Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Prion diseases (mmu05020)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Bax
KLA  ATP  ATP+KLA
 NM_007527 Bcl2-associated X protein (Bax), mRNA [NM_007527] KLA 1.08 1.14 1.10 1.14 1.17 1.06 .92
ATP 1.06 1.05 1.02 1.25 1.26 .90 .86
KLA/ATP 1.11 1.19 1.30 1.34 1.34 .87 .71
C1qa
KLA  ATP  ATP+KLA
 NM_007572 complement component 1, q subcomponent, alpha polypeptide (C1qa), mRNA [NM_007572] KLA 1.12 1.11 1.09 .94 1.11 1.12 1.31
ATP 1.14 1.21 .88 1.16 .90 .67 .95
KLA/ATP 1.12 1.23 .93 1.27 .86 .81 .91
C1qb
KLA  ATP  ATP+KLA
 NM_009777 complement component 1, q subcomponent, beta polypeptide (C1qb), mRNA [NM_009777] KLA 1.01 1.14 1.20 1.15 1.31 1.15 1.06
ATP 1.16 1.20 .84 1.27 1.02 .70 .76
KLA/ATP 1.29 1.36 .95 1.28 1.00 .97 .85
C1qc
KLA  ATP  ATP+KLA
 NM_007574 complement component 1, q subcomponent, C chain (C1qc), mRNA [NM_007574] KLA 1.03 .97 1.01 1.04 1.07 1.13 1.15
ATP 1.07 1.06 .91 .94 .77 .62 .82
KLA/ATP 1.08 1.02 .95 1.04 .76 .73 .66
C6
KLA  ATP  ATP+KLA
 NM_016704 complement component 6 (C6), mRNA [NM_016704] KLA 1.04 .97 1.04 1.06 .98 1.04 .95
ATP 1.02 1.00 1.02 .96 1.01 .97 1.02
KLA/ATP .94 .95 1.07 1.05 .94 .94 .94
C8a
KLA  ATP  ATP+KLA
 NM_146148 complement component 8, alpha polypeptide (C8a), mRNA [NM_146148] KLA 1.02 1.02 .99 .96 1.06 1.03 1.01
ATP 1.05 1.10 1.00 1.00 .99 1.03 .98
KLA/ATP .98 1.00 1.02 .97 .92 .93 1.03
C8b
KLA  ATP  ATP+KLA
 NM_133882 complement component 8, beta subunit (C8b), mRNA [NM_133882] KLA .95 .96 .96 .95 1.00 .98 .98
ATP 1.07 .96 1.03 1.03 .96 .96 .90
KLA/ATP .99 1.05 1.03 .99 .96 1.03 .95
C8g
KLA  ATP  ATP+KLA
 NM_027062 complement component 8, gamma subunit (C8g), mRNA [NM_027062] KLA .89 .86 .85 .81 .74 .67 .90
ATP .94 .84 .79 .77 .63 .61 .82
KLA/ATP .85 .75 .74 .72 .62 .65 .81
C9
KLA  ATP  ATP+KLA
 NM_013485 complement component 9 (C9), mRNA [NM_013485] KLA 1.01 .95 1.00 1.03 1.01 1.05 1.07
ATP .96 .99 1.01 1.05 .98 1.04 1.06
KLA/ATP 1.00 .97 .94 1.01 1.11 1.05 1.13
Casp12
KLA  ATP  ATP+KLA
 NM_009808 caspase 12 (Casp12), mRNA [NM_009808] KLA 6.56 6.38 7.54 6.85 5.36 2.61 1.46
ATP .99 .98 1.17 1.56 1.32 1.40 1.13
KLA/ATP 6.27 6.52 5.79 5.68 3.74 2.21 1.78
Ccl5
KLA  ATP  ATP+KLA
 M77747 rantes mRNA, complete cds. [M77747] KLA 63.18 60.41 56.25 63.63 58.00 66.51 67.20
ATP .91 1.08 1.25 1.90 4.34 16.10 26.07
