Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Toll-like receptor signaling pathway (mmu04620)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Akt1
KLA  ATP  ATP+KLA
 NM_009652 thymoma viral proto-oncogene 1 (Akt1), mRNA [NM_009652] KLA .80 .80 .75 .75 .71 .70 .82
ATP 1.00 1.02 .76 .85 .76 .68 .84
KLA/ATP .82 .80 .64 .68 .67 .61 .72
Akt2
KLA  ATP  ATP+KLA
 NM_007434 thymoma viral proto-oncogene 2 (Akt2), transcript variant 2, mRNA [NM_007434] KLA 1.45 1.49 1.81 1.61 1.83 1.17 .92
ATP 1.12 1.12 1.00 1.28 1.20 .94 1.06
KLA/ATP 1.48 1.70 1.69 1.58 1.57 1.32 1.27
Akt3
KLA  ATP  ATP+KLA
 NM_011785 thymoma viral proto-oncogene 3 (Akt3), mRNA [NM_011785] KLA 3.42 3.45 5.31 5.16 4.65 3.80 2.12
ATP 1.12 1.22 1.10 1.37 1.02 1.11 1.56
KLA/ATP 3.72 4.17 4.62 4.64 2.74 2.05 3.82
BB229853
KLA  ATP  ATP+KLA
 BB229853 gb|BB229853 RIKEN full-length enriched, 3 days neonate thymus Mus musculus cDNA clone A630023O21 3. [BB229853] KLA 6.32 5.94 6.13 6.41 7.39 12.33 6.08
ATP .39 .24 .33 .38 1.18 5.75 2.85
KLA/ATP 2.27 2.02 3.25 4.04 7.11 10.22 13.93
Casp8
KLA  ATP  ATP+KLA
 NM_009812 caspase 8 (Casp8), transcript variant 1, mRNA [NM_009812] KLA 2.41 2.53 3.20 3.26 2.75 2.78 1.57
ATP .91 .96 .66 .67 .54 1.53 1.52
KLA/ATP 2.47 2.52 2.08 2.41 1.41 2.50 2.77
Ccl3
KLA  ATP  ATP+KLA
 NM_011337 chemokine (C-C motif) ligand 3 (Ccl3), mRNA [NM_011337] KLA 22.83 22.40 18.03 21.58 11.57 8.28 7.46
ATP 3.19 4.67 12.12 16.50 11.13 9.49 6.12
KLA/ATP 20.09 20.92 34.53 24.06 21.64 12.34 7.43
Ccl4
KLA  ATP  ATP+KLA
 NM_013652 chemokine (C-C motif) ligand 4 (Ccl4), mRNA [NM_013652] KLA 68.93 60.20 52.12 67.06 35.78 15.78 8.82
ATP 2.26 3.82 16.88 43.14 26.67 9.47 6.75
KLA/ATP 59.57 71.75 133.98 193.53 81.76 15.96 7.62
Ccl5
KLA  ATP  ATP+KLA
 M77747 rantes mRNA, complete cds. [M77747] KLA 63.18 60.41 56.25 63.63 58.00 66.51 67.20
ATP .91 1.08 1.25 1.90 4.34 16.10 26.07
KLA/ATP 55.92 63.34 72.91 65.68 70.81 71.97 81.34
Ccl5
KLA  ATP  ATP+KLA
 NM_013653 chemokine (C-C motif) ligand 5 (Ccl5), mRNA [NM_013653] KLA 40.31 35.22 27.92 38.59 29.29 37.98 28.83
ATP .86 .92 1.43 1.66 3.86 15.09 16.66
KLA/ATP 32.14 31.72 47.19 35.89 42.00 46.15 43.89
Cd14
KLA  ATP  ATP+KLA
 NM_009841 CD14 antigen (Cd14), mRNA [NM_009841] KLA 2.35 2.68 2.54 2.21 2.39 1.52 1.57
ATP 1.44 2.28 2.82 3.98 6.68 16.14 6.92
KLA/ATP 2.92 3.79 3.96 5.12 5.29 10.42 11.50
Cd40
KLA  ATP  ATP+KLA
 NM_170701 CD40 antigen (Cd40), transcript variant 3, mRNA [NM_170701] KLA 23.87 23.62 23.26 23.98 22.07 17.37 5.34
ATP 1.00 1.01 1.06 2.96 2.65 3.03 1.70
KLA/ATP 22.77 23.79 29.67 28.85 28.08 21.62 13.02
Cd80
KLA  ATP  ATP+KLA
 NM_009855 CD80 antigen (Cd80), mRNA [NM_009855] KLA 2.13 1.91 1.89 1.78 1.29 1.00 .82
ATP .99 1.20 1.98 1.49 1.37 2.40 1.71
KLA/ATP 2.05 2.32 3.09 2.27 1.95 2.89 3.07
Cd86
KLA  ATP  ATP+KLA
 NM_019388 CD86 antigen (Cd86), mRNA [NM_019388] KLA 13.80 14.41 18.21 18.33 17.37 17.26 4.82
ATP 1.02 1.00 2.20 3.64 5.16 6.79 3.81
KLA/ATP 14.80 14.66 18.10 18.96 19.38 20.42 14.21
Chuk
KLA  ATP  ATP+KLA
 NM_007700 conserved helix-loop-helix ubiquitous kinase (Chuk), mRNA [NM_007700] KLA 1.32 1.42 1.41 1.17 1.32 1.22 1.40
ATP 1.22 1.30 1.18 .97 1.02 1.00 1.37
KLA/ATP 1.56 1.61 1.21 1.09 .83 .84 1.17
Ctsk
KLA  ATP  ATP+KLA
 NM_007802 cathepsin K (Ctsk), mRNA [NM_007802] KLA 1.02 1.14 1.16 1.37 1.40 1.95 2.05
ATP 1.04 1.06 1.34 2.32 3.59 8.92 14.36
KLA/ATP 1.08 1.23 1.62 2.29 4.63 15.04 24.14
