Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Hedgehog signaling pathway (mmu04340)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Bmp2
KLA  ATP  ATP+KLA
 NM_007553 bone morphogenetic protein 2 (Bmp2), mRNA [NM_007553] KLA 1.18 1.19 1.30 1.16 1.02 1.07 .99
ATP 1.05 1.18 1.79 4.60 2.95 2.38 .96
KLA/ATP 1.26 1.52 1.77 2.64 1.78 1.47 .97
Bmp4
KLA  ATP  ATP+KLA
 NM_007554 bone morphogenetic protein 4 (Bmp4), mRNA [NM_007554] KLA 1.02 1.04 1.04 1.09 1.08 1.12 1.06
ATP .98 1.00 1.05 1.04 .94 .97 1.00
KLA/ATP .99 1.03 1.07 1.04 .99 .99 .97
Btrc
KLA  ATP  ATP+KLA
 NM_009771 beta-transducin repeat containing protein (Btrc), transcript variant 2, mRNA [NM_009771] KLA 1.30 1.33 1.62 1.50 1.93 1.79 1.60
ATP 1.07 1.30 1.05 1.26 .67 .99 1.56
KLA/ATP 1.40 1.61 1.13 1.72 .88 1.50 1.97
Csnk1a1
KLA  ATP  ATP+KLA
 AK017353 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430427P18 product:unclassifiable, full insert sequence. [AK017353] KLA 1.75 1.68 1.55 1.76 1.33 1.34 1.16
ATP .85 .76 .85 .50 .66 1.35 1.09
KLA/ATP 1.51 1.56 1.49 .72 .76 .86 1.02
Csnk1a1
KLA  ATP  ATP+KLA
 AK152387 bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830067L20 product:casein kinase 1, alpha 1, full insert sequence [AK152387] KLA 1.58 1.39 1.32 1.47 1.46 1.42 1.06
ATP 1.07 1.05 1.31 1.40 1.63 1.57 1.34
KLA/ATP 1.54 1.51 2.07 1.98 2.12 2.22 1.90
Csnk1a1
KLA  ATP  ATP+KLA
 NM_146087 casein kinase 1, alpha 1 (Csnk1a1), mRNA [NM_146087] KLA 1.76 1.68 1.56 1.55 1.57 1.33 1.35
ATP 1.03 .86 .67 .60 .90 1.33 1.14
KLA/ATP 1.61 1.50 1.08 .92 1.02 1.46 1.87
Csnk1d
KLA  ATP  ATP+KLA
 NM_027874 casein kinase 1, delta (Csnk1d), transcript variant 2, mRNA [NM_027874] KLA 1.18 1.24 1.40 1.51 1.46 1.33 1.20
ATP 1.03 .98 .90 .97 1.70 1.81 1.18
KLA/ATP 1.30 1.36 1.20 1.37 1.98 2.29 1.67
Csnk1d
KLA  ATP  ATP+KLA
 NM_139059 casein kinase 1, delta (Csnk1d), transcript variant 1, mRNA [NM_139059] KLA 1.72 1.90 2.07 2.00 2.02 1.88 1.60
ATP .94 1.05 1.01 1.34 2.03 2.97 1.70
KLA/ATP 1.77 1.86 1.85 2.18 2.27 2.99 3.01
Csnk1e
KLA  ATP  ATP+KLA
 NM_013767 casein kinase 1, epsilon (Csnk1e), mRNA [NM_013767] KLA .75 .69 .67 .71 .68 .64 .76
ATP .98 .89 .97 .94 1.80 .90 .83
KLA/ATP .68 .66 .70 .73 1.79 .84 .72
Csnk1g1
KLA  ATP  ATP+KLA
