Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Drug metabolism - other enzymes (mmu00983)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2210023G
05Rik
KLA  ATP  ATP+KLA
 NM_197999 RIKEN cDNA 2210023G05 gene (2210023G05Rik), mRNA [NM_197999] KLA 1.00 1.06 1.03 1.00 1.03 .99 1.06
ATP 1.03 1.04 .99 1.08 1.03 1.04 1.04
KLA/ATP .95 1.00 .91 1.06 1.06 1.02 1.01
Cda
KLA  ATP  ATP+KLA
 NM_028176 cytidine deaminase (Cda), mRNA [NM_028176] KLA .92 .97 .89 .86 .87 .85 .88
ATP 1.08 1.11 1.00 1.40 1.40 1.04 1.09
KLA/ATP .98 .95 .90 .96 .88 .93 .97
Ces2
KLA  ATP  ATP+KLA
 NM_145603 carboxylesterase 2 (Ces2), mRNA [NM_145603] KLA 1.01 1.00 1.03 1.00 1.01 .96 1.03
ATP 1.00 1.01 1.01 1.00 .99 1.03 1.02
KLA/ATP 1.01 1.00 1.04 .98 1.02 1.01 .97
Ces3
KLA  ATP  ATP+KLA
 NM_053200 carboxylesterase 3 (Ces3), mRNA [NM_053200] KLA 1.04 .95 .92 1.03 1.00 1.02 .88
ATP 1.02 .98 1.01 .95 .99 1.01 .98
KLA/ATP 1.02 .93 1.03 .97 1.05 1.00 1.01
Ces5
KLA  ATP  ATP+KLA
 NM_172759 carboxylesterase 5 (Ces5), mRNA [NM_172759] KLA .96 1.00 .98 1.00 1.01 1.02 1.01
ATP 1.05 .99 1.06 1.06 1.02 1.03 1.01
KLA/ATP 1.00 .96 1.09 1.09 1.03 1.05 1.01
Ces6
KLA  ATP  ATP+KLA
 NM_133960 carboxylesterase 6 (Ces6), mRNA [NM_133960] KLA .97 1.00 1.02 .96 .99 .97 .96
ATP 1.03 .98 .96 .97 1.01 1.02 1.02
KLA/ATP .99 1.02 .94 .99 .92 .90 1.01
Cyp2a12
KLA  ATP  ATP+KLA
 NM_133657 cytochrome P450, family 2, subfamily a, polypeptide 12 (Cyp2a12), mRNA [NM_133657] KLA 1.03 1.08 1.00 .98 1.00 1.03 1.03
ATP 1.01 .98 1.03 1.08 1.02 .99 1.01
KLA/ATP .97 1.01 .97 1.06 1.03 1.03 .99
Cyp2a4
KLA  ATP  ATP+KLA
 NM_009997 cytochrome P450, family 2, subfamily a, polypeptide 4 (Cyp2a4), mRNA [NM_009997] KLA 1.02 .99 1.00 1.00 .98 1.04 1.01
ATP 1.01 1.00 1.01 1.03 .99 1.01 .99
KLA/ATP 1.03 1.03 1.01 1.04 .98 1.03 1.01
Cyp2a5
KLA  ATP  ATP+KLA
 NM_007812 cytochrome P450, family 2, subfamily a, polypeptide 5 (Cyp2a5), mRNA [NM_007812] KLA 1.04 .95 .95 1.02 1.01 .94 1.06
ATP 1.03 .95 1.05 1.08 .99 .97 1.03
KLA/ATP 1.01 1.06 .92 1.08 1.05 1.01 1.01
Cyp3a11
KLA  ATP  ATP+KLA
 NM_007818 cytochrome P450, family 3, subfamily a, polypeptide 11 (Cyp3a11), mRNA [NM_007818] KLA .96 .94 1.06 1.04 .96 .94 .97
ATP 1.00 1.01 .94 .95 .94 .92 .98
KLA/ATP .98 1.06 1.06 .98 .88 .93 .91
Cyp3a13
KLA  ATP  ATP+KLA
 NM_007819 cytochrome P450, family 3, subfamily a, polypeptide 13 (Cyp3a13), mRNA [NM_007819] KLA .99 .98 .98 1.03 .97 1.01 1.07
ATP 1.00 1.01 1.01 1.04 1.01 .99 1.00