KLA/ATP 55.92 63.34 72.91 65.68 70.81 71.97 81.34
Ccl5
KLA  ATP  ATP+KLA
 NM_013653 chemokine (C-C motif) ligand 5 (Ccl5), mRNA [NM_013653] KLA 40.31 35.22 27.92 38.59 29.29 37.98 28.83
ATP .86 .92 1.43 1.66 3.86 15.09 16.66
KLA/ATP 32.14 31.72 47.19 35.89 42.00 46.15 43.89
Egr1
KLA  ATP  ATP+KLA
 NM_007913 early growth response 1 (Egr1), mRNA [NM_007913] KLA 1.00 .56 1.72 2.17 1.88 1.59 2.89
ATP 8.02 5.01 71.67 137.15 83.52 19.89 1.19
KLA/ATP 8.95 15.55 146.78 187.64 170.49 44.28 3.89
Elk1
KLA  ATP  ATP+KLA
 AK082260 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230030F12 product:ELK1, member of ETS oncogene family, full insert sequence. [AK082260] KLA 1.02 1.01 1.01 .97 1.00 1.03 1.06
ATP 1.02 1.07 1.06 1.03 1.02 1.02 1.00
KLA/ATP 1.08 .99 .97 1.01 1.02 1.06 .95
Fyn
KLA  ATP  ATP+KLA
 U70324 Fyn(T) (L-fyn(T)) mRNA, complete cds. [U70324] KLA 1.23 1.27 1.31 1.27 1.31 .87 .48
ATP .88 .71 .66 .75 .90 1.28 .51
KLA/ATP 1.12 1.01 .94 .84 1.25 1.51 .53
Hc
KLA  ATP  ATP+KLA
 NM_010406 hemolytic complement (Hc), mRNA [NM_010406] KLA 1.07 1.12 1.05 .98 1.12 1.12 1.08
ATP .96 .93 1.12 1.07 1.34 5.60 1.48
KLA/ATP 1.05 1.18 1.12 1.05 1.13 3.40 4.37
Hspa1a
KLA  ATP  ATP+KLA
 NM_010479 heat shock protein 1A (Hspa1a), mRNA [NM_010479] KLA 7.88 6.99 4.47 5.18 7.81 11.47 4.14
ATP 1.88 5.62 43.42 58.76 55.53 28.89 9.13
KLA/ATP 7.40 7.62 28.23 54.12 70.14 43.09 22.49
Hspa1b
KLA  ATP  ATP+KLA
 NM_010478 heat shock protein 1B (Hspa1b), mRNA [NM_010478] KLA 5.01 4.73 3.77 3.62 4.81 6.53 3.12
ATP 1.34 3.07 14.11 17.14 17.51 11.21 4.82
KLA/ATP 5.04 5.15 11.63 19.94 20.84 15.79 9.30
Hspa5
KLA  ATP  ATP+KLA
 NM_022310 heat shock protein 5 (Hspa5), mRNA [NM_022310] KLA 1.58 1.55 1.47 1.58 1.81 1.30 1.22
ATP 1.10 1.23 1.04 1.19 1.61 1.72 1.20
KLA/ATP 1.80 1.85 1.54 1.66 1.67 1.80 .93
Il1a
KLA  ATP  ATP+KLA
 NM_010554 interleukin 1 alpha (Il1a), mRNA [NM_010554] KLA 32.45 35.22 31.30 20.95 28.57 18.36 19.02
ATP 1.04 1.02 2.21 5.46 11.06 32.07 3.40
KLA/ATP 32.02 41.20 35.12 46.91 28.76 42.72 57.80
Il1b
KLA  ATP  ATP+KLA
 NM_008361 interleukin 1 beta (Il1b), mRNA [NM_008361] KLA 149.78 133.59 100.91 116.58 86.48 89.37 64.72
ATP 3.49 13.96 61.44 70.91 82.12 162.79 28.18
KLA/ATP 130.32 139.00 219.12 148.17 165.44 172.57 146.98
Il6
KLA  ATP  ATP+KLA
 NM_031168 interleukin 6 (Il6), mRNA [NM_031168] KLA 352.99 378.70 276.81 168.47 59.99 18.66 8.27
