Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Carbohydrate digestion and absorption (mmu04973)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2010204N
08Rik
KLA  ATP  ATP+KLA
 NM_001081137 RIKEN cDNA 2010204N08 gene (2010204N08Rik), mRNA [NM_001081137] KLA .99 .98 1.00 .96 .98 .98 .99
ATP .96 .98 1.06 1.14 .98 .97 .99
KLA/ATP .98 1.05 1.06 1.04 .99 .98 1.94
AK078587
KLA  ATP  ATP+KLA
 AK078587 11 days embryo gonad cDNA, RIKEN full-length enriched library, clone:7030411M21 product:unclassifiable, full insert sequence [AK078587] KLA 1.37 1.28 1.13 1.06 1.15 1.31 1.22
ATP 1.04 1.08 1.21 1.22 1.27 1.12 1.14
KLA/ATP 1.48 1.66 1.97 1.26 1.17 1.03 1.28
Akt1
KLA  ATP  ATP+KLA
 NM_009652 thymoma viral proto-oncogene 1 (Akt1), mRNA [NM_009652] KLA .80 .80 .75 .75 .71 .70 .82
ATP 1.00 1.02 .76 .85 .76 .68 .84
KLA/ATP .82 .80 .64 .68 .67 .61 .72
Akt2
KLA  ATP  ATP+KLA
 NM_007434 thymoma viral proto-oncogene 2 (Akt2), transcript variant 2, mRNA [NM_007434] KLA 1.45 1.49 1.81 1.61 1.83 1.17 .92
ATP 1.12 1.12 1.00 1.28 1.20 .94 1.06
KLA/ATP 1.48 1.70 1.69 1.58 1.57 1.32 1.27
Akt3
KLA  ATP  ATP+KLA
 NM_011785 thymoma viral proto-oncogene 3 (Akt3), mRNA [NM_011785] KLA 3.42 3.45 5.31 5.16 4.65 3.80 2.12
ATP 1.12 1.22 1.10 1.37 1.02 1.11 1.56
KLA/ATP 3.72 4.17 4.62 4.64 2.74 2.05 3.82
Amy1
KLA  ATP  ATP+KLA
 NM_007446 amylase 1, salivary (Amy1), transcript variant 1, mRNA [NM_007446] KLA 1.03 1.01 1.14 1.07 1.06 1.13 1.16
ATP .99 .98 1.08 1.06 1.09 1.18 1.11
KLA/ATP 1.06 1.10 1.19 1.13 1.16 1.43 1.21
Atp1a1
KLA  ATP  ATP+KLA
 NM_144900 ATPase, Na+/K+ transporting, alpha 1 polypeptide (Atp1a1), mRNA [NM_144900] KLA .78 .94 .68 .81 .62 .55 .75
ATP 1.02 1.05 .86 .85 1.77 2.54 1.11
KLA/ATP .83 .99 .80 .75 .91 1.15 .68
Atp1a2
KLA  ATP  ATP+KLA
 NM_178405 ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2), mRNA [NM_178405] KLA 1.03 .98 1.03 1.05 1.03 .98 1.02
ATP 1.03 .98 1.06 1.05 1.05 .93 1.07
KLA/ATP 1.04 1.05 1.02 1.02 .98 .92 1.02
Atp1a3
KLA  ATP  ATP+KLA
 AK053751 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130306P09 product:ATPase, Na+/K+ transporting, alpha 3 polypeptide, full insert sequence. [AK053751] KLA .88 .87 .74 .80 .84 .88 .93
ATP .96 .83 .80 .88 .94 .89 1.15
KLA/ATP .89 .86 .79 .90 .93 .84 .92
Atp1a3
KLA  ATP  ATP+KLA
