Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

Kdo₂-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Maturity onset diabetes of the young (mmu04950)

Legend: : View data/graphs for replicates

Gene symbol	Time course plot	Accession	Description	Treatment	15min	30min	1hr	2hr	4hr	8hr	20hr
Bhlhb8	KLA  ATP  ATP+KLA	NM_010800	basic helix-loop-helix domain containing, class B, 8 (Bhlhb8), mRNA [NM_010800]	KLA	.97	1.03	1.06	1.04	1.04	1.04	1.06
				ATP	1.01	1.01	1.00	1.07	1.06	1.03	1.02
				KLA/ATP	1.04	1.02	1.08	1.10	1.00	1.04	.98
Foxa2	KLA  ATP  ATP+KLA	NM_010446	forkhead box A2 (Foxa2), mRNA [NM_010446]	KLA	.98	1.01	1.00	.99	1.01	1.00	1.02
				ATP	.99	.99	1.02	1.01	.99	1.01	1.00
				KLA/ATP	1.01	.99	1.02	1.01	1.00	.98	.99
Foxa3	KLA  ATP  ATP+KLA	NM_008260	forkhead box A3 (Foxa3), mRNA [NM_008260]	KLA	1.00	.93	.99	.99	.98	1.00	1.01
				ATP	.93	.99	1.06	.99	1.03	.98	1.03
				KLA/ATP	.95	1.05	1.05	1.01	.96	1.04	1.04
Gck	KLA  ATP  ATP+KLA	NM_010292	glucokinase (Gck), mRNA [NM_010292]	KLA	1.03	.99	1.04	1.02	.97	.98	1.00
				ATP	1.01	.97	1.08	.99	1.06	.98	.96
				KLA/ATP	1.06	1.01	.96	.98	.98	1.01	1.01
Hes1	KLA  ATP  ATP+KLA	NM_008235	hairy and enhancer of split 1 (Drosophila) (Hes1), mRNA [NM_008235]	KLA	.96	1.00	1.02	.93	1.01	.94	.99
				ATP	.93	1.03	1.05	.96	1.06	1.02	1.02
				KLA/ATP	.97	.93	1.03	1.06	1.10	1.17	1.16
Hhex	KLA  ATP  ATP+KLA	NM_008245	hematopoietically expressed homeobox (Hhex), mRNA [NM_008245]	KLA	1.79	1.67	1.40	.64	.47	1.02	.64
				ATP	.97	1.04	1.01	.74	.34	.36	.60
				KLA/ATP	1.63	1.58	1.79	1.12	.49	.44	.34
Hnf1a	KLA  ATP  ATP+KLA	M57966	gb|Mouse hepatocyte nuclear factor 1 (HNF-1) mRNA, complete cds [M57966]	KLA	1.01	1.00	.97	1.02	1.04	.99	1.01
				ATP	.99	1.04	1.02	.96	.98	.96	1.13
				KLA/ATP	1.03	.97	1.02	1.01	.90	.94	1.04
Hnf1b	KLA  ATP  ATP+KLA	NM_009330	HNF1 homeobox B (Hnf1b), mRNA [NM_009330]	KLA	1.10	1.11	1.10	1.10	1.08	1.11	1.02
				ATP	1.02	1.01	1.04	1.03	1.02	1.06	1.10
				KLA/ATP	1.08	1.03	1.06	1.19	1.13	1.03	1.05
Hnf4a	KLA  ATP  ATP+KLA	NM_008261	hepatic nuclear factor 4, alpha (Hnf4a), mRNA [NM_008261]	KLA	1.00	1.02	.98	1.02	.99	.99	1.03
				ATP	1.01	1.03	1.00	.95	.93	1.04	1.00
				KLA/ATP	1.03	1.02	1.08	.98	.98	.99	.97
Hnf4g	KLA  ATP  ATP+KLA	AK136534	adult male cecum cDNA, RIKEN full-length enriched library, clone:9130202K07 product:hypothetical protein, full insert sequence [AK136534]	KLA	1.08	1.06	1.05	1.02	.94	1.01	1.03