 NM_173185 casein kinase 1, gamma 1 (Csnk1g1), mRNA [NM_173185] KLA 1.11 1.02 1.07 1.11 1.27 1.30 1.30
ATP 1.02 .97 .93 .77 1.09 1.29 1.12
KLA/ATP 1.10 1.01 .97 .82 1.17 1.36 1.68
Csnk1g2
KLA  ATP  ATP+KLA
 NM_134002 casein kinase 1, gamma 2 (Csnk1g2), mRNA [NM_134002] KLA .54 .56 .56 .56 .67 .80 .61
ATP 1.05 1.11 .97 .99 .83 .72 .90
KLA/ATP .60 .59 .46 .47 .64 .75 .74
Csnk1g3
KLA  ATP  ATP+KLA
 NM_152809 casein kinase 1, gamma 3 (Csnk1g3), mRNA [NM_152809] KLA 1.44 1.58 1.61 1.41 1.24 1.16 1.32
ATP .98 .96 .96 .77 1.35 1.93 1.06
KLA/ATP 1.58 1.48 1.41 1.31 1.42 1.56 1.30
Dhh
KLA  ATP  ATP+KLA
 NM_007857 desert hedgehog (Dhh), mRNA [NM_007857] KLA 1.28 1.14 1.23 1.29 1.05 1.15 1.01
ATP .94 .94 1.06 .94 1.07 1.03 1.00
KLA/ATP 1.11 1.14 1.04 1.04 1.08 1.15 1.11
Fbxw11
KLA  ATP  ATP+KLA
 AK010033 adult male tongue cDNA, RIKEN full-length enriched library, clone:2310065A07 product:unclassifiable, full insert sequence. [AK010033] KLA 1.30 1.21 1.27 1.21 1.47 1.01 1.13
ATP 1.19 2.03 1.28 .95 1.43 .99 1.04
KLA/ATP 1.43 1.83 1.40 1.10 1.12 1.05 1.05
Fbxw11
KLA  ATP  ATP+KLA
 NM_134015 F-box and WD-40 domain protein 11 (Fbxw11), mRNA [NM_134015] KLA 3.11 2.78 3.05 3.43 2.16 1.58 1.20
ATP 1.03 .94 1.72 1.19 1.38 1.66 1.01
KLA/ATP 2.76 2.70 4.18 2.07 1.91 2.02 1.71
Gas1
KLA  ATP  ATP+KLA
 NM_008086 growth arrest specific 1 (Gas1), mRNA [NM_008086] KLA 1.03 .94 1.02 .99 1.04 .88 1.06
ATP 1.00 .89 .99 1.11 .98 .99 1.02
KLA/ATP 1.01 1.04 1.41 1.03 .98 1.03 .97
Gli1
KLA  ATP  ATP+KLA
 NM_010296 GLI-Kruppel family member GLI1 (Gli1), mRNA [NM_010296] KLA .97 .97 .97 .99 .97 .98 .96
ATP .98 1.01 .99 .98 .97 .96 .99
KLA/ATP .98 .98 1.01 .96 .98 .94 .95
Gli2
KLA  ATP  ATP+KLA
 NM_001081125 GLI-Kruppel family member GLI2 (Gli2), mRNA [NM_001081125] KLA 1.03 1.02 .99 1.04 1.02 1.04 1.00
ATP 1.01 1.00 1.04 1.06 1.02 .99 1.04
KLA/ATP .97 1.04 1.05 1.05 1.06 1.04 1.02
Gli3
KLA  ATP  ATP+KLA
 NM_008130 GLI-Kruppel family member GLI3 (Gli3), mRNA [NM_008130] KLA 1.01 1.01 1.01 1.01 1.01 .99 1.00
ATP 1.00 .99 1.03 1.00 1.01 1.01 1.02
KLA/ATP 1.02 1.01 1.02 .98 1.00 1.00 1.02
Gsk3b
KLA  ATP  ATP+KLA
 NM_019827 glycogen synthase kinase 3 beta (Gsk3b), mRNA [NM_019827] KLA 1.06 1.03 1.11 1.01 1.26 1.28 1.26
ATP 1.18 1.27 1.15 2.07 2.37 2.32 1.67
