Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Proteasome (mmu03050)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Ifng
KLA  ATP  ATP+KLA
 NM_008337 interferon gamma (Ifng), mRNA [NM_008337] KLA 1.05 1.02 1.01 1.01 1.01 1.04 1.00
ATP 1.00 1.01 1.01 .98 .97 1.04 1.03
KLA/ATP 1.01 1.01 1.06 1.10 1.24 1.10 1.04
Mm.37157
3
KLA  ATP  ATP+KLA
 71725357 Unknown KLA 3.95 4.01 3.86 4.78 4.90 6.06 3.35
ATP .95 .80 .85 .67 .95 2.20 2.28
KLA/ATP 3.51 3.57 4.17 3.63 4.29 4.76 5.62
Pomp
KLA  ATP  ATP+KLA
 NM_025624 proteasome maturation protein (Pomp), mRNA [NM_025624] KLA 1.14 1.11 1.08 1.28 1.25 1.59 1.63
ATP .89 .88 1.13 .94 1.03 1.21 1.56
KLA/ATP .99 1.15 1.42 1.12 1.40 1.33 1.54
Psma1
KLA  ATP  ATP+KLA
 NM_011965 proteasome (prosome, macropain) subunit, alpha type 1 (Psma1), mRNA [NM_011965] KLA .93 .93 .83 .95 .84 1.11 1.29
ATP .89 .82 1.07 .83 .77 1.07 .95
KLA/ATP .80 .80 .93 .79 .78 .92 1.21
Psma2
KLA  ATP  ATP+KLA
 NM_008944 proteasome (prosome, macropain) subunit, alpha type 2 (Psma2), mRNA [NM_008944] KLA 1.51 1.45 1.48 1.70 1.57 1.90 1.60
ATP .90 .84 1.11 .91 .99 1.24 1.08
KLA/ATP 1.31 1.39 1.83 1.50 1.78 1.69 1.33
Psma3
KLA  ATP  ATP+KLA
 NM_011184 proteasome (prosome, macropain) subunit, alpha type 3 (Psma3), mRNA [NM_011184] KLA 1.61 1.77 1.61 1.83 1.89 2.06 1.55
ATP .97 .99 .92 1.02 1.07 1.21 1.09
KLA/ATP 1.59 1.61 1.72 1.87 1.84 1.69 1.34
Psma4
KLA  ATP  ATP+KLA
 NM_011966 proteasome (prosome, macropain) subunit, alpha type 4 (Psma4), mRNA [NM_011966] KLA 1.70 1.68 1.83 2.13 2.11 1.97 1.55
ATP .99 .94 1.00 .87 .94 1.32 1.29
KLA/ATP 1.55 1.64 2.11 1.60 1.65 1.48 1.34
Psma5
KLA  ATP  ATP+KLA
 NM_011967 proteasome (prosome, macropain) subunit, alpha type 5 (Psma5), mRNA [NM_011967] KLA 2.08 2.05 2.18 2.58 2.47 2.79 2.07
ATP .91 .85 .93 .71 .89 2.08 1.26
KLA/ATP 1.72 1.97 2.12 1.77 2.34 2.94 2.28
Psma6
KLA  ATP  ATP+KLA
 NM_011968 proteasome (prosome, macropain) subunit, alpha type 6 (Psma6), mRNA [NM_011968] KLA 2.60 2.58 2.96 3.01 3.49 3.24 2.39
ATP 1.14 1.06 1.07 1.06 1.07 1.49 1.15
KLA/ATP 2.64 2.69 2.98 2.58 2.52 1.96 1.85
Psma7
KLA  ATP  ATP+KLA
 NM_011969 proteasome (prosome, macropain) subunit, alpha type 7 (Psma7), mRNA [NM_011969] KLA .99 .97 1.01 1.14 1.26 1.57 1.72
ATP .99 .96 1.16 1.01 1.00 1.11 1.05
KLA/ATP 1.08 1.03 1.32 1.14 1.20 1.14 1.07
Psma8
KLA  ATP  ATP+KLA
 XM_357002 gb|PREDICTED: Mus musculus proteasome (prosome, macropain) subunit, alpha type, 8, transcript variant 1 (Psma8), mRNA [XM_357002] KLA .86 .84 .76 .84 .66 .67 .87
ATP .84 .82 1.33 1.06 .93 .56 .59
