Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Renin-angiotensin system (mmu04614)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Ace
KLA  ATP  ATP+KLA
 J04947 gb|Mouse angiotensin-converting enzyme mRNA, 3 end, clone ACE.11. [J04947] KLA 1.06 1.03 1.08 1.11 1.10 .96 .91
ATP .99 1.11 .98 1.04 .99 1.06 1.00
KLA/ATP .91 .90 1.10 .98 .97 1.02 1.00
Ace
KLA  ATP  ATP+KLA
 NM_009598 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (Ace), transcript variant 2, mRNA [NM_009598] KLA 1.01 1.04 1.12 1.09 1.03 1.09 1.06
ATP .98 .99 1.09 1.15 1.02 1.02 1.07
KLA/ATP 1.06 1.08 1.05 1.10 1.09 1.02 1.00
Ace2
KLA  ATP  ATP+KLA
 NM_027286 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), mRNA [NM_027286] KLA 1.08 .98 .99 1.06 .98 .99 1.07
ATP 1.03 .99 1.04 .97 1.02 1.01 1.00
KLA/ATP .98 1.03 .96 1.00 1.08 1.06 1.00
Ace3
KLA  ATP  ATP+KLA
 NM_001101453 angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 (Ace3), mRNA [NM_001101453] KLA .97 1.06 1.03 1.00 1.00 1.06 1.01
ATP 1.01 .94 .98 1.03 .99 1.00 .97
KLA/ATP 1.04 .98 .96 1.04 1.01 1.12 1.02
Agt
KLA  ATP  ATP+KLA
 NM_007428 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (Agt), mRNA [NM_007428] KLA .99 .98 1.02 1.04 1.00 .96 1.07
ATP .95 .95 .99 .99 .98 1.02 1.03
KLA/ATP .96 1.00 .99 .97 1.00 1.02 1.02
Agtr1a
KLA  ATP  ATP+KLA
 NM_177322 angiotensin II receptor, type 1a (Agtr1a), mRNA [NM_177322] KLA 1.04 1.00 1.00 1.03 1.03 .95 1.00
ATP .98 .99 1.00 1.00 .95 1.05 1.06
KLA/ATP 1.00 .97 1.03 .97 .99 .96 .98
Agtr1b
KLA  ATP  ATP+KLA
 NM_175086 angiotensin II receptor, type 1b (Agtr1b), mRNA [NM_175086] KLA 1.02 .94 1.04 1.01 1.01 1.00 .95
ATP .97 1.01 1.03 .95 .98 1.09 1.02
KLA/ATP .94 .99 .99 .97 .99 .95 1.12
Agtr2
KLA  ATP  ATP+KLA
 NM_007429 angiotensin II receptor, type 2 (Agtr2), mRNA [NM_007429] KLA .99 .93 1.00 .98 .98 1.03 .96
ATP 1.03 1.10 1.02 1.01 .91 1.03 1.01
KLA/ATP .93 .95 1.01 .99 1.00 .95 .99
Anpep
KLA  ATP  ATP+KLA
 NM_008486 alanyl (membrane) aminopeptidase (Anpep), mRNA [NM_008486] KLA .93 .81 .87 .91 1.05 1.06 .71
ATP .99 .98 1.00 1.08 1.04 .93 1.45
KLA/ATP .85 .89 .82 .97 .97 .93 .90
Cma1
KLA  ATP  ATP+KLA
 NM_010780 chymase 1, mast cell (Cma1), mRNA [NM_010780] KLA 1.09 1.07 1.17 1.15 1.08 1.03 .97
ATP 1.02 .99 1.05 1.03 1.05 .99 .99
KLA/ATP 1.06 1.13 1.12 1.03 1.07 .98 1.07
Cpa3
KLA  ATP  ATP+KLA
 NM_007753 carboxypeptidase A3, mast cell (Cpa3), mRNA [NM_007753] KLA 1.03 1.11 1.20 1.04 1.10 1.05 1.00
ATP .99 .98 .99 .93 .94 1.02 .93
KLA/ATP 1.02 1.11 1.08 1.03 .96 1.02 .93
Ctsa
KLA  ATP  ATP+KLA
 NM_008906 cathepsin A (Ctsa), transcript variant 1, mRNA [NM_008906] KLA .83 .81 .76 .72 .74 .66 .70
ATP 1.03 1.06 .93 1.05 .90 .73 1.00
KLA/ATP .83 .86 .74 .91 .76 .62 .73
