Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Proximal tubule bicarbonate reclamation (mmu04964)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK078587
KLA  ATP  ATP+KLA
 AK078587 11 days embryo gonad cDNA, RIKEN full-length enriched library, clone:7030411M21 product:unclassifiable, full insert sequence [AK078587] KLA 1.37 1.28 1.13 1.06 1.15 1.31 1.22
ATP 1.04 1.08 1.21 1.22 1.27 1.12 1.14
KLA/ATP 1.48 1.66 1.97 1.26 1.17 1.03 1.28
Aqp1
KLA  ATP  ATP+KLA
 NM_007472 aquaporin 1 (Aqp1), mRNA [NM_007472] KLA 1.01 .93 .93 .97 .95 .91 .72
ATP .98 1.01 .95 .97 .90 .92 .78
KLA/ATP .95 .92 .93 .90 .93 .90 .73
Atp1a1
KLA  ATP  ATP+KLA
 NM_144900 ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900] KLA .78 .94 .68 .81 .62 .55 .75
ATP 1.02 1.05 .86 .85 1.77 2.54 1.11
KLA/ATP .83 .99 .80 .75 .91 1.15 .68
Atp1a2
KLA  ATP  ATP+KLA
 NM_178405 ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2), mRNA [NM_178405] KLA 1.03 .98 1.03 1.05 1.03 .98 1.02
ATP 1.03 .98 1.06 1.05 1.05 .93 1.07
KLA/ATP 1.04 1.05 1.02 1.02 .98 .92 1.02
Atp1a3
KLA  ATP  ATP+KLA
 AK053751 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751] KLA .88 .87 .74 .80 .84 .88 .93
ATP .96 .83 .80 .88 .94 .89 1.15
KLA/ATP .89 .86 .79 .90 .93 .84 .92
Atp1a3
KLA  ATP  ATP+KLA
 NM_144921 ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), mRNA [NM_144921] KLA .99 .87 .96 .86 .81 .61 .52
ATP 1.22 1.21 1.16 1.38 1.27 .92 1.30
KLA/ATP .96 1.10 1.17 1.42 1.11 .91 .93
Atp1b1
KLA  ATP  ATP+KLA
 NM_009721 ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA [NM_009721] KLA .97 1.02 1.08 .98 .95 1.01 1.09
ATP 1.07 1.05 1.09 1.09 1.02 1.17 1.11
KLA/ATP .99 .99 .93 1.02 1.00 1.07 1.04
Atp1b2
KLA  ATP  ATP+KLA
 NM_013415 ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2), mRNA [NM_013415] KLA 1.18 1.09 1.11 1.12 1.16 1.12 1.15
ATP .95 .98 .99 1.26 1.06 1.10 1.07
KLA/ATP 1.15 1.16 1.09 1.19 1.27 1.13 1.02
Atp1b3
KLA  ATP  ATP+KLA
 NM_007502 ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502] KLA 1.86 2.10 2.25 2.21 2.68 3.26 3.45
ATP 1.08 1.09 .93 1.13 1.55 2.14 2.38
KLA/ATP 1.95 2.10 1.84 2.34 2.20 2.96 4.69
Atp1b4
KLA  ATP  ATP+KLA
 NM_133690 ATPase, (Na+)/K+ transporting, beta 4 polypeptide (Atp1b4), mRNA [NM_133690] KLA .99 1.02 1.03 1.01 .95 .90 1.00
ATP 1.00 1.05 1.04 .98 1.07 .98 .97
KLA/ATP 1.00 1.05 1.03 1.04 .96 .97 1.01
Fxyd2
KLA  ATP  ATP+KLA
 NM_052823 FXYD domain-containing ion transport regulator 2 (Fxyd2), transcript variant b, mRNA [NM_052823] KLA 1.07 .97 1.09 .98 1.02 .96 .83
