Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: SNARE interactions in vesicular transport (mmu04130)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1110031B
06Rik
KLA  ATP  ATP+KLA
 AK049330 ES cells cDNA, RIKEN full-length enriched library, clone:C330024G07 product:hypothetical Target SNARE coiled-coil domain containing protein, full insert sequence. [AK049330] KLA .61 .59 .55 .50 .45 .57 .81
ATP .93 .89 1.09 .91 .72 .60 1.60
KLA/ATP .57 .55 .66 .53 .61 .80 1.09
1110031B
06Rik
KLA  ATP  ATP+KLA
 NM_144521 RIKEN cDNA 1110031B06 gene (1110031B06Rik), mRNA [NM_144521] KLA .68 .67 .63 .54 .51 .64 .96
ATP .96 1.06 .96 1.06 .77 .56 1.83
KLA/ATP .72 .69 .62 .65 .61 .78 1.31
Bet1
KLA  ATP  ATP+KLA
 NM_009748 blocked early in transport 1 homolog (S. cerevisiae) (Bet1), mRNA [NM_009748] KLA .86 .84 .80 .80 .74 .77 1.03
ATP 1.05 1.05 1.38 1.19 .88 .70 .98
KLA/ATP .75 .83 1.07 .90 .73 .74 .94
Bet1l
KLA  ATP  ATP+KLA
 NM_018742 blocked early in transport 1 homolog (S. cerevisiae)-like (Bet1l), mRNA [NM_018742] KLA .92 .90 .93 1.18 1.39 1.36 1.19
ATP .94 .88 .68 .54 1.81 2.64 1.32
KLA/ATP .87 .84 .76 .70 2.33 2.27 1.94
Bnip1
KLA  ATP  ATP+KLA
 AK170908 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208O05 product:BNIP1 protein homolog [Mus musculus], full insert sequence [AK170908] KLA 1.00 .90 .99 .90 1.01 .98 1.02
ATP .89 .56 .78 .79 .80 .83 .94
KLA/ATP .84 .61 .73 .97 .97 .84 .96
Bnip1
KLA  ATP  ATP+KLA
 NM_172149 BCL2/adenovirus E1B interacting protein 1, NIP1 (Bnip1), mRNA [NM_172149] KLA 1.09 1.16 1.15 1.31 1.40 1.32 1.15
ATP 1.05 1.02 1.12 1.45 .89 .91 1.08
KLA/ATP 1.24 1.16 1.36 1.68 1.28 .92 1.20
Gosr1
KLA  ATP  ATP+KLA
 NM_016810 golgi SNAP receptor complex member 1 (Gosr1), mRNA [NM_016810] KLA 3.07 2.87 3.13 3.41 2.84 2.56 2.46
ATP 1.07 1.01 1.06 1.02 1.22 2.72 2.79
KLA/ATP 2.83 3.04 3.47 3.01 2.14 3.41 6.08
Gosr2
KLA  ATP  ATP+KLA
 NM_019650 golgi SNAP receptor complex member 2 (Gosr2), mRNA [NM_019650] KLA 1.90 2.01 1.77 1.67 1.60 1.85 1.63
ATP .96 1.01 1.11 1.40 1.87 1.98 1.95
KLA/ATP 1.82 1.99 1.88 2.07 1.80 2.34 3.03
Sec22b
KLA  ATP  ATP+KLA
 NM_011342 SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (Sec22b), mRNA [NM_011342] KLA 1.18 1.18 1.22 1.35 1.29 1.23 1.19
ATP 1.06 1.03 1.09 1.02 1.34 2.84 1.53