Cxcl10
KLA  ATP  ATP+KLA
 NM_021274 chemokine (C-X-C motif) ligand 10 (Cxcl10), mRNA [NM_021274] KLA 986.69 854.98 711.49 799.39 542.62 686.82 183.27
ATP .98 1.71 9.85 73.04 100.42 184.63 8.33
KLA/ATP 842.13 793.12 ###.## ###.## ###.## 715.22 496.10
Cxcl11
KLA  ATP  ATP+KLA
 NM_019494 chemokine (C-X-C motif) ligand 11 (Cxcl11), mRNA [NM_019494] KLA 53.93 53.81 51.26 58.57 51.83 57.67 21.56
ATP 1.04 1.02 1.56 1.81 1.84 5.79 2.13
KLA/ATP 48.25 51.73 69.50 55.47 41.98 48.57 57.88
Cxcl9
KLA  ATP  ATP+KLA
 NM_008599 chemokine (C-X-C motif) ligand 9 (Cxcl9), mRNA [NM_008599] KLA 47.92 43.81 42.05 48.89 39.45 45.28 32.42
ATP 1.00 1.02 1.43 1.62 1.59 2.25 1.96
KLA/ATP 41.95 43.69 63.75 56.28 60.18 53.62 48.95
Fadd
KLA  ATP  ATP+KLA
 NM_010175 Fas (TNFRSF6)-associated via death domain (Fadd), mRNA [NM_010175] KLA .54 .54 .59 .64 .80 .97 1.16
ATP 1.05 1.09 1.03 1.65 1.18 .78 1.61
KLA/ATP .56 .56 .53 .78 .78 .82 1.34
Fos
KLA  ATP  ATP+KLA
 NM_010234 FBJ osteosarcoma oncogene (Fos), mRNA [NM_010234] KLA .42 .33 .64 .61 .71 .85 .71
ATP 3.48 5.46 23.78 25.22 1.71 2.36 1.50
KLA/ATP .90 1.74 5.97 8.62 1.28 2.42 4.52
Ifna12
KLA  ATP  ATP+KLA
 NM_177361 interferon alpha 12 (Ifna12), mRNA [NM_177361] KLA 1.25 1.26 1.34 1.16 1.06 1.10 1.09
ATP 1.01 .97 1.07 1.09 1.17 1.20 1.07
KLA/ATP 1.12 1.29 1.72 1.54 1.59 1.56 1.05
Ifna13
KLA  ATP  ATP+KLA
 NM_177347 interferon alpha 13 (Ifna13), mRNA [NM_177347] KLA 1.32 1.27 1.26 1.34 1.15 1.24 1.20
ATP .95 1.08 1.29 1.79 1.41 1.22 1.08
KLA/ATP 1.36 1.35 2.04 2.81 2.07 1.44 1.19
Ifna2
KLA  ATP  ATP+KLA
 K01411 gb|Mouse alpha-interferon (MuIFN-alpha), 3 cds & untranslated mRNA [K01411] KLA 1.02 1.03 1.10 .96 .93 .99 1.01
ATP 1.02 .98 1.00 .98 1.02 .97 .95
KLA/ATP 1.02 1.04 1.18 1.08 1.13 1.04 1.01
Ifna2
KLA  ATP  ATP+KLA
 NM_010503 interferon alpha 2 (Ifna2), mRNA [NM_010503] KLA 1.08 1.06 1.07 1.06 .98 1.02 1.05
ATP .94 1.06 1.11 1.30 1.24 1.25 1.21
KLA/ATP 1.03 1.20 1.19 1.35 1.52 1.60 1.18
Ifna4
KLA  ATP  ATP+KLA
 NM_010504 interferon alpha 4 (Ifna4), mRNA [NM_010504] KLA .99 1.04 1.05 .97 1.00 .96 .99
ATP 1.01 .96 .98 1.01 1.00 1.00 .97
KLA/ATP 1.10 1.09 1.05 1.04 1.01 .97 1.01
Ifna5
KLA  ATP  ATP+KLA
 NM_010505 interferon alpha 5 (Ifna5), mRNA [NM_010505] KLA 1.15 1.23 1.51 1.26 1.03 1.06 1.05
ATP .99 .94 1.11 1.00 1.09 1.07 1.03
KLA/ATP 1.12 1.29 1.46 1.47 1.24 1.32 1.03
Ifna9
KLA  ATP  ATP+KLA
 NM_010507 interferon alpha 9 (Ifna9), mRNA [NM_010507] KLA 1.05 1.09 1.20 1.06 1.08 1.06 1.02
ATP .99 1.08 1.18 1.21 1.09 .99 .97
KLA/ATP 1.09 1.23 1.19 1.24 1.18 1.16 1.04
Ifnab
KLA  ATP  ATP+KLA
 BC116864 interferon alpha B, mRNA (cDNA clone MGC:151241 IMAGE:40126183), complete cds [BC116864] KLA 1.20 1.33 1.29 1.30 1.20 1.20 1.08
ATP .99 .99 1.00 1.25 1.13 1.19 1.04
KLA/ATP 1.30 1.39 1.44 1.48 1.49 1.54 1.22
Ifnar1
KLA  ATP  ATP+KLA
 NM_010508 interferon (alpha and beta) receptor 1 (Ifnar1), mRNA [NM_010508] KLA 1.35 1.29 1.19 1.39 1.60 1.47 1.49
ATP 1.18 1.25 .94 1.06 1.07 1.48 1.52
KLA/ATP 1.56 1.57 .98 1.43 1.08 1.79 3.54
Ifnar2
KLA  ATP  ATP+KLA
 NM_010509 interferon (alpha and beta) receptor 2 (Ifnar2), transcript variant 1, mRNA [NM_010509] KLA 1.45 1.43 1.67 1.87 2.31 1.84 1.36
ATP .99 .92 .87 1.03 1.38 1.79 1.43
KLA/ATP 1.48 1.48 1.24 1.54 1.77 2.10 2.81
Ifnb1
KLA  ATP  ATP+KLA
 NM_010510 interferon beta 1, fibroblast (Ifnb1), mRNA [NM_010510] KLA 49.82 46.57 34.05 16.05 5.94 7.31 8.49
