03 1.02 1.02 1.01 .97 .90 .94
KLA/ATP .99 .99 .98 1.05 1.01 .93 .95
Urod
KLA  ATP  ATP+KLA
 NM_009478 uroporphyrinogen decarboxylase (Urod), mRNA [NM_009478] KLA .78 .85 .76 .71 .60 .53 .61
ATP .99 .94 1.19 1.13 .99 .97 1.27
KLA/ATP .83 .89 1.02 .99 .97 .85 1.00
Uros
KLA  ATP  ATP+KLA
 NM_009479 uroporphyrinogen III synthase (Uros), mRNA [NM_009479] KLA 1.00 1.01 .98 .92 1.01 1.30 1.36
ATP .98 .95 .95 .95 .69 .70 1.51
KLA/ATP .95 .99 .91 .90 .82 .86 1.32