Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Collecting duct acid secretion (mmu04966)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Atp4a
KLA  ATP  ATP+KLA
 NM_018731 ATPase, H+/K+ exchanging, gastric, alpha polypeptide (Atp4a), mRNA [NM_018731] KLA .91 .97 1.00 1.01 1.00 1.00 .96
ATP 1.01 1.01 .96 .96 1.01 .95 .93
KLA/ATP 1.04 .97 .98 .87 .96 .99 .95
Atp4a
KLA  ATP  ATP+KLA
 U17282 gastric H(+)-K(+)-ATPase alpha subunit mRNA, complete cds. [U17282] KLA 1.05 1.02 .93 1.03 .97 1.00 .95
ATP 1.01 1.05 1.00 .94 1.03 .99 1.05
KLA/ATP .99 1.07 1.06 .98 .94 .97 .99
Atp4b
KLA  ATP  ATP+KLA
 NM_009724 ATPase, H+/K+ exchanging, beta polypeptide (Atp4b), mRNA [NM_009724] KLA 1.07 .96 .98 1.01 1.11 1.05 .98
ATP 1.00 1.01 1.02 1.03 1.01 1.02 1.00
KLA/ATP .96 1.01 1.04 .99 1.07 1.02 .98
Atp6v0a1
KLA  ATP  ATP+KLA
 AK045877 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230316H04 product:unclassifiable, full insert sequence [AK045877] KLA .65 .64 .58 .48 .57 .46 .29
ATP .64 .28 .48 .28 .45 .30 .91
KLA/ATP .51 .26 .37 .31 .54 .45 .63
Atp6v0a1
KLA  ATP  ATP+KLA
 NM_016920 ATPase, H+ transporting, lysosomal V0 subunit A1 (Atp6v0a1), mRNA [NM_016920] KLA .88 .91 .88 .80 .66 .52 .45
ATP 1.05 1.22 .91 1.05 .58 .40 1.46
KLA/ATP .97 1.04 .80 .89 .55 .43 .75
Atp6v0a2
KLA  ATP  ATP+KLA
 AK160318 16 days embryo lung cDNA, RIKEN full-length enriched library, clone:8430408C20 product:unclassifiable, full insert sequence [AK160318] KLA 1.21 1.13 1.18 1.30 1.39 1.58 1.38
ATP 1.10 .94 .55 .35 .72 .96 .84
KLA/ATP 1.12 1.08 .82 .54 .81 1.05 .59
Atp6v0a2
KLA  ATP  ATP+KLA
 BC112905 ATPase, H+ transporting, lysosomal V0 subunit A2, mRNA (cDNA clone MGC:118073 IMAGE:3670722), complete cds [BC112905] KLA 1.65 1.66 1.74 2.07 1.97 2.78 2.71
ATP .88 .61 .53 .30 .38 1.26 2.12
KLA/ATP 1.38 1.29 .91 .62 .59 1.36 2.13
Atp6v0a2
KLA  ATP  ATP+KLA
 NM_011596 ATPase, H+ transporting, lysosomal V0 subunit A2 (Atp6v0a2), mRNA [NM_011596] KLA 2.26 2.07 2.01 2.71 2.48 3.69 2.76
ATP .79 .64 .62 .42 .62 2.31 3.11
KLA/ATP 1.69 1.57 1.47 .90 1.06 2.56 4.84
Atp6v0a4
KLA  ATP  ATP+KLA
 NM_080467 ATPase, H+ transporting, lysosomal V0 subunit A4 (Atp6v0a4), mRNA [NM_080467] KLA 1.01 1.00 .99 1.03 1.01 1.02 .98
ATP 1.02 1.05 .93 1.03 1.05 1.01 .97
KLA/ATP 1.02 .94 1.00 .99 1.00 1.01 1.03
Atp6v0c
KLA  ATP  ATP+KLA
 NM_009729 ATPase, H+ transporting, lysosomal V0 subunit C (Atp6v0c), mRNA [NM_009729] KLA .89 .98 1.05 .90 1.18 1.38 1.52
ATP 1.07 1.28 .93 1.66 1.48 1.35 2.35
KLA/ATP 1.10 1.12 .67 1.50 1.18 1.66 2.51
Atp6v0d1
KLA  ATP  ATP+KLA
 NM_013477 ATPase, H+ transporting, lysosomal V0 subunit D1 (Atp6v0d1), mRNA [NM_013477] KLA .84 .85 .94 .79 1.10 1.24 1.27
