Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Aldosterone-regulated sodium reabsorption (mmu04960)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK033698
KLA  ATP  ATP+KLA
 AK033698 adult male cecum cDNA, RIKEN full-length enriched library, clone:9130225F20 product:unclassifiable, full insert sequence. [AK033698] KLA .72 .76 .68 .65 .66 .64 .60
ATP 1.10 1.25 1.41 5.92 4.60 1.14 1.19
KLA/ATP .85 .83 .82 2.24 2.21 1.27 .97
AK078587
KLA  ATP  ATP+KLA
 AK078587 11 days embryo gonad cDNA, RIKEN full-length enriched library, clone:7030411M21 product:unclassifiable, full insert sequence [AK078587] KLA 1.37 1.28 1.13 1.06 1.15 1.31 1.22
ATP 1.04 1.08 1.21 1.22 1.27 1.12 1.14
KLA/ATP 1.48 1.66 1.97 1.26 1.17 1.03 1.28
Atp1a1
KLA  ATP  ATP+KLA
 NM_144900 ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900] KLA .78 .94 .68 .81 .62 .55 .75
ATP 1.02 1.05 .86 .85 1.77 2.54 1.11
KLA/ATP .83 .99 .80 .75 .91 1.15 .68
Atp1a2
KLA  ATP  ATP+KLA
 NM_178405 ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2), mRNA [NM_178405] KLA 1.03 .98 1.03 1.05 1.03 .98 1.02
ATP 1.03 .98 1.06 1.05 1.05 .93 1.07
KLA/ATP 1.04 1.05 1.02 1.02 .98 .92 1.02
Atp1a3
KLA  ATP  ATP+KLA
 AK053751 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751] KLA .88 .87 .74 .80 .84 .88 .93
ATP .96 .83 .80 .88 .94 .89 1.15
KLA/ATP .89 .86 .79 .90 .93 .84 .92
Atp1a3
KLA  ATP  ATP+KLA
 NM_144921 ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), mRNA [NM_144921] KLA .99 .87 .96 .86 .81 .61 .52
ATP 1.22 1.21 1.16 1.38 1.27 .92 1.30
KLA/ATP .96 1.10 1.17 1.42 1.11 .91 .93
Atp1b1
KLA  ATP  ATP+KLA
 NM_009721 ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA [NM_009721] KLA .97 1.02 1.08 .98 .95 1.01 1.09
ATP 1.07 1.05 1.09 1.09 1.02 1.17 1.11
KLA/ATP .99 .99 .93 1.02 1.00 1.07 1.04
Atp1b2
KLA  ATP  ATP+KLA
 NM_013415 ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2), mRNA [NM_013415] KLA 1.18 1.09 1.11 1.12 1.16 1.12 1.15
ATP .95 .98 .99 1.26 1.06 1.10 1.07
KLA/ATP 1.15 1.16 1.09 1.19 1.27 1.13 1.02
Atp1b3
KLA  ATP  ATP+KLA
 NM_007502 ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502] KLA 1.86 2.10 2.25 2.21 2.68 3.26 3.45
ATP 1.08 1.09 .93 1.13 1.55 2.14 2.38
KLA/ATP 1.95 2.10 1.84 2.34 2.20 2.96 4.69
Atp1b4
KLA  ATP  ATP+KLA
 NM_133690 ATPase, (Na+)/K+ transporting, beta 4 polypeptide (Atp1b4), mRNA [NM_133690] KLA .99 1.02 1.03 1.01 .95 .90 1.00
ATP 1.00 1.05 1.04 .98 1.07 .98 .97
KLA/ATP 1.00 1.05 1.03 1.04 .96 .97 1.01
Fxyd2
KLA  ATP  ATP+KLA
 NM_052823 FXYD domain-containing ion transport regulator 2 (Fxyd2), transcript variant b, mRNA [NM_052823] KLA 1.07 .97 1.09 .98 1.02 .96 .83
ATP 1.07 1.22 1.00 1.14 1.00 1.22 4.11
KLA/ATP 1.06 1.11 .96 1.13 .98 1.01 1.02
Fxyd4
KLA  ATP  ATP+KLA
 NM_033648 FXYD domain-containing ion transport regulator 4 (Fxyd4), mRNA [NM_033648] KLA 1.03 1.02 .96 1.01 1.07 .92 1.04
