Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Fanconi anemia pathway (mmu03460)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2310003H
01Rik
KLA  ATP  ATP+KLA
 AK009114 adult male tongue cDNA, RIKEN full-length enriched library, clone:2310003H01 product:hypothetical Lipocalins structure containing protein, full insert sequence. [AK009114] KLA .80 .79 .71 .89 1.00 .80 .78
ATP .75 .63 .58 .63 1.00 1.04 .88
KLA/ATP .75 .64 .62 .73 1.14 .98 .81
2310003H
01Rik
KLA  ATP  ATP+KLA
 NM_027980 RIKEN cDNA 2310003H01 gene (2310003H01Rik), mRNA [NM_027980] KLA .55 .59 .52 .60 .78 .81 .63
ATP 1.03 1.06 .79 .85 .49 .64 .76
KLA/ATP .64 .56 .48 .57 .51 .56 .56
6620401K
05Rik
KLA  ATP  ATP+KLA
 NM_172774 RIKEN cDNA 6620401K05 gene (6620401K05Rik), mRNA [NM_172774] KLA .73 .71 .66 .65 .68 .80 .95
ATP .91 .81 .93 .76 .66 .98 .98
KLA/ATP .67 .62 .70 .58 .51 .73 .99
Apitd1
KLA  ATP  ATP+KLA
 NM_027263 apoptosis-inducing, TAF9-like domain 1 (Apitd1), mRNA [NM_027263] KLA .44 .43 .41 .43 .40 .45 .45
ATP 1.04 .99 1.05 .91 .56 .53 .37
KLA/ATP .43 .43 .53 .48 .47 .50 .41
Blm
KLA  ATP  ATP+KLA
 NM_007550 Bloom syndrome homolog (human) (Blm), transcript variant 1, mRNA [NM_007550] KLA .35 .34 .34 .39 .39 .48 .40
ATP .95 .96 1.24 .90 .74 .69 .44
KLA/ATP .34 .33 .47 .47 .71 .76 .45
Brca1
KLA  ATP  ATP+KLA
 NM_009764 breast cancer 1 (Brca1), mRNA [NM_009764] KLA .40 .41 .40 .41 .38 .50 .40
ATP 1.13 1.18 1.07 .94 .76 .45 .44
KLA/ATP .42 .38 .41 .47 .50 .68 .46
Brca2
KLA  ATP  ATP+KLA
 NM_009765 breast cancer 2 (Brca2), transcript variant 2, mRNA [NM_009765] KLA .25 .23 .23 .26 .28 .29 .24
ATP .94 .94 1.19 .68 .36 .30 .28
KLA/ATP .23 .22 .33 .31 .30 .23 .19
Brip1
KLA  ATP  ATP+KLA
 NM_178309 BRCA1 interacting protein C-terminal helicase 1 (Brip1), mRNA [NM_178309] KLA .97 .86 1.06 .78 .51 .57 .35
ATP .99 .97 1.26 1.18 1.35 1.04 .37
KLA/ATP .95 .86 1.18 1.10 1.59 1.62 .45
Btbd12
KLA  ATP  ATP+KLA
 NM_177472 BTB (POZ) domain containing 12 (Btbd12), mRNA [NM_177472] KLA .59 .53 .60 .70 .84 1.12 .85
ATP 1.02 .91 .95 .41 .42 1.21 1.43
KLA/ATP .56 .48 .60 .35 .46 1.10 1.49
C230052I
12Rik
KLA  ATP  ATP+KLA
 NM_178643 RIKEN cDNA C230052I12 gene (C230052I12Rik), mRNA [NM_178643] KLA 1.05 .96 1.05 .99 1.08 1.27 1.53
ATP 1.00 .99 .74 .84 .70 1.15 1.35
KLA/ATP 1.02 .93 .62 .79 .78 1.48 1.70
Eme1
KLA  ATP  ATP+KLA
 NM_177752 essential meiotic endonuclease 1 homolog 1 (S. pombe) (Eme1), mRNA [NM_177752] KLA .81 .82 .92 .89 1.04 .96 .50
