Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Vitamin digestion and absorption (mmu04977)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2310046K
01Rik
KLA  ATP  ATP+KLA
 NM_027172 RIKEN cDNA 2310046K01 gene (2310046K01Rik), mRNA [NM_027172] KLA .89 .89 .89 .85 .85 .95 1.04
ATP .96 .99 .94 .83 .75 .91 .89
KLA/ATP .87 .86 .88 .82 .79 .82 .91
Abcc1
KLA  ATP  ATP+KLA
 NM_008576 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1), mRNA [NM_008576] KLA 1.13 1.15 .99 .80 .68 .47 .78
ATP .99 1.05 1.05 .89 1.40 1.96 1.02
KLA/ATP 1.17 1.22 1.01 .78 .64 .80 1.07
Apoa1
KLA  ATP  ATP+KLA
 NM_009692 apolipoprotein A-I (Apoa1), mRNA [NM_009692] KLA .99 1.00 1.00 1.02 1.01 1.02 .98
ATP 1.00 1.00 1.02 1.16 1.03 1.04 1.01
KLA/ATP 1.00 1.03 1.07 1.23 1.10 1.05 .98
Apoa4
KLA  ATP  ATP+KLA
 NM_007468 apolipoprotein A-IV (Apoa4), mRNA [NM_007468] KLA .95 .99 .93 .99 1.03 .99 1.02
ATP .98 1.07 .99 1.00 .99 1.04 1.01
KLA/ATP 1.00 .91 .93 1.01 1.02 1.01 1.03
Apob
KLA  ATP  ATP+KLA
 NM_009693 apolipoprotein B (Apob), mRNA [NM_009693] KLA 1.02 .97 .99 .99 1.00 1.01 .99
ATP .98 .96 1.05 1.06 1.04 .99 1.06
KLA/ATP .98 1.07 .97 1.01 .98 1.05 1.00
Btd
KLA  ATP  ATP+KLA
 NM_025295 biotinidase (Btd), mRNA [NM_025295] KLA .89 .88 .87 .74 .90 1.07 1.06
ATP .97 1.05 1.26 1.39 1.39 2.45 2.08
KLA/ATP .86 .89 1.01 1.14 1.11 1.74 2.61
Cubn
KLA  ATP  ATP+KLA
 NM_001081084 cubilin (intrinsic factor-cobalamin receptor) (Cubn), mRNA [NM_001081084] KLA 1.14 1.08 1.08 1.02 1.23 1.02 .97
ATP 1.03 .93 1.02 1.37 1.85 1.36 1.08
KLA/ATP 1.09 1.08 1.12 1.22 1.46 1.03 1.10
Dgat2l4
KLA  ATP  ATP+KLA
 NM_177746 diacylglycerol O-acyltransferase 2-like 4 (Dgat2l4), mRNA [NM_177746] KLA 1.12 1.13 1.13 1.07 1.12 1.02 .98
ATP 1.01 1.01 1.04 1.08 .93 .93 .93
KLA/ATP 1.16 1.15 1.09 1.04 .99 1.00 1.02
Folh1
KLA  ATP  ATP+KLA
 NM_016770 folate hydrolase (Folh1), mRNA [NM_016770] KLA 1.04 1.04 .99 1.06 1.03 1.00 1.02
ATP 1.08 .96 .93 1.00 1.05 .98 .99
KLA/ATP 1.02 .99 1.21 .98 1.00 1.02 .97
Gif
KLA  ATP  ATP+KLA
 NM_008118 gastric intrinsic factor (Gif), mRNA [NM_008118] KLA 1.03 1.01 .98 1.00 1.02 1.00 1.03
ATP .99 .97 1.03 1.06 1.02 1.00 .99
KLA/ATP 1.03 1.02 .84 1.04 1.02 1.05 1.03
Lmbrd1
KLA  ATP  ATP+KLA
 NM_026719 LMBR1 domain containing 1 (Lmbrd1), mRNA [NM_026719] KLA 1.15 1.16 1.09 1.02 1.16 1.22 1.42
ATP 1.09 1.22 1.12 1.49 1.50 1.28 1.23
KLA/ATP 1.21 1.18 1.06 1.44 1.32 1.45 1.32
Lrat
KLA  ATP  ATP+KLA
 NM_023624 lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) (Lrat), mRNA [NM_023624] KLA 1.01 .98 1.00 1.00 .96 1.01 1.00
ATP .97 1.05 1.04 1.04 1.00 1.06 1.01
KLA/ATP .99 1.04 1.00 1.01 1.06 1.00 1.00
Mm.16006
7
KLA  ATP  ATP+KLA
 124487226 Unknown KLA .90 .88 .87 .85 .80 .85 .64
ATP .95 .95 1.00 .94 1.00 .91 .67
KLA/ATP .89 .86 .93 .82 .85 .84 .63
Mm.26913
7
KLA  ATP  ATP+KLA
 31980799 Unknown KLA 1.04 1.07 1.01 1.02 1.00 1.03 .93
ATP 1.04 .96 1.00 .98 .98 .97 1.06
KLA/ATP 1.06 .95 .98 1.08 .99 .93 .91
Mmachc
KLA  ATP  ATP+KLA
 NM_025962 methylmalonic aciduria cblC type, with homocystinuria (Mmachc), mRNA [NM_025962] KLA .90 .87 .80 .90 .61 .59 .89
ATP .89 .88 1.29 1.06 .59 .45 .87
KLA/ATP .79 .95 1.05 .86 .75 .39 .38
Plb1
KLA  ATP  ATP+KLA
 AK015993 adult male testis cDNA, RIKEN full-length enriched library, clone:4930539A06 product:weakly similar to PHOSPHOLIPASE B [Rattus norvegicus], full insert sequence. [AK015993] KLA .99 .99 1.05 1.02 1.03 1.07 1.02