				ATP	.99	1.03	.97	.96	1.03	1.00	1.02
				KLA/ATP	.99	1.10	1.00	.99	1.02	.98	1.01
Hnf4g	KLA  ATP  ATP+KLA	NM_013920	hepatocyte nuclear factor 4, gamma (Hnf4g), mRNA [NM_013920]	KLA	1.00	.95	.95	.99	1.01	.96	.99
				ATP	.95	1.01	1.06	.95	.95	1.07	1.04
				KLA/ATP	.95	.92	.96	1.01	.99	.93	.97
Ins1	KLA  ATP  ATP+KLA	NM_008386	insulin I (Ins1), mRNA [NM_008386]	KLA	1.00	.99	.99	1.03	1.01	.98	1.06
				ATP	.97	1.03	1.00	1.03	.99	1.07	1.05
				KLA/ATP	1.03	.93	.98	1.04	1.07	1.03	1.01
Ins2	KLA  ATP  ATP+KLA	NM_008387	insulin II (Ins2), mRNA [NM_008387]	KLA	.99	1.00	1.00	1.01	1.00	1.02	1.00
				ATP	1.01	.99	1.00	1.00	.98	.99	1.01
				KLA/ATP	.99	1.01	1.00	.98	.99	.99	.98
Mafa	KLA  ATP  ATP+KLA	NM_194350	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) (Mafa), mRNA [NM_194350]	KLA	1.01	1.00	.97	1.01	.99	.98	1.10
				ATP	.98	1.08	1.08	1.11	1.04	.99	1.00
				KLA/ATP	1.00	1.02	.96	1.22	1.13	1.07	1.00
Mm.33260 7	KLA  ATP  ATP+KLA	166295201	Unknown	KLA	1.03	1.09	1.04	1.04	1.03	.98	.99
				ATP	1.03	1.04	.99	1.02	.97	1.03	1.00
				KLA/ATP	.96	.99	.88	1.08	1.07	.92	1.01
Mm.415	KLA  ATP  ATP+KLA	162135961	Unknown	KLA	1.01	1.01	1.05	.96	1.00	.94	.97
				ATP	1.06	.96	1.02	1.07	.99	.97	1.01
				KLA/ATP	1.03	1.03	.99	.98	.97	1.00	1.01
Mnx1	KLA  ATP  ATP+KLA	NM_019944	motor neuron and pancreas homeobox 1 (Mnx1), mRNA [NM_019944]	KLA	.97	1.01	.98	1.08	1.01	1.03	1.03
				ATP	1.03	1.01	1.01	1.03	.98	1.01	1.08
				KLA/ATP	1.07	.93	1.22	1.03	1.04	1.04	1.04
Neurod1	KLA  ATP  ATP+KLA	NM_010894	neurogenic differentiation 1 (Neurod1), mRNA [NM_010894]	KLA	1.00	1.05	.98	1.03	1.01	.93	.98
				ATP	.96	1.01	1.05	1.06	1.00	1.01	1.04
				KLA/ATP	.87	1.00	1.09	1.02	1.01	.96	1.02
Neurog3	KLA  ATP  ATP+KLA	NM_009719	neurogenin 3 (Neurog3), mRNA [NM_009719]	KLA	.99	.99	1.02	1.02	1.01	1.05	1.04
				ATP	.98	1.07	1.07	1.00	1.00	.95	1.04
				KLA/ATP	1.02	1.03	1.01	1.08	.96	.95	.99
Nkx2-2	KLA  ATP  ATP+KLA	NM_010919	NK2 transcription factor related, locus 2 (Drosophila) (Nkx2-2), transcript variant 1, mRNA [NM_010919]	KLA	1.00	.93	.99	1.02	.96	1.03	1.00
				ATP	1.03	.96	.98	.97	.97	.96	.98
				KLA/ATP	1.00	1.02	1.00	.96	.95	1.00	.95
Nkx6-1	KLA  ATP  ATP+KLA	NM_144955	NK6 transcription factor related, locus 1 (Drosophila) (Nkx6-1), mRNA [NM_144955]	KLA	1.24	1.14	1.23	1.20	1.23	1.16	1.24