KLA/ATP 1.06 1.01 1.00 1.08 1.09 1.01 1.09
Cyp3a16
KLA  ATP  ATP+KLA
 NM_007820 cytochrome P450, family 3, subfamily a, polypeptide 16 (Cyp3a16), mRNA [NM_007820] KLA .95 .99 .96 .96 1.00 1.03 .99
ATP 1.04 1.03 .98 .97 .98 1.03 1.01
KLA/ATP .96 .91 .96 .97 1.03 1.00 1.04
Cyp3a25
KLA  ATP  ATP+KLA
 NM_019792 cytochrome P450, family 3, subfamily a, polypeptide 25 (Cyp3a25), mRNA [NM_019792] KLA 1.00 .96 1.01 1.04 .99 .99 1.01
ATP 1.01 1.02 .97 1.01 1.02 .93 .95
KLA/ATP .97 1.09 1.04 1.01 .99 .97 .97
Cyp3a41a
KLA  ATP  ATP+KLA
 NM_017396 cytochrome P450, family 3, subfamily a, polypeptide 41A (Cyp3a41a), mRNA [NM_017396] KLA 1.02 .99 .98 .95 .93 .93 1.06
ATP 1.00 .96 1.02 .97 .97 .95 1.02
KLA/ATP 1.03 1.02 1.07 .97 .93 .97 .97
Cyp3a44
KLA  ATP  ATP+KLA
 NM_177380 cytochrome P450, family 3, subfamily a, polypeptide 44 (Cyp3a44), mRNA [NM_177380] KLA 1.05 1.03 1.05 1.02 1.08 1.00 1.03
ATP .97 1.00 1.03 1.07 .99 .99 .99
KLA/ATP 1.04 .99 .99 1.06 1.04 1.06 1.00
Dpyd
KLA  ATP  ATP+KLA
 NM_170778 dihydropyrimidine dehydrogenase (Dpyd), mRNA [NM_170778] KLA .94 .95 1.00 .98 .99 .98 .97
ATP 1.04 .95 1.02 1.01 1.02 1.02 .98
KLA/ATP 1.03 .98 .98 1.02 1.02 1.05 .93
Es1
KLA  ATP  ATP+KLA
 NM_007954 esterase 1 (Es1), mRNA [NM_007954] KLA 1.02 1.01 .99 1.03 1.03 1.00 1.03
ATP .98 1.03 1.05 1.00 .97 1.03 1.05
KLA/ATP 1.02 1.01 .99 1.03 1.00 1.01 .99
Es22
KLA  ATP  ATP+KLA
 NM_133660 esterase 22 (Es22), mRNA [NM_133660] KLA 1.14 1.11 1.11 1.11 1.03 1.00 1.00
ATP 1.01 .94 1.00 .95 1.01 .97 .96
KLA/ATP 1.05 1.13 1.08 1.01 1.00 1.00 1.02
Gmps
KLA  ATP  ATP+KLA
 NM_001033300 guanine monphosphate synthetase (Gmps), mRNA [NM_001033300] KLA 1.04 1.13 1.05 .91 .79 .75 .96
ATP 1.12 1.17 1.01 1.24 .99 1.02 .82
KLA/ATP 1.18 1.08 .92 1.11 .86 .94 .62
Gusb
KLA  ATP  ATP+KLA
 NM_010368 glucuronidase, beta (Gusb), mRNA [NM_010368] KLA .65 .67 .62 .52 .52 .47 .52
ATP 1.07 1.11 .95 1.00 .80 .57 .58
KLA/ATP .72 .71 .56 .62 .52 .48 .38
Hprt1
KLA  ATP  ATP+KLA
 NM_013556 hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1), mRNA [NM_013556] KLA .82 .77 .81 .79 .53 .43 .39
ATP .97 .89 1.40 .89 .82 .68 .25
KLA/ATP .73 .69 1.09 .68 .66 .42 .13
Impdh1
KLA  ATP  ATP+KLA
 NM_011829 inosine 5-phosphate dehydrogenase 1 (Impdh1), mRNA [NM_011829] KLA 1.03 .99 .86 .89 .71 .52 .55
ATP .89 .81 .82 .81 .90 1.01 .85
KLA/ATP .91 .79 .76 .83 .90 .99 .64
Impdh2
KLA  ATP  ATP+KLA
 NM_011830 inosine 5-phosphate dehydrogenase 2 (Impdh2), mRNA [NM_011830] KLA .88 .92 .76 .67 .48 .46 .62
