Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Vasopressin-regulated water reabsorption (mmu04962)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Adcy3
KLA  ATP  ATP+KLA
 NM_138305 adenylate cyclase 3 (Adcy3), mRNA [NM_138305] KLA .84 .84 .83 .78 .66 .55 .49
ATP 1.09 1.05 .89 1.02 .84 .62 1.52
KLA/ATP .93 .87 .75 .85 .66 .83 .77
Adcy6
KLA  ATP  ATP+KLA
 NM_007405 adenylate cyclase 6 (Adcy6), mRNA [NM_007405] KLA 1.10 1.16 1.16 1.09 1.08 1.06 .99
ATP 1.05 .97 1.08 1.12 1.08 1.08 1.04
KLA/ATP 1.14 1.20 1.29 1.30 1.25 1.11 1.07
Adcy9
KLA  ATP  ATP+KLA
 NM_009624 adenylate cyclase 9 (Adcy9), mRNA [NM_009624] KLA .18 .15 .13 .15 .17 .19 .33
ATP 1.33 1.16 .97 .98 .62 .56 .86
KLA/ATP .19 .16 .17 .18 .20 .25 .38
AK032538
KLA  ATP  ATP+KLA
 AK032538 adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430586B05 product:unclassifiable, full insert sequence [AK032538] KLA .97 .99 .99 .93 .97 .98 .97
ATP .99 .95 .99 .94 .98 1.05 1.00
KLA/ATP .93 1.02 .98 .98 1.05 .88 1.05
Aqp2
KLA  ATP  ATP+KLA
 NM_009699 aquaporin 2 (Aqp2), mRNA [NM_009699] KLA 1.20 1.22 1.36 1.36 1.37 1.34 1.29
ATP 1.07 .99 1.21 1.25 1.25 1.18 1.19
KLA/ATP 1.30 1.30 1.46 1.33 1.38 1.26 1.34
Aqp3
KLA  ATP  ATP+KLA
 NM_016689 aquaporin 3 (Aqp3), mRNA [NM_016689] KLA 1.22 1.21 1.12 1.12 1.04 .95 1.07
ATP .93 1.00 1.06 1.57 1.97 2.05 1.07
KLA/ATP 1.17 1.30 1.15 1.15 1.21 .95 1.07
Aqp4
KLA  ATP  ATP+KLA
 NM_009700 aquaporin 4 (Aqp4), mRNA [NM_009700] KLA .99 1.01 .96 1.00 1.06 1.01 1.02
ATP .99 .99 1.05 1.08 1.00 1.02 1.03
KLA/ATP 1.01 1.00 1.00 1.01 .99 1.02 1.00
Arhgdia
KLA  ATP  ATP+KLA
 NM_133796 Rho GDP dissociation inhibitor (GDI) alpha (Arhgdia), mRNA [NM_133796] KLA .86 .92 .89 .79 1.00 1.05 1.08
ATP 1.11 1.31 .73 1.29 .99 .70 .99
KLA/ATP 1.05 1.11 .61 1.14 .74 .81 .96
Arhgdib
KLA  ATP  ATP+KLA
 NM_007486 Rho, GDP dissociation inhibitor (GDI) beta (Arhgdib), mRNA [NM_007486] KLA .92 .96 .84 .91 .99 1.41 1.88
ATP 1.03 1.09 1.00 1.02 .97 .89 .94
KLA/ATP .97 .89 .77 .86 .74 .77 1.51
Arhgdig
KLA  ATP  ATP+KLA
 NM_008113 Rho GDP dissociation inhibitor (GDI) gamma (Arhgdig), mRNA [NM_008113] KLA .95 .92 .93 .88 .92 .91 .90
ATP .97 1.04 .96 .88 .91 .95 .95
KLA/ATP .99 .96 .77 .83 .83 .95 .98
Avp
KLA  ATP  ATP+KLA