ATP .98 .97 .91 .80 .70 .84 .37
KLA/ATP .87 .79 .85 .79 .70 .64 .44
Ercc1
KLA  ATP  ATP+KLA
 NM_007948 excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1), mRNA [NM_007948] KLA 1.04 1.03 1.05 .96 1.11 1.08 1.11
ATP 1.04 1.11 .97 1.26 .90 .79 .93
KLA/ATP 1.14 1.16 .84 1.25 .86 .96 1.25
Ercc4
KLA  ATP  ATP+KLA
 NM_015769 excision repair cross-complementing rodent repair deficiency, complementation group 4 (Ercc4), mRNA [NM_015769] KLA .96 .91 .93 .90 .88 .93 1.06
ATP 1.14 1.22 1.06 .99 .74 1.08 1.20
KLA/ATP .97 .95 .87 .83 .61 .88 1.00
Fanca
KLA  ATP  ATP+KLA
 NM_016925 Fanconi anemia, complementation group A (Fanca), mRNA [NM_016925] KLA 1.09 1.11 1.31 1.62 1.70 2.06 1.00
ATP .98 .91 1.27 1.15 .80 .58 .56
KLA/ATP 1.03 1.08 1.62 1.42 1.24 1.63 1.95
Fancb
KLA  ATP  ATP+KLA
 NM_175027 Fanconi anemia, complementation group B (Fancb), mRNA [NM_175027] KLA .34 .34 .43 .43 .42 .53 .38
ATP .93 .89 1.10 .64 .52 .49 .36
KLA/ATP .31 .31 .47 .42 .45 .46 .31
Fancc
KLA  ATP  ATP+KLA
 NM_007985 Fanconi anemia, complementation group C (Fancc), transcript variant 1, mRNA [NM_007985] KLA 1.23 1.46 1.47 1.39 1.11 .91 .98
ATP 1.01 1.04 1.17 1.11 .88 1.10 .85
KLA/ATP 1.48 1.56 1.59 1.59 1.12 .88 .77
Fancd2
KLA  ATP  ATP+KLA
 NM_001033244 Fanconi anemia, complementation group D2 (Fancd2), mRNA [NM_001033244] KLA .65 .67 .66 .64 .51 .44 .33
ATP 1.06 1.10 1.07 1.06 .76 .47 .29
KLA/ATP .65 .65 .67 .68 .51 .46 .30
Fance
KLA  ATP  ATP+KLA
 AK172283 activated spleen cDNA, RIKEN full-length enriched library, clone:F830113B01 product:hypothetical protein, full insert sequence [AK172283] KLA .37 .36 .33 .37 .42 .49 .47
ATP .90 .79 .98 .72 .42 .45 .55
KLA/ATP .33 .32 .37 .30 .35 .42 .33
Fancf
KLA  ATP  ATP+KLA
 AK042550 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730004C17 product:unclassifiable, full insert sequence [AK042550] KLA .98 .88 .91 .91 .91 .91 .91
ATP 1.05 .96 .89 .92 .93 .91 .92
KLA/ATP .94 .94 .87 .90 .90 .95 .92
Fancg
KLA  ATP  ATP+KLA
 BC050890 Fanconi anemia, complementation group G, mRNA (cDNA clone IMAGE:6418786), complete cds [BC050890] KLA .73 .61 .59 .68 .54 .75 .60
ATP .86 .78 1.10 .79 .56 .62 .72
KLA/ATP .56 .58 .73 .50 .50 .64 .77
Fancg
KLA  ATP  ATP+KLA
 NM_053081 Fanconi anemia, complementation group G (Fancg), mRNA [NM_053081] KLA .99 .95 .99 .91 .88 .87 .86
ATP 1.03 1.18 1.05 1.06 .76 .73 .83
KLA/ATP 1.03 .98 .89 .92 .72 .73 .86
Fanci
KLA  ATP  ATP+KLA
 NM_145946 Fanconi anemia, complementation group I (Fanci), mRNA [NM_145946] KLA .79 .84 .78 .78 .67 .61 .51
