Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Circadian rhythm (mmu04710)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Arntl
KLA  ATP  ATP+KLA
 NM_007489 aryl hydrocarbon receptor nuclear translocator-like (Arntl), mRNA [NM_007489] KLA .70 .70 .80 .60 .68 .79 .67
ATP 1.10 1.00 .65 .56 1.53 1.42 1.48
KLA/ATP .71 .60 .47 .42 1.07 1.02 1.27
Bhlhb2
KLA  ATP  ATP+KLA
 NM_011498 basic helix-loop-helix domain containing, class B2 (Bhlhb2), mRNA [NM_011498] KLA .41 .50 .42 .38 .30 .34 .62
ATP 1.08 1.26 2.07 10.84 12.33 3.03 4.01
KLA/ATP .48 .62 .91 5.38 9.38 3.20 3.73
Bhlhb3
KLA  ATP  ATP+KLA
 NM_024469 basic helix-loop-helix domain containing, class B3 (Bhlhb3), mRNA [NM_024469] KLA .74 .74 .78 .73 .67 .76 .87
ATP 1.09 1.12 .99 1.89 4.32 1.72 1.92
KLA/ATP .75 .77 .79 1.17 2.70 1.85 1.44
Btrc
KLA  ATP  ATP+KLA
 NM_009771 beta-transducin repeat containing protein (Btrc), transcript variant 2, mRNA [NM_009771] KLA 1.30 1.33 1.62 1.50 1.93 1.79 1.60
ATP 1.07 1.30 1.05 1.26 .67 .99 1.56
KLA/ATP 1.40 1.61 1.13 1.72 .88 1.50 1.97
Clock
KLA  ATP  ATP+KLA
 AK030352 adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330400M04 product:circadian locomoter output cycles kaput, full insert sequence. [AK030352] KLA .79 .74 .74 .76 .93 .88 .95
ATP 1.14 1.22 .70 .72 .98 .89 1.00
KLA/ATP .83 .80 .68 .69 .88 .81 .77
Clock
KLA  ATP  ATP+KLA
 NM_007715 circadian locomoter output cycles kaput (Clock), mRNA [NM_007715] KLA 1.18 1.05 .90 .82 .81 .85 .92
ATP 1.05 1.03 .95 .70 1.12 1.26 .96
KLA/ATP 1.13 1.05 .89 .77 1.00 .95 .93
Creb1
KLA  ATP  ATP+KLA
 NM_009952 cAMP responsive element binding protein 1 (Creb1), transcript variant B, mRNA [NM_009952] KLA 1.42 1.33 1.16 .99 .83 .97 .92
ATP .92 .91 1.18 1.38 1.51 1.02 .75
KLA/ATP 1.34 1.31 1.49 1.37 1.71 1.05 .93
Cry1
KLA  ATP  ATP+KLA
 NM_007771 cryptochrome 1 (photolyase-like) (Cry1), mRNA [NM_007771] KLA 1.13 1.14 1.08 1.00 .92 1.02 1.41
ATP .91 .89 .85 .96 1.90 1.74 1.30
KLA/ATP 1.04 1.02 .86 .94 1.39 1.62 1.07
Cry2
KLA  ATP  ATP+KLA
 NM_009963 cryptochrome 2 (photolyase-like) (Cry2), transcript variant 1, mRNA [NM_009963] KLA .90 .90 .99 .96 1.16 1.16 1.13
ATP 1.02 .98 .79 .75 3.03 2.46 1.05
KLA/ATP .93 .79 .67 .80 2.35 2.55 1.06
Csnk1d
KLA  ATP  ATP+KLA
 NM_027874 casein kinase 1, delta (Csnk1d), transcript variant 2, mRNA [NM_027874] KLA 1.18 1.24 1.40 1.51 1.46 1.33 1.20
ATP 1.03 .98 .90 .97 1.70 1.81 1.18
KLA/ATP 1.30 1.36 1.20 1.37 1.98 2.29 1.67
Csnk1d
KLA  ATP  ATP+KLA
 NM_139059 casein kinase 1, delta (Csnk1d), transcript variant 1, mRNA [NM_139059] KLA 1.72 1.90 2.07 2.00 2.02 1.88 1.60
ATP .94 1.05 1.01 1.34 2.03 2.97 1.70
KLA/ATP 1.77 1.86 1.85 2.18 2.27 2.99 3.01
Csnk1e
KLA  ATP  ATP+KLA
 NM_013767 casein kinase 1, epsilon (Csnk1e), mRNA [NM_013767] KLA .75 .69 .67 .71 .68 .64 .76
ATP .98 .89 .97 .94 1.80 .90 .83