ATP .99 1.02 1.89 4.78 6.31 4.44 1.79
KLA/ATP 49.22 61.83 134.08 144.05 110.96 31.78 11.24
Ikbkb
KLA  ATP  ATP+KLA
 NM_010546 inhibitor of kappaB kinase beta (Ikbkb), mRNA [NM_010546] KLA 1.88 2.10 2.14 1.83 1.73 1.31 1.19
ATP .81 .74 .55 .49 .59 1.05 .96
KLA/ATP 1.86 1.73 1.39 1.12 .89 1.17 1.24
Ikbke
KLA  ATP  ATP+KLA
 NM_019777 inhibitor of kappaB kinase epsilon (Ikbke), mRNA [NM_019777] KLA 6.03 5.91 6.38 6.89 7.05 6.70 4.74
ATP 1.02 1.11 .82 1.16 1.18 2.08 1.90
KLA/ATP 6.04 6.71 5.69 5.30 2.49 2.33 5.43
Ikbkg
KLA  ATP  ATP+KLA
 AK042138 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630062P04 product:unclassifiable, full insert sequence. [AK042138] KLA .92 .87 .78 .78 .87 .88 .62
ATP .84 .71 .80 .50 1.15 2.33 .61
KLA/ATP .72 .69 .74 .48 1.06 1.97 .68
Ikbkg
KLA  ATP  ATP+KLA
 NM_010547 inhibitor of kappaB kinase gamma (Ikbkg), transcript variant 1, mRNA [NM_010547] KLA 1.51 1.63 1.74 1.83 1.83 1.73 1.72
ATP .80 .79 .82 .75 .66 2.58 2.37
KLA/ATP 1.43 1.42 1.17 1.04 .71 1.54 3.17
Ikbkg
KLA  ATP  ATP+KLA
 NM_178590 inhibitor of kappaB kinase gamma (Ikbkg), transcript variant 2, mRNA [NM_178590] KLA .84 .93 .86 .91 1.03 .89 .88
ATP 1.03 .98 .68 .56 .51 .93 .68
KLA/ATP .89 .81 .55 .52 .41 .67 .65
Il12a
KLA  ATP  ATP+KLA
 NM_008351 interleukin 12a (Il12a), mRNA [NM_008351] KLA 2.37 2.47 2.17 1.49 1.46 1.12 1.20
ATP 1.01 .97 1.12 1.07 1.02 1.07 1.06
KLA/ATP 2.01 2.76 2.54 1.70 1.08 1.10 1.27
Il12b
KLA  ATP  ATP+KLA
 NM_008352 interleukin 12b (Il12b), mRNA [NM_008352] KLA 194.79 211.32 198.97 173.01 142.24 40.28 3.10
ATP 1.05 1.10 1.59 1.99 2.71 2.72 1.52
KLA/ATP 191.27 223.23 280.10 224.29 183.03 68.43 10.69
Il1b
KLA  ATP  ATP+KLA
 NM_008361 interleukin 1 beta (Il1b), mRNA [NM_008361] KLA 149.78 133.59 100.91 116.58 86.48 89.37 64.72
ATP 3.49 13.96 61.44 70.91 82.12 162.79 28.18
KLA/ATP 130.32 139.00 219.12 148.17 165.44 172.57 146.98
Il6
KLA  ATP  ATP+KLA
 NM_031168 interleukin 6 (Il6), mRNA [NM_031168] KLA 352.99 378.70 276.81 168.47 59.99 18.66 8.27
ATP 1.04 1.08 2.28 3.69 30.40 161.93 2.11
KLA/ATP 334.28 528.66 ###.## 935.86 302.45 355.36 99.65
Irak1
KLA  ATP  ATP+KLA
 NM_008363 interleukin-1 receptor-associated kinase 1 (Irak1), mRNA [NM_008363] KLA .67 .67 .64 .56 .58 .58 .84
ATP 1.02 1.10 .94 1.14 .81 .54 .87
KLA/ATP .72 .72 .57 .67 .51 .43 .62
Irak4
KLA  ATP  ATP+KLA
 NM_029926 interleukin-1 receptor-associated kinase 4 (Irak4), mRNA [NM_029926] KLA .82 .86 .78 .82 .95 1.21 1.22
ATP 1.02 1.18 .95 1.10 .79 .85 .82
KLA/ATP .86 .89 .77 .90 .78 .96 .88
Irf3
KLA  ATP  ATP+KLA
 ENSMUST00000107835 ens|Interferon regulatory factor 3 (IRF-3). [Source:Uniprot/SWISSPROT;Acc:P70671] [ENSMUST00000107835] KLA .55 .56 .60 .72 .88 .88 .98
ATP .77 .58 .50 .46 .80 .97 1.03
KLA/ATP .51 .46 .49 .53 .92 .85 .79
Irf3
KLA  ATP  ATP+KLA
 NM_016849 interferon regulatory factor 3 (Irf3), mRNA [NM_016849] KLA .79 .75 .71 .83 .88 1.07 .99
ATP .92 .84 .88 .61 .54 1.27 1.22
KLA/ATP .78 .78 .75 .58 .70 1.13 1.38
Irf5
KLA  ATP  ATP+KLA
 NM_012057 interferon regulatory factor 5 (Irf5), mRNA [NM_012057] KLA 1.76 1.72 1.85 1.47 1.59 1.74 1.78
ATP 1.06 1.13 .73 .81 .77 1.48 2.36
KLA/ATP 1.99 1.84 1.00 1.37 1.27 2.78 4.30
Irf7
KLA  ATP  ATP+KLA
 NM_016850 interferon regulatory factor 7 (Irf7), mRNA [NM_016850] KLA 4.90 4.72 5.85 5.82 7.67 10.64 15.44
ATP 1.14 1.10 .86 1.18 .96 2.46 12.17
KLA/ATP 5.41 5.22 4.15 6.29 5.31 9.74 29.08
Jun
