Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Aminoacyl-tRNA biosynthesis (mmu00970)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aars
KLA  ATP  ATP+KLA
 AK036738 adult male bone cDNA, RIKEN full-length enriched library, clone:9830169C09 product:alanyl-tRNA synthetase, full insert sequence. [AK036738] KLA .84 .81 .84 .96 1.16 1.43 1.37
ATP 1.04 .82 .71 .97 1.90 1.10 1.39
KLA/ATP .82 .72 .77 .90 1.52 1.19 1.39
Aars
KLA  ATP  ATP+KLA
 NM_146217 alanyl-tRNA synthetase (Aars), mRNA [NM_146217] KLA 1.06 1.13 1.05 .99 1.16 1.94 2.23
ATP .95 .97 .85 .84 1.83 2.37 2.21
KLA/ATP 1.17 1.12 .90 .93 1.47 2.59 3.05
Aars2
KLA  ATP  ATP+KLA
 NM_198608 alanyl-tRNA synthetase 2, mitochondrial (putative) (Aars2), nuclear gene encoding mitochondrial protein, mRNA [NM_198608] KLA .78 .79 .75 .77 .77 .80 1.15
ATP .94 .94 1.09 1.15 .83 1.08 1.09
KLA/ATP .74 .84 .89 .89 .77 .98 .75
AK052744
KLA  ATP  ATP+KLA
 AK052744 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630041L13 product:similar to ALARS A [Caenorhabditis elegans], full insert sequence. [AK052744] KLA .93 .92 .90 .96 1.06 1.20 1.19
ATP .81 .74 .88 1.02 1.68 .97 1.16
KLA/ATP .85 .76 .86 1.01 1.39 1.10 1.19
Cars
KLA  ATP  ATP+KLA
 NM_013742 cysteinyl-tRNA synthetase (Cars), mRNA [NM_013742] KLA 1.00 1.01 .92 .91 1.21 1.59 1.72
ATP 1.06 1.11 .93 1.10 2.20 1.79 1.77
KLA/ATP 1.04 1.13 1.03 1.05 1.45 1.75 2.39
Cars2
KLA  ATP  ATP+KLA
 XM_001474115 gb|PREDICTED: Mus musculus cysteinyl-tRNA synthetase 2 (mitochondrial)(putative) (Cars2), mRNA [XM_001474115] KLA .68 .68 .63 .63 .69 .81 .93
ATP .92 .90 .75 .80 .74 .63 .85
KLA/ATP .70 .67 .67 .67 .60 .60 .59
Dars
KLA  ATP  ATP+KLA
 AK051206 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130016F08 product:unclassifiable, full insert sequence. [AK051206] KLA .80 .76 .66 .76 .73 .75 .81
ATP .97 .94 .91 .72 .78 .75 .89
KLA/ATP .72 .73 .67 .81 .78 .70 .76
Dars
KLA  ATP  ATP+KLA
 NM_177445 aspartyl-tRNA synthetase (Dars), mRNA [NM_177445] KLA .92 .98 .82 .64 .45 .38 .74
ATP .96 1.20 1.08 1.27 .76 .31 .60
KLA/ATP .84 .89 .73 .93 .49 .26 .27
Dars2
KLA  ATP  ATP+KLA
 NM_172644 aspartyl-tRNA synthetase 2 (mitochondrial) (Dars2), nuclear gene encoding mitochondrial protein, mRNA [NM_172644] KLA .68 .67 .70 .73 .68 .75 .75
ATP .81 .68 .54 .38 .34 .91 .92
KLA/ATP .64 .50 .45 .40 .48 .93 .98
Ears2
KLA  ATP  ATP+KLA
 AK129469 mRNA for mKIAA1970 protein [AK129469] KLA .84 .88 .83 .81 .86 .92 .97
ATP .98 .97 .85 .85 .90 .92 .86
KLA/ATP .85 .84 .85 .97 .90 .95 .90
Ears2
KLA  ATP  ATP+KLA
