Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Terpenoid backbone biosynthesis (mmu00900)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Dhdds
KLA  ATP  ATP+KLA
 NM_026144 dehydrodolichyl diphosphate synthase (Dhdds), mRNA [NM_026144] KLA .92 .98 .90 .91 .90 1.09 1.15
ATP 1.03 1.06 1.07 1.05 .75 1.01 1.31
KLA/ATP .98 1.01 .98 .96 .73 .91 1.25
Fdps
KLA  ATP  ATP+KLA
 AK077979 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030492I17 product:farnesyl diphosphate synthetase, full insert sequence. [AK077979] KLA .76 .79 .79 .69 .65 .37 .49
ATP .63 .70 .85 .30 .46 .89 .86
KLA/ATP .54 .52 .63 .39 .42 .40 .31
Fdps
KLA  ATP  ATP+KLA
 NM_134469 farnesyl diphosphate synthetase (Fdps), mRNA [NM_134469] KLA .87 .93 .89 .97 .76 .43 .48
ATP 1.12 1.10 1.05 1.23 1.05 .60 .88
KLA/ATP .93 .99 1.00 1.02 .70 .45 .33
Fnta
KLA  ATP  ATP+KLA
 NM_008033 farnesyltransferase, CAAX box, alpha (Fnta), mRNA [NM_008033] KLA .84 .92 .92 .97 1.04 1.09 .88
ATP .97 .98 .88 .92 .72 .87 .88
KLA/ATP .87 .91 .79 .82 .84 .91 .87
Fntb
KLA  ATP  ATP+KLA
 NM_145927 farnesyltransferase, CAAX box, beta (Fntb), mRNA [NM_145927] KLA 1.04 .98 1.04 1.00 .86 .86 1.02
ATP 1.02 1.09 1.00 1.10 .78 .95 .82
KLA/ATP 1.07 1.03 .97 .98 .78 .84 .81
Ggps1
KLA  ATP  ATP+KLA
 AK138564 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330064P13 product:geranylgeranyl diphosphate synthase 1, full insert sequence [AK138564] KLA 1.17 1.19 1.22 1.09 1.12 1.25 1.22
ATP 1.02 1.06 .90 .91 1.06 1.11 .92
KLA/ATP 1.23 1.10 1.10 1.19 1.22 1.09 .89
Ggps1
KLA  ATP  ATP+KLA
 NM_010282 geranylgeranyl diphosphate synthase 1 (Ggps1), mRNA [NM_010282] KLA 1.17 1.17 1.29 1.28 1.22 1.57 1.73
ATP .88 .84 .99 .85 .97 2.03 2.04
KLA/ATP 1.08 1.10 1.34 1.11 1.23 1.95 2.71
Hmgcr
KLA  ATP  ATP+KLA
 NM_008255 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 2.15 2.09 2.02 1.44 1.13 .88 1.02
ATP 1.05 1.16 1.43 1.53 1.83 2.60 1.87
KLA/ATP 2.16 2.23 1.99 1.81 1.34 1.81 1.79
Hmgcs1
KLA  ATP  ATP+KLA
 AK078743 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743] KLA 1.06 1.08 .98 .81 .88 .71 .86
ATP 1.39 1.87 10.43 2.82 1.19 1.14 1.09
KLA/ATP 1.36 1.59 5.22 1.83 1.21 .75 .66
Hmgcs1
KLA  ATP  ATP+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA 1.16 1.10 1.26 1.16 .88 .63 .69
ATP 1.01 1.10 1.87 2.36 1.98 .89 .97
KLA/ATP 1.12 1.20 1.33 1.69 1.39 .67 .51
Hmgcs2
KLA  ATP  ATP+KLA
 NM_008256 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA .92 1.10 1.00 .99 1.08 1.06 1.14
ATP .99 1.02 1.00 1.00 .98 1.08 .92
KLA/ATP .99 1.00 1.00 1.03 1.28 1.06 1.00
Icmt
KLA  ATP  ATP+KLA
 NM_133788 isoprenylcysteine carboxyl methyltransferase (Icmt), mRNA [NM_133788] KLA .74 .74 .80 .82 .74 .81 1.05
ATP 1.09 .95 .89 .97 1.16 1.01 1.24
KLA/ATP .81 .88 .83 .71 .85 .78 .92
Idi1
KLA  ATP  ATP+KLA
 NM_177960 isopentenyl-diphosphate delta isomerase (Idi1), transcript variant 2, mRNA [NM_177960] KLA 1.43 1.49 1.51 1.22 .89 .45 .52