ATP 1.07 1.12 .90 1.26 1.15 .82 .48
KLA/ATP .97 .98 .81 .98 .79 .61 .33
Itpa
KLA  ATP  ATP+KLA
 NM_025922 inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), mRNA [NM_025922] KLA 1.02 .96 1.01 1.18 1.37 1.83 1.44
ATP .96 .93 1.08 .95 .92 1.66 1.38
KLA/ATP .86 .94 1.20 1.08 1.28 2.15 2.45
Mm.26580
KLA  ATP  ATP+KLA
 37574079 Unknown KLA 1.07 1.00 1.03 1.03 .99 .95 1.00
ATP 1.01 .99 .90 1.05 1.01 1.00 .97
KLA/ATP 1.02 .89 1.05 .97 1.02 .98 .95
Mm.30009
5
KLA  ATP  ATP+KLA
 145699117 Unknown KLA .70 .74 .85 .84 .90 .85 .90
ATP .83 .77 .93 .98 1.05 1.04 .86
KLA/ATP .72 .70 .86 .97 1.13 .80 .83
Mm.38984
8
KLA  ATP  ATP+KLA
 116268117 Unknown KLA .98 1.02 1.01 1.05 .97 .97 .96
ATP .95 1.01 1.04 1.14 .99 .91 1.01
KLA/ATP 1.08 .92 1.02 1.00 .97 .97 .99
Mm.4610
KLA  ATP  ATP+KLA
 142375308 Unknown KLA 18.33 19.27 25.23 27.01 26.13 21.96 6.28
ATP .93 .96 1.25 1.62 4.21 13.24 6.23
KLA/ATP 18.14 20.17 25.25 25.64 23.63 21.18 26.75
Mm.46685
9
KLA  ATP  ATP+KLA
 145699102 Unknown KLA .65 .64 .75 .87 .83 .79 .82
ATP .80 .77 .97 .86 1.13 1.05 .85
KLA/ATP .64 .65 .85 .86 1.16 .69 .72
Mm.47209
5
KLA  ATP  ATP+KLA
 85861217 Unknown KLA .81 .77 .71 .75 .70 .72 .87
ATP 1.08 1.12 .79 .80 .68 .62 .59
KLA/ATP .86 .83 .56 .66 .56 .63 .57
Nat1
KLA  ATP  ATP+KLA
 NM_008673 N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1), mRNA [NM_008673] KLA .97 .98 1.00 .94 1.01 .95 1.02
ATP 1.03 .96 1.01 1.04 1.03 .99 1.01
KLA/ATP 1.03 .98 .94 1.00 .99 1.05 .86
Nat2
KLA  ATP  ATP+KLA
 NM_010874 N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2), mRNA [NM_010874] KLA 3.59 3.77 3.60 2.69 2.11 2.24 1.44
ATP .96 .91 .74 .42 .39 1.32 1.45
KLA/ATP 3.43 3.33 2.84 1.60 .89 2.12 2.09
Nat3
KLA  ATP  ATP+KLA
 NM_008674 N-acetyltransferase 3 (Nat3), mRNA [NM_008674] KLA 1.00 1.06 1.05 1.02 1.07 1.05 1.11
ATP .98 .99 1.05 1.05 1.04 1.02 1.11
KLA/ATP 1.03 .95 .96 1.03 .96 1.04 .99
Tk1
KLA  ATP  ATP+KLA
 NM_009387 thymidine kinase 1 (Tk1), mRNA [NM_009387] KLA .36 .36 .31 .23 .18 .15 .14
ATP 1.04 1.13 .91 1.21 .52 .15 .09
KLA/ATP .39 .35 .29 .35 .22 .14 .11
Tk2
KLA  ATP  ATP+KLA
 NM_021028 thymidine kinase 2, mitochondrial (Tk2), nuclear gene encoding mitochondrial protein, mRNA [NM_021028] KLA .49 .53 .48 .66 .84 1.01 .86
ATP 1.07 1.02 .91 .96 .52 .41 .73
KLA/ATP .51 .48 .44 .46 .44 .56 .75
Tpmt
KLA  ATP  ATP+KLA
 NM_016785 thiopurine methyltransferase (Tpmt), mRNA [NM_016785] KLA .78 .91 .86 .85 .71 .78 1.01