ATP 1.04 1.03 1.07 1.06 1.09 1.01 1.02
KLA/ATP 1.07 1.00 .96 1.09 1.05 1.08 1.01
Plb1
KLA  ATP  ATP+KLA
 AK087596 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230021C09 product:hypothetical protein, full insert sequence. [AK087596] KLA .93 .99 .99 1.07 .98 1.00 .98
ATP 1.08 1.00 .97 1.07 1.04 1.09 .96
KLA/ATP 1.06 .96 1.00 .98 1.04 1.06 .98
Plb1
KLA  ATP  ATP+KLA
 NM_001081407 phospholipase B1 (Plb1), mRNA [NM_001081407] KLA 1.05 1.09 1.05 1.04 1.05 1.03 .85
ATP .96 1.03 1.02 .95 1.06 1.01 .92
KLA/ATP 1.00 1.00 1.09 1.00 .97 .99 .86
Pnlip
KLA  ATP  ATP+KLA
 AK007357 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810007A24 product:PANCREATIC TRIGLYCERIDE LIPASE (FRAGMENT) homolog [Rattus norvegicus], full insert sequence. [AK007357] KLA .95 1.03 1.02 1.02 1.04 1.06 1.10
ATP 1.05 1.00 .95 1.10 1.00 1.03 1.02
KLA/ATP 1.02 1.00 .89 1.09 1.09 1.06 1.06
Pnlip
KLA  ATP  ATP+KLA
 NM_026925 pancreatic lipase (Pnlip), mRNA [NM_026925] KLA 1.04 .97 1.04 1.00 1.02 .99 .97
ATP 1.04 1.04 1.04 .96 .95 1.02 .97
KLA/ATP .99 .95 .97 .99 .96 .93 1.00
Rbp2
KLA  ATP  ATP+KLA
 NM_009034 retinol binding protein 2, cellular (Rbp2), mRNA [NM_009034] KLA 1.06 1.03 1.01 1.04 1.01 1.01 1.00
ATP .99 1.02 1.01 .94 .94 1.03 1.02
KLA/ATP 1.00 1.07 1.07 1.00 .98 .98 .97
Scarb1
KLA  ATP  ATP+KLA
 NM_016741 scavenger receptor class B, member 1 (Scarb1), mRNA [NM_016741] KLA .62 .60 .60 .51 .45 .40 .48
ATP 1.04 1.14 .68 .89 .53 .46 .82
KLA/ATP .73 .67 .40 .55 .34 .30 .39
Slc19a1
KLA  ATP  ATP+KLA
 NM_031196 solute carrier family 19 (sodium/hydrogen exchanger), member 1 (Slc19a1), mRNA [NM_031196] KLA .94 .94 .87 .82 .66 .60 .78
ATP 1.03 1.16 1.08 1.23 1.13 .90 .77
KLA/ATP .95 .94 .84 .97 .72 .75 .62
Slc19a2
KLA  ATP  ATP+KLA
 NM_054087 solute carrier family 19 (thiamine transporter), member 2 (Slc19a2), mRNA [NM_054087] KLA 1.04 .89 .83 .53 .35 .34 .42
ATP .95 .77 .55 .34 1.18 2.15 .36
KLA/ATP .87 .75 .66 .32 .55 1.26 .38
Slc19a3
KLA  ATP  ATP+KLA
 AK098112 cDNA fis, clone TRACH2007674,weakly similar to FOLATE-LIKE TRANSPORTER [AK098112] KLA .95 .98 1.01 .95 .96 1.03 1.02
ATP 1.00 1.00 1.10 1.06 1.01 1.03 .99
KLA/ATP 1.01 1.03 .83 1.05 1.12 .96 1.02
Slc19a3
KLA  ATP  ATP+KLA
 NM_030556 solute carrier family 19 (sodium/hydrogen exchanger), member 3 (Slc19a3), mRNA [NM_030556] KLA 1.02 1.06 1.07 1.02 1.06 1.05 1.15
ATP 1.06 1.03 1.06 1.03 1.07 .98 1.07
KLA/ATP 1.09 1.16 1.05 1.12 1.05 1.13 1.07
Slc23a1
KLA  ATP  ATP+KLA
 NM_011397 solute carrier family 23 (nucleobase transporters), member 1 (Slc23a1), mRNA [NM_011397] KLA .94 1.00 .99 1.04 1.05 .95 1.03
ATP 1.06 1.01 1.08 .94 .99 .94 .96
KLA/ATP 1.00 1.04 1.00 .96 1.04 .97 .97
Slc46a1
KLA  ATP  ATP+KLA
 NM_026740 solute carrier family 46, member 1 (Slc46a1), mRNA [NM_026740] KLA .69 .70 .68 .63 .51 .55 .94
ATP .94 .99 1.24 1.13 .79 .49 2.42
KLA/ATP .68 .68 .78 .73 .60 .49 1.32
Slc5a6
KLA  ATP  ATP+KLA
 NM_177870 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 (Slc5a6), mRNA [NM_177870] KLA .46 .43 .42 .47 .53 .68 .99
ATP .98 .94 .79 .70 .66 .63 1.57
KLA/ATP .47 .42 .47 .48 .51 .57 1.06
Tcn2
KLA  ATP  ATP+KLA
 NM_015749 transcobalamin 2 (Tcn2), mRNA [NM_015749] KLA .93 .94 1.09 .90 .91 .81 .58
ATP 1.07 1.18 .91 1.28 1.03 .84 .96
KLA/ATP 1.13 1.11 .85 1.26 .86 .98 .89