KLA  ATP  ATP+KLA
 NM_010591 Jun oncogene (Jun), mRNA [NM_010591] KLA 1.08 .96 1.09 1.09 .75 .88 .81
ATP 1.26 1.48 4.45 8.73 4.02 1.16 1.99
KLA/ATP 1.12 1.38 3.52 5.17 3.32 .49 1.42
Lbp
KLA  ATP  ATP+KLA
 NM_008489 lipopolysaccharide binding protein (Lbp), mRNA [NM_008489] KLA 1.01 1.01 .94 1.02 1.03 1.06 1.00
ATP 1.00 .99 .96 1.03 .91 .89 .84
KLA/ATP .98 .96 1.01 .93 1.00 .95 .83
Ly96
KLA  ATP  ATP+KLA
 NM_016923 lymphocyte antigen 96 (Ly96), mRNA [NM_016923] KLA 2.25 2.07 2.39 2.38 2.38 2.30 2.14
ATP 1.19 1.02 1.35 1.20 1.69 2.83 1.93
KLA/ATP 2.36 2.28 3.07 2.62 2.68 2.34 3.13
Map2k1
KLA  ATP  ATP+KLA
 NM_008927 mitogen-activated protein kinase kinase 1 (Map2k1), mRNA [NM_008927] KLA 1.82 2.00 2.31 2.03 2.51 2.20 1.51
ATP .99 1.14 .81 .87 .90 1.57 1.11
KLA/ATP 1.90 2.03 1.50 1.93 1.63 2.03 2.06
Map2k2
KLA  ATP  ATP+KLA
 NM_023138 mitogen-activated protein kinase kinase 2 (Map2k2), mRNA [NM_023138] KLA .96 1.01 1.09 .99 1.11 1.15 1.42
ATP 1.07 1.05 .74 .86 1.04 1.16 1.21
KLA/ATP 1.14 1.03 .68 .78 .85 1.01 1.20
Map2k3
KLA  ATP  ATP+KLA
 NM_008928 mitogen-activated protein kinase kinase 3 (Map2k3), mRNA [NM_008928] KLA .88 .88 .73 .65 .99 1.34 .92
ATP 1.04 1.09 .89 1.62 1.93 1.75 1.17
KLA/ATP 1.00 .92 .66 1.21 1.80 2.24 2.10
Map2k4
KLA  ATP  ATP+KLA
 NM_009157 mitogen-activated protein kinase kinase 4 (Map2k4), mRNA [NM_009157] KLA 3.67 3.75 4.23 3.90 3.30 1.87 1.12
ATP 1.05 1.11 1.04 .93 1.16 2.62 1.02
KLA/ATP 3.70 4.13 3.27 4.13 2.98 3.03 1.82
Map2k6
KLA  ATP  ATP+KLA
 NM_011943 mitogen-activated protein kinase kinase 6 (Map2k6), mRNA [NM_011943] KLA .68 .67 .64 .67 .62 .59 .61
ATP 1.02 1.12 1.04 1.10 .79 .61 .61
KLA/ATP .73 .69 .71 .74 .66 .62 .98
Map2k7
KLA  ATP  ATP+KLA
 BC070467 mitogen activated protein kinase kinase 7, mRNA (cDNA clone MGC:96654 IMAGE:30615302), complete cds [BC070467] KLA .77 .79 .88 .77 .97 .96 1.27
ATP 1.11 1.26 .93 1.19 1.13 1.45 1.16
KLA/ATP .89 .88 .59 .89 .86 1.32 1.28
Map2k7
KLA  ATP  ATP+KLA
 NM_001042557 mitogen-activated protein kinase kinase 7 (Map2k7), transcript variant 1, mRNA [NM_001042557] KLA .96 .95 1.02 .96 .95 1.09 1.19
ATP 1.02 1.07 .88 .97 .93 1.10 1.17
KLA/ATP 1.01 .99 .80 .87 .76 1.21 1.16
Map3k7
KLA  ATP  ATP+KLA
 NM_172688 mitogen-activated protein kinase kinase kinase 7 (Map3k7), mRNA [NM_172688] KLA 1.48 1.49 1.51 1.24 1.21 1.19 1.61
ATP 1.10 1.16 1.03 1.03 1.12 1.61 1.61
KLA/ATP 1.43 1.56 1.05 1.15 .85 1.48 1.76
Map3k7ip
1
KLA  ATP  ATP+KLA
 NM_025609 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (Map3k7ip1), mRNA [NM_025609] KLA .32 .30 .35 .56 .67 .82 .76
ATP .95 .81 .80 .42 .35 .40 .80
KLA/ATP .33 .30 .37 .20 .45 .62 .65
Map3k7ip
2
KLA  ATP  ATP+KLA
 AK086230 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930015C19 product:inferred: Mus musculus, Similar to TAK1-binding protein 2; KIAA0733 protein, clone MGC:8010 IMAGE:3586132, mRNA, complete cds, full insert sequence. [A KLA 1.14 1.02 1.07 1.03 1.13 1.02 .96
ATP 1.00 .88 .92 .90 1.06 .96 .94
KLA/ATP 1.05 1.00 .90 .98 1.02 .97 .97
Map3k7ip
2
KLA  ATP  ATP+KLA
 NM_138667 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (Map3k7ip2), mRNA [NM_138667] KLA 3.43 3.22 3.19 2.41 2.13 1.51 1.10
ATP 1.08 1.08 .86 .81 1.30 1.32 1.02
KLA/ATP 3.34 3.66 3.00 2.58 1.80 1.52 1.61
Map3k8
KLA  ATP  ATP+KLA
 D13759 cot mRNA for proto-oncogene protein, complete cds. [D13759] KLA 11.38 11.64 13.24 13.31 10.92 5.26 3.31