				ATP	1.04	1.09	1.02	1.12	1.12	1.25	1.19
				KLA/ATP	1.25	1.25	1.25	1.30	1.06	1.09	1.19
Nr5a2	KLA  ATP  ATP+KLA	NM_030676	nuclear receptor subfamily 5, group A, member 2 (Nr5a2), mRNA [NM_030676]	KLA	1.02	.96	.97	1.03	1.04	.99	1.05
				ATP	.98	1.01	.94	.95	1.01	1.01	.98
				KLA/ATP	1.03	1.01	.96	.97	1.04	1.06	1.01
Onecut1	KLA  ATP  ATP+KLA	AK051235	12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130020G02 product:DNA segment, Chr 9, ERATO Doi 423, expressed, full insert sequence. [AK051235]	KLA	1.06	.94	.93	1.01	.97	1.07	.97
				ATP	1.00	.96	.99	.95	.96	.99	.97
				KLA/ATP	1.00	1.01	1.05	.99	.91	.97	1.06
Onecut1	KLA  ATP  ATP+KLA	NM_008262	one cut domain, family member 1 (Onecut1), mRNA [NM_008262]	KLA	.96	1.01	.99	.99	1.00	1.01	.94
				ATP	.98	.98	.96	.98	1.02	1.04	.96
				KLA/ATP	.97	.92	.94	1.04	1.02	.96	.97
Pax4	KLA  ATP  ATP+KLA	NM_011038	paired box gene 4 (Pax4), mRNA [NM_011038]	KLA	2.67	2.35	2.19	1.43	1.13	1.09	1.07
				ATP	1.05	.99	1.14	1.06	1.05	.96	1.04
				KLA/ATP	2.71	2.99	2.34	2.10	1.45	1.11	.97
Pax6	KLA  ATP  ATP+KLA	AK139054	7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730006J20 product:paired box gene 6, full insert sequence [AK139054]	KLA	.90	.98	.99	.94	.99	1.05	.91
				ATP	.98	1.03	.94	.93	1.02	.96	.95
				KLA/ATP	1.03	1.15	.96	.94	1.01	.97	.97
Pax6	KLA  ATP  ATP+KLA	NM_013627	paired box gene 6 (Pax6), mRNA [NM_013627]	KLA	1.03	1.03	1.03	1.04	1.02	1.02	1.03
				ATP	1.01	.99	1.09	1.11	1.19	1.18	1.04
				KLA/ATP	1.02	1.06	1.27	1.31	1.13	1.28	1.19
Pdx1	KLA  ATP  ATP+KLA	NM_008814	pancreatic and duodenal homeobox 1 (Pdx1), mRNA [NM_008814]	KLA	.92	1.07	1.11	1.03	1.02	1.09	1.06
				ATP	1.08	1.02	1.02	1.03	1.09	1.07	1.01
				KLA/ATP	1.03	1.12	.86	1.08	1.27	1.11	1.13
Pklr	KLA  ATP  ATP+KLA	NM_013631	pyruvate kinase liver and red blood cell (Pklr), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_013631]	KLA	1.06	1.01	1.12	1.00	.98	1.01	1.07
				ATP	.98	.94	1.05	1.06	1.01	1.06	1.10
				KLA/ATP	.97	1.00	1.04	.95	.89	1.05	.97
Slc2a2	KLA  ATP  ATP+KLA	NM_031197	solute carrier family 2 (facilitated glucose transporter), member 2 (Slc2a2), mRNA [NM_031197]	KLA	1.01	1.03	.97	1.00	1.01	1.02	1.04
				ATP	1.02	.97	1.07	1.00	1.00	1.03	1.00
				KLA/ATP	1.01	1.01	.95	1.00	1.05	1.02	1.01