Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Regulation of autophagy (mmu04140)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Atg12
KLA  ATP  ATP+KLA
 NM_026217 autophagy-related 12 (yeast) (Atg12), mRNA [NM_026217] KLA 1.06 1.08 1.12 1.28 1.24 1.30 1.22
ATP 1.00 .97 1.09 1.32 2.01 2.37 1.51
KLA/ATP 1.02 1.13 1.38 1.34 1.99 2.27 2.13
Atg3
KLA  ATP  ATP+KLA
 NM_026402 autophagy-related 3 (yeast) (Atg3), mRNA [NM_026402] KLA 1.29 1.33 1.38 1.40 1.38 1.33 1.10
ATP 1.00 1.06 1.06 .96 .89 .89 1.00
KLA/ATP 1.27 1.30 1.22 1.14 1.00 .93 .91
Atg4a
KLA  ATP  ATP+KLA
 NM_174875 autophagy-related 4A (yeast) (Atg4a), mRNA [NM_174875] KLA 1.31 1.33 1.26 1.31 1.64 1.93 2.00
ATP .89 1.02 1.21 1.04 .55 .67 1.15
KLA/ATP 1.14 1.28 1.39 1.22 .82 .75 1.63
Atg4b
KLA  ATP  ATP+KLA
 NM_174874 autophagy-related 4B (yeast) (Atg4b), mRNA [NM_174874] KLA .99 1.02 1.12 1.02 1.17 1.11 1.08
ATP 1.01 1.06 .89 .83 .96 1.30 1.13
KLA/ATP 1.06 1.09 1.01 1.09 1.04 1.30 1.29
Atg4c
KLA  ATP  ATP+KLA
 AK170747 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630118G04 product:APG4 (ATG4) autophagy-related homolog C (S. cerevisiae), full insert sequence [AK170747] KLA .82 .83 .89 .86 .90 .98 1.08
ATP 1.10 1.08 .87 .81 .88 .86 .97
KLA/ATP .81 .80 .83 .76 .87 .80 1.14
Atg4c
KLA  ATP  ATP+KLA
 NM_175029 autophagy-related 4C (yeast) (Atg4c), mRNA [NM_175029] KLA .60 .59 .60 .71 .65 .86 1.39
ATP 1.01 .94 1.00 .78 .61 .68 1.21
KLA/ATP .58 .57 .60 .53 .56 .60 1.12
Atg4d
KLA  ATP  ATP+KLA
 AK044798 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130002B06 product:APG4 (ATG4) autophagy-related homolog D (S. cerevisiae), full insert sequence. [AK044798] KLA .99 .93 .99 1.06 1.01 1.04 1.03
ATP .95 .93 .94 .95 1.02 .96 .97
KLA/ATP .87 .93 .91 1.01 1.00 .91 1.03
Atg4d
KLA  ATP  ATP+KLA
 NM_153583 autophagy-related 4D (yeast) (Atg4d), mRNA [NM_153583] KLA 1.58 1.60 1.76 1.92 1.80 1.64 1.43
ATP 1.04 1.05 1.13 1.24 1.21 1.74 1.40
KLA/ATP 1.53 1.69 1.70 1.57 1.31 1.83 2.13
Atg5
KLA  ATP  ATP+KLA
 NM_053069 autophagy-related 5 (yeast) (Atg5), mRNA [NM_053069] KLA 1.09 1.12 .93 1.12 1.26 1.63 2.23
ATP .95 .96 1.01 .89 .80 1.87 1.85
KLA/ATP .99 .98 .90 .90 .92 1.81 2.10
Atg7
KLA  ATP  ATP+KLA
 AK076330 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732437I21 product:unclassifiable, full insert sequence. [AK076330] KLA .69 .64 .60 .77 .88 .84 .82
ATP 1.05 1.04 1.09 .92 1.07 1.10 1.07
KLA/ATP .67 .60 .66 .79 1.09 1.06 .87
Atg7
KLA  ATP  ATP+KLA
 NM_028835 autophagy-related 7 (yeast) (Atg7), mRNA [NM_028835] KLA .85 .89 .77 .75 .71 .74 .93
ATP 1.08 1.12 1.04 1.35 1.15 .78 1.09
KLA/ATP .92 1.01 .84 .97 .72 .73 .96
Becn1
KLA  ATP  ATP+KLA