KLA/ATP 1.17 1.27 1.42 1.29 1.28 1.69 1.90
Snap23
KLA  ATP  ATP+KLA
 NM_009222 synaptosomal-associated protein 23 (Snap23), mRNA [NM_009222] KLA 1.27 1.33 1.46 1.36 1.33 1.07 .93
ATP .94 1.02 1.17 1.18 1.02 1.03 1.11
KLA/ATP 1.14 1.32 1.43 1.37 1.13 1.05 1.20
Snap25
KLA  ATP  ATP+KLA
 M22012 synaptosomal associated protein-25 (Snap25) mRNA, complete cds. [M22012] KLA 1.04 1.01 1.00 1.06 1.05 1.07 .99
ATP .98 1.00 .98 .93 .97 1.04 1.01
KLA/ATP .97 1.00 1.09 1.03 .95 .99 1.03
Snap25
KLA  ATP  ATP+KLA
 NM_011428 synaptosomal-associated protein 25 (Snap25), mRNA [NM_011428] KLA .99 1.00 .96 1.03 1.05 1.02 1.01
ATP .98 .99 1.01 1.06 1.02 1.09 .99
KLA/ATP .98 1.02 1.01 1.00 1.03 .98 1.07
Snap29
KLA  ATP  ATP+KLA
 NM_023348 synaptosomal-associated protein 29 (Snap29), mRNA [NM_023348] KLA 2.07 2.04 2.19 2.39 2.36 2.08 1.49
ATP 1.08 1.12 1.07 1.11 1.62 1.87 1.87
KLA/ATP 1.94 2.13 2.40 2.27 2.50 2.26 2.14
Stx11
KLA  ATP  ATP+KLA
 XM_896683 gb|PREDICTED: Mus musculus syntaxin 11, transcript variant 3 (Stx11), mRNA [XM_896683] KLA 21.87 21.50 20.19 14.63 15.14 9.41 5.76
ATP 1.09 1.05 .92 4.12 18.67 18.59 5.03
KLA/ATP 22.60 19.65 13.81 13.39 16.82 21.55 16.24
Stx16
KLA  ATP  ATP+KLA
 NM_172675 syntaxin 16 (Stx16), transcript variant 1, mRNA [NM_172675] KLA 2.70 2.79 3.42 2.84 3.09 2.83 2.83
ATP 1.00 1.08 1.03 1.19 .64 1.39 2.35
KLA/ATP 2.73 2.87 2.77 3.28 1.48 2.12 4.12
Stx17
KLA  ATP  ATP+KLA
 NM_026343 syntaxin 17 (Stx17), mRNA [NM_026343] KLA .88 .83 .93 .86 .83 .90 .92
ATP 1.00 .97 .88 .84 .54 .67 .83
KLA/ATP .96 .93 .84 .85 .64 .67 .87
Stx18
KLA  ATP  ATP+KLA
 NM_026959 syntaxin 18 (Stx18), mRNA [NM_026959] KLA 1.51 1.66 1.76 2.10 2.07 1.90 1.19
ATP 1.04 .99 1.22 1.32 .82 1.47 1.30
KLA/ATP 1.54 1.64 2.15 2.24 1.65 1.64 1.60
Stx19
KLA  ATP  ATP+KLA
 NM_026588 syntaxin 19 (Stx19), mRNA [NM_026588] KLA .99 .95 1.02 .98 .96 1.03 .95
ATP 1.05 1.06 1.00 .92 .97 .95 .96
KLA/ATP 1.02 .98 1.01 .96 .98 .95 .97
Stx1a
KLA  ATP  ATP+KLA
 NM_016801 syntaxin 1A (brain) (Stx1a), mRNA [NM_016801] KLA .84 .77 .70 .80 .75 .71 .82
ATP 1.00 1.20 .92 .94 1.65 1.16 1.04
KLA/ATP .87 .76 .71 .82 1.14 .91 .88
Stx2
KLA  ATP  ATP+KLA
 NM_007941 syntaxin 2 (Stx2), mRNA [NM_007941] KLA 1.48 1.46 1.87 1.97 1.64 1.57 1.05
ATP .98 1.01 1.14 1.16 .89 .92 .92
KLA/ATP 1.38 1.60 1.85 1.80 2.06 2.42 2.70
