Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Nucleotide excision repair (mmu03420)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK163166
KLA  ATP  ATP+KLA
 AK163166 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730059H12 product:unclassifiable, full insert sequence. [AK163166] KLA .98 .93 .89 .94 1.02 .92 .86
ATP .94 1.00 .91 .87 .92 1.01 .92
KLA/ATP .94 .84 .94 .86 .87 .98 .96
BC006751
KLA  ATP  ATP+KLA
 BC006751 cDNA clone IMAGE:3256899, complete cds. [BC006751] KLA 1.11 1.06 .94 1.06 .85 1.09 1.44
ATP .90 .87 1.35 1.29 1.75 2.35 1.33
KLA/ATP .95 1.01 1.42 1.10 1.41 1.52 1.43
Ccnh
KLA  ATP  ATP+KLA
 NM_023243 cyclin H (Ccnh), mRNA [NM_023243] KLA .68 .70 .59 .60 .51 .67 .86
ATP .95 .98 1.23 1.05 .60 .37 .85
KLA/ATP .65 .63 .70 .61 .44 .33 .44
Cdk7
KLA  ATP  ATP+KLA
 NM_009874 cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) (Cdk7), mRNA [NM_009874] KLA 1.18 1.15 1.15 1.13 1.08 1.01 1.19
ATP 1.01 1.06 .92 .72 1.06 1.79 1.12
KLA/ATP 1.11 1.23 1.45 .81 .88 1.24 .93
Cetn2
KLA  ATP  ATP+KLA
 NM_019405 centrin 2 (Cetn2), mRNA [NM_019405] KLA .97 1.06 .94 1.03 .96 .96 .86
ATP .92 .93 1.23 1.14 1.07 .86 1.14
KLA/ATP .92 1.04 1.23 1.07 1.02 .83 .88
Cul4a
KLA  ATP  ATP+KLA
 NM_146207 cullin 4A (Cul4a), mRNA [NM_146207] KLA 1.11 1.11 1.22 1.09 1.08 .97 1.10
ATP 1.05 1.14 1.06 1.01 .78 .84 1.16
KLA/ATP 1.12 1.24 1.03 1.03 .79 .85 1.06
Cul4b
KLA  ATP  ATP+KLA
 NM_001110142 cullin 4B (Cul4b), transcript variant 2, mRNA [NM_001110142] KLA .81 .79 .80 .88 .82 .84 .82
ATP .95 .95 1.03 .81 .60 .65 .62
KLA/ATP .76 .76 .75 .58 .59 .65 .50
Cul4b
KLA  ATP  ATP+KLA
 NM_028288 cullin 4B (Cul4b), transcript variant 1, mRNA [NM_028288] KLA 1.00 .92 .95 1.13 .95 1.03 .98
ATP .95 .90 1.38 1.28 1.46 2.38 1.49
KLA/ATP .86 .88 1.20 .94 1.47 2.60 1.92
Ddb1
KLA  ATP  ATP+KLA
 NM_015735 damage specific DNA binding protein 1 (Ddb1), mRNA [NM_015735] KLA 1.01 1.01 1.01 .83 .75 .62 .68
ATP 1.05 1.21 .88 1.04 1.01 .76 .61
KLA/ATP 1.17 1.09 .77 .91 .58 .54 .45
Ddb2
KLA  ATP  ATP+KLA
 NM_028119 damage specific DNA binding protein 2 (Ddb2), mRNA [NM_028119] KLA .72 .69 .72 .69 .67 .75 .83
ATP 1.21 1.11 1.21 1.05 .61 .49 .87
KLA/ATP .83 .78 .80 .72 .54 .55 .77
Ercc1
KLA  ATP  ATP+KLA
 NM_007948 excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1), mRNA [NM_007948] KLA 1.04 1.03 1.05 .96 1.11 1.08 1.11
ATP 1.04 1.11 .97 1.26 .90 .79 .93
KLA/ATP 1.14 1.16 .84 1.25 .86 .96 1.25
Ercc2
KLA  ATP  ATP+KLA
 NM_007949 excision repair cross-complementing rodent repair deficiency, complementation group 2 (Ercc2), mRNA [NM_007949] KLA 1.04 1.08 1.07 1.00 1.03 1.04 1.17
