Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Biosynthesis of unsaturated fatty acids (mmu01040)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acaa1a
KLA  ATP  ATP+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 1.53 1.60 1.88 2.07 2.41 2.64 1.82
ATP 1.07 .99 .98 1.10 .94 .83 1.58
KLA/ATP 1.64 1.64 1.73 1.75 1.61 1.39 1.85
Acaa1b
KLA  ATP  ATP+KLA
 NM_146230 acetyl-Coenzyme A acyltransferase 1B (Acaa1b), mRNA [NM_146230] KLA 1.52 1.66 1.93 2.04 2.32 2.51 1.83
ATP 1.04 .95 1.06 1.12 1.03 .93 1.59
KLA/ATP 1.76 1.72 1.76 1.95 1.76 1.51 1.86
Acot1
KLA  ATP  ATP+KLA
 NM_012006 acyl-CoA thioesterase 1 (Acot1), mRNA [NM_012006] KLA .40 .34 .32 .29 .23 .17 .16
ATP 1.01 .95 1.14 1.10 .64 .26 .53
KLA/ATP .37 .37 .42 .42 .32 .20 .22
Acot2
KLA  ATP  ATP+KLA
 NM_134188 acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] KLA .46 .49 .37 .43 .34 .37 .53
ATP 1.02 1.15 .87 .99 .54 .37 .96
KLA/ATP .51 .46 .44 .49 .36 .34 .49
Acot3
KLA  ATP  ATP+KLA
 NM_134246 acyl-CoA thioesterase 3 (Acot3), mRNA [NM_134246] KLA .95 .95 1.04 .99 1.01 .97 .98
ATP 1.03 .97 1.01 .92 1.02 .99 .99
KLA/ATP .98 1.00 1.07 .96 1.01 1.00 1.01
Acot4
KLA  ATP  ATP+KLA
 NM_134247 acyl-CoA thioesterase 4 (Acot4), mRNA [NM_134247] KLA .77 .77 .72 .74 .68 .81 .85
ATP .95 .96 .97 .83 .79 .84 .99
KLA/ATP .79 .78 .76 .75 .76 .76 .84
Acot5
KLA  ATP  ATP+KLA
 NM_145444 acyl-CoA thioesterase 5 (Acot5), mRNA [NM_145444] KLA 1.03 1.07 1.00 1.02 1.05 1.06 1.07
ATP .99 .97 1.06 1.05 1.00 1.01 1.06
KLA/ATP .98 .96 1.07 1.09 1.08 1.00 1.01
Acot7
KLA  ATP  ATP+KLA
 NM_133348 acyl-CoA thioesterase 7 (Acot7), mRNA [NM_133348] KLA 1.60 1.80 1.91 1.81 1.85 1.55 1.30
ATP .99 1.08 1.07 1.46 1.32 1.25 .99
KLA/ATP 1.81 1.84 1.79 2.42 2.08 1.68 .82
Acox1
KLA  ATP  ATP+KLA
 NM_015729 acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA .79 .81 .78 .68 .66 .69 .82
ATP .97 1.09 .93 .90 .81 .78 1.22
KLA/ATP .81 .82 .69 .68 .59 .70 .88
Acox3
KLA  ATP  ATP+KLA
 NM_030721 acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA .56 .56 .63 .55 .50 .48 .68
ATP 1.10 1.00 .85 .76 .87 .44 .73
KLA/ATP .61 .66 .57 .49 .57 .48 .47
Baat
KLA  ATP  ATP+KLA
 NM_007519 bile acid-Coenzyme A: amino acid N-acyltransferase (Baat), mRNA [NM_007519] KLA .98 .99 1.01 .95 .97 .97 1.01
ATP .97 .97 1.01 .99 1.12 1.01 1.00
KLA/ATP 1.02 1.04 1.00 1.05 1.10 .99 1.01
Elovl2
KLA  ATP  ATP+KLA
 NM_019423 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), mRNA [NM_019423] KLA 1.12 1.08 1.23 1.23 1.42 1.38 1.15
ATP .89 .96 1.06 1.01 1.10 1.49 1.16
KLA/ATP 1.06 1.21 1.14 1.21 1.44 2.32 1.68
Elovl5
KLA  ATP  ATP+KLA
 NM_134255 ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA .77 .76 .78 .60 .51 .48 .65
ATP .96 .98 1.17 1.29 .91 .54 .70
KLA/ATP .75 .76 .83 .79 .62 .46 .43
Elovl6
KLA  ATP  ATP+KLA
 NM_130450 ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA [NM_130450] KLA .40 .35 .30 .23 .19 .18 .23
ATP .94 .86 1.19 .77 .43 .35 .44
KLA/ATP .38 .35 .39 .34 .34 .20 .15
Fads1
KLA  ATP  ATP+KLA
 NM_146094 fatty acid desaturase 1 (Fads1), mRNA [NM_146094] KLA .36 .37 .33 .27 .20 .23 .63
ATP .99 1.03 .82 .93 .69 .23 .87
KLA/ATP .38 .38 .29 .34 .26 .18 .33
