Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Morphine addiction (mmu05032)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Adcy1
KLA  ATP  ATP+KLA
 BC050125 adenylate cyclase 1, mRNA (cDNA clone IMAGE:30015692). [BC050125] KLA 1.05 1.03 .98 1.04 1.05 1.09 1.10
ATP .90 1.02 .99 .97 1.03 .95 1.01
KLA/ATP .99 1.04 .90 .98 .98 1.00 1.03
Adcy1
KLA  ATP  ATP+KLA
 NM_009622 adenylate cyclase 1 (Adcy1), mRNA [NM_009622] KLA 1.07 1.02 1.06 1.07 1.03 1.02 1.01
ATP 1.02 1.04 1.00 .99 .99 .95 .97
KLA/ATP .97 1.05 1.02 1.05 1.01 .98 1.05
Adcy2
KLA  ATP  ATP+KLA
 NM_153534 adenylate cyclase 2 (Adcy2), mRNA [NM_153534] KLA .79 .82 .83 .73 .61 .66 .90
ATP 1.10 1.09 1.02 1.04 .88 .58 .53
KLA/ATP .84 .87 .77 .75 .68 .60 .43
Adcy3
KLA  ATP  ATP+KLA
 NM_138305 adenylate cyclase 3 (Adcy3), mRNA [NM_138305] KLA .84 .84 .83 .78 .66 .55 .49
ATP 1.09 1.05 .89 1.02 .84 .62 1.52
KLA/ATP .93 .87 .75 .85 .66 .83 .77
Adcy4
KLA  ATP  ATP+KLA
 NM_080435 adenylate cyclase 4 (Adcy4), mRNA [NM_080435] KLA 1.05 1.07 .96 1.00 1.04 1.05 1.05
ATP 1.02 1.05 1.02 1.48 1.37 1.08 1.09
KLA/ATP 1.00 1.05 .91 1.19 1.35 1.27 1.08
Adcy5
KLA  ATP  ATP+KLA
 NM_001012765 adenylate cyclase 5 (Adcy5), mRNA [NM_001012765] KLA 1.06 1.00 .97 1.01 1.03 .95 .93
ATP .95 1.08 1.08 1.07 .97 1.03 .97
KLA/ATP .97 .92 1.04 .99 .91 .96 1.04
Adcy6
KLA  ATP  ATP+KLA
 NM_007405 adenylate cyclase 6 (Adcy6), mRNA [NM_007405] KLA 1.10 1.16 1.16 1.09 1.08 1.06 .99
ATP 1.05 .97 1.08 1.12 1.08 1.08 1.04
KLA/ATP 1.14 1.20 1.29 1.30 1.25 1.11 1.07
Adcy7
KLA  ATP  ATP+KLA
 NM_001037724 adenylate cyclase 7 (Adcy7), transcript variant 3, mRNA [NM_001037724] KLA .43 .39 .35 .32 .45 .72 .84
ATP .90 .84 .62 .41 .53 .42 .94
KLA/ATP .39 .34 .23 .17 .41 .34 .67
Adcy7
KLA  ATP  ATP+KLA
 NM_007406 adenylate cyclase 7 (Adcy7), transcript variant 1, mRNA [NM_007406] KLA .51 .52 .48 .41 .59 .81 .99
ATP 1.01 1.02 .62 .52 .53 .38 .98
KLA/ATP .53 .48 .30 .27 .42 .36 .65
Adcy8
KLA  ATP  ATP+KLA
 NM_009623 adenylate cyclase 8 (Adcy8), mRNA [NM_009623] KLA 1.00 1.00 1.07 .97 1.04 .98 1.02
ATP 1.04 1.05 1.14 1.03 .99 1.00 .97
KLA/ATP 1.05 1.04 1.00 1.03 .98 .94 .96
Adcy9
KLA  ATP  ATP+KLA
 NM_009624 adenylate cyclase 9 (Adcy9), mRNA [NM_009624] KLA .18 .15 .13 .15 .17 .19 .33
ATP 1.33 1.16 .97 .98 .62 .56 .86
KLA/ATP .19 .16 .17 .18 .20 .25 .38
Adora1
KLA  ATP  ATP+KLA
 NM_001008533 adenosine A1 receptor (Adora1), transcript variant 1, mRNA [NM_001008533] KLA 1.01 1.03 .94 1.00 1.01 1.11 1.13
ATP .99 1.02 1.06 1.05 1.07 1.02 1.16
KLA/ATP 1.05 .99 1.02 1.04 1.05 1.11 1.09
Adrbk1
KLA  ATP  ATP+KLA
 NM_130863 adrenergic receptor kinase, beta 1 (Adrbk1), mRNA [NM_130863] KLA .90 .84 .99 1.05 1.52 1.69 1.78