ATP 1.01 .92 1.01 1.01 1.03 1.00 1.08
KLA/ATP 1.02 .93 1.00 .99 1.00 1.31 1.12
Hsd11b2
KLA  ATP  ATP+KLA
 NM_008289 hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), mRNA [NM_008289] KLA 1.06 1.09 1.02 1.09 1.03 1.06 1.09
ATP 1.02 1.07 1.13 1.08 .93 1.01 1.05
KLA/ATP 1.07 1.04 .98 1.04 1.12 1.00 1.03
Igf1
KLA  ATP  ATP+KLA
 AK050118 adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730016P09 product:unclassifiable, full insert sequence. [AK050118] KLA .13 .14 .15 .16 .22 .34 .48
ATP 1.78 2.05 1.37 .72 .34 .41 .58
KLA/ATP .24 .45 .50 .24 .20 .26 .68
Igf1
KLA  ATP  ATP+KLA
 NM_010512 insulin-like growth factor 1 (Igf1), transcript variant 1, mRNA [NM_010512] KLA .84 .78 .76 .67 .54 .48 .59
ATP .97 .98 1.13 1.13 1.03 .88 .89
KLA/ATP .82 .81 .93 .86 .83 .65 .89
Igf1
KLA  ATP  ATP+KLA
 NM_184052 insulin-like growth factor 1 (Igf1), transcript variant 2, mRNA [NM_184052] KLA .77 .82 .76 .65 .60 .52 .69
ATP 1.01 1.07 .98 1.06 1.03 .78 .94
KLA/ATP .89 .86 .77 .80 .75 .65 .89
Ins1
KLA  ATP  ATP+KLA
 NM_008386 insulin I (Ins1), mRNA [NM_008386] KLA 1.00 .99 .99 1.03 1.01 .98 1.06
ATP .97 1.03 1.00 1.03 .99 1.07 1.05
KLA/ATP 1.03 .93 .98 1.04 1.07 1.03 1.01
Ins2
KLA  ATP  ATP+KLA
 NM_008387 insulin II (Ins2), mRNA [NM_008387] KLA .99 1.00 1.00 1.01 1.00 1.02 1.00
ATP 1.01 .99 1.00 1.00 .98 .99 1.01
KLA/ATP .99 1.01 1.00 .98 .99 .99 .98
Insr
KLA  ATP  ATP+KLA
 NM_010568 insulin receptor (Insr), mRNA [NM_010568] KLA .75 .81 .77 .69 .69 .69 .83
ATP 1.07 1.06 .88 .79 .73 .77 .83
KLA/ATP .80 .80 .72 .71 .64 .64 .70
Irs1
KLA  ATP  ATP+KLA
 NM_010570 insulin receptor substrate 1 (Irs1), mRNA [NM_010570] KLA .97 .96 .99 1.01 .93 .94 .94
ATP 1.00 .99 1.02 .96 .96 .94 .91
KLA/ATP .96 .96 .98 .96 .97 .98 .92
Kcnj1
KLA  ATP  ATP+KLA
 NM_019659 potassium inwardly-rectifying channel, subfamily J, member 1 (Kcnj1), mRNA [NM_019659] KLA 1.01 1.05 1.00 .98 .99 1.05 1.03
ATP 1.02 1.00 1.08 .93 .96 1.08 1.08
KLA/ATP .97 1.08 1.06 .98 .96 1.04 1.06
Kras
KLA  ATP  ATP+KLA
 NM_021284 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA [NM_021284] KLA .53 .49 .40 .42 .49 .95 1.05
ATP .98 1.01 1.16 1.17 1.39 1.29 1.74
KLA/ATP .50 .47 .50 .56 1.00 1.24 1.58
Mapk1
KLA  ATP  ATP+KLA
 NM_001038663 mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663] KLA .97 1.03 .93 .86 .79 1.01 1.04
ATP .96 1.18 1.01 1.13 .84 1.04 1.16
KLA/ATP .99 .99 .84 .87 .63 .96 1.26
Mapk1
KLA  ATP  ATP+KLA
 NM_011949 mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949] KLA .88 .80 .80 .73 .75 .76 .65
ATP .97 .96 1.06 .88 .90 .68 .48
KLA/ATP .82 .81 .78 .65 .64 .64 .45
Mapk3
KLA  ATP  ATP+KLA
 NM_011952 mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952] KLA .81 .85 .88 .72 .79 .73 .90
ATP 1.13 1.30 .92 1.48 1.08 .68 1.03
KLA/ATP 1.01 1.01 .66 1.13 .77 .77 1.16
Mm.21312
8
KLA  ATP  ATP+KLA