 NM_144921 ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), mRNA [NM_144921] KLA .99 .87 .96 .86 .81 .61 .52
ATP 1.22 1.21 1.16 1.38 1.27 .92 1.30
KLA/ATP .96 1.10 1.17 1.42 1.11 .91 .93
Atp1b1
KLA  ATP  ATP+KLA
 NM_009721 ATPase, Na+/K+ transporting, beta 1 polypeptide (Atp1b1), mRNA [NM_009721] KLA .97 1.02 1.08 .98 .95 1.01 1.09
ATP 1.07 1.05 1.09 1.09 1.02 1.17 1.11
KLA/ATP .99 .99 .93 1.02 1.00 1.07 1.04
Atp1b2
KLA  ATP  ATP+KLA
 NM_013415 ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2), mRNA [NM_013415] KLA 1.18 1.09 1.11 1.12 1.16 1.12 1.15
ATP .95 .98 .99 1.26 1.06 1.10 1.07
KLA/ATP 1.15 1.16 1.09 1.19 1.27 1.13 1.02
Atp1b3
KLA  ATP  ATP+KLA
 NM_007502 ATPase, Na+/K+ transporting, beta 3 polypeptide (Atp1b3), mRNA [NM_007502] KLA 1.86 2.10 2.25 2.21 2.68 3.26 3.45
ATP 1.08 1.09 .93 1.13 1.55 2.14 2.38
KLA/ATP 1.95 2.10 1.84 2.34 2.20 2.96 4.69
Atp1b4
KLA  ATP  ATP+KLA
 NM_133690 ATPase, (Na+)/K+ transporting, beta 4 polypeptide (Atp1b4), mRNA [NM_133690] KLA .99 1.02 1.03 1.01 .95 .90 1.00
ATP 1.00 1.05 1.04 .98 1.07 .98 .97
KLA/ATP 1.00 1.05 1.03 1.04 .96 .97 1.01
Cacna1d
KLA  ATP  ATP+KLA
 NM_001083616 calcium channel, voltage-dependent, L type, alpha 1D subunit (Cacna1d), transcript variant 2, mRNA [NM_001083616] KLA 1.57 1.58 2.50 3.62 4.55 2.93 .99
ATP 1.12 .99 .97 .94 .75 1.71 1.48
KLA/ATP 1.47 1.51 1.82 1.56 1.67 2.93 4.60
Cacna1d
KLA  ATP  ATP+KLA
 NM_028981 calcium channel, voltage-dependent, L type, alpha 1D subunit (Cacna1d), transcript variant 1, mRNA [NM_028981] KLA 1.20 1.26 1.43 1.62 2.07 1.66 1.00
ATP 1.03 1.03 .97 .97 .93 1.20 1.26
KLA/ATP 1.16 1.12 1.10 1.14 1.08 1.44 2.56
Fxyd2
KLA  ATP  ATP+KLA
 NM_052823 FXYD domain-containing ion transport regulator 2 (Fxyd2), transcript variant b, mRNA [NM_052823] KLA 1.07 .97 1.09 .98 1.02 .96 .83
ATP 1.07 1.22 1.00 1.14 1.00 1.22 4.11
KLA/ATP 1.06 1.11 .96 1.13 .98 1.01 1.02
G6pc
KLA  ATP  ATP+KLA
 NM_008061 glucose-6-phosphatase, catalytic (G6pc), mRNA [NM_008061] KLA .96 .94 1.04 1.07 1.09 1.06 1.02
ATP .98 1.05 1.09 1.04 1.05 1.00 1.01
KLA/ATP 1.03 1.05 1.06 .96 1.02 1.00 .99
G6pc2
KLA  ATP  ATP+KLA
 NM_021331 glucose-6-phosphatase, catalytic, 2 (G6pc2), mRNA [NM_021331] KLA .99 1.03 1.00 .98 .95 1.02 .98
ATP .95 1.06 .97 1.08 1.16 1.26 1.04
KLA/ATP .94 .99 1.05 6.99 3.55 1.48 1.11
G6pc3
KLA  ATP  ATP+KLA
 NM_175935 glucose 6 phosphatase, catalytic, 3 (G6pc3), mRNA [NM_175935] KLA .88 .89 .89 .80 .75 .68 .88
