Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Protein export (mmu03060)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Hspa5
KLA  ATP  ATP+KLA
 NM_022310 heat shock protein 5 (Hspa5), mRNA [NM_022310] KLA 1.58 1.55 1.47 1.58 1.81 1.30 1.22
ATP 1.10 1.23 1.04 1.19 1.61 1.72 1.20
KLA/ATP 1.80 1.85 1.54 1.66 1.67 1.80 .93
Immp1l
KLA  ATP  ATP+KLA
 NM_028260 IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) (Immp1l), nuclear gene encoding mitochondrial protein, mRNA [NM_028260] KLA 1.14 1.12 1.05 1.19 1.04 1.13 1.36
ATP .92 .92 1.40 1.19 1.07 .99 .96
KLA/ATP .99 1.11 1.44 1.17 1.08 1.04 1.06
Immp2l
KLA  ATP  ATP+KLA
 NM_053122 IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) (Immp2l), nuclear gene encoding mitochondrial protein, mRNA [NM_053122] KLA 1.17 1.23 1.18 1.18 1.00 .76 .50
ATP .98 .89 1.35 1.21 1.30 .95 .37
KLA/ATP 1.19 1.18 1.54 1.18 1.19 .86 .40
Mm.12848
KLA  ATP  ATP+KLA
 149263137 Unknown KLA .99 .98 .89 .97 .95 .87 .94
ATP .99 .97 .84 .90 .83 .91 .85
KLA/ATP .91 .96 .94 .90 .89 .90 .80
Oxa1l
KLA  ATP  ATP+KLA
 NM_026936 oxidase assembly 1-like (Oxa1l), mRNA [NM_026936] KLA .76 .78 .83 .86 .91 .98 1.00
ATP 1.08 1.11 .94 .99 .84 .74 .88
KLA/ATP .85 .85 .80 .81 .76 .86 .89
Sec11a
KLA  ATP  ATP+KLA
 NM_019951 SEC11 homolog A (S. cerevisiae) (Sec11a), mRNA [NM_019951] KLA .72 .81 .67 .75 .70 .85 1.03
ATP .94 .87 1.12 .91 1.04 1.20 1.01
KLA/ATP .70 .69 .87 .69 .79 .89 .79
Sec11c
KLA  ATP  ATP+KLA
 NM_025468 SEC11 homolog C (S. cerevisiae) (Sec11c), mRNA [NM_025468] KLA 1.15 1.13 1.03 .98 .89 .73 .72
ATP 1.13 1.14 1.28 1.29 1.52 1.20 1.17
KLA/ATP 1.06 1.17 1.26 1.26 1.10 .99 .85
Sec61a1
KLA  ATP  ATP+KLA
 NM_016906 Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), mRNA [NM_016906] KLA .97 .99 .99 1.04 1.05 1.07 1.21
ATP 1.03 1.02 .87 .94 .94 .96 1.23
KLA/ATP .98 .99 .90 .96 .77 .89 1.02
Sec61a2
KLA  ATP  ATP+KLA
 NM_021305 Sec61, alpha subunit 2 (S. cerevisiae) (Sec61a2), mRNA [NM_021305] KLA .86 .92 .91 .78 .84 .85 1.21
ATP 1.05 1.08 .72 .79 1.33 .93 1.13
KLA/ATP .91 .92 .68 .79 .88 1.03 1.02
Sec61b
KLA  ATP  ATP+KLA
 NM_024171 Sec61 beta subunit (Sec61b), mRNA [NM_024171] KLA .95 .88 .80 .87 .74 .76 .93
ATP .93 .97 1.17 1.20 1.01 .84 .89
KLA/ATP .81 .89 1.04 .99 1.00 .82 .56
Sec61g
KLA  ATP  ATP+KLA
 NM_011343 SEC61, gamma subunit (Sec61g), transcript variant 1, mRNA [NM_011343] KLA 1.19 1.06 1.12 1.34 1.13 1.11 1.10
ATP 1.09 .98 1.22 1.13 1.22 1.39 1.01
KLA/ATP 1.16 1.19 1.63 1.25 1.58 1.41 .96
Sec63
KLA  ATP  ATP+KLA
 NM_153055 SEC63-like (S. cerevisiae) (Sec63), mRNA [NM_153055] KLA 1.08 1.10 1.04 .98 .87 .78 .72
ATP 1.02 .95 1.00 .87 .90 .81 .72
KLA/ATP 1.01 1.11 1.17 .99 .85 .67 .48
Spcs1
KLA  ATP  ATP+KLA