Stx3
KLA  ATP  ATP+KLA
 AK137098 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430075B11 product:unclassifiable, full insert sequence. [AK137098] KLA .95 .87 .92 .89 .90 1.08 .98
ATP .94 1.00 .89 .91 .94 .97 .94
KLA/ATP .91 .97 .80 .76 .76 1.01 .78
Stx3
KLA  ATP  ATP+KLA
 NM_001025307 syntaxin 3 (Stx3), transcript variant B, mRNA [NM_001025307] KLA 1.02 1.02 1.29 1.22 1.18 1.29 1.12
ATP .95 .88 .84 .87 1.72 1.74 1.71
KLA/ATP 1.03 .91 .93 .86 1.37 2.24 2.36
Stx3
KLA  ATP  ATP+KLA
 NM_152220 syntaxin 3 (Stx3), transcript variant A, mRNA [NM_152220] KLA .97 .98 1.33 1.35 1.25 1.51 1.44
ATP 1.22 1.22 1.02 1.25 3.83 2.92 3.59
KLA/ATP 1.29 1.16 1.11 1.36 3.34 3.10 3.76
Stx4a
KLA  ATP  ATP+KLA
 NM_009294 syntaxin 4A (placental) (Stx4a), mRNA [NM_009294] KLA 1.23 1.37 1.43 1.38 1.46 1.26 1.31
ATP 1.00 .90 .85 .95 .94 .72 1.19
KLA/ATP 1.30 1.24 1.23 1.22 1.24 .71 1.14
Stx5a
KLA  ATP  ATP+KLA
 NM_019829 syntaxin 5A (Stx5a), mRNA [NM_019829] KLA .97 .98 1.07 1.06 1.34 1.33 1.12
ATP 1.03 .99 .73 .89 .91 1.33 1.17
KLA/ATP 1.05 .96 .84 .99 .85 1.45 1.78
Stx6
KLA  ATP  ATP+KLA
 NM_021433 syntaxin 6 (Stx6), mRNA [NM_021433] KLA 2.73 2.79 2.82 2.62 2.13 1.45 1.23
ATP .97 .89 .67 .71 1.11 1.79 1.23
KLA/ATP 3.00 2.63 1.69 1.51 1.08 1.48 1.90
Stx7
KLA  ATP  ATP+KLA
 NM_016797 syntaxin 7 (Stx7), mRNA [NM_016797] KLA 1.16 1.06 1.31 1.15 1.38 1.31 1.11
ATP 1.15 1.02 .79 .72 .75 .70 1.15
KLA/ATP 1.15 1.10 .95 .84 .88 .76 1.10
Stx8
KLA  ATP  ATP+KLA
 AF093064 syntaxin-like protein 3I35 mRNA, complete cds. [AF093064] KLA 1.01 1.10 1.05 1.20 1.26 1.61 1.32
ATP .93 .89 1.22 1.21 1.17 1.02 1.08
KLA/ATP 1.03 1.18 1.41 1.41 1.65 1.64 1.52
Stx8
KLA  ATP  ATP+KLA
 NM_018768 syntaxin 8 (Stx8), mRNA [NM_018768] KLA 1.18 1.25 1.21 1.29 1.39 1.66 1.47
ATP .96 1.01 1.14 1.43 1.19 .96 1.13
KLA/ATP 1.11 1.20 1.38 1.66 1.52 1.61 1.63
Use1
KLA  ATP  ATP+KLA
 NM_025917 unconventional SNARE in the ER 1 homolog (S. cerevisiae) (Use1), transcript variant 1, mRNA [NM_025917] KLA .90 .87 .89 .80 .92 1.01 .93
ATP 1.03 .94 1.11 1.15 .99 .83 .85
KLA/ATP .93 .89 .99 .98 .92 .89 1.00
Vamp1
KLA  ATP  ATP+KLA
 NM_009496 vesicle-associated membrane protein 1 (Vamp1), transcript variant 1, mRNA [NM_009496] KLA .59 .59 .56 .63 .62 .67 .84
ATP .61 .45 .54 .53 .64 .67 1.21
KLA/ATP .65 .53 .58 .59 .55 .64 1.06
