Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Homologous recombination (mmu03440)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK085134
KLA  ATP  ATP+KLA
 AK085134 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430042D16 product:unclassifiable, full insert sequence. [AK085134] KLA 1.06 .99 .97 1.10 1.08 1.04 .98
ATP 1.01 1.12 1.51 2.07 1.56 1.16 1.05
KLA/ATP 1.03 1.07 1.28 1.32 1.19 1.07 1.05
Blm
KLA  ATP  ATP+KLA
 NM_007550 Bloom syndrome homolog (human) (Blm), transcript variant 1, mRNA [NM_007550] KLA .35 .34 .34 .39 .39 .48 .40
ATP .95 .96 1.24 .90 .74 .69 .44
KLA/ATP .34 .33 .47 .47 .71 .76 .45
Brca2
KLA  ATP  ATP+KLA
 NM_009765 breast cancer 2 (Brca2), transcript variant 2, mRNA [NM_009765] KLA .25 .23 .23 .26 .28 .29 .24
ATP .94 .94 1.19 .68 .36 .30 .28
KLA/ATP .23 .22 .33 .31 .30 .23 .19
E130016E
03Rik
KLA  ATP  ATP+KLA
 AK147819 melanocyte cDNA, RIKEN full-length enriched library, clone:G270053E10 product:Fibrinogen silencer binding protein homolog, full insert sequence [AK147819] KLA .74 .73 .78 .88 .75 .75 .66
ATP 1.06 1.09 1.12 .89 .79 .75 .63
KLA/ATP .76 .76 .80 .77 .72 .72 .66
E130016E
03Rik
KLA  ATP  ATP+KLA
 NM_001039556 RIKEN cDNA E130016E03 gene (E130016E03Rik), mRNA [NM_001039556] KLA .73 .73 .75 .73 .68 .68 .61
ATP 1.09 1.06 1.10 .89 .74 .67 .57
KLA/ATP .74 .71 .82 .77 .72 .68 .57
Eme1
KLA  ATP  ATP+KLA
 NM_177752 essential meiotic endonuclease 1 homolog 1 (S. pombe) (Eme1), mRNA [NM_177752] KLA .81 .82 .92 .89 1.04 .96 .50
ATP .98 .97 .91 .80 .70 .84 .37
KLA/ATP .87 .79 .85 .79 .70 .64 .44
Mm.23625
6
KLA  ATP  ATP+KLA
 124487408 Unknown KLA .24 .22 .23 .24 .24 .30 .25
ATP .90 .95 1.24 .70 .34 .27 .28
KLA/ATP .21 .23 .31 .30 .30 .23 .18
Mm.29073
KLA  ATP  ATP+KLA
 146141223 Unknown KLA .48 .44 .52 .52 .40 .48 .44
ATP 1.03 .81 1.38 1.13 .59 .41 .38
KLA/ATP .45 .50 .74 .47 .37 .41 .31
Mre11a
KLA  ATP  ATP+KLA
 AK161013 15 days embryo head cDNA, RIKEN full-length enriched library, clone:4022449A05 product:meiotic recombination 11 homolog A (S. cerevisiae), full insert sequence [AK161013] KLA .77 .79 .63 .60 .50 .55 .57
ATP .92 .97 .85 .73 .74 .55 .43
KLA/ATP .79 .77 .67 .63 .69 .58 .45
Mre11a
KLA  ATP  ATP+KLA
 NM_018736 meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a), mRNA [NM_018736] KLA 1.40 1.34 1.27 1.22 .95 .77 .93
ATP 1.06 1.20 1.08 1.04 .67 .70 .83
KLA/ATP 1.38 1.41 1.30 1.37 .84 .56 .75
Mus81
KLA  ATP  ATP+KLA
 NM_027877 MUS81 endonuclease homolog (yeast) (Mus81), mRNA [NM_027877] KLA .95 1.00 .93 1.05 1.35 1.36 1.24
ATP .95 .84 .44 .46 .40 .95 1.11
KLA/ATP .94 .82 .47 .48 .43 .92 1.11
Nbn
KLA  ATP  ATP+KLA
 NM_013752 nibrin (Nbn), mRNA [NM_013752] KLA .96 .98 .98 .95 .93 1.04 1.07
ATP .94 .95 1.14 1.31 1.61 .83 .88