 NM_026911 signal peptidase complex subunit 1 homolog (S. cerevisiae) (Spcs1), mRNA [NM_026911] KLA .97 1.04 .97 .94 .97 .99 .99
ATP 1.05 1.11 1.02 1.13 1.09 1.03 1.17
KLA/ATP 1.05 1.03 .89 1.11 .97 1.06 1.17
Spcs2
KLA  ATP  ATP+KLA
 NM_025668 signal peptidase complex subunit 2 homolog (S. cerevisiae) (Spcs2), mRNA [NM_025668] KLA .97 .86 .82 .87 .81 .89 1.03
ATP .99 1.01 1.17 1.21 1.07 1.05 1.08
KLA/ATP .84 .91 1.04 1.01 1.07 1.02 .90
Spcs3
KLA  ATP  ATP+KLA
 NM_029701 signal peptidase complex subunit 3 homolog (S. cerevisiae) (Spcs3), mRNA [NM_029701] KLA .85 .87 .79 .69 .67 .65 1.01
ATP 1.05 1.13 1.05 1.00 .85 .73 .78
KLA/ATP .85 .88 .76 .78 .58 .51 .53
Srp14
KLA  ATP  ATP+KLA
 NM_009273 signal recognition particle 14 (Srp14), mRNA [NM_009273] KLA .85 .84 .89 .95 .82 .80 .84
ATP 1.06 .99 1.23 1.17 1.18 .97 .96
KLA/ATP .91 .96 1.14 .94 1.06 .99 .82
Srp19
KLA  ATP  ATP+KLA
 NM_025527 signal recognition particle 19 (Srp19), mRNA [NM_025527] KLA .90 .87 .86 .95 .89 .97 1.04
ATP .89 .83 1.20 .91 .98 1.45 1.14
KLA/ATP .76 .79 1.08 .75 .99 1.21 .93
Srp54a
KLA  ATP  ATP+KLA
 NM_011899 signal recognition particle 54a (Srp54a), mRNA [NM_011899] KLA 1.43 1.55 1.47 1.28 1.14 1.06 1.20
ATP .97 .91 .75 .73 .89 1.03 .99
KLA/ATP 1.46 1.42 1.18 .95 .92 .96 .89
Srp68
KLA  ATP  ATP+KLA
 NM_146032 signal recognition particle 68 (Srp68), mRNA [NM_146032] KLA 1.00 1.04 1.10 .91 .96 .89 .92
ATP 1.12 1.08 .99 1.19 1.28 1.23 1.31
KLA/ATP 1.05 1.15 1.11 1.02 .89 .92 1.07
Srp72
KLA  ATP  ATP+KLA
 NM_025691 signal recognition particle 72 (Srp72), mRNA [NM_025691] KLA 1.18 1.18 1.01 1.00 1.12 1.03 1.34
ATP 1.05 1.08 .95 1.16 .96 .77 .94
KLA/ATP 1.16 1.16 .88 1.21 .80 .75 .77
Srp9
KLA  ATP  ATP+KLA
 AK003606 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110011E08 product:unclassifiable, full insert sequence. [AK003606] KLA 1.02 .90 .78 1.06 1.00 .92 .98
ATP .72 .66 .60 .77 1.18 1.28 .89
KLA/ATP .71 .74 .73 .94 1.23 1.08 1.00
Srp9
KLA  ATP  ATP+KLA
 NM_012058 signal recognition particle 9 (Srp9), mRNA [NM_012058] KLA .93 .91 .87 1.05 .98 .97 1.10
ATP .99 .93 1.16 1.06 1.16 1.39 1.31
KLA/ATP .84 .91 1.11 1.04 1.08 1.30 1.19
Srpr
KLA  ATP  ATP+KLA
 NM_026130 signal recognition particle receptor (docking protein) (Srpr), mRNA [NM_026130] KLA 1.29 1.44 1.44 1.44 1.64 1.67 1.48
ATP 1.00 1.26 .87 1.19 .99 1.12 1.35
KLA/ATP 1.44 1.72 1.13 1.73 1.14 1.43 1.73
Srprb
KLA  ATP  ATP+KLA
 NM_009275 signal recognition particle receptor, B subunit (Srprb), mRNA [NM_009275] KLA .93 1.00 .94 .89 .83 .79 1.21
ATP 1.07 1.18 .99 1.19 1.02 .94 1.12
KLA/ATP 1.03 1.08 .90 1.10 .83 .88 .90
Tloc1
KLA  ATP  ATP+KLA
 NM_027016 translocation protein 1 (Tloc1), mRNA [NM_027016] KLA 1.04 1.09 1.05 1.01 .94 .86 .92
ATP 1.05 1.10 1.11 1.03 .87 .76 .73
KLA/ATP 1.06 1.12 1.04 1.07 .88 .70 .54