ATP .95 1.04 .86 .82 .81 1.01 .98
KLA/ATP 1.03 1.08 1.00 .83 .71 .84 .85
Ercc3
KLA  ATP  ATP+KLA
 NM_133658 excision repair cross-complementing rodent repair deficiency, complementation group 3 (Ercc3), mRNA [NM_133658] KLA .96 1.06 1.09 1.04 1.10 1.22 1.08
ATP 1.08 1.15 1.02 1.04 .81 1.05 1.53
KLA/ATP 1.07 1.16 .98 1.06 .83 1.08 1.52
Ercc4
KLA  ATP  ATP+KLA
 NM_015769 excision repair cross-complementing rodent repair deficiency, complementation group 4 (Ercc4), mRNA [NM_015769] KLA .96 .91 .93 .90 .88 .93 1.06
ATP 1.14 1.22 1.06 .99 .74 1.08 1.20
KLA/ATP .97 .95 .87 .83 .61 .88 1.00
Ercc5
KLA  ATP  ATP+KLA
 NM_011729 excision repair cross-complementing rodent repair deficiency, complementation group 5 (Ercc5), mRNA [NM_011729] KLA .95 .96 .98 .91 .90 1.02 1.02
ATP 1.04 1.04 .94 .92 .69 .79 .95
KLA/ATP .95 1.02 .90 .87 .70 .93 1.06
Ercc6
KLA  ATP  ATP+KLA
 AK028576 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732403I04 product:weakly similar to DNA repair helicase ERCC6 [Homo sapiens], full insert sequence. [AK028576] KLA .95 .92 .82 .94 .96 .90 .96
ATP 1.09 1.01 1.01 1.12 1.14 .97 1.03
KLA/ATP 1.00 .95 .81 .89 .97 .94 .95
Ercc6
KLA  ATP  ATP+KLA
 NM_001081221 excision repair cross-complementing rodent repair deficiency, complementation group 6 (Ercc6), mRNA [NM_001081221] KLA .51 .56 .42 .42 .49 .51 .60
ATP 1.03 .95 .78 .69 .65 .51 .75
KLA/ATP .53 .51 .39 .44 .51 .48 .47
Ercc8
KLA  ATP  ATP+KLA
 AK045333 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130065P18 product:unclassifiable, full insert sequence. [AK045333] KLA .77 .73 .64 .65 .80 .85 1.11
ATP .70 .49 .45 .61 .82 1.07 .97
KLA/ATP .57 .42 .47 .56 .68 .76 .59
Ercc8
KLA  ATP  ATP+KLA
 NM_028042 excision repaiross-complementing rodent repair deficiency, complementation group 8 (Ercc8), mRNA [NM_028042] KLA 1.05 .98 .92 .88 .79 .97 1.18
ATP .93 .83 .70 .62 .73 1.12 1.03
KLA/ATP .92 .88 .72 .65 .62 .84 .77
Gtf2h1
KLA  ATP  ATP+KLA
 NM_008186 general transcription factor II H, polypeptide 1 (Gtf2h1), mRNA [NM_008186] KLA .96 .91 .87 1.10 1.18 1.19 1.30
ATP 1.04 .96 1.16 1.24 1.93 1.49 1.38
KLA/ATP .88 .84 .93 1.15 2.20 1.65 1.38
Gtf2h2
KLA  ATP  ATP+KLA
 BC016231 general transcription factor II H, polypeptide 2, mRNA (cDNA clone MGC:28787 IMAGE:4488798), complete cds. [BC016231] KLA .77 .82 .79 .88 1.07 1.44 1.58
ATP 1.03 1.00 1.15 .96 .77 .97 1.42
KLA/ATP .82 .79 .85 .82 1.12 1.95 1.99
Gtf2h2
KLA  ATP  ATP+KLA
 NM_022011 general transcription factor II H, polypeptide 2 (Gtf2h2), mRNA [NM_022011] KLA .77 .82 .76 .74 .81 1.02 1.46