ATP .99 1.05 .95 1.14 .92 .64 .81
KLA/ATP .92 .90 .79 .94 .70 .62 .58
Hk1
KLA  ATP  ATP+KLA
 J05277 gb|Mouse hexokinase mRNA, complete cds [J05277] KLA 1.49 1.45 1.66 1.78 1.51 1.29 .99
ATP 1.11 1.05 1.15 1.20 2.31 2.17 1.09
KLA/ATP 1.63 1.51 1.70 1.47 1.94 1.92 1.40
Hk1
KLA  ATP  ATP+KLA
 NM_010438 hexokinase 1 (Hk1), nuclear gene encoding mitochondrial protein, mRNA [NM_010438] KLA 1.58 1.75 2.05 1.84 1.96 1.67 1.31
ATP 1.06 1.25 1.01 1.49 2.23 1.79 1.20
KLA/ATP 1.87 1.96 1.51 1.93 1.71 1.94 1.72
Hk2
KLA  ATP  ATP+KLA
 NM_013820 hexokinase 2 (Hk2), mRNA [NM_013820] KLA 4.09 4.09 3.17 2.37 1.53 1.62 2.02
ATP .98 .92 1.08 2.24 3.82 3.86 .97
KLA/ATP 4.07 3.94 4.17 3.53 5.42 4.65 1.54
Hk3
KLA  ATP  ATP+KLA
 NM_001033245 hexokinase 3 (Hk3), nuclear gene encoding mitochondrial protein, mRNA [NM_001033245] KLA 1.52 1.68 1.94 1.85 2.21 2.89 1.98
ATP 1.01 1.07 .87 .99 1.01 1.26 2.62
KLA/ATP 1.63 1.74 1.67 1.69 1.44 2.01 3.53
Hkdc1
KLA  ATP  ATP+KLA
 NM_145419 hexokinase domain containing 1 (Hkdc1), mRNA [NM_145419] KLA 1.10 1.08 1.12 1.12 1.02 1.07 1.04
ATP .96 1.04 1.06 4.28 10.50 3.91 1.34
KLA/ATP .98 1.04 1.14 5.33 12.44 8.68 1.77
Lct
KLA  ATP  ATP+KLA
 NM_001081078 lactase (Lct), mRNA [NM_001081078] KLA .93 .83 .71 .83 .89 .99 .84
ATP 1.03 .98 .86 .92 .82 .85 .85
KLA/ATP .80 .88 .75 .78 .89 .87 .86
Mgam
KLA  ATP  ATP+KLA
 AK033548 adult male colon cDNA, RIKEN full-length enriched library, clone:9030616M21 product:hypothetical protein, full insert sequence. [AK033548] KLA 1.16 1.20 1.22 1.21 1.01 1.02 1.07
ATP 1.01 1.01 1.11 2.86 5.71 5.58 1.53
KLA/ATP 1.24 1.24 1.29 1.64 3.84 3.69 1.98
Mgam
KLA  ATP  ATP+KLA
 XM_001481277 gb|PREDICTED: Mus musculus maltase-glucoamylase (Mgam), mRNA [XM_001481277] KLA 1.03 1.04 1.03 1.04 .95 .98 1.06
ATP 1.06 .94 1.05 1.42 2.38 2.12 1.16
KLA/ATP 1.10 1.06 1.06 1.15 1.52 1.64 1.20
Mm.21312
8
KLA  ATP  ATP+KLA
 141801344 Unknown KLA .96 .95 .83 .77 .52 .99 1.32
ATP .80 .82 1.09 .80 .83 1.19 1.46
KLA/ATP .78 .92 .98 .62 .71 .94 1.41
Mm.25237
KLA  ATP  ATP+KLA
 141802859 Unknown KLA 1.03 1.07 1.05 1.08 1.02 1.02 1.00
ATP .98 1.02 .89 .99 .99 1.03 1.09
KLA/ATP .92 .94 1.11 1.03 1.02 .97 1.09
Mm.25381
9
KLA  ATP  ATP+KLA
 118130676 Unknown KLA 1.81 1.88 1.96 1.62 1.89 2.44 1.56
ATP .92 .91 1.24 1.01 1.16 2.06 1.95
