Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Phototransduction (mmu04744)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Arrb1
KLA  ATP  ATP+KLA
 NM_177231 arrestin, beta 1 (Arrb1), transcript variant a, mRNA [NM_177231] KLA .41 .42 .32 .32 .31 .56 .80
ATP .97 .86 .81 .62 .47 .59 1.16
KLA/ATP .43 .37 .38 .36 .35 .35 .89
Calm1
KLA  ATP  ATP+KLA
 NM_009790 calmodulin 1 (Calm1), mRNA [NM_009790] KLA 1.20 1.26 1.30 1.06 1.16 1.09 1.18
ATP 1.07 1.20 1.00 1.29 .99 .64 .58
KLA/ATP 1.31 1.31 .93 1.31 .97 .83 .59
Calm2
KLA  ATP  ATP+KLA
 NM_007589 calmodulin 2 (Calm2), mRNA [NM_007589] KLA .79 .81 .71 .67 .54 .45 .64
ATP .99 1.03 1.04 .93 .82 .52 .76
KLA/ATP .76 .78 .76 .77 .73 .47 .42
Calm3
KLA  ATP  ATP+KLA
 NM_007590 calmodulin 3 (Calm3), mRNA [NM_007590] KLA .95 .96 .93 1.03 1.05 1.08 1.00
ATP .93 .96 .99 .97 .93 .84 .72
KLA/ATP .89 .93 .90 .91 1.02 .98 .70
Calm4
KLA  ATP  ATP+KLA
 NM_020036 calmodulin 4 (Calm4), mRNA [NM_020036] KLA 1.02 .96 1.05 1.00 .99 1.00 1.01
ATP 1.10 1.05 1.03 1.01 .94 .98 .98
KLA/ATP .99 1.12 1.01 1.03 .98 1.07 1.02
Calm5
KLA  ATP  ATP+KLA
 NM_001008706 calmodulin 5 (Calm5), mRNA [NM_001008706] KLA 1.02 1.11 .99 .98 1.07 1.01 1.09
ATP 1.07 1.05 1.04 1.04 1.01 1.04 .99
KLA/ATP 1.00 1.00 .97 1.07 1.00 1.07 .98
Calml3
KLA  ATP  ATP+KLA
 NM_027416 calmodulin-like 3 (Calml3), mRNA [NM_027416] KLA 1.01 .95 1.05 .91 1.01 .98 .89
ATP .91 1.05 1.04 1.01 .93 1.07 .99
KLA/ATP 1.01 .96 .97 .96 .97 .92 .99
Cnga1
KLA  ATP  ATP+KLA
 U19717 cGMP-gated cation channel mRNA, clone mIMCD-K2 no.1, complete cds. [U19717] KLA .96 1.02 1.01 1.03 .98 .97 .99
ATP 1.03 1.01 .96 .94 .93 1.03 1.02
KLA/ATP .99 1.04 1.05 1.04 1.00 1.20 .97
Cngb1
KLA  ATP  ATP+KLA
 BC045114 cyclic nucleotide gated channel beta 1, mRNA (cDNA clone IMAGE:4504353), partial cds [BC045114] KLA 1.02 1.14 .96 .94 .93 .90 .92
ATP .94 1.04 1.03 .87 1.05 1.00 .98
KLA/ATP .99 1.02 .99 .94 .90 .98 .95
Gnat1
KLA  ATP  ATP+KLA
 NM_008140 guanine nucleotide binding protein, alpha transducing 1 (Gnat1), mRNA [NM_008140] KLA 1.00 1.03 .99 .99 .99 .98 .96
ATP 1.01 1.00 1.03 1.02 .97 1.01 1.02
KLA/ATP .98 1.00 1.03 1.04 1.03 .99 1.01
Gnat2
KLA  ATP  ATP+KLA
 NM_008141 guanine nucleotide binding protein, alpha transducing 2 (Gnat2), mRNA [NM_008141] KLA .95 .98 .95 1.02 .95 .98 .94
ATP .96 1.06 .92 .97 1.01 1.00 .97
KLA/ATP 1.01 .97 .93 .95 .91 .97 .97
Gnb1
KLA  ATP  ATP+KLA
 NM_008142 guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142] KLA 1.11 1.18 1.22 1.19 1.29 1.32 1.76
ATP 1.02 1.09 .84 .99 .97 .89 1.22
KLA/ATP 1.20 1.25 .85 1.01 .86 .91 1.57
Gngt1
KLA  ATP  ATP+KLA
 NM_010314 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (Gngt1), mRNA [NM_010314] KLA 1.06 .99 .95 .98 1.03 1.10 .98
ATP .96 1.02 1.03 1.03 .94 1.06 .95
KLA/ATP .98 1.03 1.04 1.04 1.01 1.03 1.01
Grk1
KLA  ATP  ATP+KLA
 NM_011881 G protein-coupled receptor kinase 1 (Grk1), mRNA [NM_011881] KLA 1.10 1.03 .96 .96 1.08 .98 1.01
ATP 1.04 .99 .95 1.04 1.03 .96 1.06
KLA/ATP .99 1.05 .95 1.02 1.05 1.02 1.06
Guca1a
KLA  ATP  ATP+KLA