ATP 1.36 1.09 1.75 6.27 10.51 3.58 1.60
KLA/ATP 12.58 11.57 8.93 14.10 13.92 4.98 4.09
Mapk1
KLA  ATP  ATP+KLA
 NM_001038663 mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663] KLA .97 1.03 .93 .86 .79 1.01 1.04
ATP .96 1.18 1.01 1.13 .84 1.04 1.16
KLA/ATP .99 .99 .84 .87 .63 .96 1.26
Mapk1
KLA  ATP  ATP+KLA
 NM_011949 mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949] KLA .88 .80 .80 .73 .75 .76 .65
ATP .97 .96 1.06 .88 .90 .68 .48
KLA/ATP .82 .81 .78 .65 .64 .64 .45
Mapk10
KLA  ATP  ATP+KLA
 AK076990 adult male testis cDNA, RIKEN full-length enriched library, clone:4930597C01 product:mitogen activated protein kinase 10, full insert sequence. [AK076990] KLA 1.03 1.05 .98 1.04 .94 .95 1.02
ATP 1.00 .99 1.06 .97 1.01 .96 .99
KLA/ATP 1.07 1.01 .95 1.05 .82 .95 .87
Mapk10
KLA  ATP  ATP+KLA
 NM_009158 mitogen-activated protein kinase 10 (Mapk10), transcript variant 1, mRNA [NM_009158] KLA .95 1.00 .97 1.01 .99 1.01 .95
ATP 1.01 1.02 .98 1.01 1.04 1.01 .99
KLA/ATP 1.05 .99 1.01 .98 .92 .97 .98
Mapk11
KLA  ATP  ATP+KLA
 NM_011161 mitogen-activated protein kinase 11 (Mapk11), mRNA [NM_011161] KLA 1.28 1.30 1.41 1.46 1.58 1.29 .98
ATP .96 .95 .89 .82 .79 1.09 .85
KLA/ATP 1.44 1.42 1.32 1.23 1.23 .74 .66
Mapk12
KLA  ATP  ATP+KLA
 NM_013871 mitogen-activated protein kinase 12 (Mapk12), mRNA [NM_013871] KLA .94 .86 .87 .81 .77 .68 .49
ATP .97 .83 .92 .90 .86 .90 .51
KLA/ATP .91 .89 .88 .85 1.12 1.14 .53
Mapk13
KLA  ATP  ATP+KLA
 NM_011950 mitogen-activated protein kinase 13 (Mapk13), mRNA [NM_011950] KLA 1.22 1.21 1.35 1.26 1.24 1.13 1.01
ATP 1.08 1.00 1.20 1.20 1.13 1.22 1.39
KLA/ATP 1.22 1.27 1.30 1.30 1.21 1.11 1.47
Mapk14
KLA  ATP  ATP+KLA
 NM_011951 mitogen-activated protein kinase 14 (Mapk14), mRNA [NM_011951] KLA .70 .70 .62 .54 .67 .88 1.11
ATP 1.03 .98 .87 .69 .48 .78 .66
KLA/ATP .74 .68 .52 .46 .38 .45 .62
Mapk3
KLA  ATP  ATP+KLA
 NM_011952 mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952] KLA .81 .85 .88 .72 .79 .73 .90
ATP 1.13 1.30 .92 1.48 1.08 .68 1.03
KLA/ATP 1.01 1.01 .66 1.13 .77 .77 1.16
Mapk8
KLA  ATP  ATP+KLA
 AK162915 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330031O19 product:mitogen activated protein kinase 8, full insert sequence [AK162915] KLA .94 .86 .80 .83 .77 .85 .83
ATP 1.08 1.12 .94 .80 .83 .71 .75
KLA/ATP .83 .81 .80 .74 .74 .75 .67
Mapk8
KLA  ATP  ATP+KLA
 AK163829 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130070A06 product:mitogen activated protein kinase 8, full insert sequence [AK163829] KLA .65 .61 .66 .70 .90 1.02 1.03
ATP .99 .94 1.68 1.44 1.75 1.84 1.10
KLA/ATP .63 .67 1.11 1.00 2.01 1.68 1.15
Mapk8
KLA  ATP  ATP+KLA
 NM_016700 mitogen-activated protein kinase 8 (Mapk8), mRNA [NM_016700] KLA .96 1.00 .94 .96 .94 .99 1.04
ATP 1.01 1.05 1.01 .99 1.03 .98 1.02
KLA/ATP .96 .97 .96 .97 .93 .94 .96
Mapk9
KLA  ATP  ATP+KLA
 NM_016961 mitogen-activated protein kinase 9 (Mapk9), transcript variant 2, mRNA [NM_016961] KLA 1.28 1.37 1.59 1.60 1.61 1.43 1.38
ATP 1.03 .99 .74 .71 .79 1.20 1.01
KLA/ATP 1.53 1.30 1.07 .99 .83 1.10 1.40
Mapk9
KLA  ATP  ATP+KLA
 NM_207692 mitogen-activated protein kinase 9 (Mapk9), transcript variant 1, mRNA [NM_207692] KLA 1.39 1.53 1.69 1.69 1.55 1.44 1.51
ATP .95 .92 .75 .85 .70 1.46 1.17
KLA/ATP 1.37 1.35 .99 1.18 .91 1.22 1.62
Mm.11689
4
KLA  ATP  ATP+KLA
 124248589 Unknown KLA .85 .82 .79 .95 .77 .84 .58