ATP 1.04 1.08 2.28 3.69 30.40 161.93 2.11
KLA/ATP 334.28 528.66 ###.## 935.86 302.45 355.36 99.65
Lamc1
KLA  ATP  ATP+KLA
 J03484 gb|Mouse laminin B2 chain mRNA, complete cds [J03484] KLA 1.14 1.01 1.04 .87 .82 .63 .75
ATP .99 1.09 1.07 1.14 1.36 2.38 .66
KLA/ATP 1.04 1.10 .95 1.12 1.30 1.70 .68
Map2k1
KLA  ATP  ATP+KLA
 NM_008927 mitogen-activated protein kinase kinase 1 (Map2k1), mRNA [NM_008927] KLA 1.82 2.00 2.31 2.03 2.51 2.20 1.51
ATP .99 1.14 .81 .87 .90 1.57 1.11
KLA/ATP 1.90 2.03 1.50 1.93 1.63 2.03 2.06
Map2k2
KLA  ATP  ATP+KLA
 NM_023138 mitogen-activated protein kinase kinase 2 (Map2k2), mRNA [NM_023138] KLA .96 1.01 1.09 .99 1.11 1.15 1.42
ATP 1.07 1.05 .74 .86 1.04 1.16 1.21
KLA/ATP 1.14 1.03 .68 .78 .85 1.01 1.20
Mapk1
KLA  ATP  ATP+KLA
 NM_001038663 mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663] KLA .97 1.03 .93 .86 .79 1.01 1.04
ATP .96 1.18 1.01 1.13 .84 1.04 1.16
KLA/ATP .99 .99 .84 .87 .63 .96 1.26
Mapk1
KLA  ATP  ATP+KLA
 NM_011949 mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949] KLA .88 .80 .80 .73 .75 .76 .65
ATP .97 .96 1.06 .88 .90 .68 .48
KLA/ATP .82 .81 .78 .65 .64 .64 .45
Mapk3
KLA  ATP  ATP+KLA
 NM_011952 mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952] KLA .81 .85 .88 .72 .79 .73 .90
ATP 1.13 1.30 .92 1.48 1.08 .68 1.03
KLA/ATP 1.01 1.01 .66 1.13 .77 .77 1.16
Mm.19763
8
KLA  ATP  ATP+KLA
 22122666 Unknown KLA .93 1.02 .99 .99 1.03 1.02 1.04
ATP 1.01 1.00 1.05 .88 .98 .98 1.01
KLA/ATP 1.03 1.01 1.00 .97 1.00 1.07 .96
Mm.42163
KLA  ATP  ATP+KLA
 157951683 Unknown KLA 1.15 1.26 1.21 1.33 1.13 1.06 .99
ATP 1.07 1.05 1.10 1.32 1.03 1.01 1.00
KLA/ATP 1.19 1.16 1.15 1.47 1.11 1.12 .96
Mm.45825
9
KLA  ATP  ATP+KLA
 116292181 Unknown KLA .84 .86 .91 .85 .98 .98 1.00
ATP 1.05 1.06 .94 .95 1.00 .89 .89
KLA/ATP .92 .84 .87 .93 .91 .92 .82
Ncam1
KLA  ATP  ATP+KLA
 NM_001113204 neural cell adhesion molecule 1 (Ncam1), transcript variant 3, mRNA [NM_001113204] KLA 1.02 1.03 1.01 1.00 .95 .94 1.01
ATP 1.02 .99 .98 1.07 .98 .97 1.03
KLA/ATP 1.02 .99 1.03 1.01 1.01 1.00 .99
Ncam1
KLA  ATP  ATP+KLA
 NM_010875 neural cell adhesion molecule 1 (Ncam1), transcript variant 2, mRNA [NM_010875] KLA 1.02 1.02 1.02 1.02 1.02 1.00 .99
ATP 1.02 1.03 1.01 1.00 1.01 1.00 1.00
KLA/ATP 1.04 1.05 1.05 1.02 1.00 .99 .98
Ncam2
KLA  ATP  ATP+KLA