ATP 1.04 1.02 1.07 1.00 .60 .76 .96
KLA/ATP .71 .75 .73 .69 .52 .88 .91
Gtf2h3
KLA  ATP  ATP+KLA
 NM_181410 general transcription factor IIH, polypeptide 3 (Gtf2h3), mRNA [NM_181410] KLA 1.02 1.09 1.11 1.16 1.31 1.44 1.51
ATP .94 .97 .97 .95 .51 .70 1.43
KLA/ATP 1.00 1.06 1.05 1.12 .76 .82 1.32
Gtf2h4
KLA  ATP  ATP+KLA
 NM_010364 general transcription factor II H, polypeptide 4 (Gtf2h4), mRNA [NM_010364] KLA .96 1.08 .98 .99 .94 .88 .98
ATP 1.00 .98 .71 .69 .50 .77 .91
KLA/ATP 1.09 1.09 .78 .80 .56 .64 .57
Gtf2h5
KLA  ATP  ATP+KLA
 NM_181392 general transcription factor IIH, polypeptide 5 (Gtf2h5), mRNA [NM_181392] KLA 1.05 1.04 .95 1.00 1.01 .94 1.08
ATP 1.09 .98 1.38 1.23 1.20 .95 .96
KLA/ATP .90 1.02 1.47 1.23 1.13 .89 .92
Lig1
KLA  ATP  ATP+KLA
 NM_010715 ligase I, DNA, ATP-dependent (Lig1), transcript variant 2, mRNA [NM_010715] KLA .53 .54 .51 .42 .30 .28 .27
ATP .97 .93 1.02 .96 .73 .29 .30
KLA/ATP .55 .50 .57 .48 .43 .26 .20
Mm.29073
KLA  ATP  ATP+KLA
 146141223 Unknown KLA .48 .44 .52 .52 .40 .48 .44
ATP 1.03 .81 1.38 1.13 .59 .41 .38
KLA/ATP .45 .50 .74 .47 .37 .41 .31
Mm.30344
1
KLA  ATP  ATP+KLA
 157951656 Unknown KLA .88 .91 .88 .95 .86 1.05 1.11
ATP .86 .78 1.35 1.07 1.00 .99 .96
KLA/ATP .87 .89 1.17 .98 1.03 .85 .91
Mm.31831
0
KLA  ATP  ATP+KLA
 124487018 Unknown KLA .91 .84 .86 .79 .88 .91 .92
ATP .95 .93 .91 .91 .88 .95 .97
KLA/ATP .87 .90 .80 .80 .85 .92 .89
Mm.38683
5
KLA  ATP  ATP+KLA
 21703947 Unknown KLA .41 .36 .37 .36 .33 .47 .36
ATP 1.06 .92 1.29 1.00 .55 .46 .34
KLA/ATP .41 .36 .50 .37 .32 .38 .24
Mm.42112
9
KLA  ATP  ATP+KLA
 133892806 Unknown KLA .56 .53 .50 .43 .25 .23 .19
ATP .91 .89 1.16 .93 .74 .27 .22
KLA/ATP .52 .48 .64 .47 .43 .21 .14
Mnat1
KLA  ATP  ATP+KLA
 AK029174 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831405B13 product:menage a trois 1, full insert sequence. [AK029174] KLA 1.04 .95 .97 .96 .99 .99 1.09
ATP .98 .96 .98 1.01 1.01 .94 1.01
KLA/ATP .96 1.01 .98 1.01 1.00 .96 .87
Mnat1
KLA  ATP  ATP+KLA
 NM_008612 menage a trois 1 (Mnat1), mRNA [NM_008612] KLA 1.16 1.36 1.22 1.18 1.18 1.03 .97
ATP .95 .99 1.11 1.06 .70 .86 .78
KLA/ATP 1.22 1.25 1.37 1.29 .90 .67 .81
Pcna
KLA  ATP  ATP+KLA
 NM_011045 proliferating cell nuclear antigen (Pcna), mRNA [NM_011045] KLA .70 .69 .73 .56 .46 .66 .55
ATP .98 .95 1.12 .81 .74 .49 .92
KLA/ATP .69 .66 .78 .60 .63 .59 .62
Pold1
KLA  ATP  ATP+KLA
 NM_011131 polymerase (DNA directed), delta 1, catalytic subunit (Pold1), mRNA [NM_011131] KLA .24 .21 .20 .18 .18 .29 .36
ATP 1.05 1.05 .96 .99 .52 .26 .32