ATP 1.04 1.03 .99 .93 .82 .79 .78
KLA/ATP .92 .86 .85 .79 .78 .79 .64
Mm.14928
0
KLA  ATP  ATP+KLA
 34328395 Unknown KLA 1.35 1.44 1.59 1.51 1.51 1.28 1.54
ATP .98 .97 1.05 1.08 1.19 .75 .71
KLA/ATP 1.31 1.34 1.22 1.42 1.28 .89 .95
Mm.21312
8
KLA  ATP  ATP+KLA
 141801344 Unknown KLA .96 .95 .83 .77 .52 .99 1.32
ATP .80 .82 1.09 .80 .83 1.19 1.46
KLA/ATP .78 .92 .98 .62 .71 .94 1.41
Mm.25381
9
KLA  ATP  ATP+KLA
 118130676 Unknown KLA 1.81 1.88 1.96 1.62 1.89 2.44 1.56
ATP .92 .91 1.24 1.01 1.16 2.06 1.95
KLA/ATP 1.62 1.86 1.86 1.41 1.89 2.37 1.97
Mm.27970
KLA  ATP  ATP+KLA
 13994135 Unknown KLA 1.06 1.11 1.16 1.07 1.11 1.08 .95
ATP 1.02 1.09 1.05 1.05 .94 1.16 1.32
KLA/ATP 1.10 1.19 1.11 1.04 1.08 1.02 1.33
Mm.37708
7
KLA  ATP  ATP+KLA
 158631169 Unknown KLA .98 .98 1.06 1.06 .91 .97 1.04
ATP 1.00 1.07 1.01 1.06 1.09 .99 1.02
KLA/ATP 1.08 1.06 1.16 1.11 1.16 1.12 1.04
Mm.38049
KLA  ATP  ATP+KLA
 118130391 Unknown KLA .67 .65 .73 .92 .63 .81 .76
ATP .93 .92 1.08 .54 .45 1.48 1.56
KLA/ATP .57 .65 .98 .67 .44 .78 1.16
Mm.41292
2
KLA  ATP  ATP+KLA
 145966829 Unknown KLA 3.65 3.76 3.75 3.79 3.42 1.75 1.10
ATP 1.11 1.17 1.04 .90 1.37 2.90 1.00
KLA/ATP 3.31 3.97 3.38 3.84 3.04 3.31 2.09
Mm.44889
KLA  ATP  ATP+KLA
 157057165 Unknown KLA 1.20 1.25 1.45 1.49 1.63 1.70 1.66
ATP 1.00 1.03 1.03 1.00 1.12 1.06 1.23
KLA/ATP 1.25 1.15 1.16 1.16 1.15 1.41 1.71
Mm.46002
4
KLA  ATP  ATP+KLA
 38348245 Unknown KLA 1.22 1.25 1.25 1.19 1.22 1.47 1.14
ATP 1.03 .94 1.01 1.01 2.67 2.31 1.37
KLA/ATP 1.35 1.19 1.27 1.22 1.99 1.83 1.45
Mm.5126
KLA  ATP  ATP+KLA
 158508678 Unknown KLA .70 .71 .73 .79 .87 1.11 1.25
ATP 1.22 1.37 1.08 1.54 1.38 1.01 1.26
KLA/ATP .85 .83 .75 .90 1.12 .96 1.17
Mm.57127
KLA  ATP  ATP+KLA
 117168292 Unknown KLA 1.20 1.25 1.28 1.18 1.14 1.13 1.12
ATP .98 .95 1.11 1.06 1.05 1.05 1.09
KLA/ATP 1.22 1.24 1.48 1.55 1.40 1.21 1.07
Myd88
KLA  ATP  ATP+KLA
 NM_010851 myeloid differentiation primary response gene 88 (Myd88), mRNA [NM_010851] KLA 3.35 3.51 3.91 4.13 4.13 3.62 2.53
ATP .99 .96 .79 .75 .93 2.15 1.60
KLA/ATP 3.37 3.52 3.52 3.48 2.81 3.03 3.33
Nfkb1
KLA  ATP  ATP+KLA
 BC050841 nuclear factor of kappa light chain gene enhancer in B-cells 1, p105, mRNA (cDNA clone IMAGE:6392793), complete cds. [BC050841] KLA 5.81 4.96 4.77 3.21 3.37 2.00 1.71
ATP 1.39 1.52 3.25 12.63 13.64 4.80 1.08
KLA/ATP 7.21 8.69 19.53 23.93 11.70 2.85 2.01
Nfkb1
KLA  ATP  ATP+KLA
 M57999 gb|Mouse transcription factor NF-kappa-B DNA binding subunit mRNA, complete cds. [M57999] KLA 8.55 7.87 7.35 6.13 3.51 1.85 1.38
ATP .98 .96 1.21 3.06 5.29 4.67 .69
KLA/ATP 7.32 7.20 8.71 10.82 5.55 2.77 1.54
Nfkbia
KLA  ATP  ATP+KLA
 NM_010907 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (Nfkbia), mRNA [NM_010907] KLA 18.65 18.46 13.63 17.88 14.25 9.17 7.92
ATP .91 1.09 7.11 32.39 17.44 10.49 1.72
KLA/ATP 15.57 17.66 15.73 23.91 13.83 10.73 9.48
Pik3ca
KLA  ATP  ATP+KLA
 ENSMUST00000108243 ens|Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K). [Source:Uniprot/SWISSPROT;Acc:P42337] [ENSMUST00000108243] KLA 1.07 1.01 .91 .90 .98 .96 .86
ATP 1.03 .87 1.12 .63 1.22 1.86 .60
KLA/ATP 1.05 .82 .91 .61 1.17 1.26 .63
Pik3ca
KLA  ATP  ATP+KLA
 NM_008839 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA [NM_008839] KLA 1.15 1.11 1.05 .82 .99 1.03 1.27
ATP .98 1.00 .79 .75 .96 1.32 1.10
KLA/ATP 1.10 .98 .64 .72 .80 1.20 1.41
Pik3cb
KLA  ATP  ATP+KLA
