Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: DNA replication (mmu03030)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK047274
KLA  ATP  ATP+KLA
 AK047274 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930044L01 product:unclassifiable, full insert sequence. [AK047274] KLA .92 .85 .90 .92 .98 .93 .92
ATP 1.03 1.11 1.07 .90 .89 .93 .94
KLA/ATP .89 .96 .94 .84 .93 .92 .92
Dna2
KLA  ATP  ATP+KLA
 AK129051 mRNA for mKIAA0083 protein [AK129051] KLA .46 .34 .34 .39 .34 .34 .34
ATP 1.10 1.15 .89 .65 .40 .40 .56
KLA/ATP .40 .32 .45 .39 .39 .37 .40
Dna2
KLA  ATP  ATP+KLA
 NM_177372 DNA replication helicase 2 homolog (yeast) (Dna2), mRNA [NM_177372] KLA .47 .47 .47 .45 .43 .52 .44
ATP 1.01 .98 .85 .67 .47 .49 .60
KLA/ATP .46 .43 .50 .47 .48 .48 .47
Fen1
KLA  ATP  ATP+KLA
 NM_007999 flap structure specific endonuclease 1 (Fen1), mRNA [NM_007999] KLA .37 .38 .37 .34 .41 .57 .44
ATP .98 1.04 .81 .78 .74 .72 .53
KLA/ATP .42 .37 .33 .38 .60 1.03 .43
Lig1
KLA  ATP  ATP+KLA
 NM_010715 ligase I, DNA, ATP-dependent (Lig1), transcript variant 2, mRNA [NM_010715] KLA .53 .54 .51 .42 .30 .28 .27
ATP .97 .93 1.02 .96 .73 .29 .30
KLA/ATP .55 .50 .57 .48 .43 .26 .20
Mcm2
KLA  ATP  ATP+KLA
 NM_008564 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) (Mcm2), mRNA [NM_008564] KLA .24 .24 .17 .13 .12 .35 .23
ATP 1.00 1.01 1.06 1.02 .54 .18 .33
KLA/ATP .28 .23 .20 .21 .17 .19 .11
Mcm3
KLA  ATP  ATP+KLA
 AK088142 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430004P22 product:mini chromosome maintenance deficient (S. cerevisiae), full insert sequence [AK088142] KLA .33 .29 .27 .22 .20 .37 .31
ATP .88 .90 1.19 1.06 .67 .29 .30
KLA/ATP .30 .28 .33 .30 .25 .22 .13
Mcm3
KLA  ATP  ATP+KLA
 NM_008563 minichromosome maintenance deficient 3 (S. cerevisiae) (Mcm3), mRNA [NM_008563] KLA .37 .36 .32 .24 .22 .38 .34
ATP 1.01 1.07 1.03 1.17 .75 .30 .32
KLA/ATP .36 .35 .35 .37 .27 .21 .15
Mcm4
KLA  ATP  ATP+KLA
 AK083618 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030054K02 product:mini chromosome maintenance deficient 4 homolog (S. cerevisiae), full insert sequence. [AK083618] KLA .94 .94 .95 .94 .98 .95 .94
ATP .93 .91 .92 .93 1.06 .93 1.02
KLA/ATP .95 .95 .95 .91 .93 .95 .95
Mcm4
KLA  ATP  ATP+KLA
 NM_008565 minichromosome maintenance deficient 4 homolog (S. cerevisiae) (Mcm4), mRNA [NM_008565] KLA .37 .37 .29 .20 .18 .37 .25
ATP .95 .97 1.11 .88 .67 .31 .28
KLA/ATP .36 .33 .35 .27 .25 .32 .14
Mcm5
KLA  ATP  ATP+KLA
