Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Dorso-ventral axis formation (mmu04320)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Cpeb1
KLA  ATP  ATP+KLA
 NM_007755 cytoplasmic polyadenylation element binding protein 1 (Cpeb1), mRNA [NM_007755] KLA .58 .50 .48 .45 .32 .30 .36
ATP 1.11 1.07 .89 .83 .72 .59 .47
KLA/ATP .55 .56 .67 .58 .60 .48 .26
Egfr
KLA  ATP  ATP+KLA
 NM_007912 epidermal growth factor receptor (Egfr), transcript variant 2, mRNA [NM_007912] KLA 1.10 1.07 1.14 1.11 1.08 1.03 .90
ATP .99 1.00 1.04 .98 .97 1.15 1.14
KLA/ATP 1.07 1.10 1.16 1.08 1.01 .97 .94
Egfr
KLA  ATP  ATP+KLA
 NM_207655 epidermal growth factor receptor (Egfr), transcript variant 1, mRNA [NM_207655] KLA 1.57 1.44 1.47 1.31 .96 .92 .76
ATP .97 .93 1.10 1.00 1.41 2.97 .86
KLA/ATP 1.44 1.50 1.61 1.30 1.14 1.21 .82
Ets1
KLA  ATP  ATP+KLA
 NM_011808 E26 avian leukemia oncogene 1, 5 domain (Ets1), transcript variant 1, mRNA [NM_011808] KLA .55 .54 .49 .66 .62 .58 .67
ATP 1.01 1.14 .98 1.11 1.59 1.48 .67
KLA/ATP .58 .53 .58 .70 .80 .76 .76
Ets1
KLA  ATP  ATP+KLA
 X55787 gb|M.musculus c-ets-1 gene. [X55787] KLA .83 .93 .85 .89 .94 .90 1.03
ATP 1.08 1.11 .92 1.04 1.19 1.19 .98
KLA/ATP .94 .90 .88 .98 .91 .92 .95
Ets2
KLA  ATP  ATP+KLA
 NM_011809 E26 avian leukemia oncogene 2, 3 domain (Ets2), mRNA [NM_011809] KLA .79 .82 1.09 1.44 1.83 1.08 1.46
ATP 1.23 1.59 1.97 3.69 7.13 4.30 .90
KLA/ATP .84 1.33 2.37 5.17 6.58 5.50 3.04
Etv6
KLA  ATP  ATP+KLA
 NM_007961 ets variant gene 6 (TEL oncogene) (Etv6), mRNA [NM_007961] KLA 6.52 6.81 7.26 6.58 5.39 3.34 2.03
ATP .98 1.00 1.01 1.45 2.23 4.97 2.55
KLA/ATP 6.58 6.68 6.84 7.28 4.17 5.81 5.08
Fmn2
KLA  ATP  ATP+KLA
 NM_019445 formin 2 (Fmn2), mRNA [NM_019445] KLA 1.02 1.08 1.05 1.05 1.04 1.06 1.05
ATP .99 .97 1.02 1.01 1.00 .98 1.01
KLA/ATP 1.06 1.00 1.07 1.03 1.00 1.06 1.05
Grb2
KLA  ATP  ATP+KLA
 NM_008163 growth factor receptor bound protein 2 (Grb2), mRNA [NM_008163] KLA .92 .88 .90 1.27 1.43 1.22 1.00
ATP 1.02 .83 .51 .42 .92 .70 .57
KLA/ATP .84 .77 .61 .56 1.56 1.49 .52
Grb2
KLA  ATP  ATP+KLA
 U07617 Grb2 adaptor protein (grb2) mRNA, complete cds. [U07617] KLA .83 .80 .95 1.13 1.38 1.36 1.06
ATP .84 .74 .51 .41 .82 .74 .59
KLA/ATP .77 .70 .57 .54 1.49 1.39 .53
Kras
KLA  ATP  ATP+KLA
 NM_021284 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA [NM_021284] KLA .53 .49 .40 .42 .49 .95 1.05
ATP .98 1.01 1.16 1.17 1.39 1.29 1.74
KLA/ATP .50 .47 .50 .56 1.00 1.24 1.58
Map2k1
KLA  ATP  ATP+KLA
 NM_008927 mitogen-activated protein kinase kinase 1 (Map2k1), mRNA [NM_008927] KLA 1.82 2.00 2.31 2.03 2.51 2.20 1.51
ATP .99 1.14 .81 .87 .90 1.57 1.11
KLA/ATP 1.90 2.03 1.50 1.93 1.63 2.03 2.06
Mapk1
KLA  ATP  ATP+KLA
 NM_001038663 mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663] KLA .97 1.03 .93 .86 .79 1.01 1.04
ATP .96 1.18 1.01 1.13 .84 1.04 1.16
KLA/ATP .99 .99 .84 .87 .63 .96 1.26
Mapk1
KLA  ATP  ATP+KLA
 NM_011949 mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949] KLA .88 .80 .80 .73 .75 .76 .65
ATP .97 .96 1.06 .88 .90 .68 .48
KLA/ATP .82 .81 .78 .65 .64 .64 .45
Mapk3
KLA  ATP  ATP+KLA