Fads2
KLA  ATP  ATP+KLA
 NM_019699 fatty acid desaturase 2 (Fads2), mRNA [NM_019699] KLA .84 .82 .87 .71 .55 .37 .31
ATP 1.04 1.10 1.03 1.27 .98 .58 .49
KLA/ATP .84 .83 .86 .97 .72 .44 .23
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hsd17b12
KLA  ATP  ATP+KLA
 AK076088 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810004A21 product:hydroxysteroid (17-beta) dehydrogenase 12, full insert sequence. [AK076088] KLA 1.03 .87 .97 1.11 1.17 1.00 1.15
ATP 1.03 1.11 1.81 1.27 1.57 1.18 1.14
KLA/ATP 1.00 .90 1.26 .97 1.03 .97 .98
Hsd17b12
KLA  ATP  ATP+KLA
 NM_019657 hydroxysteroid (17-beta) dehydrogenase 12 (Hsd17b12), mRNA [NM_019657] KLA 1.12 1.30 1.47 1.16 1.07 1.34 1.20
ATP 1.01 1.28 1.28 1.14 1.06 1.05 .93
KLA/ATP 1.21 1.44 1.63 1.51 .91 .81 .87
Mm.1978
KLA  ATP  ATP+KLA
 118129966 Unknown KLA .41 .34 .33 .29 .20 .17 .15
ATP 1.01 .98 1.28 1.12 .67 .28 .49
KLA/ATP .35 .38 .45 .37 .33 .22 .20
Mm.29150
3
KLA  ATP  ATP+KLA
 34328333 Unknown KLA .61 .60 .60 .53 .51 .56 .69
ATP 1.05 .96 .93 .75 .81 .44 .78
KLA/ATP .66 .58 .67 .52 .58 .47 .55
Mm.31411
3
KLA  ATP  ATP+KLA
 91598889 Unknown KLA .40 .36 .31 .30 .23 .18 .26
ATP 1.02 .86 1.23 .79 .49 .38 .44
KLA/ATP .42 .38 .47 .37 .33 .25 .16
Pecr
KLA  ATP  ATP+KLA
 NM_023523 peroxisomal trans-2-enoyl-CoA reductase (Pecr), mRNA [NM_023523] KLA .99 1.01 .91 .91 .68 .46 .48
ATP .94 .90 1.34 1.29 1.06 .56 .28
KLA/ATP .92 1.06 1.37 1.20 1.06 .65 .26
Ptplb
KLA  ATP  ATP+KLA
 AF169286 protein tyrosine phosphatase-like protein PTPLB (Ptplb) mRNA, complete cds. [AF169286] KLA 1.47 1.72 1.47 1.36 1.23 .75 .81
ATP .97 .98 .98 1.16 1.25 1.00 .66
KLA/ATP 1.48 1.64 1.69 1.76 1.61 1.19 .68
Ptplb
KLA  ATP  ATP+KLA
 NM_023587 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b (Ptplb), mRNA [NM_023587] KLA 1.28 1.38 1.30 1.29 1.10 .93 .79
ATP 1.00 1.08 1.14 1.15 .95 .82 .57
KLA/ATP 1.40 1.41 1.20 1.23 1.10 .88 .60
Scd1
KLA  ATP  ATP+KLA
 NM_009127 stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA [NM_009127] KLA .79 .81 .86 .72 .59 .43 .33
ATP .97 .87 .82 .75 .68 .62 .72
KLA/ATP .78 .74 .67 .68 .54 .45 .28
Scd2
KLA  ATP  ATP+KLA
 NM_009128 stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA [NM_009128] KLA .10 .08 .08 .07 .11 .19 .48
ATP 1.02 .63 .27 .13 .12 .33 .59
KLA/ATP .09 .06 .05 .04 .05 .06 .07
Scd3
KLA  ATP  ATP+KLA
 NM_024450 stearoyl-coenzyme A desaturase 3 (Scd3), mRNA [NM_024450] KLA 1.06 1.01 1.07 1.08 1.14 1.21 1.43
ATP 1.02 1.04 1.06 1.02 1.06 1.03 1.07
KLA/ATP 1.06 1.06 .96 1.10 1.19 1.15 1.30
Scd4
KLA  ATP  ATP+KLA
 BC038322 stearoyl-coenzyme A desaturase 4, mRNA (cDNA clone IMAGE:1479917), complete cds. [BC038322] KLA .95 1.03 1.02 1.01 .94 1.07 1.09
ATP 1.03 1.03 1.07 1.04 1.06 1.03 1.04
KLA/ATP 1.03 1.00 1.09 1.06 1.06 1.10 1.06
Scd4
KLA  ATP  ATP+KLA
 NM_183216 stearoyl-coenzyme A desaturase 4 (Scd4), mRNA [NM_183216] KLA 1.01 .97 .92 .93 .92 .94 .89
ATP .97 1.01 .98 .91 .86 1.03 1.00
KLA/ATP .96 .90 1.02 .94 .97 .86 .89
Tecr
KLA  ATP  ATP+KLA
 NM_134118 trans-2,3-enoyl-CoA reductase KLA .83 .95 .97 .79 .84 .77 .75
ATP 1.20 1.35 .82 1.40 1.07 .73 .70
KLA/ATP 1.19 .99 .64 1.28 .69 .69 .59