KLA/ATP .26 .22 .21 .22 .16 .17 .18
Pold2
KLA  ATP  ATP+KLA
 NM_008894 polymerase (DNA directed), delta 2, regulatory subunit (Pold2), mRNA [NM_008894] KLA .77 .83 .69 .68 .59 .49 .57
ATP 1.05 1.09 .97 1.24 .89 .44 .43
KLA/ATP .79 .78 .70 .84 .60 .41 .30
Pold3
KLA  ATP  ATP+KLA
 NM_133692 polymerase (DNA-directed), delta 3, accessory subunit (Pold3), mRNA [NM_133692] KLA 1.14 1.07 1.22 1.22 1.12 1.40 1.10
ATP .99 .95 1.17 .89 1.46 1.74 1.55
KLA/ATP 1.01 1.08 1.54 1.28 1.86 2.34 2.11
Pold4
KLA  ATP  ATP+KLA
 NM_027196 polymerase (DNA-directed), delta 4 (Pold4), mRNA [NM_027196] KLA .81 .88 .80 .78 .85 1.04 1.40
ATP .97 1.07 1.12 1.37 1.19 .86 1.27
KLA/ATP .85 .90 .89 1.07 .90 .94 1.62
Pole
KLA  ATP  ATP+KLA
 AK086490 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930032B21 product:DNA polymerase epsilon, full insert sequence. [AK086490] KLA 1.00 1.00 1.04 .96 .94 .99 1.04
ATP .97 .95 .91 .95 .97 1.06 .95
KLA/ATP .96 .93 1.00 1.01 1.08 1.02 1.01
Pole
KLA  ATP  ATP+KLA
 NM_011132 polymerase (DNA directed), epsilon (Pole), mRNA [NM_011132] KLA .50 .44 .38 .31 .25 .21 .17
ATP 1.12 1.03 1.28 .89 .68 .30 .16
KLA/ATP .45 .44 .56 .38 .30 .21 .14
Pole2
KLA  ATP  ATP+KLA
 NM_011133 polymerase (DNA directed), epsilon 2 (p59 subunit) (Pole2), mRNA [NM_011133] KLA .25 .24 .22 .21 .21 .37 .34
ATP .93 .98 1.11 1.00 .36 .30 .35
KLA/ATP .22 .22 .29 .30 .26 .28 .19
Pole3
KLA  ATP  ATP+KLA
 BC034004 polymerase (DNA directed), epsilon 3 (p17 subunit), mRNA (cDNA clone IMAGE:5117478) [BC034004] KLA .69 .72 .63 .69 .68 .81 .61
ATP .91 .86 1.29 .96 .81 .94 .51
KLA/ATP .62 .54 .85 .64 .70 .75 .44
Pole3
KLA  ATP  ATP+KLA
 NM_021498 polymerase (DNA directed), epsilon 3 (p17 subunit) (Pole3), mRNA [NM_021498] KLA 1.14 1.14 1.23 1.36 1.18 1.15 1.01
ATP 1.02 .98 1.17 1.44 1.40 1.27 1.25
KLA/ATP 1.20 1.24 1.58 1.57 1.60 1.25 1.23
Pole4
KLA  ATP  ATP+KLA
 NM_025882 polymerase (DNA-directed), epsilon 4 (p12 subunit) (Pole4), mRNA [NM_025882] KLA 1.11 1.15 1.15 1.22 1.19 1.31 1.26
ATP 1.00 .99 1.36 1.32 1.34 1.19 .98
KLA/ATP 1.02 1.15 1.58 1.47 1.52 1.10 .85
Rad23a
KLA  ATP  ATP+KLA
 NM_009010 RAD23a homolog (S. cerevisiae) (Rad23a), mRNA [NM_009010] KLA 1.06 1.04 1.05 .99 1.14 1.23 1.52
ATP .98 1.08 .91 1.23 .92 .47 .89
KLA/ATP 1.11 1.18 .91 1.25 .80 .56 .85
Rad23b
KLA  ATP  ATP+KLA
 AK084917 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430011I09 product:RAD23b homolog (S. cerevisiae), full insert sequence. [AK084917] KLA .89 .81 .75 .76 .94 .93 .99
ATP 1.04 1.10 1.31 1.52 1.05 .85 .90
KLA/ATP .89 .90 .84 1.02 .82 .83 .89
Rad23b