ATP 1.07 1.17 .92 1.19 .76 .60 1.08
KLA/ATP .93 .98 .66 .95 .63 .76 1.59
Arrb1
KLA  ATP  ATP+KLA
 NM_177231 arrestin, beta 1 (Arrb1), transcript variant a, mRNA [NM_177231] KLA .41 .42 .32 .32 .31 .56 .80
ATP .97 .86 .81 .62 .47 .59 1.16
KLA/ATP .43 .37 .38 .36 .35 .35 .89
BB548379
KLA  ATP  ATP+KLA
 BB548379 gb|BB548379 RIKEN full-length enriched, 2 days pregnant adult female oviduct Mus musculus cDNA clone E230007L20 3. [BB548379] KLA .98 1.05 1.00 .99 1.04 1.04 1.05
ATP 1.01 .98 1.01 1.02 .98 1.08 .92
KLA/ATP .98 1.06 1.03 1.03 1.00 1.00 .99
Cacna1a
KLA  ATP  ATP+KLA
 NM_007578 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Cacna1a), mRNA [NM_007578] KLA .71 .66 .61 .63 .60 .71 .72
ATP 1.07 1.04 .89 1.08 .71 .56 .75
KLA/ATP .71 .72 .85 .69 .64 .63 .68
Cacna1b
KLA  ATP  ATP+KLA
 U04999 N-type calcium channel alpha1 subunit mRNA, complete cds [U04999] KLA .94 .94 .95 .88 1.09 .85 .92
ATP 1.06 1.17 1.00 1.24 1.59 1.15 1.17
KLA/ATP .91 .91 .95 .95 .90 .97 1.01
Drd1a
KLA  ATP  ATP+KLA
 NM_010076 dopamine receptor D1A (Drd1a), mRNA [NM_010076] KLA .94 .99 1.02 .98 .98 .99 1.06
ATP 1.07 1.03 1.01 1.08 1.08 .96 1.04
KLA/ATP 1.04 1.00 1.01 1.06 1.08 1.06 1.09
Gabbr1
KLA  ATP  ATP+KLA
 NM_019439 gamma-aminobutyric acid (GABA-B) receptor, 1 (Gabbr1), mRNA [NM_019439] KLA 1.00 1.03 1.04 1.01 .97 1.01 .99
ATP .98 .96 1.03 1.01 .96 1.03 .99
KLA/ATP .97 1.00 .97 1.02 1.02 .97 1.01
Gabbr2
KLA  ATP  ATP+KLA
 NM_001081141 gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2), mRNA [NM_001081141] KLA 1.06 .98 .99 1.03 1.09 1.06 1.02
ATP 1.03 1.06 1.05 1.14 1.10 1.00 1.04
KLA/ATP 1.09 1.10 1.12 1.11 1.06 1.04 1.06
Gabra1
KLA  ATP  ATP+KLA
 NM_010250 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1 (Gabra1), mRNA [NM_010250] KLA 1.01 .99 1.01 1.06 1.00 1.07 1.04
ATP 1.03 1.04 1.07 1.05 1.02 .99 .99
KLA/ATP 1.05 1.02 1.04 1.06 1.05 1.06 1.01
Gabra2
KLA  ATP  ATP+KLA
 AK048165 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130038H23 product:gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2, full insert sequence [AK048165] KLA .98 1.06 1.03 1.01 1.03 1.03 .98
ATP 1.00 1.00 1.05 1.07 .96 .92 1.04
KLA/ATP 1.02 1.09 .97 1.02 .99 .98 .80
Gabra2
KLA  ATP  ATP+KLA
 NM_008066 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 (Gabra2), mRNA [NM_008066] KLA .99 1.01 1.10 1.05 .96 .93 .98
ATP 1.09 .99 .99 .98 .97 .93 .94
KLA/ATP .99 .97 .97 .96 1.02 .97 1.04
Gabra3
KLA  ATP  ATP+KLA
 NM_008067 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3 (Gabra3), mRNA [NM_008067] KLA 1.00 1.01 1.03 .99 1.01 1.00 1.01
ATP 1.03 .97 1.03 .98 .98 .97 1.00