ATP .98 .96 1.10 .94 .75 .57 .47
KLA/ATP .82 .73 .82 .75 .67 .57 .47
Fancl
KLA  ATP  ATP+KLA
 NM_025923 Fanconi anemia, complementation group L (Fancl), mRNA [NM_025923] KLA .93 .94 1.02 .97 .80 .70 .53
ATP .92 .90 1.40 1.08 .69 .56 .70
KLA/ATP .86 .89 1.32 .96 .85 .53 .43
Fancm
KLA  ATP  ATP+KLA
 NM_178912 Fanconi anemia, complementation group M (Fancm), mRNA [NM_178912] KLA .63 .61 .62 .63 .60 .60 .58
ATP 1.05 .91 .75 .63 .75 .69 .58
KLA/ATP .63 .57 .63 .60 .63 .63 .54
Giyd2
KLA  ATP  ATP+KLA
 NM_029420 GIY-YIG domain containing 2 (Giyd2), mRNA [NM_029420] KLA .73 .66 .67 .78 .77 .96 1.05
ATP 1.00 .96 .89 .87 .62 .86 1.21
KLA/ATP .68 .65 .80 .75 .72 .87 1.28
Hes1
KLA  ATP  ATP+KLA
 NM_008235 hairy and enhancer of split 1 (Drosophila) (Hes1), mRNA [NM_008235] KLA .96 1.00 1.02 .93 1.01 .94 .99
ATP .93 1.03 1.05 .96 1.06 1.02 1.02
KLA/ATP .97 .93 1.03 1.06 1.10 1.17 1.16
Mlh1
KLA  ATP  ATP+KLA
 NM_026810 mutL homolog 1 (E. coli) (Mlh1), mRNA [NM_026810] KLA .58 .55 .46 .47 .38 .49 .66
ATP .93 .95 1.06 1.02 .50 .80 .77
KLA/ATP .59 .56 .59 .55 .41 1.31 1.86
Mm.18614
3
KLA  ATP  ATP+KLA
 30795234 Unknown KLA .73 .68 .78 .69 .47 .45 .27
ATP .96 .93 1.09 .86 .65 .53 .24
KLA/ATP .68 .64 .82 .70 .67 .54 .22
Mm.23625
6
KLA  ATP  ATP+KLA
 124487408 Unknown KLA .24 .22 .23 .24 .24 .30 .25
ATP .90 .95 1.24 .70 .34 .27 .28
KLA/ATP .21 .23 .31 .30 .30 .23 .18
Mm.29073
KLA  ATP  ATP+KLA
 146141223 Unknown KLA .48 .44 .52 .52 .40 .48 .44
ATP 1.03 .81 1.38 1.13 .59 .41 .38
KLA/ATP .45 .50 .74 .47 .37 .41 .31
Mm.2950
KLA  ATP  ATP+KLA
 121583909 Unknown KLA .85 .79 .75 .75 .81 .75 .79
ATP .94 1.13 .91 .71 .69 .73 .78
KLA/ATP .78 .73 .79 .74 .71 .71 .67
Mm.32577
7
KLA  ATP  ATP+KLA
 85701779 Unknown KLA .99 1.01 1.04 .95 1.00 .96 .99
ATP 1.01 1.02 .94 1.02 .98 1.01 .97
KLA/ATP 1.05 .90 .99 1.05 .98 .90 .99
Mm.43972
3
KLA  ATP  ATP+KLA
 153792336 Unknown KLA .39 .33 .34 .30 .39 .58 .97
ATP 1.12 1.02 1.23 1.06 1.41 1.10 1.25
KLA/ATP .42 .35 .50 .59 1.68 1.10 1.36
Mus81
KLA  ATP  ATP+KLA
 NM_027877 MUS81 endonuclease homolog (yeast) (Mus81), mRNA [NM_027877] KLA .95 1.00 .93 1.05 1.35 1.36 1.24
ATP .95 .84 .44 .46 .40 .95 1.11
KLA/ATP .94 .82 .47 .48 .43 .92 1.11
Palb2
KLA  ATP  ATP+KLA
 AK028653 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732427B05 product:hypothetical protein, full insert sequence. [AK028653] KLA .66 .65 .65 .65 .75 .83 .66
ATP .86 .78 .68 .64 .75 .77 .67
