Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: RNA polymerase (mmu03020)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Mm.13558
1
KLA  ATP  ATP+KLA
 34328145 Unknown KLA .73 .64 .50 .54 .38 .49 1.02
ATP .88 .84 1.16 .94 .66 .72 .68
KLA/ATP .56 .62 .71 .49 .40 .30 .42
Mm.21511
5
KLA  ATP  ATP+KLA
 146149315 Unknown KLA .94 .93 .96 .95 .89 .95 1.08
ATP 1.02 .93 1.00 .83 .78 .92 1.58
KLA/ATP .90 .96 .93 .85 .77 .83 .83
Mm.3458
KLA  ATP  ATP+KLA
 119226250 Unknown KLA .85 .78 .75 .84 .74 .81 .79
ATP .97 .83 1.09 .93 2.03 1.96 .89
KLA/ATP .81 .72 .89 .63 1.72 1.77 .79
Polr1e
KLA  ATP  ATP+KLA
 NM_022811 polymerase (RNA) I polypeptide E (Polr1e), mRNA [NM_022811] KLA 1.01 1.06 .93 .81 .72 .80 1.37
ATP 1.04 1.10 1.09 1.06 .68 1.06 .85
KLA/ATP 1.15 1.13 .87 .96 .60 .72 .56
Polr2a
KLA  ATP  ATP+KLA
 NM_009089 polymerase (RNA) II (DNA directed) polypeptide A (Polr2a), mRNA [NM_009089] KLA 1.21 1.16 1.15 1.16 1.16 1.25 1.12
ATP 1.00 1.09 1.07 1.39 1.35 1.28 1.16
KLA/ATP 1.20 1.18 1.26 1.30 1.30 1.51 1.37
Polr2b
KLA  ATP  ATP+KLA
 NM_153798 polymerase (RNA) II (DNA directed) polypeptide B (Polr2b), mRNA [NM_153798] KLA .91 .91 .92 .73 .77 .80 .83
ATP 1.09 1.18 .96 .80 .64 .75 .93
KLA/ATP 1.01 .98 .74 .74 .53 .72 .71
Polr2c
KLA  ATP  ATP+KLA
 NM_009090 polymerase (RNA) II (DNA directed) polypeptide C (Polr2c), mRNA [NM_009090] KLA 1.45 1.41 1.48 1.33 1.24 1.24 1.34
ATP .97 1.07 1.01 1.06 1.09 1.27 1.13
KLA/ATP 1.48 1.46 1.34 1.46 1.27 1.50 1.26
Polr2d
KLA  ATP  ATP+KLA
 NM_027101 polymerase (RNA) II (DNA directed) polypeptide D (Polr2d), transcript variant 2, mRNA [NM_027101] KLA .89 .90 .80 .87 .86 .94 .99
ATP .95 .95 1.15 1.05 .93 1.45 .80
KLA/ATP .81 .88 .99 .96 .99 1.33 .89
Polr2e
KLA  ATP  ATP+KLA
 AK010567 ES cells cDNA, RIKEN full-length enriched library, clone:2410021N14 product:polymerase (RNA) II (DNA directed) polypeptide E, full insert sequence. [AK010567] KLA .67 .68 .68 .56 .58 .45 .67
ATP 1.14 1.18 1.05 1.26 .91 .63 .80
KLA/ATP .80 .77 .71 .81 .75 .50 .49
Polr2e
KLA  ATP  ATP+KLA
 NM_025554 polymerase (RNA) II (DNA directed) polypeptide E (Polr2e), mRNA [NM_025554] KLA .69 .74 .69 .61 .56 .49 .70
ATP 1.00 1.06 1.02 1.20 .88 .67 .73
KLA/ATP .79 .76 .72 .80 .77 .55 .45
Polr2f
KLA  ATP  ATP+KLA
 NM_027231 polymerase (RNA) II (DNA directed) polypeptide F (Polr2f), mRNA [NM_027231] KLA 1.01 .99 .92 .94 .86 .78 .84
ATP .94 1.00 1.18 1.34 1.14 .88 .91
KLA/ATP .96 1.07 1.23 1.38 1.16 .96 .70
Polr2g
KLA  ATP  ATP+KLA
 NM_026329 polymerase (RNA) II (DNA directed) polypeptide G (Polr2g), mRNA [NM_026329] KLA 2.39 2.22 2.36 2.22 1.69 1.12 1.08
ATP .93 .91 1.27 1.12 1.19 1.43 1.23
KLA/ATP 2.24 2.26 3.23 2.51 3.15 2.36 1.54
Polr2h
KLA  ATP  ATP+KLA