 NM_008566 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) (Mcm5), mRNA [NM_008566] KLA .48 .49 .44 .34 .28 .34 .30
ATP 1.04 1.09 .86 1.11 .67 .32 .29
KLA/ATP .52 .50 .37 .50 .35 .28 .23
Mcm6
KLA  ATP  ATP+KLA
 NM_008567 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) (Mcm6), mRNA [NM_008567] KLA .59 .54 .53 .54 .37 .45 .24
ATP .99 .89 1.17 .80 .58 .16 .23
KLA/ATP .51 .53 .65 .43 .41 .17 .08
Mcm7
KLA  ATP  ATP+KLA
 NM_008568 minichromosome maintenance deficient 7 (S. cerevisiae) (Mcm7), mRNA [NM_008568] KLA .31 .31 .25 .16 .12 .21 .14
ATP 1.08 1.10 1.01 1.01 .59 .21 .16
KLA/ATP .36 .29 .26 .26 .18 .16 .09
Mm.29073
KLA  ATP  ATP+KLA
 146141223 Unknown KLA .48 .44 .52 .52 .40 .48 .44
ATP 1.03 .81 1.38 1.13 .59 .41 .38
KLA/ATP .45 .50 .74 .47 .37 .41 .31
Mm.38683
5
KLA  ATP  ATP+KLA
 21703947 Unknown KLA .41 .36 .37 .36 .33 .47 .36
ATP 1.06 .92 1.29 1.00 .55 .46 .34
KLA/ATP .41 .36 .50 .37 .32 .38 .24
Mm.42112
9
KLA  ATP  ATP+KLA
 133892806 Unknown KLA .56 .53 .50 .43 .25 .23 .19
ATP .91 .89 1.16 .93 .74 .27 .22
KLA/ATP .52 .48 .64 .47 .43 .21 .14
Pcna
KLA  ATP  ATP+KLA
 NM_011045 proliferating cell nuclear antigen (Pcna), mRNA [NM_011045] KLA .70 .69 .73 .56 .46 .66 .55
ATP .98 .95 1.12 .81 .74 .49 .92
KLA/ATP .69 .66 .78 .60 .63 .59 .62
Pola1
KLA  ATP  ATP+KLA
 NM_008892 polymerase (DNA directed), alpha 1 (Pola1), mRNA [NM_008892] KLA .72 .68 .59 .56 .27 .19 .21
ATP .81 .97 1.41 1.22 .71 .29 .16
KLA/ATP .58 .70 .81 .56 .39 .27 .12
Pola2
KLA  ATP  ATP+KLA
 BC006945 polymerase (DNA directed), alpha 2, mRNA (cDNA clone MGC:11533 IMAGE:3602559), complete cds [BC006945] KLA .74 .76 .70 .74 .88 .91 .98
ATP .99 1.03 .83 .78 .96 .76 .92
KLA/ATP .67 .69 .65 .77 .88 .83 1.02
Pola2
KLA  ATP  ATP+KLA
 NM_008893 polymerase (DNA directed), alpha 2 (Pola2), mRNA [NM_008893] KLA .82 .76 .91 .72 .73 .74 .85
ATP 1.12 1.12 .88 1.20 .86 .82 .64
KLA/ATP .89 .84 .75 .84 .78 .91 1.16
Pold1
KLA  ATP  ATP+KLA
 NM_011131 polymerase (DNA directed), delta 1, catalytic subunit (Pold1), mRNA [NM_011131] KLA .24 .21 .20 .18 .18 .29 .36
ATP 1.05 1.05 .96 .99 .52 .26 .32
KLA/ATP .26 .22 .21 .22 .16 .17 .18
Pold2
KLA  ATP  ATP+KLA
 NM_008894 polymerase (DNA directed), delta 2, regulatory subunit (Pold2), mRNA [NM_008894] KLA .77 .83 .69 .68 .59 .49 .57
ATP 1.05 1.09 .97 1.24 .89 .44 .43
KLA/ATP .79 .78 .70 .84 .60 .41 .30
Pold3
KLA  ATP  ATP+KLA
 NM_133692 polymerase (DNA-directed), delta 3, accessory subunit (Pold3), mRNA [NM_133692] KLA 1.14 1.07 1.22 1.22 1.12 1.40 1.10
ATP .99 .95 1.17 .89 1.46 1.74 1.55