 NM_010954 neural cell adhesion molecule 2 (Ncam2), transcript variant 2, mRNA [NM_010954] KLA 1.03 1.00 1.01 .97 1.03 1.00 .99
ATP .98 1.04 .99 1.02 1.01 1.01 1.05
KLA/ATP .98 1.01 1.06 .97 1.01 .95 1.00
Notch1
KLA  ATP  ATP+KLA
 NM_008714 Notch gene homolog 1 (Drosophila) (Notch1), mRNA [NM_008714] KLA 7.88 6.28 6.84 5.57 5.54 2.82 1.81
ATP 1.21 1.37 1.42 1.46 6.51 6.30 2.62
KLA/ATP 6.74 8.26 8.17 7.73 8.90 5.34 4.14
Notch1
KLA  ATP  ATP+KLA
 Z11886 gb|M.musculus notch-1 mRNA. [Z11886] KLA 8.43 7.03 7.93 7.02 5.78 3.21 1.90
ATP 1.08 1.18 1.52 1.48 7.39 7.40 2.89
KLA/ATP 7.94 8.61 10.64 8.15 11.74 7.12 4.49
Prkaca
KLA  ATP  ATP+KLA
 NM_008854 protein kinase, cAMP dependent, catalytic, alpha (Prkaca), mRNA [NM_008854] KLA .71 .74 .72 .70 .72 .84 .85
ATP 1.05 .98 .89 .92 .76 .60 1.02
KLA/ATP .79 .74 .55 .65 .60 .65 .93
Prkacb
KLA  ATP  ATP+KLA
 NM_011100 protein kinase, cAMP dependent, catalytic, beta (Prkacb), mRNA [NM_011100] KLA .69 .70 .66 .58 .51 .55 .59
ATP 1.02 1.19 .97 1.01 .69 .38 .56
KLA/ATP .72 .73 .57 .62 .47 .41 .45
Prkx
KLA  ATP  ATP+KLA
 NM_016979 protein kinase, X-linked (Prkx), mRNA [NM_016979] KLA 3.61 3.79 4.67 4.66 4.85 4.19 1.43
ATP .98 .90 .63 .61 1.12 1.90 1.29
KLA/ATP 3.56 3.36 2.62 2.06 2.26 2.87 2.31
Prnp
KLA  ATP  ATP+KLA
 NM_011170 prion protein (Prnp), mRNA [NM_011170] KLA 2.90 3.03 3.38 3.28 2.79 2.05 .44
ATP 1.07 1.07 1.22 1.17 1.13 1.39 1.46
KLA/ATP 2.90 3.15 3.61 3.51 3.12 3.26 1.80
Sod1
KLA  ATP  ATP+KLA
 AK080908 4 days neonate male adipose cDNA, RIKEN full-length enriched library, clone:B430204E11 product:superoxide dismutase 1, soluble, full insert sequence [AK080908] KLA .70 .66 .60 .58 .66 .71 .86
ATP .93 .82 .78 .90 1.22 .91 .84
KLA/ATP .66 .64 .71 .75 .74 .73 .77
Sod1
KLA  ATP  ATP+KLA
 NM_011434 superoxide dismutase 1, soluble (Sod1), mRNA [NM_011434] KLA .71 .80 .65 .90 .69 .53 .53
ATP 1.03 .84 1.06 .96 1.27 1.34 .66
KLA/ATP .78 .79 1.12 .77 .96 .82 .52
Stip1
KLA  ATP  ATP+KLA
 AK080936 4 days neonate male adipose cDNA, RIKEN full-length enriched library, clone:B430214C18 product:unclassifiable, full insert sequence [AK080936] KLA 1.02 .97 1.01 1.02 .94 .97 1.01
ATP 1.00 .96 .99 1.07 .97 .96 .99
KLA/ATP .99 .99 .99 .97 .95 1.00 .95
Stip1
KLA  ATP  ATP+KLA
 NM_016737 stress-induced phosphoprotein 1 (Stip1), mRNA [NM_016737] KLA 1.68 1.75 1.91 1.57 1.74 1.16 1.23
ATP 1.18 1.27 1.05 1.48 1.30 .88 .89
KLA/ATP 2.11 2.03 1.79 2.36 1.55 .95 .92