 141801344 Unknown KLA .96 .95 .83 .77 .52 .99 1.32
ATP .80 .82 1.09 .80 .83 1.19 1.46
KLA/ATP .78 .92 .98 .62 .71 .94 1.41
Mm.25381
9
KLA  ATP  ATP+KLA
 118130676 Unknown KLA 1.81 1.88 1.96 1.62 1.89 2.44 1.56
ATP .92 .91 1.24 1.01 1.16 2.06 1.95
KLA/ATP 1.62 1.86 1.86 1.41 1.89 2.37 1.97
Nedd4l
KLA  ATP  ATP+KLA
 NM_031881 neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l), transcript variant 2, mRNA [NM_031881] KLA 1.42 1.30 1.43 .83 .53 .47 .54
ATP 1.01 1.24 1.06 2.34 8.62 2.38 1.38
KLA/ATP 1.65 1.59 1.17 1.66 3.43 2.75 1.38
Nr3c2
KLA  ATP  ATP+KLA
 NM_001083906 nuclear receptor subfamily 3, group C, member 2 (Nr3c2), mRNA [NM_001083906] KLA 1.00 .99 .99 1.01 .96 1.00 .98
ATP .98 1.01 1.02 1.01 .98 1.04 1.02
KLA/ATP .99 1.00 1.04 1.02 1.02 1.02 .98
Pdpk1
KLA  ATP  ATP+KLA
 NM_011062 3-phosphoinositide dependent protein kinase-1 (Pdpk1), transcript variant 1, mRNA [NM_011062] KLA .90 .90 .84 1.00 1.32 1.19 1.15
ATP 1.05 1.09 1.04 1.14 1.31 .97 1.17
KLA/ATP .90 .89 .91 1.02 1.27 .96 1.42
Pik3ca
KLA  ATP  ATP+KLA
 ENSMUST00000108243 ens|Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K). [Source:Uniprot/SWISSPROT;Acc:P42337] [ENSMUST00000108243] KLA 1.07 1.01 .91 .90 .98 .96 .86
ATP 1.03 .87 1.12 .63 1.22 1.86 .60
KLA/ATP 1.05 .82 .91 .61 1.17 1.26 .63
Pik3ca
KLA  ATP  ATP+KLA
 NM_008839 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA [NM_008839] KLA 1.15 1.11 1.05 .82 .99 1.03 1.27
ATP .98 1.00 .79 .75 .96 1.32 1.10
KLA/ATP 1.10 .98 .64 .72 .80 1.20 1.41
Pik3cb
KLA  ATP  ATP+KLA
 NM_029094 phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb), mRNA [NM_029094] KLA 1.06 1.06 1.03 .73 .68 .98 1.69
ATP 1.04 1.21 .95 1.02 .85 .93 1.73
KLA/ATP 1.15 1.27 .73 .83 .58 .81 1.81
Pik3cd
KLA  ATP  ATP+KLA
 NM_008840 phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd), transcript variant 1, mRNA [NM_008840] KLA 2.28 2.42 3.10 4.17 3.35 2.31 1.34
ATP 1.02 .91 .99 .63 .30 .67 .80
KLA/ATP 2.14 2.23 2.70 1.51 1.17 .85 .72
Pik3cd
KLA  ATP  ATP+KLA
 U86587 phosphatidylinositol 3-kinase catalytic subunit p110 delta mRNA, complete cds. [U86587] KLA 2.21 2.24 3.71 3.17 3.67 2.66 1.48
ATP 1.00 1.03 .93 .96 .46 .75 .97
KLA/ATP 2.27 2.32 1.97 2.02 1.01 .99 .98
Pik3cg
KLA  ATP  ATP+KLA
 NM_020272 phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg), mRNA [NM_020272] KLA .53 .53 .61 .64 .97 .86 .79
ATP 1.01 1.13 .88 .89 .52 .53 .53
KLA/ATP .58 .53 .43 .60 .40 .43 .62
Pik3r1
KLA  ATP  ATP+KLA
 NM_001077495 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 2, mRNA [NM_001077495] KLA 1.05 1.07 1.03 1.00 1.01 1.20 .85
ATP .97 1.02 1.48 1.42 1.76 1.33 1.23
KLA/ATP 1.11 1.12 1.06 1.17 1.24 .99 1.12
Pik3r2
KLA  ATP  ATP+KLA
 NM_008841 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) (Pik3r2), mRNA [NM_008841] KLA .50 .50 .48 .43 .46 .66 .75
ATP .78 .68 .45 .43 .28 .57 1.37
KLA/ATP .49 .38 .32 .33 .38 .67 1.10