 NM_019584 beclin 1, autophagy related (Becn1), mRNA [NM_019584] KLA 1.18 1.23 1.25 1.15 1.26 1.26 1.19
ATP .97 1.01 .80 .92 .96 .91 1.15
KLA/ATP 1.14 1.15 .99 1.10 .95 .98 1.33
Gabarap
KLA  ATP  ATP+KLA
 NM_019749 gamma-aminobutyric acid receptor associated protein (Gabarap), mRNA [NM_019749] KLA .93 .88 .95 .99 1.07 1.06 1.22
ATP 1.22 1.27 .95 1.38 1.44 1.25 1.51
KLA/ATP 1.02 1.11 .86 1.30 1.17 1.49 2.13
Gabarapl
1
KLA  ATP  ATP+KLA
 NM_020590 gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1 (Gabarapl1), mRNA [NM_020590] KLA .68 .67 .64 .55 .50 .58 .81
ATP 1.03 1.09 1.28 1.46 3.14 3.86 .91
KLA/ATP .69 .75 .80 .92 1.74 2.32 1.07
Gabarapl
2
KLA  ATP  ATP+KLA
 AK049819 adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630001N14 product:GABA(A) receptor-associated protein like 2, full insert sequence [AK049819] KLA .92 .94 .93 .95 .85 .85 .86
ATP .98 1.03 1.17 1.18 1.19 1.04 .86
KLA/ATP .98 1.04 1.09 1.03 1.06 .91 .87
Ifna12
KLA  ATP  ATP+KLA
 NM_177361 interferon alpha 12 (Ifna12), mRNA [NM_177361] KLA 1.25 1.26 1.34 1.16 1.06 1.10 1.09
ATP 1.01 .97 1.07 1.09 1.17 1.20 1.07
KLA/ATP 1.12 1.29 1.72 1.54 1.59 1.56 1.05
Ifna13
KLA  ATP  ATP+KLA
 NM_177347 interferon alpha 13 (Ifna13), mRNA [NM_177347] KLA 1.32 1.27 1.26 1.34 1.15 1.24 1.20
ATP .95 1.08 1.29 1.79 1.41 1.22 1.08
KLA/ATP 1.36 1.35 2.04 2.81 2.07 1.44 1.19
Ifna2
KLA  ATP  ATP+KLA
 K01411 gb|Mouse alpha-interferon (MuIFN-alpha), 3 cds & untranslated mRNA [K01411] KLA 1.02 1.03 1.10 .96 .93 .99 1.01
ATP 1.02 .98 1.00 .98 1.02 .97 .95
KLA/ATP 1.02 1.04 1.18 1.08 1.13 1.04 1.01
Ifna2
KLA  ATP  ATP+KLA
 NM_010503 interferon alpha 2 (Ifna2), mRNA [NM_010503] KLA 1.08 1.06 1.07 1.06 .98 1.02 1.05
ATP .94 1.06 1.11 1.30 1.24 1.25 1.21
KLA/ATP 1.03 1.20 1.19 1.35 1.52 1.60 1.18
Ifna4
KLA  ATP  ATP+KLA
 NM_010504 interferon alpha 4 (Ifna4), mRNA [NM_010504] KLA .99 1.04 1.05 .97 1.00 .96 .99
ATP 1.01 .96 .98 1.01 1.00 1.00 .97
KLA/ATP 1.10 1.09 1.05 1.04 1.01 .97 1.01
Ifna5
KLA  ATP  ATP+KLA
 NM_010505 interferon alpha 5 (Ifna5), mRNA [NM_010505] KLA 1.15 1.23 1.51 1.26 1.03 1.06 1.05
ATP .99 .94 1.11 1.00 1.09 1.07 1.03
KLA/ATP 1.12 1.29 1.46 1.47 1.24 1.32 1.03
Ifna9
KLA  ATP  ATP+KLA
 NM_010507 interferon alpha 9 (Ifna9), mRNA [NM_010507] KLA 1.05 1.09 1.20 1.06 1.08 1.06 1.02
ATP .99 1.08 1.18 1.21 1.09 .99 .97
KLA/ATP 1.09 1.23 1.19 1.24 1.18 1.16 1.04
Ifnab
KLA  ATP  ATP+KLA
 BC116864 interferon alpha B, mRNA (cDNA clone MGC:151241 IMAGE:40126183), complete cds [BC116864] KLA 1.20 1.33 1.29 1.30 1.20 1.20 1.08
ATP .99 .99 1.00 1.25 1.13 1.19 1.04
KLA/ATP 1.30 1.39 1.44 1.48 1.49 1.54 1.22
Ifng
KLA  ATP  ATP+KLA
 NM_008337 interferon gamma (Ifng), mRNA [NM_008337] KLA 1.05 1.02 1.01 1.01 1.01 1.04 1.00
