Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Sulfur metabolism (mmu00920)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Bpnt1
KLA  ATP  ATP+KLA
NM_011794 bisphosphate 3-nucleotidase 1 (Bpnt1), mRNA [NM_011794] KLA 1.14 1.15 1.07 1.09 .98 .90 1.07
ATP .93 .96 1.17 1.28 1.02 1.02 1.16
KLA/ATP 1.06 1.15 1.27 1.28 1.01 .90 .85
Chst11
KLA  ATP  ATP+KLA
NM_021439 carbohydrate sulfotransferase 11 (Chst11), mRNA [NM_021439] KLA 1.26 1.30 1.19 1.08 1.28 1.35 .63
ATP 1.05 1.23 1.16 1.10 2.16 4.45 2.87
KLA/ATP 1.48 1.47 1.17 1.21 1.51 3.33 3.04
Chst12
KLA  ATP  ATP+KLA
NM_021528 carbohydrate sulfotransferase 12 (Chst12), mRNA [NM_021528] KLA .30 .28 .31 .45 .65 .78 .81
ATP 1.09 1.12 1.17 1.01 .59 1.01 1.06
KLA/ATP .28 .31 .37 .40 .65 .95 1.20
Chst13
KLA  ATP  ATP+KLA
XM_978459 gb|PREDICTED: Mus musculus carbohydrate (chondroitin 4) sulfotransferase 13 (Chst13), mRNA [XM_978459] KLA .89 1.03 .99 1.02 .98 .99 .97
ATP .99 1.03 1.00 .99 .98 .89 .97
KLA/ATP .99 1.00 .99 .96 .97 .99 .99
Impad1
KLA  ATP  ATP+KLA
AK147096 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920165A15 product:hypothetical protein, full insert sequence [AK147096] KLA 1.24 1.16 1.08 .87 .84 .79 .67
ATP 1.01 .98 .87 .50 1.58 1.49 .50
KLA/ATP 1.17 1.08 .95 .59 1.31 .99 .41
Impad1
KLA  ATP  ATP+KLA
NM_177730 inositol monophosphatase domain containing 1 (Impad1), mRNA [NM_177730] KLA 1.83 1.73 1.69 1.97 1.48 1.27 1.26
ATP 1.04 .91 .89 .57 1.14 3.17 2.06
KLA/ATP 1.67 1.65 1.64 .98 1.14 2.21 3.24
Papss1
KLA  ATP  ATP+KLA
NM_011863 3-phosphoadenosine 5-phosphosulfate synthase 1 (Papss1), mRNA [NM_011863] KLA .86 .95 .84 .89 .77 .70 .81
ATP .99 1.02 1.06 1.10 .74 .64 .75
KLA/ATP .93 .89 .86 .93 .68 .56 .69
Papss2
KLA  ATP  ATP+KLA
AK029185 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831410G12 product:3-phosphoadenosine 5-phosphosulfate synthase 2, full insert sequence. [AK029185] KLA 1.04 1.07 .97 .95 1.08 1.07 .94
ATP .96 1.01 1.00 1.02 .96 1.01 .97
KLA/ATP .99 1.01 1.02 1.11 1.01 .98 1.02
Papss2
KLA  ATP  ATP+KLA
NM_011864 3-phosphoadenosine 5-phosphosulfate synthase 2 (Papss2), mRNA [NM_011864] KLA 1.72 1.84 1.85 1.50 1.56 1.01 1.14
ATP 1.07 1.14 1.07 1.00 1.19 1.75 1.07
KLA/ATP 1.64 1.73 1.57 1.58 1.46 1.54 1.10
Sult1a1
KLA  ATP  ATP+KLA
NM_133670 sulfotransferase family 1A, phenol-preferring, member 1 (Sult1a1), mRNA [NM_133670] KLA .66 .67 .66 .63 .44 .28 .09
ATP .96 .88 .95 .99 .73 .30 .08
KLA/ATP .66 .63 .70 .71 .62 .34 .10
Sult1e1
KLA  ATP  ATP+KLA
NM_023135 sulfotransferase family 1E, member 1 (Sult1e1), mRNA [NM_023135] KLA .98 1.00 1.01 1.03 .98 1.02 1.05
ATP 1.03 .99 1.05 1.06 1.00 .94 1.04
KLA/ATP 1.00 .99 .92 .97 .98 1.00 .96
Sult2b1
KLA  ATP  ATP+KLA
NM_017465 sulfotransferase family, cytosolic, 2B, member 1 (Sult2b1), mRNA [NM_017465] KLA .99 .94 .94 .97 .97 .94 .91
ATP .95 1.02 .99 .98 1.07 1.07 .94
KLA/ATP .91 1.00 1.03 .94 1.06 1.23 1.06
Suox
KLA  ATP  ATP+KLA
NM_173733 sulfite oxidase (Suox), nuclear gene encoding mitochondrial protein, mRNA [NM_173733] KLA .52 .46 .44 .46 .40 .38 .37
ATP .89 .80 1.38 .98 .56 1.02 .94
KLA/ATP .43 .47 .67 .52 .59 .86 .58