KLA/ATP .68 .66 .70 .73 1.79 .84 .72
Cul1
KLA  ATP  ATP+KLA
 NM_012042 cullin 1 (Cul1), mRNA [NM_012042] KLA 1.54 1.57 1.59 1.36 1.13 1.06 1.15
ATP 1.02 1.15 1.00 1.02 1.00 1.16 1.10
KLA/ATP 1.54 1.68 1.30 1.46 .98 1.02 1.12
Fbxl3
KLA  ATP  ATP+KLA
 NM_015822 F-box and leucine-rich repeat protein 3 (Fbxl3), mRNA [NM_015822] KLA 2.60 2.69 2.70 1.74 1.93 1.34 1.30
ATP 1.07 1.30 1.27 1.68 3.09 2.00 1.32
KLA/ATP 2.51 2.68 2.05 1.97 2.42 1.76 1.42
Fbxw11
KLA  ATP  ATP+KLA
 AK010033 adult male tongue cDNA, RIKEN full-length enriched library, clone:2310065A07 product:unclassifiable, full insert sequence. [AK010033] KLA 1.30 1.21 1.27 1.21 1.47 1.01 1.13
ATP 1.19 2.03 1.28 .95 1.43 .99 1.04
KLA/ATP 1.43 1.83 1.40 1.10 1.12 1.05 1.05
Fbxw11
KLA  ATP  ATP+KLA
 NM_134015 F-box and WD-40 domain protein 11 (Fbxw11), mRNA [NM_134015] KLA 3.11 2.78 3.05 3.43 2.16 1.58 1.20
ATP 1.03 .94 1.72 1.19 1.38 1.66 1.01
KLA/ATP 2.76 2.70 4.18 2.07 1.91 2.02 1.71
Mm.12136
1
KLA  ATP  ATP+KLA
 144922673 Unknown KLA .57 .51 .45 .48 .64 .77 .35
ATP 1.08 1.09 .83 .61 .53 .51 .23
KLA/ATP .54 .53 .63 .53 .63 .54 .21
Mm.44266
8
KLA  ATP  ATP+KLA
 21703801 Unknown KLA .22 .18 .13 .12 .11 .16 .29
ATP .80 .65 .69 .53 .38 .54 .41
KLA/ATP .17 .15 .13 .11 .28 .48 .12
Mm.7373
KLA  ATP  ATP+KLA
 141803296 Unknown KLA .24 .24 .28 .55 .90 1.30 1.06
ATP 1.11 1.29 3.81 6.45 4.44 2.96 1.65
KLA/ATP .24 .31 1.21 3.13 8.41 4.94 2.50
Npas2
KLA  ATP  ATP+KLA
 NM_008719 neuronal PAS domain protein 2 (Npas2), mRNA [NM_008719] KLA .93 .93 .84 .86 .79 .83 .86
ATP .98 1.05 .98 1.04 .86 .84 .90
KLA/ATP .92 .95 .93 .90 .77 .85 .87
Nr1d1
KLA  ATP  ATP+KLA
 NM_145434 nuclear receptor subfamily 1, group D, member 1 (Nr1d1), mRNA [NM_145434] KLA .95 .99 .92 .98 1.04 1.10 .85
ATP .96 1.00 .94 2.91 2.80 1.14 1.03
KLA/ATP .97 .97 .95 1.42 1.90 1.25 1.10
Per1
KLA  ATP  ATP+KLA
 NM_011065 period homolog 1 (Drosophila) (Per1), mRNA [NM_011065] KLA .34 .30 .37 .63 1.06 1.49 1.15
ATP 1.16 1.43 3.32 7.74 4.34 2.71 1.69
KLA/ATP .34 .39 1.13 3.82 7.74 4.59 2.55
Per2
KLA  ATP  ATP+KLA
 NM_011066 period homolog 2 (Drosophila) (Per2), mRNA [NM_011066] KLA .81 .79 .76 .78 1.01 1.24 1.11
ATP 1.03 1.03 1.07 1.09 .98 1.23 .98
KLA/ATP .79 .75 .81 .81 1.03 1.15 .81
Per3
KLA  ATP  ATP+KLA
 NM_011067 period homolog 3 (Drosophila) (Per3), mRNA [NM_011067] KLA .97 .90 .84 .90 .96 .98 .71
ATP .97 1.04 1.01 .92 .94 .84 .67
KLA/ATP .91 .86 .78 .81 .90 .84 .58
Prkaa1
KLA  ATP  ATP+KLA
 NM_001013367 protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1), mRNA [NM_001013367] KLA 1.10 1.03 1.17 1.25 1.24 1.61 2.29
ATP 1.04 1.07 1.10 1.08 1.04 2.01 2.13
KLA/ATP 1.07 1.04 1.04 1.17 .95 1.90 3.90
Prkaa2
KLA  ATP  ATP+KLA
 NM_178143 protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), mRNA [NM_178143] KLA .93 .94 .94 .90 .92 .92 .99
ATP 1.00 1.14 .93 1.01 1.00 1.11 .98