 NM_009732 arginine vasopressin (Avp), mRNA [NM_009732] KLA .98 .99 1.04 1.02 1.03 1.09 1.05
ATP 1.02 1.06 1.03 .99 1.01 1.01 1.08
KLA/ATP 1.00 1.02 1.10 1.01 .99 1.02 1.02
Avpr2
KLA  ATP  ATP+KLA
 NM_019404 arginine vasopressin receptor 2 (Avpr2), mRNA [NM_019404] KLA .98 1.00 .99 1.01 .98 1.05 .95
ATP .99 1.00 1.02 1.01 1.01 1.05 1.01
KLA/ATP 1.00 .98 1.02 .98 .98 1.01 1.02
BC005774
KLA  ATP  ATP+KLA
 BC005774 cDNA clone MGC:12006 IMAGE:3602466, complete cds [BC005774] KLA .95 1.08 .93 1.05 .99 .98 .95
ATP 1.21 1.29 1.09 1.16 1.16 1.04 1.00
KLA/ATP .99 1.00 .92 1.02 1.00 .90 .91
Creb1
KLA  ATP  ATP+KLA
 NM_009952 cAMP responsive element binding protein 1 (Creb1), transcript variant B, mRNA [NM_009952] KLA 1.42 1.33 1.16 .99 .83 .97 .92
ATP .92 .91 1.18 1.38 1.51 1.02 .75
KLA/ATP 1.34 1.31 1.49 1.37 1.71 1.05 .93
Creb3
KLA  ATP  ATP+KLA
 NM_013497 cAMP responsive element binding protein 3 (Creb3), mRNA [NM_013497] KLA 1.21 1.21 1.23 1.53 1.77 1.77 1.31
ATP 1.02 1.03 .99 1.05 .82 .83 1.48
KLA/ATP 1.15 1.18 1.20 1.26 1.13 1.15 1.86
Creb3l1
KLA  ATP  ATP+KLA
 NM_011957 cAMP responsive element binding protein 3-like 1 (Creb3l1), mRNA [NM_011957] KLA 1.18 1.17 1.53 1.28 1.22 1.11 1.23
ATP 1.01 1.09 .98 1.17 1.22 1.01 1.15
KLA/ATP 1.22 1.29 1.08 1.34 1.14 1.36 1.12
Creb3l2
KLA  ATP  ATP+KLA
 AK082964 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530025K05 product:unclassifiable, full insert sequence [AK082964] KLA .44 .38 .37 .40 .45 .42 .47
ATP .90 .78 1.22 .79 .54 .46 .44
KLA/ATP .41 .41 .49 .43 .50 .51 .23
Creb3l2
KLA  ATP  ATP+KLA
 NM_178661 cAMP responsive element binding protein 3-like 2 (Creb3l2), mRNA [NM_178661] KLA .98 .87 .76 .98 1.03 .87 1.12
ATP 1.20 1.18 1.50 1.35 .86 1.32 1.50
KLA/ATP .98 1.04 1.15 1.05 .79 1.27 1.25
Creb3l3
KLA  ATP  ATP+KLA
 NM_145365 cAMP responsive element binding protein 3-like 3 (Creb3l3), mRNA [NM_145365] KLA .66 .75 .65 .85 1.04 1.44 1.73
ATP 1.02 .98 .97 1.09 .85 .69 1.11
KLA/ATP .70 .66 .71 .83 .80 .85 1.05
Creb3l4
KLA  ATP  ATP+KLA
 NM_030080 cAMP responsive element binding protein 3-like 4 (Creb3l4), mRNA [NM_030080] KLA 1.55 1.42 1.51 1.73 1.76 2.54 1.38
ATP 1.07 .81 .89 1.08 .94 1.08 1.08
KLA/ATP 1.44 1.38 1.44 1.25 1.30 1.26 2.24
Creb5
KLA  ATP  ATP+KLA
