Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Fat digestion and absorption (mmu04975)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Abca1
KLA  ATP  ATP+KLA
 NM_013454 ATP-binding cassette, sub-family A (ABC1), member 1 (Abca1), mRNA [NM_013454] KLA .69 .60 .65 .69 1.48 1.80 1.46
ATP 1.23 1.10 .81 1.24 2.92 5.72 1.45
KLA/ATP .77 .62 .54 1.00 2.34 4.04 2.36
Abcg5
KLA  ATP  ATP+KLA
 NM_031884 ATP-binding cassette, sub-family G (WHITE), member 5 (Abcg5), mRNA [NM_031884] KLA 1.03 1.03 1.03 1.03 .98 .94 .99
ATP 1.14 .98 .96 .94 1.04 .99 .96
KLA/ATP .98 1.00 .99 .92 .91 1.04 1.03
Abcg8
KLA  ATP  ATP+KLA
 NM_026180 ATP-binding cassette, sub-family G (WHITE), member 8 (Abcg8), mRNA [NM_026180] KLA 1.01 1.03 1.03 .99 1.02 1.06 .98
ATP .99 1.00 1.01 1.00 .97 1.04 1.05
KLA/ATP .98 .94 1.06 1.01 .99 .98 1.08
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Agpat1
KLA  ATP  ATP+KLA
 NM_018862 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (Agpat1), mRNA [NM_018862] KLA 1.24 1.27 1.16 1.37 1.37 1.51 1.65
ATP .99 1.09 1.19 1.29 1.20 1.03 1.27
KLA/ATP 1.27 1.33 1.37 1.49 1.28 1.17 1.55
Agpat2
KLA  ATP  ATP+KLA
 NM_026212 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2), mRNA [NM_026212] KLA .88 .86 1.05 1.00 1.28 1.13 1.05
ATP 1.06 1.15 .95 1.09 .97 1.22 1.04
KLA/ATP .96 .94 .73 .87 .78 .97 .63
Apoa1
KLA  ATP  ATP+KLA
 NM_009692 apolipoprotein A-I (Apoa1), mRNA [NM_009692] KLA .99 1.00 1.00 1.02 1.01 1.02 .98
ATP 1.00 1.00 1.02 1.16 1.03 1.04 1.01
KLA/ATP 1.00 1.03 1.07 1.23 1.10 1.05 .98
Apoa4
KLA  ATP  ATP+KLA
 NM_007468 apolipoprotein A-IV (Apoa4), mRNA [NM_007468] KLA .95 .99 .93 .99 1.03 .99 1.02
ATP .98 1.07 .99 1.00 .99 1.04 1.01
KLA/ATP 1.00 .91 .93 1.01 1.02 1.01 1.03
Apob
KLA  ATP  ATP+KLA
 NM_009693 apolipoprotein B (Apob), mRNA [NM_009693] KLA 1.02 .97 .99 .99 1.00 1.01 .99
ATP .98 .96 1.05 1.06 1.04 .99 1.06
KLA/ATP .98 1.07 .97 1.01 .98 1.05 1.00
Cd36
KLA  ATP  ATP+KLA
 L23108 CD36 antigen mRNA, complete cds. [L23108] KLA .75 .74 .73 .57 .51 .40 .54
ATP .94 .93 .74 .61 .63 1.01 2.07
KLA/ATP .70 .67 .53 .47 .40 .58 1.13
Cd36
KLA  ATP  ATP+KLA
 NM_007643 CD36 antigen (Cd36), mRNA [NM_007643] KLA .70 .75 .67 .54 .45 .35 .42
ATP 1.06 1.04 .73 .58 .62 .81 1.44
KLA/ATP .83 .73 .45 .46 .35 .45 .82
Cel
KLA  ATP  ATP+KLA
 NM_009885 carboxyl ester lipase (Cel), mRNA [NM_009885] KLA 1.06 1.02 1.06 1.07 1.07 1.08 1.11
ATP 1.01 1.04 1.18 1.09 1.09 1.21 1.09
KLA/ATP 1.06 .97 1.24 1.16 1.19 1.21 1.10
Clps
KLA  ATP  ATP+KLA