 NM_029094 phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb), mRNA [NM_029094] KLA 1.06 1.06 1.03 .73 .68 .98 1.69
ATP 1.04 1.21 .95 1.02 .85 .93 1.73
KLA/ATP 1.15 1.27 .73 .83 .58 .81 1.81
Pik3cd
KLA  ATP  ATP+KLA
 NM_008840 phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd), transcript variant 1, mRNA [NM_008840] KLA 2.28 2.42 3.10 4.17 3.35 2.31 1.34
ATP 1.02 .91 .99 .63 .30 .67 .80
KLA/ATP 2.14 2.23 2.70 1.51 1.17 .85 .72
Pik3cd
KLA  ATP  ATP+KLA
 U86587 phosphatidylinositol 3-kinase catalytic subunit p110 delta mRNA, complete cds. [U86587] KLA 2.21 2.24 3.71 3.17 3.67 2.66 1.48
ATP 1.00 1.03 .93 .96 .46 .75 .97
KLA/ATP 2.27 2.32 1.97 2.02 1.01 .99 .98
Pik3cg
KLA  ATP  ATP+KLA
 NM_020272 phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg), mRNA [NM_020272] KLA .53 .53 .61 .64 .97 .86 .79
ATP 1.01 1.13 .88 .89 .52 .53 .53
KLA/ATP .58 .53 .43 .60 .40 .43 .62
Pik3r1
KLA  ATP  ATP+KLA
 NM_001077495 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 2, mRNA [NM_001077495] KLA 1.05 1.07 1.03 1.00 1.01 1.20 .85
ATP .97 1.02 1.48 1.42 1.76 1.33 1.23
KLA/ATP 1.11 1.12 1.06 1.17 1.24 .99 1.12
Pik3r2
KLA  ATP  ATP+KLA
 NM_008841 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) (Pik3r2), mRNA [NM_008841] KLA .50 .50 .48 .43 .46 .66 .75
ATP .78 .68 .45 .43 .28 .57 1.37
KLA/ATP .49 .38 .32 .33 .38 .67 1.10
Pik3r3
KLA  ATP  ATP+KLA
 NM_181585 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) (Pik3r3), mRNA [NM_181585] KLA 1.59 1.49 1.37 1.17 1.05 1.55 1.41
ATP 1.12 1.00 1.33 1.70 2.01 2.37 2.02
KLA/ATP 1.63 1.54 1.58 1.70 2.43 2.68 1.92
Pik3r5
KLA  ATP  ATP+KLA
 NM_177320 phosphoinositide-3-kinase, regulatory subunit 5, p101 (Pik3r5), mRNA [NM_177320] KLA 3.57 3.58 4.16 3.54 4.11 2.59 2.39
ATP 1.08 1.08 .93 1.67 3.11 1.88 1.34
KLA/ATP 3.91 3.70 3.30 3.80 2.70 2.04 3.00
Rac1
KLA  ATP  ATP+KLA
 NM_009007 RAS-related C3 botulinum substrate 1 (Rac1), mRNA [NM_009007] KLA 1.02 1.01 1.02 .99 1.03 1.15 1.08
ATP .99 1.15 1.01 1.27 1.06 1.20 1.06
KLA/ATP 1.00 1.04 .88 1.16 .91 1.21 1.38
Rela
KLA  ATP  ATP+KLA
 NM_009045 v-rel reticuloendotheliosis viral oncogene homolog A (avian) (Rela), mRNA [NM_009045] KLA 2.05 2.05 2.07 1.75 1.83 1.58 1.33
ATP 1.03 1.08 1.10 1.44 1.61 2.48 1.05
KLA/ATP 2.17 2.27 2.05 2.47 1.93 2.35 2.02
Ripk1
KLA  ATP  ATP+KLA
 NM_009068 receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1), mRNA [NM_009068] KLA 1.32 1.33 1.50 1.09 1.00 1.11 1.13
ATP .98 .94 .60 .59 1.35 1.56 1.45
KLA/ATP 1.48 1.30 1.01 1.05 1.36 1.53 1.37
Spp1
KLA  ATP  ATP+KLA
 NM_009263 secreted phosphoprotein 1 (Spp1), mRNA [NM_009263] KLA 1.41 1.62 1.39 1.31 1.31 1.00 .51
ATP 1.08 1.21 1.49 1.79 2.55 3.51 3.41
KLA/ATP 1.40 1.54 1.51 1.43 2.01 3.18 2.46
Stat1
KLA  ATP  ATP+KLA
 NM_009283 signal transducer and activator of transcription 1 (Stat1), mRNA [NM_009283] KLA 2.90 2.72 3.00 3.64 4.58 6.51 5.58
ATP 1.01 .92 .89 .72 .51 2.22 3.07
KLA/ATP 2.73 2.65 2.34 1.95 1.99 4.70 8.66
Tbk1
KLA  ATP  ATP+KLA
 NM_019786 TANK-binding kinase 1 (Tbk1), mRNA [NM_019786] KLA 2.55 2.76 3.22 2.67 2.56 2.29 1.96
ATP 1.13 1.30 1.12 1.07 1.29 1.41 1.40
KLA/ATP 2.84 3.17 2.58 2.43 1.70 2.15 2.37
Ticam1
KLA  ATP  ATP+KLA
 NM_174989 toll-like receptor adaptor molecule 1 (Ticam1), mRNA [NM_174989] KLA 1.45 1.63 2.02 2.36 3.12 2.34 2.21
ATP 1.16 1.19 .90 2.58 4.78 2.04 1.80
KLA/ATP 1.79 1.71 1.07 2.89 5.60 3.26 3.50
Ticam2
KLA  ATP  ATP+KLA