 AK051306 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130032G03 product:unclassifiable, full insert sequence. [AK051306] KLA 2.18 2.13 2.42 1.97 1.57 1.94 1.98
ATP 1.11 1.09 1.47 1.74 1.36 1.44 1.62
KLA/ATP 2.55 2.77 3.02 3.15 2.51 2.52 2.61
Creb5
KLA  ATP  ATP+KLA
 NM_172728 cAMP responsive element binding protein 5 (Creb5), mRNA [NM_172728] KLA 3.70 3.60 2.84 2.39 1.92 2.81 1.84
ATP .92 .89 1.19 1.93 1.51 1.55 1.44
KLA/ATP 3.16 3.51 4.33 5.35 5.78 3.23 3.03
Dctn1
KLA  ATP  ATP+KLA
 NM_007835 dynactin 1 (Dctn1), mRNA [NM_007835] KLA .88 .91 .99 .90 .94 .89 .82
ATP 1.01 1.05 .96 1.10 .85 .65 .82
KLA/ATP 1.00 1.00 .96 .98 .75 .70 .85
Dctn2
KLA  ATP  ATP+KLA
 NM_027151 dynactin 2 (Dctn2), mRNA [NM_027151] KLA .86 .87 .88 .87 .96 .99 .95
ATP .97 1.05 .93 1.08 1.01 .70 .89
KLA/ATP .87 .90 .84 .95 .88 .64 .84
Dctn4
KLA  ATP  ATP+KLA
 AK162552 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630003N14 product:dynactin 4, full insert sequence. [AK162552] KLA 1.30 1.28 1.37 1.50 1.66 1.41 1.54
ATP .92 .79 .56 .79 1.49 1.33 1.01
KLA/ATP 1.20 1.00 .85 1.33 2.11 1.20 1.51
Dctn4
KLA  ATP  ATP+KLA
 NM_026302 dynactin 4 (Dctn4), mRNA [NM_026302] KLA 1.10 1.14 1.23 1.46 1.56 1.41 1.35
ATP 1.05 .98 .87 .80 .93 1.11 1.17
KLA/ATP 1.18 1.14 .99 .93 1.00 1.16 1.60
Dctn5
KLA  ATP  ATP+KLA
 NM_021608 dynactin 5 (Dctn5), mRNA [NM_021608] KLA .93 .88 .93 1.11 1.17 1.30 1.11
ATP 1.02 .97 1.03 1.00 .61 .95 1.46
KLA/ATP .88 .93 1.00 1.00 .87 .95 1.85
Dctn6
KLA  ATP  ATP+KLA
 NM_011722 dynactin 6 (Dctn6), mRNA [NM_011722] KLA .79 .79 .77 .75 .77 .85 .93
ATP 1.00 .95 1.03 1.11 .89 .66 .90
KLA/ATP .85 .81 .76 .96 .82 .72 .73
Dync1h1
KLA  ATP  ATP+KLA
 NM_030238 dynein cytoplasmic 1 heavy chain 1 (Dync1h1), mRNA [NM_030238] KLA 1.78 1.64 2.10 1.64 1.91 1.55 1.26
ATP 1.16 1.06 1.00 .56 1.07 1.46 1.19
KLA/ATP 1.98 1.98 1.86 1.05 1.64 1.66 1.75
Dync1h1
KLA  ATP  ATP+KLA
 Z83808 gb|M.musculus mRNA for cytoplasmic dynein heavy chain (partial, ID mdhc10). [Z83808] KLA 1.48 1.24 1.23 1.53 1.45 1.52 1.26
ATP 1.13 1.04 .97 1.04 1.10 1.31 1.09
KLA/ATP 1.55 1.62 1.64 1.29 1.30 1.33 1.35
Dync1i1
KLA  ATP  ATP+KLA
 NM_010063 dynein cytoplasmic 1 intermediate chain 1 (Dync1i1), mRNA [NM_010063] KLA .81 .84 .79 .81 .84 .85 .93
ATP 1.05 1.00 .92 .96 .85 .82 .91
KLA/ATP .88 .84 .86 .79 .80 .81 .97