KLA/ATP 1.15 1.21 .98 1.50 1.67 2.50 2.99
Hhip
KLA  ATP  ATP+KLA
 NM_020259 Hedgehog-interacting protein (Hhip), mRNA [NM_020259] KLA 1.03 1.00 .96 1.04 1.07 1.01 .98
ATP 1.00 .96 1.07 1.01 1.00 1.07 .98
KLA/ATP .99 1.00 1.06 1.02 1.09 1.09 1.04
Ihh
KLA  ATP  ATP+KLA
 AK090147 adult male intestinal mucosa cDNA, RIKEN full-length enriched library, clone:G630005N21 product:Indian hedgehog homolog, (Drosophila), full insert sequence. [AK090147] KLA 1.11 .94 .98 .96 .99 .98 .97
ATP 1.02 1.02 1.02 .92 1.00 1.02 1.11
KLA/ATP .90 .94 1.05 1.09 1.05 1.03 1.00
Ihh
KLA  ATP  ATP+KLA
 NM_010544 Indian hedgehog (Ihh), mRNA [NM_010544] KLA 1.00 .98 .98 .98 .99 .99 .99
ATP 1.00 1.00 1.01 .99 1.04 1.05 1.01
KLA/ATP 1.00 .96 .95 .99 1.05 1.05 1.00
Lrp2
KLA  ATP  ATP+KLA
 NM_001081088 low density lipoprotein receptor-related protein 2 (Lrp2), mRNA [NM_001081088] KLA .99 .98 1.02 .97 .96 .95 .99
ATP 1.01 .96 .92 .98 .97 .95 1.02
KLA/ATP .98 .99 .98 .97 1.00 1.00 .97
Mm.21516
1
KLA  ATP  ATP+KLA
 141801906 Unknown KLA 1.08 1.09 1.10 1.08 1.09 1.05 1.12
ATP .95 .94 1.05 1.16 1.05 1.08 1.14
KLA/ATP 1.07 1.15 1.16 1.16 1.10 1.14 1.14
Mm.29279
KLA  ATP  ATP+KLA
 171543834 Unknown KLA .71 .71 .59 .63 .49 .40 .28
ATP .81 .73 .76 .63 .48 .39 .26
KLA/ATP .57 .64 .60 .55 .54 .37 .32
Mm.56964
KLA  ATP  ATP+KLA
 144227223 Unknown KLA .96 .99 1.00 .99 .97 1.01 1.05
ATP .99 .94 1.00 .94 .97 .99 .91
KLA/ATP 1.05 .97 1.02 .97 .91 1.00 1.02
Prkaca
KLA  ATP  ATP+KLA
 NM_008854 protein kinase, cAMP dependent, catalytic, alpha (Prkaca), mRNA [NM_008854] KLA .71 .74 .72 .70 .72 .84 .85
ATP 1.05 .98 .89 .92 .76 .60 1.02
KLA/ATP .79 .74 .55 .65 .60 .65 .93
Prkacb
KLA  ATP  ATP+KLA
 NM_011100 protein kinase, cAMP dependent, catalytic, beta (Prkacb), mRNA [NM_011100] KLA .69 .70 .66 .58 .51 .55 .59
ATP 1.02 1.19 .97 1.01 .69 .38 .56
KLA/ATP .72 .73 .57 .62 .47 .41 .45
Prkx
KLA  ATP  ATP+KLA
 NM_016979 protein kinase, X-linked (Prkx), mRNA [NM_016979] KLA 3.61 3.79 4.67 4.66 4.85 4.19 1.43
ATP .98 .90 .63 .61 1.12 1.90 1.29
KLA/ATP 3.56 3.36 2.62 2.06 2.26 2.87 2.31
Ptch1
KLA  ATP  ATP+KLA
 AK147626 cDNA, RIKEN full-length enriched library, clone:M5C1096C04 product:patched homolog 1, full insert sequence [AK147626] KLA 1.35 1.31 1.25 1.03 1.06 .89 .89
ATP 1.00 1.08 1.01 .90 1.09 1.20 1.03