KLA  ATP  ATP+KLA
 NM_009011 RAD23b homolog (S. cerevisiae) (Rad23b), mRNA [NM_009011] KLA 1.12 1.07 1.06 1.08 .99 1.07 1.24
ATP 1.10 1.19 1.30 1.60 1.65 .87 .68
KLA/ATP 1.26 1.14 1.20 1.35 .99 .68 .45
Rbx1
KLA  ATP  ATP+KLA
 NM_019712 ring-box 1 (Rbx1), mRNA [NM_019712] KLA 1.04 1.01 .98 1.09 1.06 1.14 1.09
ATP .92 .89 1.13 1.16 1.68 1.07 .83
KLA/ATP .99 .99 1.25 1.31 2.63 2.06 .67
Rfc1
KLA  ATP  ATP+KLA
 NM_011258 replication factor C (activator 1) 1 (Rfc1), mRNA [NM_011258] KLA .37 .35 .39 .42 .46 .67 .75
ATP .96 .95 1.13 .76 .45 .40 .62
KLA/ATP .36 .38 .42 .30 .29 .38 .36
Rfc2
KLA  ATP  ATP+KLA
 NM_020022 replication factor C (activator 1) 2 (Rfc2), mRNA [NM_020022] KLA .51 .52 .53 .57 .61 .86 .75
ATP .96 .91 1.11 1.11 .70 .35 .86
KLA/ATP .51 .50 .62 .54 .57 .56 .76
Rfc3
KLA  ATP  ATP+KLA
 NM_027009 replication factor C (activator 1) 3 (Rfc3), mRNA [NM_027009] KLA 1.71 1.88 2.23 1.86 1.17 1.37 .82
ATP .93 .90 1.00 .94 .72 .77 .68
KLA/ATP 1.74 1.98 2.39 2.16 1.50 1.24 .82
Rfc4
KLA  ATP  ATP+KLA
 NM_145480 replication factor C (activator 1) 4 (Rfc4), mRNA [NM_145480] KLA .39 .38 .36 .37 .31 .44 .35
ATP .97 .92 1.27 1.00 .55 .45 .32
KLA/ATP .39 .36 .50 .36 .33 .38 .24
Rfc5
KLA  ATP  ATP+KLA
 NM_028128 replication factor C (activator 1) 5 (Rfc5), mRNA [NM_028128] KLA .67 .65 .67 .61 .50 .52 .41
ATP .95 .90 1.04 1.05 .59 .34 .42
KLA/ATP .60 .60 .69 .64 .53 .45 .48
Rpa1
KLA  ATP  ATP+KLA
 NM_026653 replication protein A1 (Rpa1), mRNA [NM_026653] KLA .51 .51 .42 .36 .30 .42 .32
ATP 1.01 1.10 1.09 .92 .66 .38 .43
KLA/ATP .54 .49 .44 .41 .32 .30 .27
Rpa2
KLA  ATP  ATP+KLA
 D00812 mRNA for 30-kDa subunit of replication protein A, complete cds. [D00812] KLA .34 .36 .38 .32 .33 .42 .36
ATP 1.03 1.00 .91 .81 .43 .55 .27
KLA/ATP .39 .34 .39 .42 .35 .44 .27
Rpa2
KLA  ATP  ATP+KLA
 NM_011284 replication protein A2 (Rpa2), mRNA [NM_011284] KLA .34 .37 .38 .35 .36 .42 .36
ATP .98 .93 .87 .81 .47 .53 .26
KLA/ATP .36 .34 .40 .42 .36 .47 .24
Rpa3
KLA  ATP  ATP+KLA
 NM_026632 replication protein A3 (Rpa3), mRNA [NM_026632] KLA .54 .49 .54 .52 .46 .55 .48
ATP .89 .88 1.39 1.24 .56 .41 .39
KLA/ATP .48 .54 .77 .61 .41 .42 .32
Xpa
KLA  ATP  ATP+KLA
 NM_011728 xeroderma pigmentosum, complementation group A (Xpa), mRNA [NM_011728] KLA .88 1.04 .86 1.04 1.06 1.28 1.09
ATP 1.02 .98 1.00 1.04 .67 .82 .68
KLA/ATP .89 .88 .95 .92 .76 .91 .82
Xpc
KLA  ATP  ATP+KLA
 NM_009531 xeroderma pigmentosum, complementation group C (Xpc), mRNA [NM_009531] KLA .36 .34 .34 .40 .45 .63 .70
ATP .94 .90 .90 .65 .54 .70 .77
KLA/ATP .34 .34 .40 .34 .46 .59 .52