ATP 1.18 1.48 .94 1.40 1.12 .75 1.85
KLA/ATP 1.05 1.06 .59 1.06 .83 .85 1.96
Atp6v0d2
KLA  ATP  ATP+KLA
 NM_175406 ATPase, H+ transporting, lysosomal V0 subunit D2 (Atp6v0d2), mRNA [NM_175406] KLA .77 .72 .64 .54 .43 .27 .18
ATP 1.19 1.35 1.06 1.47 1.46 .79 .96
KLA/ATP .78 .95 .63 1.12 1.21 1.01 .50
Atp6v0e
KLA  ATP  ATP+KLA
 AK134836 adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330589P19 product:ATPase, H+ transporting, V0 subunit, full insert sequence. [AK134836] KLA 1.09 1.06 1.02 1.42 1.32 1.14 .92
ATP .93 1.18 1.02 1.34 1.72 1.34 1.44
KLA/ATP .97 .89 .94 1.32 2.01 1.43 1.72
Atp6v0e
KLA  ATP  ATP+KLA
 NM_025272 ATPase, H+ transporting, lysosomal V0 subunit E (Atp6v0e), mRNA [NM_025272] KLA 1.00 .95 .87 .99 .98 1.20 1.26
ATP .91 .98 1.11 1.17 1.29 1.54 1.59
KLA/ATP .86 .94 1.07 1.05 1.29 1.57 1.83
Atp6v0e2
KLA  ATP  ATP+KLA
 NM_133764 ATPase, H+ transporting, lysosomal V0 subunit E2 (Atp6v0e2), mRNA [NM_133764] KLA .98 .93 .90 .99 .88 .90 .92
ATP 1.08 1.02 1.03 1.07 .98 .88 .94
KLA/ATP .98 .99 .97 1.00 .89 .90 .88
Atp6v1a
KLA  ATP  ATP+KLA
 NM_007508 ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), mRNA [NM_007508] KLA .77 .77 .70 .59 .58 .61 .84
ATP 1.04 1.45 .99 1.82 1.34 1.00 1.21
KLA/ATP .82 .97 .55 1.13 .73 .99 1.09
Atp6v1b1
KLA  ATP  ATP+KLA
 NM_134157 ATPase, H+ transporting, lysosomal V1 subunit B1 (Atp6v1b1), mRNA [NM_134157] KLA 1.00 1.03 1.11 .95 1.01 1.00 1.03
ATP 1.02 1.05 1.01 .97 1.02 .97 1.02
KLA/ATP .98 .94 1.03 1.02 .99 1.00 .96
Atp6v1b2
KLA  ATP  ATP+KLA
 NM_007509 ATPase, H+ transporting, lysosomal V1 subunit B2 (Atp6v1b2), mRNA [NM_007509] KLA .89 .98 1.11 1.07 1.24 1.13 1.12
ATP 1.05 1.11 1.02 1.09 1.03 .79 1.39
KLA/ATP .97 1.05 .95 1.12 1.12 1.37 1.67
Atp6v1c1
KLA  ATP  ATP+KLA
 NM_025494 ATPase, H+ transporting, lysosomal V1 subunit C1 (Atp6v1c1), mRNA [NM_025494] KLA .61 .62 .59 .51 .56 .71 .92
ATP .98 .97 .93 1.07 1.42 1.00 1.28
KLA/ATP .61 .57 .48 .57 1.04 1.18 1.18
Atp6v1c2
KLA  ATP  ATP+KLA
 NM_133699 ATPase, H+ transporting, lysosomal V1 subunit C2 (Atp6v1c2), mRNA [NM_133699] KLA 1.00 .93 .98 .97 1.04 .99 .97
ATP 1.07 .97 .99 .97 .97 1.04 1.06
KLA/ATP 1.01 1.03 1.00 1.03 1.00 .91 .97
Atp6v1d
KLA  ATP  ATP+KLA
 NM_023721 ATPase, H+ transporting, lysosomal V1 subunit D (Atp6v1d), mRNA [NM_023721] KLA 1.45 1.39 1.73 1.95 1.83 2.08 1.29
ATP .91 .88 1.19 1.12 1.73 1.64 2.34
KLA/ATP 1.25 1.32 1.80 1.46 2.05 2.00 2.22
Atp6v1e1
KLA  ATP  ATP+KLA
 NM_007510 VATPase, H+ transporting, lysosomal V1 subunit E1 (Atp6v1e1), mRNA [NM_007510] KLA 1.48 1.55 1.79 1.73 1.79 1.59 1.37
ATP .88 .73 .59 .73 1.30 1.59 1.40