KLA/ATP 1.27 1.29 1.34 1.24 1.22 1.21 1.01
Ptch1
KLA  ATP  ATP+KLA
 NM_008957 patched homolog 1 (Ptch1), mRNA [NM_008957] KLA 1.10 1.05 1.10 1.03 .99 .99 1.01
ATP 1.02 1.01 1.04 1.01 1.07 1.14 1.05
KLA/ATP 1.12 1.10 1.05 1.08 1.06 1.11 .98
Ptch2
KLA  ATP  ATP+KLA
 BC058397 patched homolog 2, mRNA (cDNA clone IMAGE:6832070), partial cds [BC058397] KLA 1.10 1.01 1.01 .94 .99 1.07 .96
ATP .92 .99 1.07 1.03 .98 .99 1.01
KLA/ATP 1.01 .98 .98 1.03 1.03 .98 .98
Ptch2
KLA  ATP  ATP+KLA
 NM_008958 patched homolog 2 (Ptch2), mRNA [NM_008958] KLA 1.03 1.13 1.11 1.13 1.14 1.19 1.15
ATP 1.01 .97 1.08 1.10 1.03 1.15 1.07
KLA/ATP 1.05 1.05 .98 1.16 1.25 1.27 1.22
Rab23
KLA  ATP  ATP+KLA
 AK164057 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430038D19 product:RAB23, member RAS oncogene family, full insert sequence [AK164057] KLA .71 .79 .71 .71 .63 .67 .73
ATP .86 .73 .63 .49 .60 .86 .65
KLA/ATP .68 .62 .64 .55 .63 .73 .45
Rab23
KLA  ATP  ATP+KLA
 NM_008999 RAB23, member RAS oncogene family (Rab23), mRNA [NM_008999] KLA .82 .76 .81 .78 .70 .77 .99
ATP .83 .71 .61 .48 .55 1.31 .99
KLA/ATP .72 .67 .67 .49 .53 1.01 .65
Shh
KLA  ATP  ATP+KLA
 NM_009170 sonic hedgehog (Shh), mRNA [NM_009170] KLA .99 1.01 1.02 .99 1.00 1.02 1.02
ATP 1.00 .99 1.00 .98 1.01 1.00 1.01
KLA/ATP 1.00 1.01 1.03 1.02 1.02 1.03 1.00
Smo
KLA  ATP  ATP+KLA
 NM_176996 smoothened homolog (Drosophila) (Smo), mRNA [NM_176996] KLA .67 .64 .53 .53 .39 .30 .20
ATP .78 .69 .74 .61 .43 .30 .21
KLA/ATP .56 .53 .57 .51 .42 .29 .24
Stk36
KLA  ATP  ATP+KLA
 NM_175031 serine/threonine kinase 36 (fused homolog, Drosophila) (Stk36), mRNA [NM_175031] KLA .94 .91 .93 1.02 1.06 1.16 1.13
ATP 1.03 1.01 .99 .96 .85 .96 1.25
KLA/ATP .94 .91 1.00 .93 .88 1.06 1.37
Sufu
KLA  ATP  ATP+KLA
 BC048168 suppressor of fused homolog (Drosophila), mRNA (cDNA clone MGC:61295 IMAGE:6821477), complete cds [BC048168] KLA .88 .82 .87 .84 .93 .84 .93
ATP 1.17 1.08 .86 .71 .73 .95 .83
KLA/ATP .99 .92 .69 .66 .71 .87 .92
Sufu
KLA  ATP  ATP+KLA
 NM_015752 suppressor of fused homolog (Drosophila) (Sufu), transcript variant 1, mRNA [NM_015752] KLA 1.24 1.24 1.28 1.22 1.27 1.21 1.15
ATP 1.00 1.10 1.01 .99 .90 1.72 1.98
KLA/ATP 1.19 1.24 1.19 1.10 .93 1.54 2.62
Wnt1
KLA  ATP  ATP+KLA