KLA/ATP 1.00 .97 .99 1.01 .98 1.02 .98
Prkab1
KLA  ATP  ATP+KLA
 NM_031869 protein kinase, AMP-activated, beta 1 non-catalytic subunit (Prkab1), mRNA [NM_031869] KLA .68 .70 .95 1.10 1.43 1.66 1.22
ATP 1.02 .93 .93 .95 .92 1.62 1.46
KLA/ATP .72 .73 .84 .85 1.12 1.68 2.36
Prkab2
KLA  ATP  ATP+KLA
 NM_182997 protein kinase, AMP-activated, beta 2 non-catalytic subunit (Prkab2), mRNA [NM_182997] KLA .55 .56 .46 .65 .78 .68 .59
ATP .95 .74 .78 1.43 2.06 1.50 .70
KLA/ATP .60 .49 .51 .65 1.36 .94 .58
Prkag1
KLA  ATP  ATP+KLA
 NM_016781 protein kinase, AMP-activated, gamma 1 non-catalytic subunit (Prkag1), mRNA [NM_016781] KLA .66 .70 .71 .83 .92 1.02 1.02
ATP 1.06 1.00 .97 1.04 .81 1.09 1.16
KLA/ATP .67 .74 .75 .74 .76 1.15 1.37
Prkag2
KLA  ATP  ATP+KLA
 NM_145401 protein kinase, AMP-activated, gamma 2 non-catalytic subunit (Prkag2), mRNA [NM_145401] KLA .41 .39 .30 .35 .30 .34 .45
ATP .88 .86 .65 .68 .46 .52 .47
KLA/ATP .39 .37 .32 .37 .38 .48 .30
Prkag3
KLA  ATP  ATP+KLA
 NM_153744 protein kinase, AMP-activated, gamma 3 non-catatlytic subunit (Prkag3), transcript variant 1, mRNA [NM_153744] KLA 1.01 .99 1.03 1.04 1.12 1.00 1.15
ATP .97 1.07 1.10 1.11 1.05 1.09 1.04
KLA/ATP 1.06 1.02 1.11 1.15 1.11 1.07 .98
Rbx1
KLA  ATP  ATP+KLA
 NM_019712 ring-box 1 (Rbx1), mRNA [NM_019712] KLA 1.04 1.01 .98 1.09 1.06 1.14 1.09
ATP .92 .89 1.13 1.16 1.68 1.07 .83
KLA/ATP .99 .99 1.25 1.31 2.63 2.06 .67
Rora
KLA  ATP  ATP+KLA
 AK087905 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330039D10 product:unclassifiable, full insert sequence [AK087905] KLA .92 .92 .81 .82 .86 .81 .78
ATP .97 1.00 .91 1.01 1.67 .88 .88
KLA/ATP .84 .84 .89 .93 1.18 .96 .80
Rora
KLA  ATP  ATP+KLA
 NM_013646 RAR-related orphan receptor alpha (Rora), mRNA [NM_013646] KLA .43 .42 .38 .40 .40 .38 .48
ATP .91 .75 .81 1.32 3.69 1.38 .62
KLA/ATP .39 .36 .44 .59 2.33 1.28 .49
Rorb
KLA  ATP  ATP+KLA
 AK044421 adult retina cDNA, RIKEN full-length enriched library, clone:A930011O08 product:RAR-related orphan receptor beta, full insert sequence. [AK044421] KLA .96 1.01 .96 .96 1.00 1.02 1.06
ATP 1.00 1.01 1.02 .98 1.01 .95 1.02
KLA/ATP 1.03 .99 1.04 .98 .95 .99 1.02
Rorb
KLA  ATP  ATP+KLA
 NM_001043354 RAR-related orphan receptor beta (Rorb), transcript variant 1, mRNA [NM_001043354] KLA .98 1.07 .95 1.02 .99 1.01 .97
ATP .95 1.01 1.00 1.02 .98 1.00 1.02
KLA/ATP .99 1.00 .95 1.01 1.00 .98 .96
Rorc
KLA  ATP  ATP+KLA
 NM_011281 RAR-related orphan receptor gamma (Rorc), mRNA [NM_011281] KLA .99 1.03 1.02 1.03 1.03 .95 .98
ATP 1.01 1.01 1.02 1.03 .95 .96 1.02
KLA/ATP 1.03 1.01 1.06 1.02 .99 1.01 1.02
Skp1a
KLA  ATP  ATP+KLA
 NM_011543 S-phase kinase-associated protein 1A (Skp1a), mRNA [NM_011543] KLA 1.05 1.00 .92 .92 .88 .89 1.02
ATP .90 .98 1.21 1.43 1.32 1.46 1.09
KLA/ATP .93 1.01 1.11 1.31 1.21 1.27 1.21