KLA/ATP .91 .94 1.18 1.25 1.46 1.10 .96
Pold1
KLA  ATP  ATP+KLA
 NM_011131 polymerase (DNA directed), delta 1, catalytic subunit (Pold1), mRNA [NM_011131] KLA .24 .21 .20 .18 .18 .29 .36
ATP 1.05 1.05 .96 .99 .52 .26 .32
KLA/ATP .26 .22 .21 .22 .16 .17 .18
Pold2
KLA  ATP  ATP+KLA
 NM_008894 polymerase (DNA directed), delta 2, regulatory subunit (Pold2), mRNA [NM_008894] KLA .77 .83 .69 .68 .59 .49 .57
ATP 1.05 1.09 .97 1.24 .89 .44 .43
KLA/ATP .79 .78 .70 .84 .60 .41 .30
Pold3
KLA  ATP  ATP+KLA
 NM_133692 polymerase (DNA-directed), delta 3, accessory subunit (Pold3), mRNA [NM_133692] KLA 1.14 1.07 1.22 1.22 1.12 1.40 1.10
ATP .99 .95 1.17 .89 1.46 1.74 1.55
KLA/ATP 1.01 1.08 1.54 1.28 1.86 2.34 2.11
Pold4
KLA  ATP  ATP+KLA
 NM_027196 polymerase (DNA-directed), delta 4 (Pold4), mRNA [NM_027196] KLA .81 .88 .80 .78 .85 1.04 1.40
ATP .97 1.07 1.12 1.37 1.19 .86 1.27
KLA/ATP .85 .90 .89 1.07 .90 .94 1.62
Rad50
KLA  ATP  ATP+KLA
 BC002033 RAD50 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3491597), complete cds. [BC002033] KLA .90 .83 .86 .80 .94 .86 .85
ATP .89 .86 .83 .83 .83 .89 .91
KLA/ATP .82 .82 .78 .77 .80 .86 .91
Rad50
KLA  ATP  ATP+KLA
 NM_009012 RAD50 homolog (S. cerevisiae) (Rad50), mRNA [NM_009012] KLA .51 .53 .51 .50 .51 .62 .73
ATP 1.03 1.02 1.04 .85 .74 .50 .64
KLA/ATP .58 .55 .56 .52 .58 .45 .41
Rad51
KLA  ATP  ATP+KLA
 NM_011234 RAD51 homolog (S. cerevisiae) (Rad51), mRNA [NM_011234] KLA .44 .39 .39 .29 .16 .14 .12
ATP 1.13 .90 .69 .63 .38 .25 .09
KLA/ATP .47 .38 .35 .23 .18 .10 .06
Rad51c
KLA  ATP  ATP+KLA
 NM_053269 Rad51 homolog c (S. cerevisiae) (Rad51c), mRNA [NM_053269] KLA .58 .53 .65 .68 .60 .67 .57
ATP .97 1.03 1.02 .94 .75 .59 .61
KLA/ATP .53 .57 .68 .69 .68 .66 .61
Rad51l1
KLA  ATP  ATP+KLA
 NM_009014 RAD51-like 1 (S. cerevisiae) (Rad51l1), mRNA [NM_009014] KLA .89 .88 .81 .77 .65 .57 .50
ATP 1.01 1.02 .99 1.05 .81 .71 .58
KLA/ATP .91 .85 .87 .86 .82 .66 .51
Rad51l3
KLA  ATP  ATP+KLA
 NM_011235 RAD51-like 3 (S. cerevisiae) (Rad51l3), mRNA [NM_011235] KLA .79 .77 .78 .82 .97 .96 .94
ATP 1.07 1.01 .99 .87 .68 .79 .79
KLA/ATP .80 .80 .86 .76 .78 .80 .84
Rad52
KLA  ATP  ATP+KLA
 NM_011236 RAD52 homolog (S. cerevisiae) (Rad52), mRNA [NM_011236] KLA 1.20 1.28 1.32 1.33 1.37 1.20 1.14
ATP 1.09 1.00 .79 .98 1.04 1.21 1.05
KLA/ATP 1.26 1.28 1.09 1.01 .87 1.00 1.19
Rad54l
KLA  ATP  ATP+KLA
 AK017045 adult male testis cDNA, RIKEN full-length enriched library, clone:4933433M02 product:RAD54 like (S. cerevisiae), full insert sequence. [AK017045] KLA .99 1.00 .93 .95 1.02 1.00 1.01
ATP .98 1.01 1.04 1.07 .99 .97 1.02
KLA/ATP 1.04 1.02 1.01 1.02 .96 .98 .95
Rad54l
KLA  ATP  ATP+KLA