 NM_026140 glutamyl-tRNA synthetase 2 (mitochondrial)(putative) (Ears2), nuclear gene encoding mitochondrial protein, mRNA [NM_026140] KLA .75 .73 .71 .69 .75 .84 1.22
ATP 1.12 1.02 .87 .70 .41 .53 .83
KLA/ATP .79 .84 .72 .56 .42 .38 .44
Eprs
KLA  ATP  ATP+KLA
 NM_029735 glutamyl-prolyl-tRNA synthetase (Eprs), mRNA [NM_029735] KLA .91 .97 .84 .80 .73 .74 1.32
ATP .97 1.13 1.17 1.10 1.19 .83 1.03
KLA/ATP .95 .98 .91 .76 .72 .61 .70
Fars2
KLA  ATP  ATP+KLA
 NM_024274 phenylalanine-tRNA synthetase 2 (mitochondrial) (Fars2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_024274] KLA .94 .95 .99 .89 .91 1.06 1.16
ATP 1.02 .97 1.00 1.21 1.30 1.57 1.24
KLA/ATP .95 1.00 .98 .95 .82 .96 1.11
Farsa
KLA  ATP  ATP+KLA
 NM_025648 phenylalanyl-tRNA synthetase, alpha subunit (Farsa), mRNA [NM_025648] KLA 1.55 1.70 1.76 1.69 1.49 1.07 1.20
ATP 1.05 1.09 .91 1.22 .98 .85 .95
KLA/ATP 1.78 1.77 1.63 2.11 1.56 .85 .67
Farsb
KLA  ATP  ATP+KLA
 NM_011811 phenylalanyl-tRNA synthetase, beta subunit (Farsb), mRNA [NM_011811] KLA .78 .82 .77 .63 .55 .55 .93
ATP 1.04 1.16 1.06 1.18 .99 .46 .74
KLA/ATP .87 .80 .65 .82 .59 .34 .25
Gars
KLA  ATP  ATP+KLA
 NM_180678 glycyl-tRNA synthetase (Gars), mRNA [NM_180678] KLA 1.16 1.31 1.23 1.14 1.14 1.24 1.54
ATP 1.07 1.18 .94 1.17 1.44 1.08 1.11
KLA/ATP 1.44 1.37 1.04 1.38 1.02 .91 1.03
Hars
KLA  ATP  ATP+KLA
 AK077437 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730408P20 product:histidyl tRNA synthetase, full insert sequence. [AK077437] KLA .86 .80 .95 .80 1.04 .98 1.10
ATP .86 .68 .62 .69 1.85 1.47 1.01
KLA/ATP .82 .65 .66 .70 1.36 1.46 .84
Hars
KLA  ATP  ATP+KLA
 NM_008214 histidyl-tRNA synthetase (Hars), mRNA [NM_008214] KLA 1.03 1.10 1.08 .96 .91 .87 1.05
ATP .97 1.05 1.08 1.13 .98 1.01 .93
KLA/ATP 1.05 1.15 1.11 1.17 .95 .88 .63
Hars2
KLA  ATP  ATP+KLA
 NM_080636 histidyl-tRNA synthetase 2, mitochondrial (putative) (Hars2), nuclear gene encoding mitochondrial protein, mRNA [NM_080636] KLA 1.02 .97 .98 1.00 1.08 1.10 1.21
ATP .88 .89 .94 .85 .77 1.11 1.19
KLA/ATP .90 .89 1.00 .85 .95 1.02 1.17
Iars
KLA  ATP  ATP+KLA
 AK010975 13 days embryo liver cDNA, RIKEN full-length enriched library, clone:2510016L12 product:unclassifiable, full insert sequence. [AK010975] KLA .77 .78 .63 .74 .85 .84 .88
ATP 1.07 1.07 .74 .73 1.13 .82 .97
KLA/ATP .79 .73 .72 .74 .84 .72 .75
Iars
KLA  ATP  ATP+KLA
 NM_172015 isoleucine-tRNA synthetase (Iars), mRNA [NM_172015] KLA .78 .81 .68 .52 .42 .50 .71
ATP .97 1.06 1.03 1.00 1.16 .69 .68
KLA/ATP .85 .84 .67 .66 .47 .31 .29
Iars2
KLA  ATP  ATP+KLA