KLA/ATP .99 1.08 1.05 .98 1.00 1.03 .96
Gabra4
KLA  ATP  ATP+KLA
 NM_010251 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 (Gabra4), mRNA [NM_010251] KLA .98 1.01 1.02 .99 1.03 .95 1.02
ATP .98 .94 1.03 1.09 1.00 1.06 1.03
KLA/ATP 1.04 1.00 1.02 .97 1.02 1.05 .98
Gabra5
KLA  ATP  ATP+KLA
 NM_176942 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5 (Gabra5), mRNA [NM_176942] KLA .97 .92 1.00 .97 1.01 .99 .97
ATP 1.02 .99 1.03 .98 1.00 .98 1.00
KLA/ATP .97 .99 1.01 1.00 .97 .97 .92
Gabra6
KLA  ATP  ATP+KLA
 NM_008068 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6 (Gabra6), transcript variant 2, mRNA [NM_008068] KLA 1.05 1.02 .96 1.06 .96 1.02 1.07
ATP 1.01 .96 1.03 1.00 .99 .94 1.07
KLA/ATP .99 .99 1.09 1.01 1.13 .97 1.07
Gabrb1
KLA  ATP  ATP+KLA
 NM_008069 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1 (Gabrb1), mRNA [NM_008069] KLA .99 .98 .99 1.00 1.02 .99 .95
ATP 1.00 1.04 .98 1.01 1.05 1.02 1.03
KLA/ATP 1.00 .96 1.00 .96 1.05 1.03 1.04
Gabrb2
KLA  ATP  ATP+KLA
 NM_008070 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2 (Gabrb2), mRNA [NM_008070] KLA 1.04 1.04 1.03 1.04 1.00 .98 1.03
ATP .99 1.01 1.00 1.01 1.03 .99 .93
KLA/ATP 1.05 1.06 1.05 .96 .97 .94 1.00
Gabrb3
KLA  ATP  ATP+KLA
 NM_008071 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3 (Gabrb3), transcript variant 1, mRNA [NM_008071] KLA .99 .99 .99 1.01 .99 .97 1.00
ATP .98 1.02 1.00 .99 .99 .99 1.00
KLA/ATP 1.00 1.03 1.05 .97 .98 .99 .99
Gabrd
KLA  ATP  ATP+KLA
 NM_008072 gamma-aminobutyric acid (GABA-A) receptor, subunit delta (Gabrd), mRNA [NM_008072] KLA 1.36 1.25 1.30 1.25 1.16 1.42 1.07
ATP .97 .82 .91 .80 .74 1.02 .96
KLA/ATP 1.12 1.10 1.06 .87 .89 1.04 1.12
Gabre
KLA  ATP  ATP+KLA
 NM_017369 gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon (Gabre), mRNA [NM_017369] KLA .97 1.04 .98 1.01 1.03 .99 1.05
ATP .96 1.00 .96 1.04 .98 .99 1.02
KLA/ATP 1.00 1.02 1.01 .97 .93 .93 .89
Gabrg1
KLA  ATP  ATP+KLA
 AK038686 adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230055A07 product:gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1, full insert sequence. [AK038686] KLA .98 1.06 1.09 1.00 1.01 1.05 1.07
ATP .96 .99 1.03 1.03 1.03 1.00 1.08
KLA/ATP 1.04 1.04 .90 1.04 1.04 1.08 1.07
Gabrg1
KLA  ATP  ATP+KLA
 NM_010252 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1 (Gabrg1), mRNA [NM_010252] KLA 1.00 1.00 .98 .99 1.01 1.01 1.01
ATP 1.00 .99 1.00 1.03 1.01 1.02 1.01
KLA/ATP .98 .98 1.00 1.00 1.00 1.00 1.02
Gabrg2
KLA  ATP  ATP+KLA
 NM_008073 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2 (Gabrg2), transcript variant 1, mRNA [NM_008073] KLA 1.04 1.03 1.03 .97 .99 .98 1.03