 NM_009015 RAD54 like (S. cerevisiae) (Rad54l), transcript variant 1, mRNA [NM_009015] KLA .43 .48 .43 .41 .33 .38 .22
ATP 1.05 .93 .79 .72 .45 .33 .21
KLA/ATP .48 .42 .40 .47 .36 .25 .17
Rpa1
KLA  ATP  ATP+KLA
 NM_026653 replication protein A1 (Rpa1), mRNA [NM_026653] KLA .51 .51 .42 .36 .30 .42 .32
ATP 1.01 1.10 1.09 .92 .66 .38 .43
KLA/ATP .54 .49 .44 .41 .32 .30 .27
Rpa2
KLA  ATP  ATP+KLA
 D00812 mRNA for 30-kDa subunit of replication protein A, complete cds. [D00812] KLA .34 .36 .38 .32 .33 .42 .36
ATP 1.03 1.00 .91 .81 .43 .55 .27
KLA/ATP .39 .34 .39 .42 .35 .44 .27
Rpa2
KLA  ATP  ATP+KLA
 NM_011284 replication protein A2 (Rpa2), mRNA [NM_011284] KLA .34 .37 .38 .35 .36 .42 .36
ATP .98 .93 .87 .81 .47 .53 .26
KLA/ATP .36 .34 .40 .42 .36 .47 .24
Rpa3
KLA  ATP  ATP+KLA
 NM_026632 replication protein A3 (Rpa3), mRNA [NM_026632] KLA .54 .49 .54 .52 .46 .55 .48
ATP .89 .88 1.39 1.24 .56 .41 .39
KLA/ATP .48 .54 .77 .61 .41 .42 .32
Shfm1
KLA  ATP  ATP+KLA
 NM_009169 split hand/foot malformation (ectrodactyly) type 1 (Shfm1), mRNA [NM_009169] KLA 1.04 1.01 .96 1.15 1.07 1.17 1.15
ATP .92 .88 1.07 .98 1.00 1.07 1.07
KLA/ATP .90 .94 1.19 1.11 1.25 1.23 1.08
Ssbp1
KLA  ATP  ATP+KLA
 NM_028358 single-stranded DNA binding protein 1 (Ssbp1), transcript variant 2, mRNA [NM_028358] KLA .85 .82 .84 .89 .78 .95 .97
ATP .79 .68 .85 .69 .77 1.24 .85
KLA/ATP .72 .71 .95 .72 .86 .94 .66
Ssbp1
KLA  ATP  ATP+KLA
 NM_212468 single-stranded DNA binding protein 1 (Ssbp1), transcript variant 1, mRNA [NM_212468] KLA .87 .89 .86 .81 .82 .89 .86
ATP .87 .84 .89 .78 .78 .77 .72
KLA/ATP .83 .79 .82 .71 .78 .75 .63
Top3a
KLA  ATP  ATP+KLA
 NM_009410 topoisomerase (DNA) III alpha (Top3a), mRNA [NM_009410] KLA 1.66 1.66 1.68 1.48 1.66 1.69 1.49
ATP 1.09 1.08 .93 .88 1.48 2.32 1.51
KLA/ATP 1.81 1.77 1.56 1.30 1.68 3.13 3.21
Top3b
KLA  ATP  ATP+KLA
 NM_011624 topoisomerase (DNA) III beta (Top3b), mRNA [NM_011624] KLA .92 .89 .87 1.01 1.00 .96 1.03
ATP .99 .87 1.03 .65 .48 .84 1.07
KLA/ATP .87 .86 .99 .59 .51 .71 1.07
Xrcc2
KLA  ATP  ATP+KLA
 AK085093 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430035K04 product:hypothetical protein, full insert sequence. [AK085093] KLA .88 1.06 .93 .89 .96 1.01 .98
ATP .95 1.00 1.01 1.00 .90 .99 1.01
KLA/ATP .97 .96 1.03 1.12 .93 1.03 1.06
Xrcc2
KLA  ATP  ATP+KLA
 NM_020570 X-ray repair complementing defective repair in Chinese hamster cells 2 (Xrcc2), mRNA [NM_020570] KLA .68 .70 .75 .69 .67 .69 .76
ATP 1.01 1.07 1.03 .84 .63 .86 .83
KLA/ATP .68 .68 .76 .71 .66 .70 .72
Xrcc3
KLA  ATP  ATP+KLA
 NM_028875 X-ray repair complementing defective repair in Chinese hamster cells 3 (Xrcc3), mRNA [NM_028875] KLA .45 .41 .43 .46 .47 .60 .47
ATP 1.01 .94 .62 .55 .44 .53 .47
KLA/ATP .40 .42 .48 .43 .42 .49 .42