Dync1i2
KLA  ATP  ATP+KLA
 NM_010064 dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), mRNA [NM_010064] KLA 2.07 2.25 2.75 2.53 2.86 2.50 1.24
ATP 1.03 1.12 .99 1.05 .88 .92 1.60
KLA/ATP 2.16 2.32 2.03 2.39 1.81 1.77 2.27
Dync1li1
KLA  ATP  ATP+KLA
 NM_146229 dynein cytoplasmic 1 light intermediate chain 1 (Dync1li1), mRNA [NM_146229] KLA 1.59 1.52 1.69 1.43 1.36 1.25 1.27
ATP 1.23 1.44 1.25 1.78 1.97 1.33 1.27
KLA/ATP 1.72 1.86 1.35 2.03 1.57 1.58 1.52
Dync1li2
KLA  ATP  ATP+KLA
 AK140743 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130001C04 product:Dynein light intermediate chain 2, cytosolic (LIC53 [AK140743] KLA .51 .51 .43 .50 .70 .76 .89
ATP .98 .82 .67 .45 .62 .68 .71
KLA/ATP .49 .46 .36 .32 .55 .48 .51
Dync1li2
KLA  ATP  ATP+KLA
 NM_001013380 dynein, cytoplasmic 1 light intermediate chain 2 (Dync1li2), mRNA [NM_001013380] KLA 1.11 1.12 1.12 1.10 1.28 1.37 1.41
ATP 1.00 1.04 .93 .97 1.06 1.52 1.75
KLA/ATP 1.12 1.18 1.00 1.10 1.03 1.32 2.18
Dync2h1
KLA  ATP  ATP+KLA
 NM_029851 dynein cytoplasmic 2 heavy chain 1 (Dync2h1), mRNA [NM_029851] KLA 1.12 1.12 1.20 1.24 1.30 1.32 .94
ATP 1.04 .96 .89 .71 .71 1.08 .92
KLA/ATP 1.09 1.10 1.09 .89 .94 1.34 1.36
Dync2li1
KLA  ATP  ATP+KLA
 NM_172256 dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), mRNA [NM_172256] KLA .94 .93 .93 .91 .79 .59 .69
ATP 1.00 1.02 1.19 1.21 .78 .47 .69
KLA/ATP .93 .99 1.09 .99 .70 .55 .52
Dynll1
KLA  ATP  ATP+KLA
 AK147977 melanocyte cDNA, RIKEN full-length enriched library, clone:G270124L07 product:dynein, cytoplasmic, light chain 1, full insert sequence. [AK147977] KLA .78 .81 .72 .83 1.01 1.11 1.06
ATP 1.00 .94 1.08 1.27 1.26 1.15 .85
KLA/ATP .80 .84 .84 .87 .99 1.26 1.29
Dynll1
KLA  ATP  ATP+KLA
 NM_019682 dynein light chain LC8-type 1 (Dynll1), mRNA [NM_019682] KLA .75 .63 .69 .65 .76 1.17 1.48
ATP 1.20 1.09 1.22 1.69 1.41 1.23 2.14
KLA/ATP .78 .78 .83 1.00 1.14 1.25 3.35
Dynll2
KLA  ATP  ATP+KLA
 NM_026556 dynein light chain LC8-type 2 (Dynll2), mRNA [NM_026556] KLA .73 .72 .66 .68 .61 .72 .94
ATP 1.02 .99 .86 .93 1.08 1.34 1.25
KLA/ATP .72 .77 .75 .75 .95 1.05 1.44
Gnas
KLA  ATP  ATP+KLA
 AF107847 neuroendocrine-specific Golgi protein p55 isoform 1 (XLalphas) alternatively spliced mRNA, complete cds. [AF107847] KLA 1.04 .94 1.00 1.05 1.04 .98 1.00