ATP 1.00 1.01 1.01 .98 .97 1.04 1.03
KLA/ATP 1.01 1.01 1.06 1.10 1.24 1.10 1.04
Ins1
KLA  ATP  ATP+KLA
 NM_008386 insulin I (Ins1), mRNA [NM_008386] KLA 1.00 .99 .99 1.03 1.01 .98 1.06
ATP .97 1.03 1.00 1.03 .99 1.07 1.05
KLA/ATP 1.03 .93 .98 1.04 1.07 1.03 1.01
Ins2
KLA  ATP  ATP+KLA
 NM_008387 insulin II (Ins2), mRNA [NM_008387] KLA .99 1.00 1.00 1.01 1.00 1.02 1.00
ATP 1.01 .99 1.00 1.00 .98 .99 1.01
KLA/ATP .99 1.01 1.00 .98 .99 .99 .98
Mm.37708
7
KLA  ATP  ATP+KLA
 158631169 Unknown KLA .98 .98 1.06 1.06 .91 .97 1.04
ATP 1.00 1.07 1.01 1.06 1.09 .99 1.02
KLA/ATP 1.08 1.06 1.16 1.11 1.16 1.12 1.04
Mm.57127
KLA  ATP  ATP+KLA
 117168292 Unknown KLA 1.20 1.25 1.28 1.18 1.14 1.13 1.12
ATP .98 .95 1.11 1.06 1.05 1.05 1.09
KLA/ATP 1.22 1.24 1.48 1.55 1.40 1.21 1.07
Pik3c3
KLA  ATP  ATP+KLA
 NM_181414 phosphoinositide-3-kinase, class 3 (Pik3c3), mRNA [NM_181414] KLA .85 .82 .90 .91 .99 1.01 .87
ATP .92 1.02 .97 1.08 .60 .82 .87
KLA/ATP .80 .86 .79 .90 .66 .94 .92
Pik3r4
KLA  ATP  ATP+KLA
 AK042361 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630085D04 product:similar to ADAPTOR PROTEIN [Homo sapiens], full insert sequence. [AK042361] KLA .96 .91 .90 .94 .94 .79 .95
ATP .94 .88 .80 .78 .83 .88 .91
KLA/ATP .91 .91 .80 .77 .80 .93 .86
Prkaa1
KLA  ATP  ATP+KLA
 NM_001013367 protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1), mRNA [NM_001013367] KLA 1.10 1.03 1.17 1.25 1.24 1.61 2.29
ATP 1.04 1.07 1.10 1.08 1.04 2.01 2.13
KLA/ATP 1.07 1.04 1.04 1.17 .95 1.90 3.90
Prkaa2
KLA  ATP  ATP+KLA
 NM_178143 protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), mRNA [NM_178143] KLA .93 .94 .94 .90 .92 .92 .99
ATP 1.00 1.14 .93 1.01 1.00 1.11 .98
KLA/ATP 1.00 .97 .99 1.01 .98 1.02 .98
Ulk1
KLA  ATP  ATP+KLA
 NM_009469 Unc-51 like kinase 1 (C. elegans) (Ulk1), mRNA [NM_009469] KLA .53 .52 .53 .56 .64 .75 .75
ATP .94 .90 1.05 1.13 1.49 1.82 .61
KLA/ATP .53 .49 .56 .62 1.32 2.23 1.24
Ulk2
KLA  ATP  ATP+KLA
 AK087234 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030037L18 product:unclassifiable, full insert sequence. [AK087234] KLA .76 .67 .70 .77 .91 .80 .73
ATP 1.13 1.07 .75 .65 .88 .75 .67
KLA/ATP .75 .66 .90 .74 .88 .74 .74
Ulk2
KLA  ATP  ATP+KLA
 NM_013881 Unc-51 like kinase 2 (C. elegans) (Ulk2), mRNA [NM_013881] KLA .62 .59 .58 .56 .51 .48 .62
ATP 1.06 .99 .79 .63 .40 .35 .48
KLA/ATP .61 .61 .49 .51 .37 .28 .38
Ulk3
KLA  ATP  ATP+KLA
 AK004783 adult male lung cDNA, RIKEN full-length enriched library, clone:1200015E14 product:hypothetical Serine [AK004783] KLA .64 .62 .68 .90 1.07 1.24 1.11
ATP .98 .92 1.13 .81 .52 .96 1.03
KLA/ATP .66 .67 .80 .68 .82 .92 .96