 NM_021279 wingless-related MMTV integration site 1 (Wnt1), mRNA [NM_021279] KLA 1.01 1.01 1.05 1.03 1.04 1.04 1.01
ATP .99 .99 1.01 .97 .96 1.01 1.00
KLA/ATP 1.01 1.04 1.06 1.02 1.00 .98 .98
Wnt10a
KLA  ATP  ATP+KLA
 NM_009518 wingless related MMTV integration site 10a (Wnt10a), mRNA [NM_009518] KLA 1.73 1.66 1.33 1.17 1.10 1.02 1.03
ATP 1.03 1.04 .93 1.02 1.04 1.07 1.06
KLA/ATP 1.83 1.67 1.53 1.21 1.10 1.12 1.09
Wnt10b
KLA  ATP  ATP+KLA
 NM_011718 wingless related MMTV integration site 10b (Wnt10b), mRNA [NM_011718] KLA 1.10 .98 1.13 1.01 .96 1.00 .96
ATP 1.02 1.02 .99 1.01 .96 1.02 1.01
KLA/ATP 1.01 1.18 .97 .97 1.03 1.04 .98
Wnt11
KLA  ATP  ATP+KLA
 NM_009519 wingless-related MMTV integration site 11 (Wnt11), mRNA [NM_009519] KLA .97 1.00 .97 1.03 1.16 1.08 1.11
ATP 1.03 1.06 1.08 1.23 1.13 1.03 1.08
KLA/ATP .95 1.00 .95 1.02 .97 1.04 1.04
Wnt16
KLA  ATP  ATP+KLA
 NM_053116 wingless-related MMTV integration site 16 (Wnt16), mRNA [NM_053116] KLA 1.00 1.02 .97 1.02 .96 1.02 1.05
ATP 1.01 1.00 .97 .98 .97 .95 1.02
KLA/ATP .96 1.01 .98 1.03 .99 1.00 .97
Wnt2
KLA  ATP  ATP+KLA
 NM_023653 wingless-related MMTV integration site 2 (Wnt2), mRNA [NM_023653] KLA 1.01 1.00 1.02 .96 1.06 1.03 .94
ATP .97 1.01 1.02 .98 1.00 1.05 1.01
KLA/ATP .97 .94 1.03 1.02 1.00 .99 1.05
Wnt2b
KLA  ATP  ATP+KLA
 NM_009520 wingless related MMTV integration site 2b (Wnt2b), mRNA [NM_009520] KLA 1.04 1.03 .99 1.01 .95 1.02 .99
ATP .95 1.00 .95 .99 .97 1.03 1.01
KLA/ATP 1.02 .99 1.01 1.06 .99 .99 1.02
Wnt3
KLA  ATP  ATP+KLA
 NM_009521 wingless-related MMTV integration site 3 (Wnt3), mRNA [NM_009521] KLA 1.04 1.02 1.04 1.02 1.00 .99 1.00
ATP 1.03 .98 1.04 1.04 .96 1.00 1.02
KLA/ATP 1.03 .99 .98 1.03 1.04 .94 1.03
Wnt3a
KLA  ATP  ATP+KLA
 NM_009522 wingless-related MMTV integration site 3A (Wnt3a), mRNA [NM_009522] KLA 1.01 1.00 1.06 1.02 .99 1.02 .99
ATP .96 .97 1.05 1.04 1.02 1.02 1.04
KLA/ATP 1.02 1.03 .96 1.01 .99 1.06 1.00
Wnt4
KLA  ATP  ATP+KLA
 NM_009523 wingless-related MMTV integration site 4 (Wnt4), mRNA [NM_009523] KLA 1.01 1.01 .97 1.06 1.12 1.02 .93
ATP 1.02 1.06 1.03 1.02 1.00 1.02 .98
KLA/ATP .94 1.01 1.06 1.05 .96 .96 1.00
Wnt5a
KLA  ATP  ATP+KLA
 NM_009524 wingless-related MMTV integration site 5A (Wnt5a), mRNA [NM_009524] KLA .98 1.06 1.01 .96 1.03 1.02 1.07