 NM_025469 colipase, pancreatic (Clps), mRNA [NM_025469] KLA 1.03 1.04 1.04 1.02 1.04 1.06 1.08
ATP .97 .98 1.04 1.05 1.00 1.01 1.05
KLA/ATP .98 .96 1.08 1.09 1.12 .93 1.04
Dgat1
KLA  ATP  ATP+KLA
 NM_010046 diacylglycerol O-acyltransferase 1 (Dgat1), mRNA [NM_010046] KLA 1.05 1.03 1.09 .93 1.04 1.06 1.42
ATP 1.06 1.12 1.23 1.57 1.34 2.37 1.50
KLA/ATP 1.11 1.10 .97 1.24 1.10 2.12 2.03
Dgat2
KLA  ATP  ATP+KLA
 NM_026384 diacylglycerol O-acyltransferase 2 (Dgat2), mRNA [NM_026384] KLA 2.44 2.65 2.86 3.52 3.45 2.83 1.41
ATP .97 .97 1.07 1.81 1.69 2.29 1.29
KLA/ATP 2.21 2.45 2.36 2.76 3.16 4.51 3.63
Fabp1
KLA  ATP  ATP+KLA
 NM_017399 fatty acid binding protein 1, liver (Fabp1), mRNA [NM_017399] KLA 1.07 1.05 1.02 .97 1.02 1.00 1.02
ATP 1.04 1.04 1.06 .99 .99 .97 .90
KLA/ATP .96 1.03 1.02 .99 .94 .97 .94
Fabp2
KLA  ATP  ATP+KLA
 NM_007980 fatty acid binding protein 2, intestinal (Fabp2), mRNA [NM_007980] KLA 1.87 1.96 2.32 1.82 2.37 1.80 1.89
ATP 1.05 1.10 1.03 1.26 1.09 1.07 1.37
KLA/ATP 2.04 2.14 1.41 1.96 1.38 1.34 1.69
Got2
KLA  ATP  ATP+KLA
 NM_010325 glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325] KLA .84 .86 .88 .75 .75 .63 .61
ATP 1.02 1.12 .98 1.15 .98 .67 .86
KLA/ATP .92 .89 .75 .89 .68 .70 .77
Lipf
KLA  ATP  ATP+KLA
 NM_026334 lipase, gastric (Lipf), mRNA [NM_026334] KLA .98 1.00 1.09 1.07 1.04 1.12 1.11
ATP .96 .98 1.02 1.03 1.00 .99 1.05
KLA/ATP 1.03 1.05 .99 1.03 1.04 1.08 1.05
Mm.21249
2
KLA  ATP  ATP+KLA
 46402232 Unknown KLA 1.00 1.02 .97 1.02 1.09 1.02 1.03
ATP .99 1.06 1.00 .99 1.00 1.09 1.01
KLA/ATP .97 .99 1.01 1.04 1.05 1.00 .93
Mm.24244
KLA  ATP  ATP+KLA
 23956161 Unknown KLA 1.04 1.00 .96 1.04 1.53 1.13 1.09
ATP 1.17 1.30 .97 1.10 1.09 1.26 1.10
KLA/ATP .92 1.07 .82 .97 .80 .96 .74
Mm.27737
6
KLA  ATP  ATP+KLA
 90568037 Unknown KLA .66 .59 .62 .83 1.44 1.94 1.41
ATP .95 .79 .79 1.03 2.52 6.30 1.26
KLA/ATP .52 .48 .55 .90 2.69 4.57 1.99
Mm.28873
KLA  ATP  ATP+KLA
 110431340 Unknown KLA .79 .72 .69 .71 .44 .32 .37
ATP .89 .88 1.17 .98 1.11 .98 .73
KLA/ATP .67 .72 .87 .74 .75 .53 .30
Mm.71913
KLA  ATP  ATP+KLA
 118130231 Unknown KLA .93 1.00 1.06 .97 .95 .98 1.04
ATP 1.00 .98 1.08 1.02 .92 .90 .99
KLA/ATP .99 1.01 1.00 .99 .99 .99 1.01
Mogat2
KLA  ATP  ATP+KLA
 NM_177448 monoacylglycerol O-acyltransferase 2 (Mogat2), mRNA [NM_177448] KLA .96 .98 1.08 1.04 1.11 .99 1.00
ATP 1.15 1.06 1.20 1.19 1.24 1.48 1.06
KLA/ATP .91 .97 1.25 1.24 1.47 1.31 1.22
Mttp
KLA  ATP  ATP+KLA