ATP .98 .97 .96 1.00 .99 .98 1.02
KLA/ATP 1.04 1.02 .96 .95 1.01 .96 1.01
Gnas
KLA  ATP  ATP+KLA
 AK017423 10 days neonate head cDNA, RIKEN full-length enriched library, clone:5530400H20 product:novel noncoding RNA overlapping the exon 1A, 1 and 2 of Gnas, full insert sequence. [AK017423] KLA .85 1.08 .97 .92 1.05 1.03 1.08
ATP .99 1.30 2.11 1.73 1.23 1.01 1.02
KLA/ATP .96 1.06 1.58 1.34 1.29 1.05 .91
Gnas
KLA  ATP  ATP+KLA
 NM_001077510 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 8, mRNA [NM_001077510] KLA .99 1.03 .97 .91 1.03 .95 .97
ATP 1.04 1.19 1.15 1.61 1.24 .91 1.00
KLA/ATP 1.06 .97 1.01 1.46 1.04 .85 1.01
Gnas
KLA  ATP  ATP+KLA
 S49980 gb|stimulatory G protein alpha subunit {clone WC-16} [mice, whole cochlea, mRNA Partial, 356 nt]. [S49980] KLA .91 .88 1.03 .87 .90 .84 1.01
ATP 1.16 1.22 1.02 1.55 1.16 .80 .99
KLA/ATP 1.01 1.13 .86 1.12 .97 .85 1.08
Mm.16753
7
KLA  ATP  ATP+KLA
 28076934 Unknown KLA .84 .87 .78 .87 .88 1.00 1.01
ATP .91 .92 .97 .96 .85 .69 .95
KLA/ATP .79 .79 .81 .81 .85 .64 .87
Mm.18143
0
KLA  ATP  ATP+KLA
 134288916 Unknown KLA 1.92 1.66 1.89 1.74 1.97 1.74 1.15
ATP 1.14 .96 .93 .44 .91 1.60 1.19
KLA/ATP 1.77 1.70 2.16 .89 1.58 1.61 1.64
Mm.38317
1
KLA  ATP  ATP+KLA
 9506412 Unknown KLA .98 1.08 .95 .98 1.01 1.09 1.13
ATP 1.04 1.03 1.03 1.02 .95 .93 1.00
KLA/ATP .98 1.06 .98 1.02 .91 .91 1.10
Nsf
KLA  ATP  ATP+KLA
 NM_008740 N-ethylmaleimide sensitive fusion protein (Nsf), mRNA [NM_008740] KLA .84 .83 .76 .70 .78 .80 .94
ATP 1.14 1.15 .99 1.08 .95 .96 1.19
KLA/ATP .93 .90 .80 .85 .72 .80 1.17
Prkaca
KLA  ATP  ATP+KLA
 NM_008854 protein kinase, cAMP dependent, catalytic, alpha (Prkaca), mRNA [NM_008854] KLA .71 .74 .72 .70 .72 .84 .85
ATP 1.05 .98 .89 .92 .76 .60 1.02
KLA/ATP .79 .74 .55 .65 .60 .65 .93
Prkacb
KLA  ATP  ATP+KLA
 NM_011100 protein kinase, cAMP dependent, catalytic, beta (Prkacb), mRNA [NM_011100] KLA .69 .70 .66 .58 .51 .55 .59
ATP 1.02 1.19 .97 1.01 .69 .38 .56
KLA/ATP .72 .73 .57 .62 .47 .41 .45
Prkx
KLA  ATP  ATP+KLA
 NM_016979 protein kinase, X-linked (Prkx), mRNA [NM_016979] KLA 3.61 3.79 4.67 4.66 4.85 4.19 1.43
ATP .98 .90 .63 .61 1.12 1.90 1.29
KLA/ATP 3.56 3.36 2.62 2.06 2.26 2.87 2.31
Rab11a