Ctsg
KLA  ATP  ATP+KLA
 NM_007800 cathepsin G (Ctsg), mRNA [NM_007800] KLA 1.15 1.23 1.36 1.24 1.14 1.09 1.22
ATP .97 1.04 1.19 1.22 1.30 1.19 .98
KLA/ATP 1.19 1.30 1.52 1.58 1.34 1.23 1.07
Enpep
KLA  ATP  ATP+KLA
 NM_007934 glutamyl aminopeptidase (Enpep), mRNA [NM_007934] KLA 1.01 1.00 1.02 1.03 .96 1.04 .98
ATP .95 .92 1.00 1.06 .97 .94 1.08
KLA/ATP 1.01 1.06 .84 1.05 .98 .97 1.01
Lnpep
KLA  ATP  ATP+KLA
 AK147232 cDNA, RIKEN full-length enriched library, clone:M5C1000C02 product:hypothetical protein, full insert sequence [AK147232] KLA 2.63 2.64 2.98 2.67 2.89 2.27 1.30
ATP 1.05 1.14 .92 .81 .69 .63 .42
KLA/ATP 2.58 2.72 2.41 2.29 1.07 .95 .66
Lnpep
KLA  ATP  ATP+KLA
 NM_172827 leucyl/cystinyl aminopeptidase (Lnpep), mRNA [NM_172827] KLA 4.76 4.75 4.97 6.68 6.25 5.31 3.19
ATP 1.02 1.01 1.49 1.13 1.23 3.52 3.77
KLA/ATP 4.35 4.86 7.23 4.89 3.77 2.87 7.28
Mas1
KLA  ATP  ATP+KLA
 NM_008552 MAS1 oncogene (Mas1), mRNA [NM_008552] KLA 1.01 .96 1.01 1.00 .99 1.05 1.01
ATP 1.00 .97 .99 1.00 .99 .99 1.01
KLA/ATP .98 1.04 1.01 1.03 1.00 .94 .84
Mm.13451
KLA  ATP  ATP+KLA
 194473665 Unknown KLA 1.01 1.05 .93 1.09 1.00 1.00 1.00
ATP 1.00 .96 1.01 .98 .94 1.02 1.05
KLA/ATP .97 .97 1.01 .98 .99 .93 1.03
Mm.22095
5
KLA  ATP  ATP+KLA
 149234179 Unknown KLA 1.21 1.27 1.37 1.38 1.38 1.44 1.28
ATP .97 .96 1.06 1.20 1.08 1.24 1.22
KLA/ATP 1.30 1.30 1.32 1.30 1.52 1.51 1.59
Mm.26995
KLA  ATP  ATP+KLA
 141801686 Unknown KLA .97 .97 .91 .96 .93 .86 1.03
ATP 1.09 .99 .94 .98 .96 .82 .96
KLA/ATP .97 1.01 1.01 .92 .87 .84 .87
Mm.29669
9
KLA  ATP  ATP+KLA
 82935400 Unknown KLA 1.02 1.02 1.14 1.10 1.03 1.14 1.02
ATP .98 1.05 1.17 1.14 1.08 1.04 1.01
KLA/ATP 1.13 1.11 1.17 1.11 1.06 1.09 1.04
Mme
KLA  ATP  ATP+KLA
 NM_008604 membrane metallo endopeptidase (Mme), mRNA [NM_008604] KLA 1.01 1.04 1.00 1.02 1.02 .98 .98
ATP .95 .98 .97 .99 1.04 .96 1.01
KLA/ATP 1.04 1.06 1.05 1.01 .98 .91 1.00
Nln
KLA  ATP  ATP+KLA
 NM_029447 neurolysin (metallopeptidase M3 family) (Nln), mRNA [NM_029447] KLA 1.09 1.11 1.33 1.32 1.67 1.47 1.10
ATP 1.08 1.19 1.02 1.07 1.07 1.29 .93
KLA/ATP 1.17 1.16 .97 1.13 1.19 1.23 .64
Ren1
KLA  ATP  ATP+KLA
 NM_031192 renin 1 structural (Ren1), mRNA [NM_031192] KLA 1.04 .99 1.01 1.01 1.01 1.02 1.06
ATP .99 1.01 1.05 .95 .99 .96 1.02
KLA/ATP 1.02 1.00 1.03 .97 .99 1.03 1.04
Ren2
KLA  ATP  ATP+KLA
 NM_031193 renin 2 tandem duplication of Ren1 (Ren2), mRNA [NM_031193] KLA 1.04 .97 1.00 .95 .95 .99 .98
ATP .99 1.00 .99 .97 .92 .96 1.03
KLA/ATP 1.00 1.01 1.06 1.01 .99 .96 .99
Thop1
KLA  ATP  ATP+KLA
 NM_022653 thimet oligopeptidase 1 (Thop1), mRNA [NM_022653] KLA .91 .95 .89 .76 .69 .59 .80
ATP 1.03 1.17 .91 1.22 .83 .65 .93
KLA/ATP .98 1.01 .70 .91 .59 .57 .48