KLA/ATP .76 .90 1.19 .91 .89 .47 .34
Psmb1
KLA  ATP  ATP+KLA
 NM_011185 proteasome (prosome, macropain) subunit, beta type 1 (Psmb1), mRNA [NM_011185] KLA 1.04 1.10 1.07 1.14 1.07 1.21 1.23
ATP 1.04 1.01 1.07 1.15 1.02 .86 .86
KLA/ATP 1.08 1.08 1.33 1.29 1.22 1.00 .84
Psmb10
KLA  ATP  ATP+KLA
 NM_013640 proteasome (prosome, macropain) subunit, beta type 10 (Psmb10), mRNA [NM_013640] KLA 3.87 4.00 3.91 4.43 4.79 5.21 3.08
ATP .97 .91 .92 .85 .95 1.53 2.21
KLA/ATP 3.47 3.72 3.97 4.12 4.72 4.80 4.26
Psmb11
KLA  ATP  ATP+KLA
 NM_175204 proteasome (prosome, macropain) subunit, beta type, 11 (Psmb11), mRNA [NM_175204] KLA 1.00 .93 1.02 1.03 1.03 1.03 1.03
ATP 1.02 .96 1.06 1.03 1.02 1.02 1.00
KLA/ATP .99 1.09 1.02 .98 1.03 1.01 .97
Psmb2
KLA  ATP  ATP+KLA
 NM_011970 proteasome (prosome, macropain) subunit, beta type 2 (Psmb2), mRNA [NM_011970] KLA 1.54 1.59 1.59 1.52 1.69 1.98 1.81
ATP 1.05 1.18 1.18 1.59 1.13 .87 .99
KLA/ATP 1.50 1.63 1.36 2.21 1.42 1.53 1.43
Psmb3
KLA  ATP  ATP+KLA
 NM_011971 proteasome (prosome, macropain) subunit, beta type 3 (Psmb3), mRNA [NM_011971] KLA 1.01 1.01 .96 .99 1.05 1.34 1.47
ATP 1.02 1.03 1.13 1.10 1.12 1.15 1.23
KLA/ATP 1.05 .99 1.05 1.16 1.05 1.18 1.38
Psmb4
KLA  ATP  ATP+KLA
 NM_008945 proteasome (prosome, macropain) subunit, beta type 4 (Psmb4), mRNA [NM_008945] KLA 1.13 1.09 1.08 1.17 1.16 1.39 1.45
ATP .88 .90 1.07 1.08 .99 1.10 1.13
KLA/ATP 1.06 1.15 1.31 1.24 1.36 1.31 1.31
Psmb5
KLA  ATP  ATP+KLA
 NM_011186 proteasome (prosome, macropain) subunit, beta type 5 (Psmb5), mRNA [NM_011186] KLA .91 1.01 .95 .93 1.05 1.19 2.02
ATP .96 1.01 .95 1.06 .96 1.32 1.64
KLA/ATP 1.01 1.00 .95 1.09 .91 1.28 2.00
Psmb6
KLA  ATP  ATP+KLA
 NM_008946 proteasome (prosome, macropain) subunit, beta type 6 (Psmb6), mRNA [NM_008946] KLA 1.23 1.21 1.29 1.53 1.40 1.50 1.74
ATP 1.08 .96 1.14 1.25 2.01 2.67 1.76
KLA/ATP 1.32 1.35 1.74 1.65 2.55 2.59 2.34
Psmb7
KLA  ATP  ATP+KLA
 NM_011187 proteasome (prosome, macropain) subunit, beta type 7 (Psmb7), mRNA [NM_011187] KLA 1.21 1.43 1.39 1.29 1.48 1.59 1.78
ATP 1.24 1.32 1.07 1.61 1.32 1.15 1.26
KLA/ATP 1.69 1.51 1.21 2.08 1.40 1.38 1.53
Psmb8
KLA  ATP  ATP+KLA
 NM_010724 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8), mRNA [NM_010724] KLA 2.46 2.52 2.94 3.07 3.70 4.20 3.49
ATP 1.11 1.04 .93 1.24 1.10 1.39 2.24
KLA/ATP 2.64 2.71 2.69 3.37 3.44 3.67 4.79
Psmb9
KLA  ATP  ATP+KLA
 NM_013585 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) (Psmb9), mRNA [NM_013585] KLA 3.76 3.63 3.80 4.68 5.09 5.21 2.86