 AK043729 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830026B15 product:similar to MITOCHONDRIAL ISOLEUCINE TRNA SYNTHETASE (FRAGMENT) [Homo sapiens], full insert sequence. [AK043729] KLA .87 .80 .83 .88 .81 .80 .99
ATP 1.04 1.17 1.39 1.12 1.03 .84 .94
KLA/ATP .83 .80 .85 .93 .80 .75 .68
Iars2
KLA  ATP  ATP+KLA
 AK078172 adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430402E09 product:unclassifiable, full insert sequence. [AK078172] KLA .86 .81 .74 .68 .73 .76 .78
ATP 1.00 .96 .89 .94 1.00 .80 .65
KLA/ATP .87 .74 .78 .74 .88 .83 .63
Iars2
KLA  ATP  ATP+KLA
 NM_198653 isoleucine-tRNA synthetase 2, mitochondrial (Iars2), nuclear gene encoding mitochondrial protein, mRNA [NM_198653] KLA .94 .87 .80 .75 .68 .68 1.08
ATP 1.11 1.19 .95 .95 .78 .53 1.02
KLA/ATP .92 .96 .87 .77 .55 .49 .64
Kars
KLA  ATP  ATP+KLA
 NM_053092 lysyl-tRNA synthetase (Kars), mRNA [NM_053092] KLA 1.65 1.76 1.79 1.66 1.69 1.37 1.19
ATP 1.01 1.06 .95 1.20 .99 .82 .91
KLA/ATP 1.73 1.79 1.62 2.00 1.49 1.44 1.20
Lars
KLA  ATP  ATP+KLA
 NM_134137 leucyl-tRNA synthetase (Lars), mRNA [NM_134137] KLA 1.00 .98 .76 .78 .68 .76 .96
ATP .99 .94 1.17 .85 .90 .62 .96
KLA/ATP .88 .98 1.09 .78 .68 .54 .65
Lars2
KLA  ATP  ATP+KLA
 NM_153168 leucyl-tRNA synthetase, mitochondrial (Lars2), nuclear gene encoding mitochondrial protein, mRNA [NM_153168] KLA 1.01 .85 1.13 1.07 1.05 1.34 .86
ATP 1.02 1.02 1.18 .89 1.14 1.59 1.26
KLA/ATP 1.08 1.07 1.39 1.14 1.44 2.13 1.67
Mars
KLA  ATP  ATP+KLA
 NM_001003913 methionine-tRNA synthetase (Mars), mRNA [NM_001003913] KLA .82 .84 .78 .65 .59 .79 1.13
ATP .92 .99 1.04 1.19 1.17 .87 1.42
KLA/ATP .86 .83 .85 .85 .74 .76 1.06
Mars2
KLA  ATP  ATP+KLA
 NM_175439 methionine-tRNA synthetase 2 (mitochondrial) (Mars2), nuclear gene encoding mitochondrial protein, mRNA [NM_175439] KLA .55 .60 .56 .53 .52 .61 .83
ATP .91 .85 .65 .48 .79 .71 1.01
KLA/ATP .55 .56 .53 .45 .47 .62 .61
Mm.28173
KLA  ATP  ATP+KLA
 51491851 Unknown KLA .67 .68 .50 .52 .39 .62 .93
ATP .89 .83 1.21 .91 1.09 .95 1.27
KLA/ATP .61 .61 .75 .54 .63 .63 .88
Mm.28270
0
KLA  ATP  ATP+KLA
 18079342 Unknown KLA 1.05 1.05 .96 1.07 1.27 1.17 1.31
ATP .96 .92 1.02 .71 .78 1.37 1.49
KLA/ATP 1.05 .92 1.11 .82 .89 1.38 1.40
Mtfmt
KLA  ATP  ATP+KLA
 NM_027134 mitochondrial methionyl-tRNA formyltransferase (Mtfmt), nuclear gene encoding mitochondrial protein, mRNA [NM_027134] KLA .87 .84 .86 .93 .93 1.02 .98
ATP .88 .89 .83 .32 .86 1.29 .97
KLA/ATP .80 .80 .85 .33 1.01 1.28 .95
Nars
KLA  ATP  ATP+KLA
 NM_027350 asparaginyl-tRNA synthetase (Nars), mRNA [NM_027350] KLA .88 .90 .80 .69 .66 .74 1.13
ATP 1.04 1.22 .97 1.17 1.41 1.18 .89
KLA/ATP .98 .98 .60 .85 .69 .79 .56