KLA/ATP .63 .59 .64 .63 .77 .78 .60
Palb2
KLA  ATP  ATP+KLA
 NM_001081238 partner and localizer of BRCA2 (Palb2), mRNA [NM_001081238] KLA .69 .68 .71 .75 .67 .75 .72
ATP .95 1.03 .92 .79 .69 .66 .70
KLA/ATP .64 .68 .74 .67 .67 .84 .59
Pms2
KLA  ATP  ATP+KLA
 NM_008886 postmeiotic segregation increased 2 (S. cerevisiae) (Pms2), mRNA [NM_008886] KLA .42 .43 .46 .51 .70 .69 .61
ATP 1.12 1.11 .78 .52 .37 .47 .55
KLA/ATP .47 .44 .47 .40 .38 .43 .40
Polh
KLA  ATP  ATP+KLA
 BC049159 cDNA clone IMAGE:6391802, containing frame-shift errors [BC049159] KLA .40 .37 .36 .44 .45 .56 .41
ATP .97 1.07 1.20 .91 .54 .79 .43
KLA/ATP .40 .39 .47 .42 .38 .52 .29
Polh
KLA  ATP  ATP+KLA
 NM_030715 polymerase (DNA directed), eta (RAD 30 related) (Polh), mRNA [NM_030715] KLA .73 .67 .67 .75 .68 .67 .62
ATP 1.07 1.27 .93 .94 .68 .72 .57
KLA/ATP .71 .71 .68 .71 .56 .61 .50
Poli
KLA  ATP  ATP+KLA
 NM_011972 polymerase (DNA directed), iota (Poli), mRNA [NM_011972] KLA .61 .60 .63 .60 .61 .74 .81
ATP .99 1.00 .98 .49 .29 .36 .70
KLA/ATP .57 .59 .63 .44 .38 .34 .37
Polk
KLA  ATP  ATP+KLA
 NM_012048 polymerase (DNA directed), kappa (Polk), mRNA [NM_012048] KLA .91 .87 1.00 .92 .77 .84 .86
ATP 1.20 1.18 1.10 .90 .74 .77 1.00
KLA/ATP 1.00 .93 .95 .81 .81 .83 1.01
Poln
KLA  ATP  ATP+KLA
 NM_181857 DNA polymerase N (Poln), mRNA [NM_181857] KLA 1.01 1.02 1.06 1.06 1.01 1.08 1.01
ATP 1.02 1.10 1.04 1.03 1.01 1.04 1.00
KLA/ATP 1.01 .95 1.03 1.08 1.07 1.00 .99
Rad51
KLA  ATP  ATP+KLA
 NM_011234 RAD51 homolog (S. cerevisiae) (Rad51), mRNA [NM_011234] KLA .44 .39 .39 .29 .16 .14 .12
ATP 1.13 .90 .69 .63 .38 .25 .09
KLA/ATP .47 .38 .35 .23 .18 .10 .06
Rad51c
KLA  ATP  ATP+KLA
 NM_053269 Rad51 homolog c (S. cerevisiae) (Rad51c), mRNA [NM_053269] KLA .58 .53 .65 .68 .60 .67 .57
ATP .97 1.03 1.02 .94 .75 .59 .61
KLA/ATP .53 .57 .68 .69 .68 .66 .61
Rev1
KLA  ATP  ATP+KLA
 NM_019570 REV1 homolog (S. cerevisiae) (Rev1), mRNA [NM_019570] KLA .64 .57 .62 .60 .76 .83 .94
ATP 1.08 1.01 .82 .63 1.78 1.31 .96
KLA/ATP .60 .58 .54 .55 1.53 1.05 .91
Rev3l
KLA  ATP  ATP+KLA
 NM_011264 REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae) (Rev3l), mRNA [NM_011264] KLA .38 .33 .34 .31 .36 .53 1.02
ATP 1.14 .97 1.14 1.03 1.41 1.09 1.27
KLA/ATP .42 .36 .44 .51 1.81 1.08 1.39
Rmi1
KLA  ATP  ATP+KLA
 NM_028904 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (Rmi1), mRNA [NM_028904] KLA .32 .31 .33 .41 .56 .90 .81
ATP .90 .84 .87 .78 .54 .49 1.40
KLA/ATP .29 .28 .30 .36 .53 .59 1.15