 NM_008642 microsomal triglyceride transfer protein (Mttp), mRNA [NM_008642] KLA 1.09 1.17 1.31 1.23 1.36 1.19 1.19
ATP 1.04 1.09 .98 .90 .86 .91 1.13
KLA/ATP 1.19 1.15 1.01 1.03 .96 .94 1.27
Npc1l1
KLA  ATP  ATP+KLA
 AK078947 adult male cecum cDNA, RIKEN full-length enriched library, clone:9130221N23 product:similar to NIEMANN-PICK C3 PROTEIN [Homo sapiens], full insert sequence [AK078947] KLA .93 .91 1.05 .99 .98 1.06 .92
ATP .99 .98 1.09 .98 1.12 1.08 .98
KLA/ATP .97 .97 .96 .93 .98 .96 1.03
Pla2g10
KLA  ATP  ATP+KLA
 NM_011987 phospholipase A2, group X (Pla2g10), mRNA [NM_011987] KLA .99 1.11 1.02 .99 1.00 1.01 1.02
ATP 1.02 .97 1.01 1.03 1.00 1.02 1.04
KLA/ATP 1.04 .96 .95 1.04 1.06 1.05 1.01
Pla2g12a
KLA  ATP  ATP+KLA
 NM_023196 phospholipase A2, group XIIA (Pla2g12a), transcript variant 1, mRNA [NM_023196] KLA 1.03 1.06 .97 1.00 .78 .75 .92
ATP .91 .99 1.29 1.30 1.20 1.48 1.71
KLA/ATP .92 .99 1.19 1.16 1.06 1.12 1.36
Pla2g12a
KLA  ATP  ATP+KLA
 NM_183423 phospholipase A2, group XIIA (Pla2g12a), transcript variant 2, mRNA [NM_183423] KLA .90 1.00 .87 .95 .76 .68 .88
ATP .96 .94 1.26 1.24 1.19 1.47 1.88
KLA/ATP .89 .90 1.08 1.07 1.06 1.02 1.59
Pla2g12b
KLA  ATP  ATP+KLA
 NM_023530 phospholipase A2, group XIIB (Pla2g12b), mRNA [NM_023530] KLA .98 .95 1.05 .99 1.03 .99 .94
ATP 1.02 1.04 1.07 1.05 .92 1.04 1.00
KLA/ATP .98 .92 1.10 1.11 1.09 1.03 1.04
Pla2g1b
KLA  ATP  ATP+KLA
 NM_011107 phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.00 1.01 1.01 1.11 1.00 1.28 1.00
ATP .98 1.03 1.09 1.03 1.01 1.02 1.04
KLA/ATP .93 .94 1.01 1.00 .94 1.09 1.07
Pla2g2a
KLA  ATP  ATP+KLA
 NM_001082531 phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), mRNA [NM_001082531] KLA 1.08 .99 1.00 1.06 .98 1.01 .94
ATP 1.07 .98 1.04 1.06 .90 .98 .98
KLA/ATP .98 1.03 1.00 1.04 .94 .97 .96
Pla2g2c
KLA  ATP  ATP+KLA
 NM_008868 phospholipase A2, group IIC (Pla2g2c), mRNA [NM_008868] KLA .98 .99 1.05 .98 1.01 1.00 1.04
ATP 1.08 1.06 1.09 .93 .92 .92 1.00
KLA/ATP 1.03 1.04 1.02 1.04 .98 1.01 1.02
Pla2g2d
KLA  ATP  ATP+KLA
 NM_011109 phospholipase A2, group IID (Pla2g2d), mRNA [NM_011109] KLA 1.02 1.02 .99 .99 1.00 1.01 1.00
ATP .95 1.11 1.10 1.11 .98 .99 1.12
KLA/ATP 1.02 1.00 1.19 1.11 1.00 .96 1.01
Pla2g2e
KLA  ATP  ATP+KLA
 NM_012044 phospholipase A2, group IIE (Pla2g2e), mRNA [NM_012044] KLA .78 .75 .74 .72 .62 .69 1.40
ATP 1.06 1.00 .92 1.04 .83 .76 3.74
KLA/ATP .78 .80 .69 .74 .70 .74 2.24
Pla2g2f
KLA  ATP  ATP+KLA
 NM_012045 phospholipase A2, group IIF (Pla2g2f), mRNA [NM_012045] KLA 1.02 .99 1.03 1.01 1.00 .95 .99