 NM_145632 polymerase (RNA) II (DNA directed) polypeptide H (Polr2h), mRNA [NM_145632] KLA .80 .76 .66 .62 .73 .87 1.14
ATP .90 .91 1.01 .99 1.10 1.32 .98
KLA/ATP .68 .72 .69 .65 .90 1.01 .62
Polr2i
KLA  ATP  ATP+KLA
 NM_027259 polymerase (RNA) II (DNA directed) polypeptide I (Polr2i), mRNA [NM_027259] KLA .67 .69 .68 .78 .80 .90 .99
ATP .98 .88 1.10 .84 .77 1.13 1.17
KLA/ATP .64 .68 .85 .70 .91 1.10 1.03
Polr2j
KLA  ATP  ATP+KLA
 NM_011293 polymerase (RNA) II (DNA directed) polypeptide J (Polr2j), mRNA [NM_011293] KLA .96 .89 .88 1.01 .88 .92 .85
ATP 1.09 1.12 1.38 1.58 1.39 1.15 .89
KLA/ATP 1.05 1.05 1.46 1.33 1.51 1.25 .88
Polr2l
KLA  ATP  ATP+KLA
 XM_888022 gb|PREDICTED: Mus musculus polymerase (RNA) II (DNA directed) polypeptide L (Polr2l), mRNA [XM_888022] KLA .82 .92 .85 .82 .77 .73 .88
ATP .95 1.00 1.15 1.42 1.20 .91 .99
KLA/ATP .86 .89 1.04 1.23 1.25 .91 .59
Polr3a
KLA  ATP  ATP+KLA
 AK039440 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330043C08 product:hypothetical protein, full insert sequence. [AK039440] KLA 1.02 .94 .96 .97 1.13 .97 1.02
ATP .71 .55 .59 .69 .88 .93 .94
KLA/ATP .81 .65 .65 .80 .83 .88 .75
Polr3a
KLA  ATP  ATP+KLA
 NM_001081247 polymerase (RNA) III (DNA directed) polypeptide A (Polr3a), mRNA [NM_001081247] KLA 1.16 1.20 1.27 1.15 1.26 1.17 1.32
ATP .98 1.08 1.07 .92 .80 .99 1.26
KLA/ATP 1.22 1.30 1.18 .99 .78 1.24 1.27
Polr3b
KLA  ATP  ATP+KLA
 NM_027423 polymerase (RNA) III (DNA directed) polypeptide B (Polr3b), mRNA [NM_027423] KLA 1.03 1.05 1.02 1.07 1.11 1.15 1.05
ATP 1.09 1.15 .96 .97 .73 .75 .93
KLA/ATP 1.04 1.12 1.00 1.00 .74 .75 .77
Polr3c
KLA  ATP  ATP+KLA
 XM_131049 gb|PREDICTED: Mus musculus polymerase (RNA) III (DNA directed) polypeptide C, transcript variant 1 (Polr3c), mRNA [XM_131049] KLA 2.33 2.34 2.59 2.37 2.10 1.82 1.42
ATP 1.02 .97 1.12 1.19 .99 1.10 1.14
KLA/ATP 2.34 2.54 2.70 2.54 2.18 1.75 1.88
Polr3d
KLA  ATP  ATP+KLA
 NM_025945 polymerase (RNA) III (DNA directed) polypeptide D (Polr3d), mRNA [NM_025945] KLA 1.08 1.08 .90 .88 .98 .99 1.60
ATP .95 1.00 .94 .89 1.23 1.19 1.21
KLA/ATP 1.06 1.13 .88 .82 .68 .72 .55
Polr3e
KLA  ATP  ATP+KLA
 AK162059 adult male adrenal gland cDNA, RIKEN full-length enriched library, clone:7330401M11 product:sex-lethal interactor homolog (Drosophila), full insert sequence [AK162059] KLA .48 .46 .37 .33 .47 .53 .72
ATP 1.06 .96 .57 .49 .65 .27 .29
KLA/ATP .54 .43 .28 .37 .44 .27 .18
Polr3e
KLA  ATP  ATP+KLA
 NM_025298 polymerase (RNA) III (DNA directed) polypeptide E (Polr3e), mRNA [NM_025298] KLA .66 .69 .61 .58 .65 .72 1.37
ATP 1.01 .95 .80 .74 .58 .58 1.01
KLA/ATP .71 .69 .52 .57 .46 .42 .49
Polr3f
KLA  ATP  ATP+KLA