ATP 1.10 1.02 .97 .96 .73 1.10 1.99
KLA/ATP 3.55 3.84 4.52 4.43 4.25 3.57 4.98
Psmc1
KLA  ATP  ATP+KLA
 NM_008947 protease (prosome, macropain) 26S subunit, ATPase 1 (Psmc1), mRNA [NM_008947] KLA .77 .81 .78 .77 .96 1.40 1.65
ATP .98 1.02 .93 .98 1.01 1.61 1.77
KLA/ATP .83 .78 .71 .72 .83 1.58 2.21
Psmc2
KLA  ATP  ATP+KLA
 AK083989 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130073K11 product:proteasome (prosome, macropain) 26S subunit, ATPase 2, full insert sequence. [AK083989] KLA .98 .99 .95 .94 1.12 1.15 1.15
ATP .95 .83 .73 .80 1.17 1.17 .98
KLA/ATP .94 .88 .77 .93 1.04 1.02 .96
Psmc2
KLA  ATP  ATP+KLA
 NM_011188 proteasome (prosome, macropain) 26S subunit, ATPase 2 (Psmc2), mRNA [NM_011188] KLA 1.00 .97 1.00 1.04 1.16 1.36 1.63
ATP 1.14 1.04 .91 .91 .94 1.25 1.26
KLA/ATP 1.06 1.05 1.05 .97 .98 1.01 1.33
Psmc3
KLA  ATP  ATP+KLA
 NM_008948 proteasome (prosome, macropain) 26S subunit, ATPase 3 (Psmc3), mRNA [NM_008948] KLA .97 1.03 .97 .90 .99 .98 1.14
ATP 1.03 1.03 .85 1.10 1.00 .96 1.01
KLA/ATP 1.00 1.02 .85 1.04 .84 .84 .94
Psmc4
KLA  ATP  ATP+KLA
 NM_011874 proteasome (prosome, macropain) 26S subunit, ATPase, 4 (Psmc4), mRNA [NM_011874] KLA 1.08 1.20 1.14 1.27 1.37 1.27 1.57
ATP 1.06 1.10 .98 1.24 1.20 1.15 1.25
KLA/ATP 1.21 1.29 1.25 1.45 1.19 1.18 1.43
Psmc5
KLA  ATP  ATP+KLA
 NM_008950 protease (prosome, macropain) 26S subunit, ATPase 5 (Psmc5), mRNA [NM_008950] KLA 1.11 1.15 1.12 1.02 1.27 1.38 1.70
ATP 1.05 1.12 .93 1.31 1.24 1.19 1.41
KLA/ATP 1.21 1.26 .98 1.49 1.12 1.17 1.42
Psmc6
KLA  ATP  ATP+KLA
 BC043044 proteasome (prosome, macropain) 26S subunit, ATPase, 6, mRNA (cDNA clone IMAGE:5701431), partial cds [BC043044] KLA 1.42 1.35 1.26 1.08 1.05 .99 1.08
ATP 1.09 1.01 1.38 .90 .94 .76 .82
KLA/ATP 1.17 1.25 1.53 .99 .91 .76 .57
Psmc6
KLA  ATP  ATP+KLA
 NM_025959 proteasome (prosome, macropain) 26S subunit, ATPase, 6 (Psmc6), mRNA [NM_025959] KLA 1.02 1.00 .96 .91 .88 1.07 1.62
ATP .97 .94 1.04 .89 1.07 1.40 1.16
KLA/ATP .97 .98 .98 .81 .95 1.07 1.13
Psmd1
KLA  ATP  ATP+KLA
 NM_027357 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 (Psmd1), mRNA [NM_027357] KLA .74 .83 .77 .69 .77 .92 1.20
ATP 1.11 1.16 1.00 1.02 1.05 1.22 1.31
KLA/ATP .92 .89 .76 .78 .74 .84 1.09
Psmd11
KLA  ATP  ATP+KLA
 AK007029 adult male testis cDNA, RIKEN full-length enriched library, clone:1700089D09 product:unclassifiable, full insert sequence. [AK007029] KLA .96 1.04 1.01 1.05 1.00 1.06 .97
ATP .91 1.04 1.01 1.12 1.07 1.05 1.07
KLA/ATP .98 1.01 1.08 1.00 1.06 .96 .95
Psmd11
KLA  ATP  ATP+KLA
