Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Non-homologous end-joining (mmu03450)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Dclre1c
KLA  ATP  ATP+KLA
 NM_146114 DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c), transcript variant 1, mRNA [NM_146114] KLA 1.68 1.46 1.87 1.85 2.42 2.17 1.44
ATP 1.27 1.51 2.01 1.89 1.54 1.19 .92
KLA/ATP 1.83 1.78 2.18 2.18 2.20 1.96 2.29
Dclre1c
KLA  ATP  ATP+KLA
 NM_175683 DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c), transcript variant 2, mRNA [NM_175683] KLA 1.53 1.60 1.78 1.77 2.20 2.56 1.37
ATP .91 .95 1.00 .93 .91 1.61 1.45
KLA/ATP 1.39 1.43 1.50 1.40 1.57 2.02 2.93
Dntt
KLA  ATP  ATP+KLA
 NM_001043228 deoxynucleotidyltransferase, terminal (Dntt), transcript variant 2, mRNA [NM_001043228] KLA 1.01 1.00 1.02 1.01 1.02 1.00 1.07
ATP .94 1.03 1.08 .99 1.08 1.09 1.05
KLA/ATP 1.00 1.00 1.01 1.04 1.06 1.05 1.12
Dntt
KLA  ATP  ATP+KLA
 NM_009345 deoxynucleotidyltransferase, terminal (Dntt), transcript variant 1, mRNA [NM_009345] KLA 1.22 1.15 1.23 1.25 1.17 1.15 1.12
ATP 1.09 1.03 1.27 1.22 2.08 2.71 1.39
KLA/ATP 1.19 1.21 1.44 1.29 1.60 2.51 1.92
Fen1
KLA  ATP  ATP+KLA
 NM_007999 flap structure specific endonuclease 1 (Fen1), mRNA [NM_007999] KLA .37 .38 .37 .34 .41 .57 .44
ATP .98 1.04 .81 .78 .74 .72 .53
KLA/ATP .42 .37 .33 .38 .60 1.03 .43
Lig4
KLA  ATP  ATP+KLA
 NM_176953 ligase IV, DNA, ATP-dependent (Lig4), mRNA [NM_176953] KLA .81 .79 .80 .80 .91 1.18 1.34
ATP .96 1.00 1.10 .69 1.28 1.58 2.03
KLA/ATP .76 .84 .85 .58 1.22 1.53 1.22
Mm.71
KLA  ATP  ATP+KLA
 124517705 Unknown KLA .65 .58 .48 .42 .35 .47 .60
ATP .96 .95 1.22 1.00 .55 .33 .76
KLA/ATP .62 .60 .66 .43 .36 .31 .45
Mre11a
KLA  ATP  ATP+KLA
 AK161013 15 days embryo head cDNA, RIKEN full-length enriched library, clone:4022449A05 product:meiotic recombination 11 homolog A (S. cerevisiae), full insert sequence [AK161013] KLA .77 .79 .63 .60 .50 .55 .57
ATP .92 .97 .85 .73 .74 .55 .43
KLA/ATP .79 .77 .67 .63 .69 .58 .45
Mre11a
KLA  ATP  ATP+KLA
 NM_018736 meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a), mRNA [NM_018736] KLA 1.40 1.34 1.27 1.22 .95 .77 .93
ATP 1.06 1.20 1.08 1.04 .67 .70 .83
KLA/ATP 1.38 1.41 1.30 1.37 .84 .56 .75
Nhej1
KLA  ATP  ATP+KLA
 NM_029342 nonhomologous end-joining factor 1 (Nhej1), mRNA [NM_029342] KLA .99 .97 .90 .98 .91 .84 1.09
ATP .98 .99 1.04 1.11 .87 1.04 .82
KLA/ATP .95 1.00 .96 1.00 .92 1.14 .81
Poll
KLA  ATP  ATP+KLA
 NM_020032 polymerase (DNA directed), lambda (Poll), mRNA [NM_020032] KLA 1.12 1.16 1.24 1.46 1.53 1.42 .89
ATP 1.00 .85 .72 .66 .56 1.50 1.20
KLA/ATP 1.05 1.02 .99 .84 1.14 2.30 1.69
Polm
KLA  ATP  ATP+KLA
 NM_017401 polymerase (DNA directed), mu (Polm), mRNA [NM_017401] KLA 2.06 1.90 1.91 2.43 2.42 1.83 1.15
ATP .93 .81 1.02 .64 .64 1.41 1.30
KLA/ATP 1.56 1.56 2.21 1.36 1.04 1.35 1.88
Prkdc
KLA  ATP  ATP+KLA
 NM_011159 protein kinase, DNA activated, catalytic polypeptide (Prkdc), mRNA [NM_011159] KLA .69 .67 .58 .52 .47 .54 .73
ATP 1.12 1.12 1.09 1.05 .60 .42 .83
KLA/ATP .74 .71 .65 .57 .45 .41 .55
Rad50
KLA  ATP  ATP+KLA
 BC002033 RAD50 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3491597), complete cds. [BC002033] KLA .90 .83 .86 .80 .94 .86 .85
ATP .89 .86 .83 .83 .83 .89 .91
KLA/ATP .82 .82 .78 .77 .80 .86 .91
Rad50
KLA  ATP  ATP+KLA
 NM_009012 RAD50 homolog (S. cerevisiae) (Rad50), mRNA [NM_009012] KLA .51 .53 .51 .50 .51 .62 .73
ATP 1.03 1.02 1.04 .85 .74 .50 .64
KLA/ATP .58 .55 .56 .52 .58 .45 .41
Xrcc4
KLA  ATP  ATP+KLA
 AK053612 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130114F22 product:XRCC4 homolog [Mus musculus], full insert sequence. [AK053612] KLA 1.04 .95 .98 .96 1.01 1.00 .99
ATP .96 .96 .95 1.10 .95 1.00 1.07
KLA/ATP .99 .98 .97 .99 1.01 1.01 .81
Xrcc4
KLA  ATP  ATP+KLA
 NM_028012 X-ray repair complementing defective repair in Chinese hamster cells 4 (Xrcc4), mRNA [NM_028012] KLA 1.39 1.48 1.59 1.70 1.56 1.32 1.22
ATP .99 .99 1.34 1.23 .92 .97 1.30
KLA/ATP 1.37 1.53 1.91 1.64 1.28 .99 1.33
Xrcc5
KLA  ATP  ATP+KLA
 NM_009533 X-ray repair complementing defective repair in Chinese hamster cells 5 (Xrcc5), mRNA [NM_009533] KLA .75 .81 .73 .67 .52 .45 .59
ATP 1.01 1.03 1.09 .97 .74 .45 .57
KLA/ATP .83 .85 .85 .68 .57 .58 .58
Xrcc6
KLA  ATP  ATP+KLA
 NM_010247 X-ray repair complementing defective repair in Chinese hamster cells 6 (Xrcc6), mRNA [NM_010247] KLA .67 .67 .60 .49 .38 .39 .56
ATP 1.06 1.12 1.10 1.26 .74 .32 .46
KLA/ATP .72 .66 .66 .62 .45 .28 .23