 NM_011952 mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952] KLA .81 .85 .88 .72 .79 .73 .90
ATP 1.13 1.30 .92 1.48 1.08 .68 1.03
KLA/ATP 1.01 1.01 .66 1.13 .77 .77 1.16
Mm.25401
7
KLA  ATP  ATP+KLA
 134288852 Unknown KLA 6.34 5.36 6.08 5.24 3.13 1.46 1.16
ATP .93 .83 1.19 .99 2.79 3.68 1.03
KLA/ATP 5.46 5.61 8.68 4.23 2.95 2.17 1.52
Notch1
KLA  ATP  ATP+KLA
 NM_008714 Notch gene homolog 1 (Drosophila) (Notch1), mRNA [NM_008714] KLA 7.88 6.28 6.84 5.57 5.54 2.82 1.81
ATP 1.21 1.37 1.42 1.46 6.51 6.30 2.62
KLA/ATP 6.74 8.26 8.17 7.73 8.90 5.34 4.14
Notch1
KLA  ATP  ATP+KLA
 Z11886 gb|M.musculus notch-1 mRNA. [Z11886] KLA 8.43 7.03 7.93 7.02 5.78 3.21 1.90
ATP 1.08 1.18 1.52 1.48 7.39 7.40 2.89
KLA/ATP 7.94 8.61 10.64 8.15 11.74 7.12 4.49
Notch2
KLA  ATP  ATP+KLA
 NM_010928 Notch gene homolog 2 (Drosophila) (Notch2), mRNA [NM_010928] KLA 6.46 5.78 6.73 5.12 3.74 1.77 1.43
ATP 1.14 1.03 1.41 1.60 4.21 4.00 1.53
KLA/ATP 6.27 7.06 8.81 6.35 3.59 2.69 2.38
Notch3
KLA  ATP  ATP+KLA
 NM_008716 Notch gene homolog 3 (Drosophila) (Notch3), mRNA [NM_008716] KLA .98 1.03 1.03 1.00 1.01 .84 .92
ATP .91 1.02 1.05 1.01 .99 .99 1.05
KLA/ATP .94 .98 1.09 1.05 1.01 .97 .98
Notch4
KLA  ATP  ATP+KLA
 NM_010929 Notch gene homolog 4 (Drosophila) (Notch4), mRNA [NM_010929] KLA .72 .74 .52 .54 .51 .71 1.01
ATP .98 1.05 1.03 .96 .72 .67 1.14
KLA/ATP .70 .69 .55 .56 .56 .72 1.24
Piwil1
KLA  ATP  ATP+KLA
 NM_021311 piwi-like homolog 1 (Drosophila) (Piwil1), mRNA [NM_021311] KLA 1.02 .98 1.01 .99 1.03 1.12 1.10
ATP .95 .98 1.02 1.06 1.08 1.01 1.03
KLA/ATP 1.00 1.00 .93 1.16 1.11 1.06 1.00
Piwil2
KLA  ATP  ATP+KLA
 NM_021308 piwi-like homolog 2 (Drosophila) (Piwil2), mRNA [NM_021308] KLA .89 .95 .98 .96 1.07 1.16 1.02
ATP 1.02 .95 1.03 .88 2.06 5.74 1.60
KLA/ATP .88 .95 .95 .80 1.40 4.93 2.84
Piwil4
KLA  ATP  ATP+KLA
 AB258534 piwiL4 mRNA for PiwiL4, complete cds [AB258534] KLA 2.99 2.74 2.87 3.53 2.97 3.89 2.64
ATP .98 .84 1.13 .93 .84 1.48 2.14
KLA/ATP 2.46 2.36 2.37 1.72 1.63 2.53 4.62
Sos1
KLA  ATP  ATP+KLA
 NM_009231 Son of sevenless homolog 1 (Drosophila) (Sos1), mRNA [NM_009231] KLA 2.36 2.40 3.42 3.15 2.78 1.81 1.71
ATP .99 1.00 .99 1.15 1.14 1.25 1.24
KLA/ATP 2.41 2.26 1.95 2.44 1.47 1.66 1.37
Sos2
KLA  ATP  ATP+KLA
 XM_127051 gb|PREDICTED: Mus musculus Son of sevenless homolog 2 (Drosophila) (Sos2), mRNA [XM_127051] KLA .81 .77 .79 .92 1.04 1.06 1.20
ATP 1.00 1.00 1.09 .79 .68 .81 .94
KLA/ATP .77 .69 .71 .60 .64 .77 1.07
Spire1
KLA  ATP  ATP+KLA
 NM_176832 spire homolog 1 (Drosophila) (Spire1), transcript variant 2, mRNA [NM_176832] KLA 1.02 1.11 .95 .93 .84 1.04 1.12
ATP 1.03 1.09 .94 .95 1.27 1.16 1.33
KLA/ATP 1.13 1.14 .88 .95 .94 .96 1.20
Spire1
KLA  ATP  ATP+KLA
 NM_194355 spire homolog 1 (Drosophila) (Spire1), transcript variant 1, mRNA [NM_194355] KLA 1.37 1.17 1.11 .80 .54 .72 .84
ATP 1.12 1.12 1.12 1.00 1.39 1.71 1.19
KLA/ATP 1.39 1.27 .96 .81 .77 1.03 .78
Spire2
KLA  ATP  ATP+KLA
 NM_172287 spire homolog 2 (Drosophila) (Spire2), mRNA [NM_172287] KLA .99 .94 1.01 .99 .99 .91 1.03
ATP 1.04 1.00 .98 .97 .97 .97 .95
KLA/ATP .96 .96 .95 .95 .94 .96 .96