ATP .97 1.00 1.05 1.00 1.01 1.01 1.01
KLA/ATP 1.01 .94 1.04 1.06 1.01 .95 1.02
Gabrg3
KLA  ATP  ATP+KLA
 NM_008074 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 3 (Gabrg3), mRNA [NM_008074] KLA .98 1.03 1.01 1.05 1.01 1.08 1.09
ATP 1.04 1.09 1.02 1.06 1.07 1.05 1.06
KLA/ATP 1.01 1.14 1.07 1.04 1.04 1.15 1.01
Gabrp
KLA  ATP  ATP+KLA
 NM_146017 gamma-aminobutyric acid (GABA-A) receptor, pi (Gabrp), mRNA [NM_146017] KLA 1.03 .97 .99 1.08 .98 1.08 1.00
ATP .95 1.04 1.03 .95 .95 .95 1.05
KLA/ATP .97 .98 .98 .98 .95 .94 .86
Gabrq
KLA  ATP  ATP+KLA
 NM_020488 gamma-aminobutyric acid (GABA-A) receptor, subunit theta (Gabrq), mRNA [NM_020488] KLA 1.00 .97 1.04 1.02 1.02 .88 .96
ATP 1.03 1.03 .99 .94 1.05 .94 .90
KLA/ATP .94 1.00 1.03 .93 .98 1.01 1.01
Gabrr1
KLA  ATP  ATP+KLA
 NM_008075 gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1 (Gabrr1), mRNA [NM_008075] KLA 1.37 1.28 1.42 1.45 1.28 1.19 1.01
ATP .99 1.01 1.30 1.10 1.13 1.05 .80
KLA/ATP 1.25 1.36 1.40 1.29 1.16 1.00 .79
Gabrr2
KLA  ATP  ATP+KLA
 NM_008076 gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2 (Gabrr2), mRNA [NM_008076] KLA 1.03 1.04 .99 1.02 1.05 .98 1.12
ATP 1.07 .98 1.00 1.08 1.04 .97 1.02
KLA/ATP 1.04 1.00 .94 .99 1.05 1.05 1.05
Gnai1
KLA  ATP  ATP+KLA
 NM_010305 guanine nucleotide binding protein (G protein), alpha inhibiting 1 (Gnai1), mRNA [NM_010305] KLA .95 1.01 1.01 1.00 1.09 1.10 1.08
ATP 1.06 1.06 .99 1.15 1.02 .94 .99
KLA/ATP 1.02 1.04 .99 1.16 1.01 1.02 1.13
Gnai2
KLA  ATP  ATP+KLA
 NM_008138 guanine nucleotide binding protein (G protein), alpha inhibiting 2 (Gnai2), mRNA [NM_008138] KLA .74 .79 .82 .74 .91 .97 1.10
ATP 1.07 1.16 .78 1.12 .78 .48 .82
KLA/ATP .91 .81 .53 .80 .60 .68 .87
Gnai3
KLA  ATP  ATP+KLA
 NM_010306 guanine nucleotide binding protein (G protein), alpha inhibiting 3 (Gnai3), mRNA [NM_010306] KLA 1.23 1.24 1.14 1.06 .99 1.15 1.09
ATP .96 .93 .86 .64 1.34 2.02 1.35
KLA/ATP 1.20 1.24 .97 .76 1.21 1.62 1.17
Gnao1
KLA  ATP  ATP+KLA
 NM_001113384 guanine nucleotide binding protein, alpha O (Gnao1), transcript variant B, mRNA [NM_001113384] KLA .95 .98 1.03 1.00 1.02 1.02 .99
ATP .95 1.02 1.01 1.08 .99 .97 .95
KLA/ATP 1.05 1.04 1.10 .99 1.01 .98 1.03
Gnao1
KLA  ATP  ATP+KLA
 NM_010308 guanine nucleotide binding protein, alpha O (Gnao1), transcript variant A, mRNA [NM_010308] KLA .98 .96 1.00 .97 .96 .97 1.01
ATP 1.12 .99 1.05 .87 .97 1.02 1.01
KLA/ATP .93 1.00 .99 1.01 1.05 1.07 .98
Gnas
KLA  ATP  ATP+KLA
 AF107847 neuroendocrine-specific Golgi protein p55 isoform 1 (XLalphas) alternatively spliced mRNA, complete cds. [AF107847] KLA 1.04 .94 1.00 1.05 1.04 .98 1.00