Pik3r3
KLA  ATP  ATP+KLA
 NM_181585 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) (Pik3r3), mRNA [NM_181585] KLA 1.59 1.49 1.37 1.17 1.05 1.55 1.41
ATP 1.12 1.00 1.33 1.70 2.01 2.37 2.02
KLA/ATP 1.63 1.54 1.58 1.70 2.43 2.68 1.92
Pik3r5
KLA  ATP  ATP+KLA
 NM_177320 phosphoinositide-3-kinase, regulatory subunit 5, p101 (Pik3r5), mRNA [NM_177320] KLA 3.57 3.58 4.16 3.54 4.11 2.59 2.39
ATP 1.08 1.08 .93 1.67 3.11 1.88 1.34
KLA/ATP 3.91 3.70 3.30 3.80 2.70 2.04 3.00
Prkca
KLA  ATP  ATP+KLA
 NM_011101 protein kinase C, alpha (Prkca), mRNA [NM_011101] KLA 1.00 .96 .94 .95 .95 .89 .96
ATP 1.00 1.03 .91 .94 .82 .87 1.13
KLA/ATP 1.02 .95 .91 .86 .78 .84 .94
Prkcb1
KLA  ATP  ATP+KLA
 NM_008855 protein kinase C, beta 1 (Prkcb1), mRNA [NM_008855] KLA .92 .95 .93 .78 .77 1.08 1.83
ATP 1.03 1.12 1.09 1.23 .90 2.08 .96
KLA/ATP .98 .99 .82 .89 .62 1.01 1.08
Prkcc
KLA  ATP  ATP+KLA
 NM_011102 protein kinase C, gamma (Prkcc), mRNA [NM_011102] KLA 1.02 1.04 1.11 1.04 .96 1.02 1.05
ATP .98 .98 1.05 1.03 1.08 .96 .95
KLA/ATP 1.21 1.16 1.09 1.07 1.04 .98 .93
Scnn1a
KLA  ATP  ATP+KLA
 NM_011324 sodium channel, nonvoltage-gated, type I, alpha (Scnn1a), mRNA [NM_011324] KLA .86 .87 .83 .83 .84 .95 1.22
ATP 1.03 .97 .91 .90 .81 .73 .87
KLA/ATP .88 .85 .87 .76 .77 .76 .81
Scnn1b
KLA  ATP  ATP+KLA
 NM_011325 sodium channel, nonvoltage-gated 1 beta (Scnn1b), mRNA [NM_011325] KLA 1.00 .99 1.05 1.04 .98 1.01 1.11
ATP 1.00 .99 .93 1.03 1.04 .96 .96
KLA/ATP .98 1.03 .94 .97 .97 1.01 .86
Scnn1g
KLA  ATP  ATP+KLA
 NM_011326 sodium channel, nonvoltage-gated 1 gamma (Scnn1g), mRNA [NM_011326] KLA .97 .98 1.05 1.04 1.00 1.00 .96
ATP 1.04 .99 .99 1.01 .98 1.04 .95
KLA/ATP .94 .96 .99 .94 .99 1.00 1.02
Sfn
KLA  ATP  ATP+KLA
 AF058798 14-3-3 protein sigma mRNA, complete cds. [AF058798] KLA 1.07 1.11 1.08 .99 .94 .97 1.05
ATP 1.06 1.05 1.04 1.29 3.02 3.37 1.05
KLA/ATP 1.13 1.13 1.06 1.17 2.83 3.94 2.23
Sfn
KLA  ATP  ATP+KLA
 NM_018754 stratifin (Sfn), mRNA [NM_018754] KLA .97 1.07 1.09 .99 .96 .97 1.02
ATP 1.03 1.08 1.07 1.33 1.98 2.15 .90
KLA/ATP 1.10 1.02 .97 1.23 1.99 2.58 1.39
Sgk1
KLA  ATP  ATP+KLA
 AK043284 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730081A20 product:unclassifiable, full insert sequence. [AK043284] KLA .94 1.04 1.04 1.00 .97 .96 1.03
ATP 1.08 .99 1.01 .96 1.00 .93 1.00
KLA/ATP .95 .95 1.02 .96 .97 1.00 .94
Sgk1
KLA  ATP  ATP+KLA
 NM_011361 serum/glucocorticoid regulated kinase 1 (Sgk1), mRNA [NM_011361] KLA 1.34 1.00 1.31 .82 1.31 2.97 2.62
ATP 1.05 1.05 3.10 12.21 20.68 7.13 1.80
KLA/ATP 1.31 1.17 2.98 10.32 15.03 6.81 4.65
Slc9a3r2
KLA  ATP  ATP+KLA
 NM_023449 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (Slc9a3r2), transcript variant B, mRNA [NM_023449] KLA 1.03 .99 1.12 1.01 1.07 1.00 .96
ATP 1.08 1.02 1.08 1.01 .97 .97 .98
KLA/ATP 1.05 .96 1.05 1.02 1.03 .99 .99