KLA/ATP 1.62 1.86 1.86 1.41 1.89 2.37 1.97
Mm.26105
4
KLA  ATP  ATP+KLA
 124487274 Unknown KLA .95 1.04 .97 .98 1.01 .94 1.10
ATP 1.00 1.06 .94 1.07 1.01 1.00 .98
KLA/ATP 1.04 .99 .93 1.01 1.11 1.07 1.04
Mm.26930
KLA  ATP  ATP+KLA
 124487296 Unknown KLA 1.16 1.07 1.03 1.13 1.13 1.32 1.25
ATP .99 1.00 1.05 1.24 1.38 1.37 1.06
KLA/ATP 1.03 1.16 1.14 1.22 1.32 1.29 1.32
Mm.33401
KLA  ATP  ATP+KLA
 149255058 Unknown KLA 1.03 1.07 1.00 1.03 1.01 1.03 1.06
ATP 1.12 .98 1.12 1.36 2.32 2.03 1.10
KLA/ATP 1.03 1.00 .99 1.21 1.39 1.58 1.20
Pik3ca
KLA  ATP  ATP+KLA
 ENSMUST00000108243 ens|Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K). [Source:Uniprot/SWISSPROT;Acc:P42337] [ENSMUST00000108243] KLA 1.07 1.01 .91 .90 .98 .96 .86
ATP 1.03 .87 1.12 .63 1.22 1.86 .60
KLA/ATP 1.05 .82 .91 .61 1.17 1.26 .63
Pik3ca
KLA  ATP  ATP+KLA
 NM_008839 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca), mRNA [NM_008839] KLA 1.15 1.11 1.05 .82 .99 1.03 1.27
ATP .98 1.00 .79 .75 .96 1.32 1.10
KLA/ATP 1.10 .98 .64 .72 .80 1.20 1.41
Pik3cb
KLA  ATP  ATP+KLA
 NM_029094 phosphatidylinositol 3-kinase, catalytic, beta polypeptide (Pik3cb), mRNA [NM_029094] KLA 1.06 1.06 1.03 .73 .68 .98 1.69
ATP 1.04 1.21 .95 1.02 .85 .93 1.73
KLA/ATP 1.15 1.27 .73 .83 .58 .81 1.81
Pik3cd
KLA  ATP  ATP+KLA
 NM_008840 phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd), transcript variant 1, mRNA [NM_008840] KLA 2.28 2.42 3.10 4.17 3.35 2.31 1.34
ATP 1.02 .91 .99 .63 .30 .67 .80
KLA/ATP 2.14 2.23 2.70 1.51 1.17 .85 .72
Pik3cd
KLA  ATP  ATP+KLA
 U86587 phosphatidylinositol 3-kinase catalytic subunit p110 delta mRNA, complete cds. [U86587] KLA 2.21 2.24 3.71 3.17 3.67 2.66 1.48
ATP 1.00 1.03 .93 .96 .46 .75 .97
KLA/ATP 2.27 2.32 1.97 2.02 1.01 .99 .98
Pik3cg
KLA  ATP  ATP+KLA
 NM_020272 phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg), mRNA [NM_020272] KLA .53 .53 .61 .64 .97 .86 .79
ATP 1.01 1.13 .88 .89 .52 .53 .53
KLA/ATP .58 .53 .43 .60 .40 .43 .62
Pik3r1
KLA  ATP  ATP+KLA
 NM_001077495 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 2, mRNA [NM_001077495] KLA 1.05 1.07 1.03 1.00 1.01 1.20 .85
ATP .97 1.02 1.48 1.42 1.76 1.33 1.23
KLA/ATP 1.11 1.12 1.06 1.17 1.24 .99 1.12
Pik3r2
KLA  ATP  ATP+KLA
 NM_008841 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) (Pik3r2), mRNA [NM_008841] KLA .50 .50 .48 .43 .46 .66 .75