 NM_008189 guanylate cyclase activator 1a (retina) (Guca1a), mRNA [NM_008189] KLA .87 .93 .86 .91 .88 .89 1.02
ATP .92 1.01 1.05 1.06 .93 .85 .90
KLA/ATP .96 .87 .98 .97 .84 .88 .67
Guca1b
KLA  ATP  ATP+KLA
 NM_146079 guanylate cyclase activator 1B (Guca1b), mRNA [NM_146079] KLA 1.30 1.26 1.14 1.30 1.34 1.15 1.14
ATP 1.10 1.12 1.11 1.23 1.38 1.15 1.04
KLA/ATP 1.44 1.32 1.62 1.39 1.57 1.37 1.31
Gucy2e
KLA  ATP  ATP+KLA
 BC057954 guanylate cyclase 2e, mRNA (cDNA clone MGC:68216 IMAGE:5360206), complete cds. [BC057954] KLA 1.04 .98 .97 1.00 1.00 .98 .95
ATP 1.04 1.01 .96 .98 .95 1.03 1.01
KLA/ATP 1.00 .98 1.04 .98 1.00 1.01 1.07
Gucy2e
KLA  ATP  ATP+KLA
 NM_008192 guanylate cyclase 2e (Gucy2e), mRNA [NM_008192] KLA 1.02 1.04 1.01 1.04 1.02 1.02 1.07
ATP .99 1.07 1.02 1.01 .98 1.05 1.05
KLA/ATP 1.03 .99 1.02 1.02 1.02 .99 1.04
Gucy2f
KLA  ATP  ATP+KLA
 NM_001007576 guanylate cyclase 2f (Gucy2f), mRNA [NM_001007576] KLA .98 .99 1.00 .93 1.00 1.01 1.02
ATP 1.00 1.02 1.05 1.08 1.03 .98 1.02
KLA/ATP 1.05 .94 .81 1.05 .97 1.10 .96
Mm.20374
7
KLA  ATP  ATP+KLA
 146149233 Unknown KLA .34 .30 .28 .41 .80 1.31 1.29
ATP .93 .83 .82 .76 .43 .46 .88
KLA/ATP .30 .28 .27 .27 .27 .51 1.11
Mm.40615
6
KLA  ATP  ATP+KLA
 21717804 Unknown KLA 1.05 1.07 1.03 .98 .94 .98 .94
ATP .98 .98 1.05 .99 .99 .96 .97
KLA/ATP .95 1.05 .96 1.00 .98 1.02 1.01
Mm.43972
6
KLA  ATP  ATP+KLA
 162951841 Unknown KLA 1.79 1.71 1.90 1.80 2.00 1.41 1.00
ATP 1.04 1.05 1.40 1.67 1.94 3.13 1.06
KLA/ATP 1.81 1.89 3.29 3.44 2.89 2.73 2.23
Pde6a
KLA  ATP  ATP+KLA
 NM_146086 phosphodiesterase 6A, cGMP-specific, rod, alpha (Pde6a), mRNA [NM_146086] KLA 1.06 1.01 1.04 .97 .98 .97 .94
ATP 1.01 .97 1.06 .95 1.02 1.01 .95
KLA/ATP .95 1.04 1.06 .94 1.08 .98 1.02
Pde6b
KLA  ATP  ATP+KLA
 NM_008806 phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide (Pde6b), mRNA [NM_008806] KLA 1.08 1.07 1.14 1.15 1.24 1.33 1.14
ATP 1.07 .89 1.06 1.12 1.03 .99 1.02
KLA/ATP 1.06 1.11 1.01 1.07 1.05 1.12 1.10
Pde6g
KLA  ATP  ATP+KLA
 NM_012065 phosphodiesterase 6G, cGMP-specific, rod, gamma (Pde6g), mRNA [NM_012065] KLA 1.23 1.11 1.17 1.10 1.21 1.09 1.11
ATP 1.06 1.00 1.10 .99 .94 .97 .90
KLA/ATP 1.14 1.23 1.10 1.44 1.04 .91 1.13
Rcvrn
KLA  ATP  ATP+KLA
 X66196 gb|M.musculus mRNA for 23 kDa photoreceptor cell-specific protein. [X66196] KLA 2.01 1.85 2.38 2.06 2.31 1.55 1.14
ATP .98 1.01 1.51 2.25 2.14 3.32 1.16
KLA/ATP 2.04 2.26 3.49 4.13 3.45 3.13 2.61
Rgs9
KLA  ATP  ATP+KLA
 NM_011268 regulator of G-protein signaling 9 (Rgs9), mRNA [NM_011268] KLA 1.06 .99 1.02 1.01 1.02 1.06 1.03
ATP 1.03 .95 1.06 1.09 1.15 1.24 1.00
KLA/ATP 1.07 1.02 1.05 1.08 1.17 1.28 1.41
Rho
KLA  ATP  ATP+KLA
 NM_145383 rhodopsin (Rho), mRNA [NM_145383] KLA 1.00 1.03 .90 1.05 1.02 1.03 .98
ATP .97 .99 1.10 1.00 .94 .99 1.09
KLA/ATP .94 .92 1.06 1.04 1.04 .96 1.05
Slc24a1
KLA  ATP  ATP+KLA
 NM_144813 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 (Slc24a1), mRNA [NM_144813] KLA 1.08 .98 .93 1.02 .99 1.01 .93
ATP 1.00 1.01 1.04 .95 .95 1.00 1.03
KLA/ATP .99 .95 1.02 .97 1.00 .97 1.04