Vamp2
KLA  ATP  ATP+KLA
 NM_009497 vesicle-associated membrane protein 2 (Vamp2), mRNA [NM_009497] KLA .99 1.02 1.03 1.07 1.34 1.25 1.58
ATP 1.03 1.12 .88 1.22 .94 .99 1.62
KLA/ATP 1.03 1.15 .82 1.10 .87 .93 1.86
Vamp3
KLA  ATP  ATP+KLA
 NM_009498 vesicle-associated membrane protein 3 (Vamp3), mRNA [NM_009498] KLA 1.20 1.23 1.47 1.36 1.53 1.52 1.10
ATP 1.05 1.18 1.09 1.35 1.14 1.24 1.22
KLA/ATP 1.39 1.38 1.09 1.61 1.18 1.44 1.63
Vamp4
KLA  ATP  ATP+KLA
 NM_016796 vesicle-associated membrane protein 4 (Vamp4), mRNA [NM_016796] KLA .76 .72 .76 .76 1.01 1.17 1.60
ATP .99 .96 1.03 1.07 1.10 1.47 1.87
KLA/ATP .69 .71 .74 .82 .94 1.54 1.92
Vamp5
KLA  ATP  ATP+KLA
 NM_016872 vesicle-associated membrane protein 5 (Vamp5), transcript variant 1, mRNA [NM_016872] KLA .89 .95 .93 .98 .94 1.02 1.06
ATP .99 1.00 1.17 1.17 .96 .80 1.07
KLA/ATP .94 .91 1.02 1.03 .99 .88 .89
Vamp7
KLA  ATP  ATP+KLA
 NM_011515 vesicle-associated membrane protein 7 (Vamp7), mRNA [NM_011515] KLA 1.10 1.05 .99 1.05 .86 .89 .83
ATP .87 .86 1.37 1.08 .90 .74 .57
KLA/ATP .93 1.02 1.21 1.03 .90 .69 .47
Vamp8
KLA  ATP  ATP+KLA
 NM_016794 vesicle-associated membrane protein 8 (Vamp8), mRNA [NM_016794] KLA 1.33 1.37 1.28 1.32 1.56 1.60 1.87
ATP 1.08 1.15 1.02 1.32 1.12 .95 1.55
KLA/ATP 1.32 1.45 1.25 1.69 1.47 1.42 2.39
Vti1a
KLA  ATP  ATP+KLA
 AK014541 0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4631433P05 product:vesicle transport through interaction with t-SNAREs 1 homolog, full insert sequence. [AK014541] KLA 1.11 1.13 1.16 1.17 1.24 1.26 1.19
ATP 1.04 1.03 .98 1.01 1.00 1.02 1.04
KLA/ATP 1.13 1.04 1.01 1.05 .97 1.12 1.03
Vti1a
KLA  ATP  ATP+KLA
 NM_016862 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) (Vti1a), mRNA [NM_016862] KLA 1.18 1.11 1.14 1.33 1.61 2.23 1.91
ATP 1.07 1.05 .97 .86 .73 .58 .73
KLA/ATP 1.03 1.15 1.48 1.13 .93 .76 .68
Vti1b
KLA  ATP  ATP+KLA
 NM_016800 vesicle transport through interaction with t-SNAREs 1B homolog (Vti1b), mRNA [NM_016800] KLA .81 .85 .76 .78 .87 1.05 1.27
ATP .94 .95 1.02 .92 .92 .72 1.11
KLA/ATP .77 .79 .70 .78 .81 .69 .77
Ykt6
KLA  ATP  ATP+KLA
 NM_019661 YKT6 homolog (S. Cerevisiae) (Ykt6), mRNA [NM_019661] KLA 1.00 1.06 .98 1.01 1.06 1.43 1.32
ATP .96 1.02 .98 .96 1.45 2.30 3.23
KLA/ATP .99 1.03 .96 .90 1.17 2.01 3.77