Rpa1
KLA  ATP  ATP+KLA
 NM_026653 replication protein A1 (Rpa1), mRNA [NM_026653] KLA .51 .51 .42 .36 .30 .42 .32
ATP 1.01 1.10 1.09 .92 .66 .38 .43
KLA/ATP .54 .49 .44 .41 .32 .30 .27
Rpa2
KLA  ATP  ATP+KLA
 D00812 mRNA for 30-kDa subunit of replication protein A, complete cds. [D00812] KLA .34 .36 .38 .32 .33 .42 .36
ATP 1.03 1.00 .91 .81 .43 .55 .27
KLA/ATP .39 .34 .39 .42 .35 .44 .27
Rpa2
KLA  ATP  ATP+KLA
 NM_011284 replication protein A2 (Rpa2), mRNA [NM_011284] KLA .34 .37 .38 .35 .36 .42 .36
ATP .98 .93 .87 .81 .47 .53 .26
KLA/ATP .36 .34 .40 .42 .36 .47 .24
Rpa3
KLA  ATP  ATP+KLA
 NM_026632 replication protein A3 (Rpa3), mRNA [NM_026632] KLA .54 .49 .54 .52 .46 .55 .48
ATP .89 .88 1.39 1.24 .56 .41 .39
KLA/ATP .48 .54 .77 .61 .41 .42 .32
Stra13
KLA  ATP  ATP+KLA
 NM_016665 stimulated by retinoic acid 13 (Stra13), mRNA [NM_016665] KLA .95 1.02 1.09 .94 1.02 .87 .65
ATP 1.13 1.18 1.02 1.46 1.17 .83 .61
KLA/ATP 1.14 1.19 .88 1.48 1.05 .88 .56
Telo2
KLA  ATP  ATP+KLA
 NM_027880 TEL2, telomere maintenance 2, homolog (S. cerevisiae) (Telo2), mRNA [NM_027880] KLA .68 .69 .63 .60 .58 .60 .79
ATP .97 .90 .89 .84 .93 .58 .72
KLA/ATP .68 .69 .60 .66 .83 .47 .36
Top3a
KLA  ATP  ATP+KLA
 NM_009410 topoisomerase (DNA) III alpha (Top3a), mRNA [NM_009410] KLA 1.66 1.66 1.68 1.48 1.66 1.69 1.49
ATP 1.09 1.08 .93 .88 1.48 2.32 1.51
KLA/ATP 1.81 1.77 1.56 1.30 1.68 3.13 3.21
Top3b
KLA  ATP  ATP+KLA
 NM_011624 topoisomerase (DNA) III beta (Top3b), mRNA [NM_011624] KLA .92 .89 .87 1.01 1.00 .96 1.03
ATP .99 .87 1.03 .65 .48 .84 1.07
KLA/ATP .87 .86 .99 .59 .51 .71 1.07
Ube2t
KLA  ATP  ATP+KLA
 AK039874 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430024C02 product:unclassifiable, full insert sequence [AK039874] KLA .97 .96 1.02 1.06 1.08 .97 .98
ATP .98 1.11 1.00 1.00 1.00 .98 .98
KLA/ATP 1.00 .98 1.15 .79 1.02 1.02 1.03
Ube2t
KLA  ATP  ATP+KLA
 NM_026024 ubiquitin-conjugating enzyme E2T (putative) (Ube2t), mRNA [NM_026024] KLA .20 .18 .20 .16 .14 .19 .17
ATP .74 .65 1.01 .62 .40 .46 .19
KLA/ATP .16 .15 .28 .27 .19 .29 .09
Usp1
KLA  ATP  ATP+KLA
 NM_146144 ubiquitin specific peptdiase 1 (Usp1), mRNA [NM_146144] KLA .63 .56 .74 .61 .42 .53 .52
ATP .90 .84 .89 .65 .59 .74 .50
KLA/ATP .53 .50 .59 .46 .58 .74 .50
Wdr48
KLA  ATP  ATP+KLA
 NM_026236 WD repeat domain 48 (Wdr48), mRNA [NM_026236] KLA 1.89 1.99 1.79 1.80 1.60 1.55 1.36
ATP .93 1.02 .89 .86 .94 1.66 1.55
KLA/ATP 1.83 1.97 1.57 1.57 1.15 1.44 2.38