KLA  ATP  ATP+KLA
 NM_017382 RAB11a, member RAS oncogene family (Rab11a), mRNA [NM_017382] KLA .96 .92 .94 .94 1.01 1.05 1.00
ATP 1.04 1.08 1.09 1.15 .88 .73 .87
KLA/ATP .99 .98 .96 1.03 .84 .74 .97
Rab11b
KLA  ATP  ATP+KLA
 NM_008997 RAB11B, member RAS oncogene family (Rab11b), mRNA [NM_008997] KLA 1.00 .99 1.02 .93 1.03 1.00 .95
ATP 1.10 1.20 .97 1.33 1.13 1.13 .90
KLA/ATP 1.12 1.11 .87 1.26 1.00 1.14 1.12
Rab5a
KLA  ATP  ATP+KLA
 AK036011 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630027A13 product:hypothetical protein, full insert sequence. [AK036011] KLA .98 1.01 .98 .93 1.04 .95 1.02
ATP 1.01 1.02 1.03 .96 1.08 1.04 1.08
KLA/ATP 1.06 1.02 1.02 .92 .99 1.01 1.08
Rab5a
KLA  ATP  ATP+KLA
 NM_025887 RAB5A, member RAS oncogene family (Rab5a), mRNA [NM_025887] KLA 1.88 1.84 2.12 2.01 1.68 1.40 1.18
ATP 1.00 .95 .93 .81 1.10 1.57 1.09
KLA/ATP 1.87 1.86 1.87 1.72 1.71 1.63 1.47
Rab5b
KLA  ATP  ATP+KLA
 AK144551 adult male intestinal mucosa cDNA, RIKEN full-length enriched library, clone:G630095F06 product:RAB5B, member RAS oncogene family, full insert sequence. [AK144551] KLA .84 .93 1.00 .83 1.07 .95 1.19
ATP 1.11 1.01 .75 .84 .97 .93 .88
KLA/ATP .95 .87 .64 .88 .98 .99 .93
Rab5b
KLA  ATP  ATP+KLA
 NM_011229 RAB5B, member RAS oncogene family (Rab5b), mRNA [NM_011229] KLA 1.07 1.13 1.29 1.05 1.14 1.06 1.16
ATP 1.15 1.16 .78 .83 .93 .92 1.15
KLA/ATP 1.22 1.15 .77 .86 .87 .93 1.30
Rab5b
KLA  ATP  ATP+KLA
 NM_177411 RAB5B, member RAS oncogene family (Rab5b), mRNA [NM_177411] KLA 1.38 1.33 1.46 1.18 1.23 1.31 1.30
ATP 1.07 1.32 .83 1.08 .71 1.02 1.34
KLA/ATP 1.57 1.58 .95 1.38 .76 1.04 1.55
Rab5c
KLA  ATP  ATP+KLA
 NM_024456 RAB5C, member RAS oncogene family (Rab5c), mRNA [NM_024456] KLA .96 1.26 1.45 1.13 1.14 1.50 1.17
ATP .95 1.30 1.32 1.01 .98 1.03 1.04
KLA/ATP 1.11 1.37 1.61 1.15 1.00 1.18 1.52
Stx4a
KLA  ATP  ATP+KLA
 NM_009294 syntaxin 4A (placental) (Stx4a), mRNA [NM_009294] KLA 1.23 1.37 1.43 1.38 1.46 1.26 1.31
ATP 1.00 .90 .85 .95 .94 .72 1.19
KLA/ATP 1.30 1.24 1.23 1.22 1.24 .71 1.14
Vamp2
KLA  ATP  ATP+KLA
 NM_009497 vesicle-associated membrane protein 2 (Vamp2), mRNA [NM_009497] KLA .99 1.02 1.03 1.07 1.34 1.25 1.58
ATP 1.03 1.12 .88 1.22 .94 .99 1.62
KLA/ATP 1.03 1.15 .82 1.10 .87 .93 1.86