KLA/ATP 1.01 1.08 1.54 1.28 1.86 2.34 2.11
Pold4
KLA  ATP  ATP+KLA
 NM_027196 polymerase (DNA-directed), delta 4 (Pold4), mRNA [NM_027196] KLA .81 .88 .80 .78 .85 1.04 1.40
ATP .97 1.07 1.12 1.37 1.19 .86 1.27
KLA/ATP .85 .90 .89 1.07 .90 .94 1.62
Pole
KLA  ATP  ATP+KLA
 AK086490 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930032B21 product:DNA polymerase epsilon, full insert sequence. [AK086490] KLA 1.00 1.00 1.04 .96 .94 .99 1.04
ATP .97 .95 .91 .95 .97 1.06 .95
KLA/ATP .96 .93 1.00 1.01 1.08 1.02 1.01
Pole
KLA  ATP  ATP+KLA
 NM_011132 polymerase (DNA directed), epsilon (Pole), mRNA [NM_011132] KLA .50 .44 .38 .31 .25 .21 .17
ATP 1.12 1.03 1.28 .89 .68 .30 .16
KLA/ATP .45 .44 .56 .38 .30 .21 .14
Pole2
KLA  ATP  ATP+KLA
 NM_011133 polymerase (DNA directed), epsilon 2 (p59 subunit) (Pole2), mRNA [NM_011133] KLA .25 .24 .22 .21 .21 .37 .34
ATP .93 .98 1.11 1.00 .36 .30 .35
KLA/ATP .22 .22 .29 .30 .26 .28 .19
Pole3
KLA  ATP  ATP+KLA
 BC034004 polymerase (DNA directed), epsilon 3 (p17 subunit), mRNA (cDNA clone IMAGE:5117478) [BC034004] KLA .69 .72 .63 .69 .68 .81 .61
ATP .91 .86 1.29 .96 .81 .94 .51
KLA/ATP .62 .54 .85 .64 .70 .75 .44
Pole3
KLA  ATP  ATP+KLA
 NM_021498 polymerase (DNA directed), epsilon 3 (p17 subunit) (Pole3), mRNA [NM_021498] KLA 1.14 1.14 1.23 1.36 1.18 1.15 1.01
ATP 1.02 .98 1.17 1.44 1.40 1.27 1.25
KLA/ATP 1.20 1.24 1.58 1.57 1.60 1.25 1.23
Pole4
KLA  ATP  ATP+KLA
 NM_025882 polymerase (DNA-directed), epsilon 4 (p12 subunit) (Pole4), mRNA [NM_025882] KLA 1.11 1.15 1.15 1.22 1.19 1.31 1.26
ATP 1.00 .99 1.36 1.32 1.34 1.19 .98
KLA/ATP 1.02 1.15 1.58 1.47 1.52 1.10 .85
Prim1
KLA  ATP  ATP+KLA
 NM_008921 DNA primase, p49 subunit (Prim1), mRNA [NM_008921] KLA .28 .26 .22 .18 .14 .24 .28
ATP .88 .80 1.35 .98 .50 .25 .26
KLA/ATP .22 .22 .33 .23 .20 .16 .10
Prim2
KLA  ATP  ATP+KLA
 NM_008922 DNA primase, p58 subunit (Prim2), mRNA [NM_008922] KLA .72 .68 .61 .54 .39 .52 .50
ATP .88 .76 .77 .64 .39 .47 .44
KLA/ATP .63 .59 .59 .44 .34 .46 .33
Rfc1
KLA  ATP  ATP+KLA
 NM_011258 replication factor C (activator 1) 1 (Rfc1), mRNA [NM_011258] KLA .37 .35 .39 .42 .46 .67 .75
ATP .96 .95 1.13 .76 .45 .40 .62
KLA/ATP .36 .38 .42 .30 .29 .38 .36
Rfc2
KLA  ATP  ATP+KLA
 NM_020022 replication factor C (activator 1) 2 (Rfc2), mRNA [NM_020022] KLA .51 .52 .53 .57 .61 .86 .75
ATP .96 .91 1.11 1.11 .70 .35 .86
KLA/ATP .51 .50 .62 .54 .57 .56 .76
Rfc3
KLA  ATP  ATP+KLA
 NM_027009 replication factor C (activator 1) 3 (Rfc3), mRNA [NM_027009] KLA 1.71 1.88 2.23 1.86 1.17 1.37 .82