ATP .98 .99 1.09 1.16 .90 .71 1.20
KLA/ATP .89 .87 .88 .91 .88 .81 .89
Tymp
KLA  ATP  ATP+KLA
 NM_138302 thymidine phosphorylase (Tymp), mRNA [NM_138302] KLA .41 .42 .37 .39 .51 .66 1.18
ATP 1.04 1.00 .86 1.08 1.04 1.25 1.40
KLA/ATP .46 .43 .34 .49 .56 .79 .64
Uck1
KLA  ATP  ATP+KLA
 NM_011675 uridine-cytidine kinase 1 (Uck1), mRNA [NM_011675] KLA .58 .60 .69 .76 .92 1.21 1.07
ATP .88 .96 .87 .78 .85 1.54 1.20
KLA/ATP .55 .59 .63 .62 .83 1.60 1.58
Uck2
KLA  ATP  ATP+KLA
 BC004016 uridine-cytidine kinase 2, mRNA (cDNA clone IMAGE:3493906), partial cds [BC004016] KLA .64 .62 .54 .44 .28 .23 .17
ATP .89 .94 1.31 1.78 2.23 2.61 .31
KLA/ATP .58 .57 .64 .67 .72 .95 .40
Uck2
KLA  ATP  ATP+KLA
 NM_030724 uridine-cytidine kinase 2 (Uck2), mRNA [NM_030724] KLA .95 .96 .77 .68 .37 .25 .10
ATP .90 .94 1.56 1.98 2.14 5.67 1.10
KLA/ATP .90 .93 1.09 1.15 .95 1.39 1.71
Uckl1
KLA  ATP  ATP+KLA
 NM_026765 uridine-cytidine kinase 1-like 1 (Uckl1), mRNA [NM_026765] KLA .97 .94 .95 1.01 .99 1.20 1.40
ATP .86 .85 .97 .84 .82 .65 1.12
KLA/ATP .89 .85 1.00 .86 .95 .76 1.37
Ugt1a1
KLA  ATP  ATP+KLA
 NM_201645 UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), mRNA [NM_201645] KLA .95 1.07 1.00 .99 .97 .98 1.02
ATP 1.08 .95 1.02 1.04 1.08 1.03 1.01
KLA/ATP 1.02 .95 .93 1.01 1.01 1.11 1.06
Ugt1a6b
KLA  ATP  ATP+KLA
 NM_201410 UDP glucuronosyltransferase 1 family, polypeptide A6B (Ugt1a6b), mRNA [NM_201410] KLA .89 .86 .93 .93 .89 .86 .89
ATP 1.10 1.05 1.15 1.07 1.01 .99 1.24
KLA/ATP .90 .94 1.02 .89 .87 .81 .92
Ugt1a9
KLA  ATP  ATP+KLA
 NM_201644 UDP glucuronosyltransferase 1 family, polypeptide A9 (Ugt1a9), mRNA [NM_201644] KLA 1.07 .96 .98 1.09 1.03 1.06 1.08
ATP 1.04 .94 1.01 1.07 1.05 1.02 1.06
KLA/ATP 1.05 1.00 .94 1.01 1.03 1.04 1.00
Ugt2a1
KLA  ATP  ATP+KLA
 NM_053184 UDP glucuronosyltransferase 2 family, polypeptide A1 (Ugt2a1), mRNA [NM_053184] KLA 1.01 1.03 .99 .99 .99 1.01 1.02
ATP 1.01 .93 1.04 1.03 1.02 1.01 1.03
KLA/ATP 1.04 1.01 1.01 1.02 1.01 1.02 1.00
Ugt2a3
KLA  ATP  ATP+KLA
 NM_028094 UDP glucuronosyltransferase 2 family, polypeptide A3 (Ugt2a3), mRNA [NM_028094] KLA 1.07 1.01 .97 1.05 1.01 .98 .99
ATP .98 .96 1.04 1.06 .95 .94 1.01
KLA/ATP 1.02 1.00 .94 1.02 1.02 1.01 1.06
Ugt2b1
KLA  ATP  ATP+KLA
 NM_152811 UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA [NM_152811] KLA 1.08 1.01 .95 1.08 1.00 1.04 .97
ATP 1.03 1.14 1.01 1.00 1.01 1.05 1.13