ATP .78 .68 .45 .43 .28 .57 1.37
KLA/ATP .49 .38 .32 .33 .38 .67 1.10
Pik3r3
KLA  ATP  ATP+KLA
 NM_181585 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) (Pik3r3), mRNA [NM_181585] KLA 1.59 1.49 1.37 1.17 1.05 1.55 1.41
ATP 1.12 1.00 1.33 1.70 2.01 2.37 2.02
KLA/ATP 1.63 1.54 1.58 1.70 2.43 2.68 1.92
Pik3r5
KLA  ATP  ATP+KLA
 NM_177320 phosphoinositide-3-kinase, regulatory subunit 5, p101 (Pik3r5), mRNA [NM_177320] KLA 3.57 3.58 4.16 3.54 4.11 2.59 2.39
ATP 1.08 1.08 .93 1.67 3.11 1.88 1.34
KLA/ATP 3.91 3.70 3.30 3.80 2.70 2.04 3.00
Plcb2
KLA  ATP  ATP+KLA
 NM_177568 phospholipase C, beta 2 (Plcb2), mRNA [NM_177568] KLA .70 .68 .64 .67 .65 .76 .88
ATP .95 .94 1.04 .94 .72 .57 1.19
KLA/ATP .69 .68 .72 .63 .65 .55 .70
Prkcb1
KLA  ATP  ATP+KLA
 NM_008855 protein kinase C, beta 1 (Prkcb1), mRNA [NM_008855] KLA .92 .95 .93 .78 .77 1.08 1.83
ATP 1.03 1.12 1.09 1.23 .90 2.08 .96
KLA/ATP .98 .99 .82 .89 .62 1.01 1.08
Slc2a2
KLA  ATP  ATP+KLA
 NM_031197 solute carrier family 2 (facilitated glucose transporter), member 2 (Slc2a2), mRNA [NM_031197] KLA 1.01 1.03 .97 1.00 1.01 1.02 1.04
ATP 1.02 .97 1.07 1.00 1.00 1.03 1.00
KLA/ATP 1.01 1.01 .95 1.00 1.05 1.02 1.01
Slc2a5
KLA  ATP  ATP+KLA
 NM_019741 solute carrier family 2 (facilitated glucose transporter), member 5 (Slc2a5), mRNA [NM_019741] KLA .96 1.10 1.00 .95 .95 1.03 .95
ATP .99 1.00 .99 .99 1.28 1.15 .72
KLA/ATP .94 .94 .87 .91 1.47 1.41 1.00
Slc37a4
KLA  ATP  ATP+KLA
 NM_008063 solute carrier family 37 (glucose-6-phosphate transporter), member 4 (Slc37a4), mRNA [NM_008063] KLA .61 .53 .54 .63 .64 .84 .82
ATP .95 .70 .60 .36 .29 .77 .94
KLA/ATP .53 .49 .46 .32 .33 .52 .72
Slc5a1
KLA  ATP  ATP+KLA
 NM_019810 solute carrier family 5 (sodium/glucose cotransporter), member 1 (Slc5a1), mRNA [NM_019810] KLA 1.02 1.02 1.03 1.04 .99 .93 1.06
ATP 1.03 1.03 1.02 1.05 1.04 .98 .97
KLA/ATP 1.02 .94 1.02 1.03 1.03 1.04 1.02
Tas1r2
KLA  ATP  ATP+KLA
 NM_031873 taste receptor, type 1, member 2 (Tas1r2), mRNA [NM_031873] KLA .98 .97 1.09 1.07 1.04 1.07 1.11
ATP .96 1.00 1.06 2.63 2.51 1.41 1.19
KLA/ATP 1.02 1.08 1.11 2.55 2.91 1.76 1.13
Tas1r3
KLA  ATP  ATP+KLA
 NM_031872 taste receptor, type 1, member 3 (Tas1r3), mRNA [NM_031872] KLA 1.11 1.20 1.23 1.21 1.17 1.44 1.13
ATP 1.05 1.07 1.09 1.20 1.07 1.05 1.14
KLA/ATP 1.18 1.18 1.03 1.19 1.18 1.10 1.25