Nars2
KLA  ATP  ATP+KLA
 NM_153591 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) (Nars2), nuclear gene encoding mitochondrial protein, mRNA [NM_153591] KLA .83 .81 .73 .72 .68 .71 .90
ATP .90 .77 .82 .65 .71 .75 .94
KLA/ATP .77 .69 .64 .64 .64 .70 .75
Pars2
KLA  ATP  ATP+KLA
 NM_172272 prolyl-tRNA synthetase (mitochondrial)(putative) (Pars2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_172272] KLA .74 .70 .76 .85 .99 1.04 .98
ATP 1.03 .97 .73 .52 .50 .90 1.01
KLA/ATP .70 .75 .66 .58 .62 1.05 .97
Pstk
KLA  ATP  ATP+KLA
 AK017332 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430423O14 product:unclassifiable, full insert sequence. [AK017332] KLA .57 .54 .54 .59 .71 .59 .77
ATP .68 .50 .48 .40 .52 .63 .84
KLA/ATP .45 .47 .50 .49 .56 .53 .50
Pstk
KLA  ATP  ATP+KLA
 NM_001039534 phosphoseryl-tRNA kinase (Pstk), mRNA [NM_001039534] KLA .46 .46 .41 .45 .47 .54 .88
ATP .93 .81 1.00 .82 .49 .55 .77
KLA/ATP .43 .42 .48 .47 .41 .45 .36
Qars
KLA  ATP  ATP+KLA
 AK161817 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030468K12 product:hypothetical protein, full insert sequence. [AK161817] KLA .86 .79 .83 .83 1.06 .97 .92
ATP .94 .84 .70 .71 1.19 1.03 .94
KLA/ATP .79 .73 .77 .73 1.06 .96 .90
Qars
KLA  ATP  ATP+KLA
 NM_133794 glutaminyl-tRNA synthetase (Qars), mRNA [NM_133794] KLA .78 .80 .80 .70 .70 .73 .76
ATP 1.09 1.06 .92 .98 .86 .83 .80
KLA/ATP .87 .84 .71 .71 .59 .78 .73
Rars
KLA  ATP  ATP+KLA
 NM_025936 arginyl-tRNA synthetase (Rars), mRNA [NM_025936] KLA 1.89 2.10 2.44 2.17 1.88 1.70 1.19
ATP 1.09 1.12 1.09 1.52 2.22 1.33 1.37
KLA/ATP 2.15 2.45 2.05 2.62 2.38 1.86 1.02
Rars2
KLA  ATP  ATP+KLA
 NM_181406 arginyl-tRNA synthetase 2, mitochondrial (putative) (Rars2), nuclear gene encoding mitochondrial protein, mRNA [NM_181406] KLA .94 .99 .95 .92 .90 .89 1.02
ATP .94 .95 1.01 1.01 .57 .45 .87
KLA/ATP .93 .97 .94 .92 .67 .44 .47
Sars
KLA  ATP  ATP+KLA
 NM_011319 seryl-aminoacyl-tRNA synthetase (Sars), mRNA [NM_011319] KLA .68 .63 .51 .51 .58 .70 1.25
ATP 1.14 1.29 1.08 1.19 1.18 1.04 1.42
KLA/ATP .62 .69 .63 .69 .60 .76 1.22
Sars2
KLA  ATP  ATP+KLA
 NM_023637 seryl-aminoacyl-tRNA synthetase 2 (Sars2), mRNA [NM_023637] KLA 1.02 1.14 1.09 1.09 1.02 .92 1.16
ATP .96 1.07 .95 1.32 .83 .75 .79
KLA/ATP 1.19 1.25 1.10 1.39 .98 .91 .83
Sepsecs
KLA  ATP  ATP+KLA
 AK088165 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430005G07 product:unclassifiable, full insert sequence. [AK088165] KLA .92 .97 1.01 .94 .96 .93 .95
ATP 1.01 1.04 1.04 1.15 1.01 1.03 .94
KLA/ATP 1.02 1.01 .92 1.04 .89 .91 .77
Sepsecs
KLA  ATP  ATP+KLA