KLA/ATP 1.05 .99 1.06 .98 1.03 .96 .98
Ugt2b34
KLA  ATP  ATP+KLA
 NM_153598 UDP glucuronosyltransferase 2 family, polypeptide B34 (Ugt2b34), mRNA [NM_153598] KLA .98 1.08 .99 1.06 .97 1.05 1.03
ATP 1.06 1.04 .96 1.01 1.03 1.01 .99
KLA/ATP 1.09 .94 1.00 1.07 1.01 1.03 .97
Ugt2b35
KLA  ATP  ATP+KLA
 NM_172881 UDP glucuronosyltransferase 2 family, polypeptide B35 (Ugt2b35), mRNA [NM_172881] KLA .99 1.02 .99 1.01 1.00 .96 1.01
ATP .96 1.02 1.02 .96 .93 1.00 1.02
KLA/ATP 1.01 .99 1.04 1.00 .97 .93 .97
Ugt2b36
KLA  ATP  ATP+KLA
 NM_001029867 UDP glucuronosyltransferase 2 family, polypeptide B36 (Ugt2b36), mRNA [NM_001029867] KLA .95 .95 1.00 1.00 1.03 1.02 .92
ATP 1.02 1.07 1.03 .95 1.01 .93 1.00
KLA/ATP .99 1.05 .98 1.04 1.02 .98 .99
Ugt2b37
KLA  ATP  ATP+KLA
 NM_053215 UDP glucuronosyltransferase 2 family, polypeptide B37 (Ugt2b37), mRNA [NM_053215] KLA 1.02 1.06 1.04 1.05 1.00 1.05 1.03
ATP 1.01 1.03 1.08 1.01 1.05 1.02 1.05
KLA/ATP 1.01 .99 1.11 1.14 1.04 1.08 1.05
Ugt2b38
KLA  ATP  ATP+KLA
 NM_133894 UDP glucuronosyltransferase 2 family, polypeptide B38 (Ugt2b38), mRNA [NM_133894] KLA 1.00 .96 1.04 .99 1.10 .97 .99
ATP 1.02 1.04 1.03 .94 .96 .93 .99
KLA/ATP .98 .97 1.00 .97 .98 1.04 1.02
Ugt2b5
KLA  ATP  ATP+KLA
 NM_009467 UDP glucuronosyltransferase 2 family, polypeptide B5 (Ugt2b5), mRNA [NM_009467] KLA 1.01 .99 1.09 .96 .97 .99 1.01
ATP 1.03 1.02 1.02 1.01 .97 .90 .94
KLA/ATP .99 .99 .98 1.05 1.01 .93 .95
Umps
KLA  ATP  ATP+KLA
 NM_009471 uridine monophosphate synthetase (Umps), mRNA [NM_009471] KLA .43 .42 .37 .41 .44 .66 .83
ATP 1.14 1.06 1.07 1.01 .89 .60 1.03
KLA/ATP .44 .44 .46 .45 .60 .56 .79
Upb1
KLA  ATP  ATP+KLA
 NM_133995 ureidopropionase, beta (Upb1), mRNA [NM_133995] KLA 1.22 1.30 1.23 1.20 1.25 1.21 1.15
ATP 1.06 1.13 1.16 1.14 1.01 1.57 1.24
KLA/ATP 1.23 1.24 1.29 1.26 1.18 1.91 2.90
Upp1
KLA  ATP  ATP+KLA
 NM_009477 uridine phosphorylase 1 (Upp1), mRNA [NM_009477] KLA 1.68 1.67 2.20 2.12 1.95 1.34 1.12
ATP .96 1.07 1.02 1.03 1.04 1.25 1.12
KLA/ATP 1.72 1.64 1.49 1.49 1.47 1.44 1.32
Upp2
KLA  ATP  ATP+KLA
 NM_029692 uridine phosphorylase 2 (Upp2), mRNA [NM_029692] KLA 1.01 1.05 1.04 1.05 1.04 1.04 1.01
ATP 1.06 1.00 1.05 1.01 1.00 1.00 1.03
KLA/ATP 1.05 1.02 1.07 1.03 1.05 1.10 1.04
Xdh
KLA  ATP  ATP+KLA
 NM_011723 xanthine dehydrogenase (Xdh), mRNA [NM_011723] KLA 1.82 1.90 2.33 2.06 2.49 2.56 1.77
ATP 1.02 1.15 .98 1.10 1.06 1.02 1.42
KLA/ATP 2.00 2.00 2.02 2.11 1.27 1.56 1.92