ATP 1.02 1.06 1.43 1.32 .86 .62 1.15
KLA/ATP 1.37 1.36 1.52 1.45 .84 .35 .32
Idi2
KLA  ATP  ATP+KLA
 AK029364 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833405L16 product:weakly similar to ISOPENTENYL PYROPHOSPHATE ISOMERASE TYPE 2 (CDNA FLJ32388 FIS, CLONE SKMUS1000129, MODERATELY SIMILAR TO ISOPENTENYL-DIPHOSPHATE DELTA KLA 1.08 1.09 1.06 1.07 1.08 1.05 1.05
ATP 1.02 1.05 1.01 1.04 1.00 1.13 1.07
KLA/ATP 1.09 1.01 1.00 1.07 1.07 1.04 1.06
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mm.36322
5
KLA  ATP  ATP+KLA
 90568029 Unknown KLA 1.15 1.22 1.31 1.18 1.00 .92 1.05
ATP 1.02 1.03 1.04 1.01 .67 .98 .98
KLA/ATP 1.16 1.27 1.10 1.10 .71 .81 .65
Mvd
KLA  ATP  ATP+KLA
 NM_138656 mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA .53 .53 .53 .53 .54 .48 .81
ATP .95 .97 1.05 1.29 1.06 .87 1.80
KLA/ATP .54 .57 .60 .73 .77 .56 .47
Mvk
KLA  ATP  ATP+KLA
 NM_023556 mevalonate kinase (Mvk), mRNA [NM_023556] KLA .87 .90 .89 .91 .90 .94 .99
ATP .91 .79 .56 .59 .35 .47 1.40
KLA/ATP .89 .74 .56 .61 .43 .43 .65
Pcyox1
KLA  ATP  ATP+KLA
 NM_025823 prenylcysteine oxidase 1 (Pcyox1), mRNA [NM_025823] KLA .65 .69 .68 .72 .59 .61 .77
ATP .94 .95 1.13 .96 1.12 1.87 .88
KLA/ATP .60 .68 .81 .65 1.04 2.16 .98
Pdss1
KLA  ATP  ATP+KLA
 NM_019501 prenyl (solanesyl) diphosphate synthase, subunit 1 (Pdss1), mRNA [NM_019501] KLA 2.67 2.92 2.90 2.83 1.95 1.19 .95
ATP .93 .93 .94 .75 .56 .68 .64
KLA/ATP 2.39 2.77 2.81 2.07 1.16 .87 .57
Pdss2
KLA  ATP  ATP+KLA
 AK017329 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430420P03 product:weakly similar to CANDIDATE TUMOR SUPPRESSOR PROTEIN [Homo sapiens], full insert sequence. [AK017329] KLA 1.02 .94 1.04 1.03 .99 1.05 1.03
ATP .98 .97 .94 1.03 .98 .91 .98
KLA/ATP 1.01 .97 1.09 1.01 1.02 .93 1.03
Pmvk
KLA  ATP  ATP+KLA
 NM_026784 phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA .89 .91 .96 .99 .92 .78 .88
ATP 1.13 .98 1.07 1.10 .70 .51 1.19
KLA/ATP .94 .95 1.06 .91 .80 .44 .53
Rce1
KLA  ATP  ATP+KLA
 NM_023131 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) (Rce1), mRNA [NM_023131] KLA .84 .80 .82 .94 .95 1.23 1.26
ATP 1.01 .93 1.29 1.04 1.04 1.17 1.13
KLA/ATP .77 .83 1.14 .87 .93 .97 1.16
Zmpste24
KLA  ATP  ATP+KLA
 AK079998 adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530043O15 product:inferred: CAAX PRENYL PROTEASE 1 HOMOLOG (EC 3.4.24.-) (PRENYL PROTEIN-SPECIFIC ENDOPROTEASE 1). [Human] {Homo, full insert sequence [AK079998] KLA 1.37 1.43 1.44 1.30 1.21 1.08 1.28
ATP 1.00 .98 .75 .78 .65 .89 1.45
KLA/ATP 1.38 1.48 1.01 1.08 .71 .74 1.07
Zmpste24
KLA  ATP  ATP+KLA
 NM_172700 zinc metallopeptidase, STE24 homolog (S. cerevisiae) (Zmpste24), mRNA [NM_172700] KLA 1.06 1.05 1.06 .86 .94 .78 .87
ATP 1.20 1.20 .64 .70 .59 .56 .89
KLA/ATP 1.24 1.17 .59 .66 .41 .45 .53