 NM_172490 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (Sepsecs), mRNA [NM_172490] KLA 1.29 1.33 1.42 1.25 1.15 1.02 1.29
ATP 1.09 1.14 .97 .88 1.09 1.22 1.52
KLA/ATP 1.38 1.53 1.26 1.05 .80 .97 1.41
Tars
KLA  ATP  ATP+KLA
 NM_033074 threonyl-tRNA synthetase (Tars), mRNA [NM_033074] KLA .89 .95 .73 .74 .68 .83 1.36
ATP 1.01 1.02 1.04 .97 1.48 1.11 1.03
KLA/ATP .87 .92 .94 .73 .73 .77 .61
Tars2
KLA  ATP  ATP+KLA
 NM_027931 threonyl-tRNA synthetase 2, mitochondrial (putative) (Tars2), nuclear gene encoding mitochondrial protein, mRNA [NM_027931] KLA .71 .71 .71 .60 .52 .46 .75
ATP 1.01 1.01 .92 .92 .66 .66 .88
KLA/ATP .79 .75 .72 .67 .60 .85 .56
Tarsl2
KLA  ATP  ATP+KLA
 NM_172310 threonyl-tRNA synthetase-like 2 (Tarsl2), mRNA [NM_172310] KLA .61 .65 .59 .50 .38 .36 .49
ATP 1.01 1.11 1.03 .93 .70 .47 .38
KLA/ATP .65 .63 .61 .54 .51 .49 .32
Vars
KLA  ATP  ATP+KLA
 NM_011690 valyl-tRNA synthetase (Vars), mRNA [NM_011690] KLA .88 .87 .88 .75 .68 .52 .58
ATP 1.14 1.26 .93 1.46 .99 .42 .44
KLA/ATP 1.10 1.06 .70 1.09 .61 .46 .29
Vars2
KLA  ATP  ATP+KLA
 NM_175137 valyl-tRNA synthetase 2, mitochondrial (putative) (Vars2), nuclear gene encoding mitochondrial protein, mRNA [NM_175137] KLA .70 .68 .67 .60 .62 .62 .80
ATP 1.08 1.07 .97 .79 .54 .56 .60
KLA/ATP .68 .70 .65 .59 .48 .43 .42
Wars
KLA  ATP  ATP+KLA
 NM_011710 tryptophanyl-tRNA synthetase (Wars), mRNA [NM_011710] KLA 3.36 3.58 4.27 3.49 4.17 3.19 1.61
ATP 1.05 1.10 .69 .82 .82 1.40 1.23
KLA/ATP 3.60 3.70 2.53 3.30 2.26 3.29 2.10
Wars2
KLA  ATP  ATP+KLA
 NM_027462 tryptophanyl tRNA synthetase 2 (mitochondrial) (Wars2), nuclear gene encoding mitochondrial protein, mRNA [NM_027462] KLA 1.16 1.20 1.11 1.07 1.01 .98 1.04
ATP 1.02 1.00 1.03 1.01 1.05 .95 .97
KLA/ATP 1.24 1.20 1.06 1.01 1.09 1.01 .84
Yars
KLA  ATP  ATP+KLA
 NM_134151 tyrosyl-tRNA synthetase (Yars), mRNA [NM_134151] KLA .80 .80 .71 .61 .60 .79 1.15
ATP 1.06 1.13 .97 1.13 1.22 .77 1.25
KLA/ATP .85 .85 .66 .79 .62 .47 .63
Yars2
KLA  ATP  ATP+KLA
 AK083653 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030059N20 product:similar to CDNA FLJ13995 FIS, CLONE Y79AA1002209, WEAKLY SIMILAR TO TYROSYL-TRNA SYNTHETASE (EC 6.1.1.1) (HYPOTHETICAL 53.2 KDA PROTEIN) [Homo sap KLA .93 .83 .81 .80 .76 .84 1.10
ATP .93 .80 .75 .82 .80 .94 .93
KLA/ATP .87 .80 .70 .68 .70 .79 .78
Yars2
KLA  ATP  ATP+KLA
 NM_198246 tyrosyl-tRNA synthetase 2 (mitochondrial) (Yars2), nuclear gene encoding mitochondrial protein, mRNA [NM_198246] KLA .93 .94 .90 .77 .64 .68 1.02
ATP 1.07 1.04 1.15 1.14 .87 .88 .85
KLA/ATP .98 .90 .90 .88 .72 .58 .49