 NM_173394 toll-like receptor adaptor molecule 2 (Ticam2), mRNA [NM_173394] KLA 1.28 1.35 1.64 1.79 1.80 1.34 2.01
ATP 1.02 1.02 1.00 1.14 1.16 .70 .88
KLA/ATP 1.49 1.50 1.14 1.41 1.13 .89 1.40
Tirap
KLA  ATP  ATP+KLA
 AK081514 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130027E04 product:toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, full insert sequence [AK081514] KLA 1.36 1.33 1.35 1.41 1.36 1.45 1.22
ATP .93 .87 .82 .45 .78 1.93 1.32
KLA/ATP 1.35 1.37 1.30 .83 1.17 1.75 2.10
Tirap
KLA  ATP  ATP+KLA
 NM_054096 toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (Tirap), mRNA [NM_054096] KLA 1.88 1.70 1.69 1.74 1.82 1.69 1.31
ATP 1.12 1.10 .75 .56 1.03 2.52 1.67
KLA/ATP 1.60 1.75 1.69 1.25 1.41 2.27 3.21
Tlr1
KLA  ATP  ATP+KLA
 NM_030682 toll-like receptor 1 (Tlr1), mRNA [NM_030682] KLA 3.57 3.84 4.75 3.97 5.29 4.83 4.46
ATP 1.08 1.06 .78 .61 .46 1.45 2.49
KLA/ATP 3.92 3.96 3.36 3.25 1.78 1.59 4.08
Tlr2
KLA  ATP  ATP+KLA
 NM_011905 toll-like receptor 2 (Tlr2), mRNA [NM_011905] KLA 13.65 11.82 8.87 7.95 4.67 2.78 2.33
ATP 1.06 1.24 2.76 6.28 11.55 13.82 .67
KLA/ATP 13.11 12.91 14.48 13.84 14.18 11.14 2.78
Tlr3
KLA  ATP  ATP+KLA
 NM_126166 toll-like receptor 3 (Tlr3), mRNA [NM_126166] KLA 8.54 10.04 12.64 11.83 10.51 7.08 3.09
ATP 1.09 1.16 1.16 1.16 .77 1.77 2.23
KLA/ATP 10.00 11.77 10.12 12.97 10.43 8.74 7.11
Tlr4
KLA  ATP  ATP+KLA
 NM_021297 toll-like receptor 4 (Tlr4), mRNA [NM_021297] KLA .69 .61 .75 .94 .64 .81 .73
ATP .95 .90 1.12 .56 .47 1.51 1.53
KLA/ATP .57 .62 1.01 .64 .39 .73 1.13
Tlr5
KLA  ATP  ATP+KLA
 AF186107 toll-like receptor 5 (Tlr5) mRNA, complete cds [AF186107] KLA .78 .75 .84 .78 .72 .74 .43
ATP .98 1.07 .99 .95 .79 .66 .61
KLA/ATP .79 .81 .77 .73 .73 .67 .50
Tlr6
KLA  ATP  ATP+KLA
 NM_011604 toll-like receptor 6 (Tlr6), mRNA [NM_011604] KLA 6.41 6.63 6.53 6.69 4.70 4.27 2.63
ATP 1.04 .95 1.02 .65 1.11 5.02 3.78
KLA/ATP 6.27 6.99 7.49 5.08 4.10 4.69 7.46
Tlr7
KLA  ATP  ATP+KLA
 NM_133211 toll-like receptor 7 (Tlr7), mRNA [NM_133211] KLA 2.03 2.09 2.28 2.43 2.56 2.48 1.32
ATP 1.01 1.06 1.05 .80 .80 .89 1.37
KLA/ATP 2.04 2.28 2.28 2.40 2.28 1.77 1.06
Tlr8
KLA  ATP  ATP+KLA
 NM_133212 toll-like receptor 8 (Tlr8), mRNA [NM_133212] KLA 1.80 2.31 2.64 2.40 2.91 2.75 1.72
ATP 1.20 1.33 .93 1.04 .56 .70 1.04
KLA/ATP 2.32 2.30 1.59 2.21 .98 1.10 1.70
Tlr9
KLA  ATP  ATP+KLA
 NM_031178 toll-like receptor 9 (Tlr9), mRNA [NM_031178] KLA 1.08 1.09 1.18 1.15 1.34 1.25 1.16
ATP 1.04 1.05 1.23 1.85 1.41 1.06 1.21
KLA/ATP 1.16 1.17 1.45 1.88 1.67 1.32 1.46
Tnf
KLA  ATP  ATP+KLA
 NM_013693 tumor necrosis factor (Tnf), mRNA [NM_013693] KLA 13.35 12.76 10.71 9.03 10.64 7.39 8.32
ATP 2.01 2.48 8.27 19.20 9.72 4.09 1.49
KLA/ATP 12.72 15.76 12.73 17.34 5.10 3.61 6.07
Tollip
KLA  ATP  ATP+KLA
 NM_023764 toll interacting protein (Tollip), mRNA [NM_023764] KLA 1.10 1.11 1.12 1.07 1.09 1.30 1.19
ATP 1.04 1.16 1.18 1.41 2.37 2.54 2.16
KLA/ATP 1.16 1.20 1.08 1.10 1.63 2.29 2.71
Traf3
KLA  ATP  ATP+KLA
 NM_011632 Tnf receptor-associated factor 3 (Traf3), transcript variant 1, mRNA [NM_011632] KLA .52 .49 .51 .49 .80 .98 1.22
ATP .93 .92 .95 1.13 2.70 1.80 1.42
KLA/ATP .56 .50 .49 1.07 2.94 1.92 1.65
Traf6
KLA  ATP  ATP+KLA
 NM_009424 Tnf receptor-associated factor 6 (Traf6), mRNA [NM_009424] KLA 1.19 1.28 1.34 1.20 1.23 1.23 1.28
ATP 1.06 1.12 .92 1.15 2.46 1.84 1.40
KLA/ATP 1.32 1.37 .89 1.16 1.45 1.49 1.46