ATP 1.07 1.22 1.00 1.14 1.00 1.22 4.11
KLA/ATP 1.06 1.11 .96 1.13 .98 1.01 1.02
Gls2
KLA  ATP  ATP+KLA
 NM_001033264 glutaminase 2 (liver, mitochondrial) (Gls2), nuclear gene encoding mitochondrial protein, mRNA [NM_001033264] KLA 1.03 .98 1.02 .97 .98 .88 .80
ATP .94 1.01 1.04 1.08 1.26 1.20 .87
KLA/ATP .95 .98 1.15 1.02 1.29 .99 .87
Glud1
KLA  ATP  ATP+KLA
 NM_008133 glutamate dehydrogenase 1 (Glud1), mRNA [NM_008133] KLA .70 .70 .63 .54 .52 .54 .59
ATP .96 .91 1.01 1.05 .96 .66 .47
KLA/ATP .67 .66 .61 .69 .70 .51 .27
Mdh1
KLA  ATP  ATP+KLA
 AK077724 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724] KLA .85 .75 .69 .67 .72 .81 .82
ATP .93 .83 .61 .59 .72 .72 .88
KLA/ATP .79 .76 .67 .58 .74 .74 .80
Mdh1
KLA  ATP  ATP+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA .79 .72 .66 .66 .52 .49 .57
ATP .98 1.00 1.17 1.09 .96 .70 .66
KLA/ATP .70 .73 .92 .78 .76 .65 .52
Mm.29656
0
KLA  ATP  ATP+KLA
 34328321 Unknown KLA 1.41 1.37 1.50 1.48 1.35 1.43 1.21
ATP 1.00 1.08 1.22 1.42 1.23 1.22 1.23
KLA/ATP 1.41 1.48 1.57 1.61 1.50 1.56 1.51
Mm.30102
KLA  ATP  ATP+KLA
 142348692 Unknown KLA 1.04 1.04 .97 1.07 1.02 .93 .90
ATP 1.06 .98 1.13 1.06 1.30 1.19 .78
KLA/ATP .94 1.05 1.13 1.05 1.24 1.12 .84
Mm.44046
5
KLA  ATP  ATP+KLA
 164607131 Unknown KLA .65 .56 .59 .51 .33 .20 .24
ATP 1.07 .90 1.30 2.88 3.61 4.46 1.07
KLA/ATP .60 .59 .95 2.38 2.99 2.31 .37
Pck2
KLA  ATP  ATP+KLA
 NM_028994 phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994] KLA .40 .37 .32 .28 .37 .56 .55
ATP .99 .96 .86 .94 1.02 .57 .77
KLA/ATP .40 .37 .31 .35 .42 .35 .46
Slc25a10
KLA  ATP  ATP+KLA
 NM_013770 solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 (Slc25a10), nuclear gene encoding mitochondrial protein, mRNA [NM_013770] KLA 1.41 1.49 1.55 1.46 1.88 2.09 2.13
ATP 1.03 1.15 1.01 1.42 .89 .55 .73
KLA/ATP 1.50 1.56 1.37 1.95 1.26 .90 1.31
Slc38a3
KLA  ATP  ATP+KLA
 NM_023805 solute carrier family 38, member 3 (Slc38a3), mRNA [NM_023805] KLA 1.18 1.02 1.01 1.03 1.04 1.04 .99
ATP 1.01 .98 1.11 1.06 .99 1.05 1.06
KLA/ATP 1.02 1.03 1.15 1.07 1.04 .96 1.06
Slc4a4
KLA  ATP  ATP+KLA
 NM_018760 solute carrier family 4 (anion exchanger), member 4 (Slc4a4), mRNA [NM_018760] KLA 1.02 1.03 1.01 1.02 .98 1.01 1.01
ATP 1.03 .97 .94 1.00 1.02 1.00 1.02
KLA/ATP 1.02 1.04 .85 1.03 .98 .97 1.00
Slc9a3
KLA  ATP  ATP+KLA
 AK033564 adult male colon cDNA, RIKEN full-length enriched library, clone:9030624O13 product:SODIUM [AK033564] KLA .96 .94 .91 .97 .95 1.03 .99
ATP 1.06 1.02 1.01 .95 .90 .95 1.08
KLA/ATP .97 .91 .93 .95 1.02 1.03 1.01