 NM_029763 polymerase (RNA) III (DNA directed) polypeptide F (Polr3f), mRNA [NM_029763] KLA 1.10 1.09 1.09 .98 .95 1.00 1.08
ATP 1.07 1.06 .84 .69 .72 .94 1.06
KLA/ATP 1.13 1.08 .80 .71 .70 .92 .92
Polr3g
KLA  ATP  ATP+KLA
 NM_001081176 polymerase (RNA) III (DNA directed) polypeptide G (Polr3g), mRNA [NM_001081176] KLA .51 .53 .43 .45 .41 .45 .57
ATP .90 .84 .68 .55 .54 .64 .60
KLA/ATP .51 .47 .46 .50 .48 .53 .46
Polr3gl
KLA  ATP  ATP+KLA
 NM_027241 polymerase (RNA) III (DNA directed) polypeptide G like (Polr3gl), mRNA [NM_027241] KLA .60 .51 .54 .55 .57 .70 .53
ATP .99 .86 1.08 .84 .48 .57 .69
KLA/ATP .55 .49 .64 .50 .53 .57 .67
Polr3h
KLA  ATP  ATP+KLA
 NM_030229 polymerase (RNA) III (DNA directed) polypeptide H (Polr3h), mRNA [NM_030229] KLA .89 .85 .75 .81 .76 .85 1.01
ATP .93 .81 .86 .71 .70 .93 .83
KLA/ATP .75 .78 .73 .70 .69 .76 .76
Polr3k
KLA  ATP  ATP+KLA
 NM_025901 polymerase (RNA) III (DNA directed) polypeptide K (Polr3k), mRNA [NM_025901] KLA .72 .72 .66 .69 .63 .74 .85
ATP .87 .84 1.14 .92 .64 .87 .72
KLA/ATP .65 .71 .90 .74 .65 .53 .44
Rpo1-1
KLA  ATP  ATP+KLA
 NM_009085 RNA polymerase 1-1 (Rpo1-1), mRNA [NM_009085] KLA .77 .81 .81 .91 .90 .68 .86
ATP 1.03 .92 .86 .94 2.06 1.70 .91
KLA/ATP .82 .85 .86 .65 1.41 1.49 .92
Rpo1-2
KLA  ATP  ATP+KLA
 AK052672 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630020H17 product:RNA polymerase 1-2 (128 kDa subunit), full insert sequence. [AK052672] KLA 1.03 .94 1.03 1.01 .97 .97 1.00
ATP 1.01 1.00 .99 .94 1.02 .94 1.00
KLA/ATP 1.04 .98 .97 .89 1.01 1.02 .93
Rpo1-2
KLA  ATP  ATP+KLA
 NM_009086 RNA polymerase 1-2 (Rpo1-2), mRNA [NM_009086] KLA 1.64 1.60 1.10 .82 .62 .63 .98
ATP 1.04 1.17 .99 .79 .50 .59 .91
KLA/ATP 1.21 1.54 1.15 .76 .37 .61 .50
Rpo1-3
KLA  ATP  ATP+KLA
 NM_009087 RNA polymerase 1-3 (Rpo1-3), transcript variant 1, mRNA [NM_009087] KLA 1.00 .98 .86 .90 .95 .76 .93
ATP 1.07 1.09 1.20 1.26 1.26 1.12 .99
KLA/ATP .89 1.04 1.10 1.08 1.01 .71 .67
Rpo1-3
KLA  ATP  ATP+KLA
 NM_181730 RNA polymerase 1-3 (Rpo1-3), transcript variant 2, mRNA [NM_181730] KLA 1.06 1.17 1.07 1.08 .99 1.04 .98
ATP .93 .97 1.12 1.27 1.36 1.31 .82
KLA/ATP 1.02 1.06 1.20 1.31 1.28 1.32 .90
Rpo1-4
KLA  ATP  ATP+KLA
 NM_009088 RNA polymerase 1-4 (Rpo1-4), mRNA [NM_009088] KLA .75 .68 .58 .60 .46 .53 1.06
ATP 1.07 .98 1.22 1.00 .69 .74 .75
KLA/ATP .68 .65 .76 .61 .45 .34 .49
Twistnb
KLA  ATP  ATP+KLA
 NM_172253 TWIST neighbor (Twistnb), mRNA [NM_172253] KLA 1.30 1.25 1.07 .87 .82 .80 1.03
ATP 1.10 1.00 .92 .87 1.26 1.07 .94
KLA/ATP 1.29 1.21 1.09 .82 .79 .85 .59
Znrd1
KLA  ATP  ATP+KLA
 NM_023162 zinc ribbon domain containing, 1 (Znrd1), mRNA [NM_023162] KLA 1.04 1.12 1.28 1.43 1.67 1.76 1.39
ATP 1.01 1.08 1.13 1.34 .81 1.14 1.30
KLA/ATP 1.00 1.16 1.22 1.53 1.21 1.74 1.97