 AK157616 activated spleen cDNA, RIKEN full-length enriched library, clone:F830226O03 product:unclassifiable, full insert sequence. [AK157616] KLA 1.10 1.12 1.06 1.17 1.13 1.29 1.37
ATP .89 1.11 1.06 .97 1.14 1.52 1.17
KLA/ATP 1.10 1.14 1.19 1.13 1.11 1.30 1.33
Psmd11
KLA  ATP  ATP+KLA
 NM_178616 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 (Psmd11), mRNA [NM_178616] KLA 1.26 1.27 1.18 1.29 1.32 1.64 1.65
ATP 1.09 1.07 1.08 .90 1.49 2.82 1.78
KLA/ATP 1.38 1.32 1.40 1.39 1.29 1.75 2.29
Psmd12
KLA  ATP  ATP+KLA
 NM_025894 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (Psmd12), mRNA [NM_025894] KLA 1.04 1.05 1.00 1.06 1.18 1.42 1.41
ATP .93 .98 1.00 1.07 1.12 1.28 1.45
KLA/ATP .96 1.01 .96 1.02 1.02 1.37 1.23
Psmd13
KLA  ATP  ATP+KLA
 NM_011875 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 (Psmd13), mRNA [NM_011875] KLA 1.11 1.16 1.02 1.21 1.26 1.35 1.36
ATP 1.03 1.11 .96 1.09 1.14 1.06 1.19
KLA/ATP 1.09 1.22 1.24 1.18 1.13 .98 1.47
Psmd14
KLA  ATP  ATP+KLA
 AK053099 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930049P07 product:unclassifiable, full insert sequence [AK053099] KLA .96 .99 .96 1.01 1.00 .98 .97
ATP 1.00 .90 .95 1.00 1.12 1.01 .93
KLA/ATP 1.01 .93 .96 .96 .95 .94 .99
Psmd14
KLA  ATP  ATP+KLA
 NM_021526 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (Psmd14), mRNA [NM_021526] KLA 1.20 1.23 1.30 1.14 1.13 1.11 1.36
ATP 1.02 .97 1.06 1.01 1.09 1.58 1.15
KLA/ATP 1.19 1.23 1.22 1.05 .98 1.07 1.11
Psmd2
KLA  ATP  ATP+KLA
 NM_134101 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 (Psmd2), mRNA [NM_134101] KLA 1.00 1.00 1.07 .89 1.11 1.12 1.39
ATP 1.09 1.19 .99 1.03 1.02 1.07 1.53
KLA/ATP 1.09 1.11 .95 .98 .80 .97 1.48
Psmd3
KLA  ATP  ATP+KLA
 NM_009439 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 (Psmd3), mRNA [NM_009439] KLA .98 1.01 .91 .98 1.04 1.40 1.52
ATP .97 .91 1.01 .86 .87 1.10 1.18
KLA/ATP .94 .95 .95 .85 .93 .88 .99
Psmd4
KLA  ATP  ATP+KLA
 AB029144 mRNA for pUb-R3, complete cds. [AB029144] KLA 1.20 1.00 1.07 1.07 1.43 1.48 1.29
ATP 1.26 1.30 1.25 .95 1.58 2.04 1.34
KLA/ATP 1.11 1.23 1.31 .88 1.30 1.58 1.67
Psmd4
KLA  ATP  ATP+KLA
 NM_008951 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (Psmd4), mRNA [NM_008951] KLA 1.11 1.15 1.08 1.12 1.22 1.15 1.32
ATP 1.07 1.11 .99 1.18 1.18 1.12 1.43
KLA/ATP 1.11 1.24 1.12 1.26 1.13 1.12 1.61
Psmd6
KLA  ATP  ATP+KLA
 NM_025550 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (Psmd6), mRNA [NM_025550] KLA 1.19 1.23 1.16 1.23 1.34 1.02 1.14
ATP 1.01 1.08 1.00 .88 .83 1.08 .88