KLA/ATP 1.50 1.43 1.24 1.30 1.57 1.69 1.76
Atp6v1e2
KLA  ATP  ATP+KLA
 NM_029121 ATPase, H+ transporting, lysosomal V1 subunit E2 (Atp6v1e2), mRNA [NM_029121] KLA 1.01 1.04 1.11 1.14 1.19 1.15 1.11
ATP 1.00 .97 1.11 1.06 1.07 1.02 1.08
KLA/ATP 1.03 1.10 1.19 1.10 1.13 1.06 1.09
Atp6v1f
KLA  ATP  ATP+KLA
 NM_025381 ATPase, H+ transporting, lysosomal V1 subunit F (Atp6v1f), mRNA [NM_025381] KLA .92 .94 .93 .96 .96 1.02 1.05
ATP .97 .96 1.07 1.18 1.31 1.16 1.11
KLA/ATP .92 .96 1.06 1.12 1.28 1.24 1.14
Atp6v1g1
KLA  ATP  ATP+KLA
 NM_024173 ATPase, H+ transporting, lysosomal V1 subunit G1 (Atp6v1g1), mRNA [NM_024173] KLA .97 .94 .87 .99 .98 1.01 .96
ATP 1.02 1.02 1.09 1.10 1.29 1.23 1.41
KLA/ATP .83 .92 1.12 1.10 1.23 1.04 .97
Atp6v1g2
KLA  ATP  ATP+KLA
 NM_023179 ATPase, H+ transporting, lysosomal V1 subunit G2 (Atp6v1g2), mRNA [NM_023179] KLA 1.12 1.09 1.03 1.05 1.16 1.15 1.01
ATP .96 1.01 .93 1.06 .85 .83 1.05
KLA/ATP 1.04 1.07 .99 1.07 .90 .82 .98
Atp6v1g3
KLA  ATP  ATP+KLA
 NM_177397 ATPase, H+ transporting, lysosomal V1 subunit G3 (Atp6v1g3), mRNA [NM_177397] KLA 1.05 1.03 1.00 .99 .97 1.02 1.00
ATP 1.04 1.07 1.02 .98 1.05 1.00 1.00
KLA/ATP .99 .98 1.01 1.02 1.03 1.01 1.05
Car2
KLA  ATP  ATP+KLA
 NM_009801 carbonic anhydrase 2 (Car2), mRNA [NM_009801] KLA 9.50 10.18 12.25 12.70 14.42 16.57 6.38
ATP .98 .97 1.35 1.55 3.60 9.36 8.47
KLA/ATP 8.20 10.30 10.62 13.18 12.35 14.45 22.78
Clcnkb
KLA  ATP  ATP+KLA
 BC019983 chloride channel Kb, mRNA (cDNA clone MGC:28502 IMAGE:4188062), complete cds [BC019983] KLA 1.07 1.13 .97 .86 1.01 .99 .90
ATP .91 .98 1.05 .95 .98 1.02 1.07
KLA/ATP .96 1.00 1.10 1.06 .94 .94 1.06
Mm.24882
KLA  ATP  ATP+KLA
 172072654 Unknown KLA .79 .76 .76 .87 1.09 1.04 .88
ATP 1.39 1.48 1.09 .87 .95 .78 .83
KLA/ATP .85 .82 .87 .95 1.02 .84 .89
Mm.7248
KLA  ATP  ATP+KLA
 6755559 Unknown KLA .97 1.04 1.05 1.02 .99 .95 .94
ATP 1.02 .98 1.02 1.01 .94 .96 .98
KLA/ATP .95 1.01 1.01 .97 1.00 .92 .94
Slc12a7
KLA  ATP  ATP+KLA
 NM_011390 solute carrier family 12, member 7 (Slc12a7), mRNA [NM_011390] KLA 1.24 1.21 1.34 1.01 1.02 1.00 1.08
ATP 1.22 1.21 .80 .92 .70 .30 1.03
KLA/ATP 1.45 1.46 .91 .96 .75 .42 .40
Slc4a1
KLA  ATP  ATP+KLA
 NM_011403 solute carrier family 4 (anion exchanger), member 1 (Slc4a1), mRNA [NM_011403] KLA .92 1.07 1.01 1.03 .99 1.09 1.12
ATP 1.08 1.04 .99 1.01 1.05 .96 1.10
KLA/ATP .97 1.00 1.04 1.05 1.01 1.04 1.03
Tcirg1
KLA  ATP  ATP+KLA
 NM_016921 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 (Tcirg1), mRNA [NM_016921] KLA 1.32 1.42 1.49 1.38 1.94 2.26 1.98
ATP 1.01 1.16 .69 .96 1.24 1.32 2.03
KLA/ATP 1.50 1.58 .90 1.29 1.37 2.08 3.28