ATP 1.01 1.06 1.11 .97 1.09 1.11 .99
KLA/ATP 1.10 1.05 1.04 .95 1.04 1.01 .96
Pla2g3
KLA  ATP  ATP+KLA
 NM_172791 phospholipase A2, group III (Pla2g3), mRNA [NM_172791] KLA 1.04 1.05 1.02 1.01 1.04 1.11 1.00
ATP .96 .97 1.10 .91 .99 .97 1.08
KLA/ATP 1.03 1.11 1.10 .98 .95 .98 1.07
Pla2g5
KLA  ATP  ATP+KLA
 NM_011110 phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA .65 .62 .56 .53 .62 1.60 3.01
ATP .90 .82 .88 1.69 1.82 1.26 6.32
KLA/ATP .63 .59 .65 .63 .91 1.56 5.59
Pnlip
KLA  ATP  ATP+KLA
 AK007357 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810007A24 product:PANCREATIC TRIGLYCERIDE LIPASE (FRAGMENT) homolog [Rattus norvegicus], full insert sequence. [AK007357] KLA .95 1.03 1.02 1.02 1.04 1.06 1.10
ATP 1.05 1.00 .95 1.10 1.00 1.03 1.02
KLA/ATP 1.02 1.00 .89 1.09 1.09 1.06 1.06
Pnlip
KLA  ATP  ATP+KLA
 NM_026925 pancreatic lipase (Pnlip), mRNA [NM_026925] KLA 1.04 .97 1.04 1.00 1.02 .99 .97
ATP 1.04 1.04 1.04 .96 .95 1.02 .97
KLA/ATP .99 .95 .97 .99 .96 .93 1.00
Pnliprp1
KLA  ATP  ATP+KLA
 NM_018874 pancreatic lipase related protein 1 (Pnliprp1), mRNA [NM_018874] KLA .99 .95 .96 .99 .94 .96 1.01
ATP 1.00 1.00 .98 .96 .99 .87 1.09
KLA/ATP 1.01 1.06 1.01 1.02 1.03 .96 .92
Pnliprp2
KLA  ATP  ATP+KLA
 NM_011128 pancreatic lipase-related protein 2 (Pnliprp2), mRNA [NM_011128] KLA 1.01 .97 1.02 1.07 1.08 .98 1.00
ATP 1.05 1.08 .98 1.02 1.00 1.00 1.02
KLA/ATP 1.05 1.04 .96 .99 1.01 1.03 1.05
Ppap2a
KLA  ATP  ATP+KLA
 NM_008903 phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 2.62 2.86 4.01 5.61 7.84 10.88 16.35
ATP 1.01 1.02 1.09 1.28 1.27 2.38 1.44
KLA/ATP 2.78 2.78 2.99 3.43 2.85 3.59 6.59
Ppap2b
KLA  ATP  ATP+KLA
 NM_080555 phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 2.73 2.72 2.65 2.39 1.07 1.48 3.26
ATP .99 .97 1.60 2.76 18.64 27.23 9.19
KLA/ATP 2.69 2.80 4.36 4.20 14.33 15.32 17.91
Ppap2c
KLA  ATP  ATP+KLA
 NM_015817 phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA .94 .88 .91 .79 .65 .46 .51
ATP 1.01 1.03 1.00 1.12 1.24 .90 .83
KLA/ATP .95 .93 .87 .95 .79 .63 .43
Scarb1
KLA  ATP  ATP+KLA
 NM_016741 scavenger receptor class B, member 1 (Scarb1), mRNA [NM_016741] KLA .62 .60 .60 .51 .45 .40 .48
ATP 1.04 1.14 .68 .89 .53 .46 .82
KLA/ATP .73 .67 .40 .55 .34 .30 .39
Slc27a4
KLA  ATP  ATP+KLA
 NM_011989 solute carrier family 27 (fatty acid transporter), member 4 (Slc27a4), mRNA [NM_011989] KLA .94 .93 .97 .87 .91 .97 1.23
ATP 1.05 1.02 .82 .75 .76 1.73 1.49
KLA/ATP 1.05 1.01 .78 .82 .75 1.31 2.26