KLA/ATP 1.17 1.15 1.22 1.19 .95 .86 .88
Psmd7
KLA  ATP  ATP+KLA
 AK158379 adult inner ear cDNA, RIKEN full-length enriched library, clone:F930111J18 product:proteasome (prosome, macropain) 26S subunit, non-ATPase, 7, full insert sequence. [AK158379] KLA 1.06 .97 1.07 1.03 1.44 1.28 1.30
ATP .85 .73 .76 .76 1.79 1.59 1.03
KLA/ATP .90 .77 .74 .79 1.32 1.15 1.03
Psmd7
KLA  ATP  ATP+KLA
 NM_010817 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Psmd7), mRNA [NM_010817] KLA 1.38 1.41 1.39 1.45 1.38 1.57 1.64
ATP 1.04 1.09 .93 .85 1.01 1.69 1.26
KLA/ATP 1.36 1.46 1.46 1.39 1.10 1.30 1.36
Psmd8
KLA  ATP  ATP+KLA
 NM_026545 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 (Psmd8), mRNA [NM_026545] KLA 1.04 1.02 1.17 1.00 1.02 1.00 .98
ATP 1.06 1.17 1.13 1.39 1.54 1.43 1.21
KLA/ATP 1.13 1.13 1.01 1.38 1.40 1.64 1.39
Psme1
KLA  ATP  ATP+KLA
 NM_011189 proteasome (prosome, macropain) 28 subunit, alpha (Psme1), mRNA [NM_011189] KLA 2.12 2.17 2.68 2.70 2.93 3.22 3.09
ATP 1.11 1.09 1.06 1.31 1.16 1.25 1.96
KLA/ATP 2.47 2.48 2.32 2.69 2.58 2.66 3.97
Psme2
KLA  ATP  ATP+KLA
 NM_011190 proteasome (prosome, macropain) 28 subunit, beta (Psme2), transcript variant 1, mRNA [NM_011190] KLA 3.70 3.57 3.81 4.38 4.59 5.38 3.35
ATP .97 .88 .85 .75 .95 2.03 2.27
KLA/ATP 3.29 3.43 3.80 3.33 4.01 4.35 5.20
Psme3
KLA  ATP  ATP+KLA
 NM_011192 proteaseome (prosome, macropain) 28 subunit, 3 (Psme3), mRNA [NM_011192] KLA 1.10 1.16 1.13 1.05 1.05 1.04 1.18
ATP 1.02 1.14 1.07 1.36 1.16 1.35 1.12
KLA/ATP 1.14 1.31 1.14 1.33 1.09 1.13 1.16
Psme4
KLA  ATP  ATP+KLA
 AK164827 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930003K08 product:proteasome (prosome, macropain) activator subunit 4, full insert sequence. [AK164827] KLA 1.26 1.16 1.13 1.11 1.29 1.26 1.20
ATP 1.11 1.13 .91 .97 1.18 1.09 1.06
KLA/ATP 1.41 1.37 1.17 1.10 1.14 1.11 1.25
Psme4
KLA  ATP  ATP+KLA
 NM_134013 proteasome (prosome, macropain) activator subunit 4 (Psme4), mRNA [NM_134013] KLA 1.49 1.55 1.71 1.68 1.81 1.84 1.71
ATP 1.05 1.06 .86 .85 .93 1.23 1.44
KLA/ATP 1.57 1.69 1.26 1.28 1.24 1.71 2.04
Psmf1
KLA  ATP  ATP+KLA
 NM_212446 proteasome (prosome, macropain) inhibitor subunit 1 (Psmf1), mRNA [NM_212446] KLA 1.17 1.15 1.19 1.24 1.26 1.22 1.16
ATP .96 .91 .80 .87 .68 .78 1.19
KLA/ATP 1.19 1.15 1.03 1.11 .86 .92 1.17
Shfm1
KLA  ATP  ATP+KLA
 NM_009169 split hand/foot malformation (ectrodactyly) type 1 (Shfm1), mRNA [NM_009169] KLA 1.04 1.01 .96 1.15 1.07 1.17 1.15
ATP .92 .88 1.07 .98 1.00 1.07 1.07
KLA/ATP .90 .94 1.19 1.11 1.25 1.23 1.08