ATP 1.01 .96 1.06 1.11 1.02 .97 1.03
KLA/ATP 1.05 .96 .96 1.04 1.12 1.06 .96
Wnt5b
KLA  ATP  ATP+KLA
 NM_009525 wingless-related MMTV integration site 5B (Wnt5b), mRNA [NM_009525] KLA 1.04 1.04 1.19 1.11 1.10 1.11 1.05
ATP 1.04 1.01 .95 1.01 .99 1.04 1.05
KLA/ATP 1.05 1.06 1.11 1.07 1.04 1.08 1.05
Wnt6
KLA  ATP  ATP+KLA
 M89800 gb|Mouse Wnt-6 mRNA, complete cds. [M89800] KLA 1.92 1.97 1.93 2.04 2.01 2.62 5.22
ATP .96 .97 1.07 1.03 .76 .94 1.18
KLA/ATP 2.04 1.91 1.96 1.72 1.40 1.31 2.45
Wnt6
KLA  ATP  ATP+KLA
 NM_009526 wingless-related MMTV integration site 6 (Wnt6), mRNA [NM_009526] KLA 2.83 2.51 2.19 2.74 2.92 3.01 5.82
ATP 1.01 .87 1.07 .77 .59 1.11 1.06
KLA/ATP 2.31 2.49 2.69 1.79 1.63 1.26 2.64
Wnt7a
KLA  ATP  ATP+KLA
 NM_009527 wingless-related MMTV integration site 7A (Wnt7a), mRNA [NM_009527] KLA .96 .92 .91 .99 .96 .98 .97
ATP 1.05 .95 .98 .98 1.03 .98 1.11
KLA/ATP .92 .89 .88 .97 1.01 1.04 1.01
Wnt7b
KLA  ATP  ATP+KLA
 NM_009528 wingless-related MMTV integration site 7B (Wnt7b), mRNA [NM_009528] KLA 1.06 1.09 .99 1.09 1.06 1.19 1.26
ATP .99 .98 1.02 1.08 1.02 1.11 1.54
KLA/ATP 1.02 1.01 .99 1.14 1.07 1.09 1.58
Wnt8a
KLA  ATP  ATP+KLA
 NM_009290 wingless-related MMTV integration site 8A (Wnt8a), mRNA [NM_009290] KLA .92 1.01 .99 1.00 1.06 1.01 1.04
ATP 1.00 1.01 1.01 1.04 1.00 1.06 1.05
KLA/ATP 1.07 1.05 .99 1.08 1.07 1.09 1.07
Wnt8b
KLA  ATP  ATP+KLA
 NM_011720 wingless related MMTV integration site 8b (Wnt8b), mRNA [NM_011720] KLA 1.00 1.00 .94 1.03 .98 .98 .97
ATP .99 1.01 1.01 1.01 1.05 1.04 1.03
KLA/ATP .98 1.03 1.00 1.01 .99 1.02 1.02
Wnt9a
KLA  ATP  ATP+KLA
 NM_139298 wingless-type MMTV integration site 9A (Wnt9a), mRNA [NM_139298] KLA .93 .95 .95 1.01 .96 .97 1.01
ATP 1.01 .98 1.01 1.08 1.43 1.02 1.44
KLA/ATP .94 .96 1.03 1.15 1.43 1.15 1.21
Wnt9b
KLA  ATP  ATP+KLA
 NM_011719 wingless-type MMTV integration site 9B (Wnt9b), mRNA [NM_011719] KLA .97 1.00 .94 1.00 .99 .97 1.02
ATP .96 1.02 1.05 .99 .92 1.11 1.08
KLA/ATP .97 .96 .99 .93 .96 1.03 .99
Zic2
KLA  ATP  ATP+KLA
 NM_009574 zinc finger protein of the cerebellum 2 (Zic2), mRNA [NM_009574] KLA .97 .99 1.02 1.00 .96 1.07 1.02
ATP .95 1.01 1.00 1.05 .95 1.04 .98
KLA/ATP .99 1.00 .77 .99 1.02 1.10 .97