ATP .93 .90 1.00 .94 .72 .77 .68
KLA/ATP 1.74 1.98 2.39 2.16 1.50 1.24 .82
Rfc4
KLA  ATP  ATP+KLA
 NM_145480 replication factor C (activator 1) 4 (Rfc4), mRNA [NM_145480] KLA .39 .38 .36 .37 .31 .44 .35
ATP .97 .92 1.27 1.00 .55 .45 .32
KLA/ATP .39 .36 .50 .36 .33 .38 .24
Rfc5
KLA  ATP  ATP+KLA
 NM_028128 replication factor C (activator 1) 5 (Rfc5), mRNA [NM_028128] KLA .67 .65 .67 .61 .50 .52 .41
ATP .95 .90 1.04 1.05 .59 .34 .42
KLA/ATP .60 .60 .69 .64 .53 .45 .48
Rnaseh1
KLA  ATP  ATP+KLA
 NM_011275 ribonuclease H1 (Rnaseh1), mRNA [NM_011275] KLA 1.40 1.35 1.20 .84 .79 .83 1.08
ATP .96 1.03 .92 .79 .53 .67 1.08
KLA/ATP 1.30 1.41 1.37 1.18 .51 .65 .76
Rnaseh2a
KLA  ATP  ATP+KLA
 NM_027187 ribonuclease H2, large subunit (Rnaseh2a), mRNA [NM_027187] KLA 1.01 1.04 1.10 1.11 .98 .70 .69
ATP 1.02 1.10 1.03 1.35 1.12 .79 .67
KLA/ATP 1.05 1.07 1.09 1.27 1.09 .89 .63
Rnaseh2b
KLA  ATP  ATP+KLA
 NM_026001 ribonuclease H2, subunit B (Rnaseh2b), mRNA [NM_026001] KLA 1.52 1.61 1.72 1.73 1.55 1.17 .80
ATP .93 .93 1.08 1.10 .89 .85 .56
KLA/ATP 1.38 1.50 1.84 1.87 1.67 1.65 1.15
Rnaseh2c
KLA  ATP  ATP+KLA
 NM_026616 ribonuclease H2, subunit C (Rnaseh2c), mRNA [NM_026616] KLA .73 .71 .68 .69 .50 .38 .42
ATP .90 .90 1.29 1.36 1.11 .88 .71
KLA/ATP .68 .72 1.03 1.02 .98 .72 .50
Rpa1
KLA  ATP  ATP+KLA
 NM_026653 replication protein A1 (Rpa1), mRNA [NM_026653] KLA .51 .51 .42 .36 .30 .42 .32
ATP 1.01 1.10 1.09 .92 .66 .38 .43
KLA/ATP .54 .49 .44 .41 .32 .30 .27
Rpa2
KLA  ATP  ATP+KLA
 D00812 mRNA for 30-kDa subunit of replication protein A, complete cds. [D00812] KLA .34 .36 .38 .32 .33 .42 .36
ATP 1.03 1.00 .91 .81 .43 .55 .27
KLA/ATP .39 .34 .39 .42 .35 .44 .27
Rpa2
KLA  ATP  ATP+KLA
 NM_011284 replication protein A2 (Rpa2), mRNA [NM_011284] KLA .34 .37 .38 .35 .36 .42 .36
ATP .98 .93 .87 .81 .47 .53 .26
KLA/ATP .36 .34 .40 .42 .36 .47 .24
Rpa3
KLA  ATP  ATP+KLA
 NM_026632 replication protein A3 (Rpa3), mRNA [NM_026632] KLA .54 .49 .54 .52 .46 .55 .48
ATP .89 .88 1.39 1.24 .56 .41 .39
KLA/ATP .48 .54 .77 .61 .41 .42 .32
Ssbp1
KLA  ATP  ATP+KLA
 NM_028358 single-stranded DNA binding protein 1 (Ssbp1), transcript variant 2, mRNA [NM_028358] KLA .85 .82 .84 .89 .78 .95 .97
ATP .79 .68 .85 .69 .77 1.24 .85
KLA/ATP .72 .71 .95 .72 .86 .94 .66
Ssbp1
KLA  ATP  ATP+KLA
 NM_212468 single-stranded DNA binding protein 1 (Ssbp1), transcript variant 1, mRNA [NM_212468] KLA .87 .89 .86 .81 .82 .89 .86
ATP .87 .84 .89 .78 .78 .77 .72
KLA/ATP .83 .79 .82 .71 .78 .75 .63