ATP .98 .97 .96 1.00 .99 .98 1.02
KLA/ATP 1.04 1.02 .96 .95 1.01 .96 1.01
Gnas
KLA  ATP  ATP+KLA
 AK017423 10 days neonate head cDNA, RIKEN full-length enriched library, clone:5530400H20 product:novel noncoding RNA overlapping the exon 1A, 1 and 2 of Gnas, full insert sequence. [AK017423] KLA .85 1.08 .97 .92 1.05 1.03 1.08
ATP .99 1.30 2.11 1.73 1.23 1.01 1.02
KLA/ATP .96 1.06 1.58 1.34 1.29 1.05 .91
Gnas
KLA  ATP  ATP+KLA
 NM_001077510 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 8, mRNA [NM_001077510] KLA .99 1.03 .97 .91 1.03 .95 .97
ATP 1.04 1.19 1.15 1.61 1.24 .91 1.00
KLA/ATP 1.06 .97 1.01 1.46 1.04 .85 1.01
Gnas
KLA  ATP  ATP+KLA
 S49980 gb|stimulatory G protein alpha subunit {clone WC-16} [mice, whole cochlea, mRNA Partial, 356 nt]. [S49980] KLA .91 .88 1.03 .87 .90 .84 1.01
ATP 1.16 1.22 1.02 1.55 1.16 .80 .99
KLA/ATP 1.01 1.13 .86 1.12 .97 .85 1.08
Gnb1
KLA  ATP  ATP+KLA
 NM_008142 guanine nucleotide binding protein (G protein), beta 1 (Gnb1), mRNA [NM_008142] KLA 1.11 1.18 1.22 1.19 1.29 1.32 1.76
ATP 1.02 1.09 .84 .99 .97 .89 1.22
KLA/ATP 1.20 1.25 .85 1.01 .86 .91 1.57
Gnb2
KLA  ATP  ATP+KLA
 NM_010312 guanine nucleotide binding protein (G protein), beta 2 (Gnb2), mRNA [NM_010312] KLA .94 .98 .94 1.08 1.23 1.32 1.16
ATP 1.04 .96 .59 .64 .59 .76 1.18
KLA/ATP 1.02 .84 .62 .64 .61 .89 1.36
Gnb3
KLA  ATP  ATP+KLA
 NM_013530 guanine nucleotide binding protein (G protein), beta 3 (Gnb3), mRNA [NM_013530] KLA .99 1.00 .98 1.03 .94 .99 .96
ATP 1.01 1.02 .97 .95 1.01 .97 .92
KLA/ATP .99 1.02 1.02 .98 .99 .85 .99
Gnb4
KLA  ATP  ATP+KLA
 AK165084 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330002E21 product:guanine nucleotide binding protein, beta 4, full insert sequence [AK165084] KLA 4.61 4.10 4.23 2.41 2.25 1.59 .93
ATP 1.21 1.17 1.04 .81 2.92 1.50 1.03
KLA/ATP 5.86 6.56 3.60 1.68 5.62 3.00 1.37
Gnb4
KLA  ATP  ATP+KLA
 NM_013531 guanine nucleotide binding protein (G protein), beta 4 (Gnb4), mRNA [NM_013531] KLA 8.41 8.09 10.57 9.44 6.06 2.97 .92
ATP 1.07 1.04 1.09 .87 1.48 2.10 1.18
KLA/ATP 8.14 8.93 9.12 7.69 5.03 5.11 2.37
Gnb5
KLA  ATP  ATP+KLA
 NM_010313 guanine nucleotide binding protein (G protein), beta 5 (Gnb5), transcript variant 1, mRNA [NM_010313] KLA .68 .75 .67 .66 .53 .50 .65
ATP 1.03 1.08 1.09 1.14 .72 .54 .77
KLA/ATP .73 .70 .71 .73 .61 .65 .58
Gng10
KLA  ATP  ATP+KLA
 NM_025277 guanine nucleotide binding protein (G protein), gamma 10 (Gng10), mRNA [NM_025277] KLA .95 .95 .86 .83 .70 .53 .43
ATP .93 1.03 1.17 1.21 .97 .60 .52
KLA/ATP .84 .91 .93 .99 .79 .47 .24
Gng11
KLA  ATP  ATP+KLA
 NM_025331 guanine nucleotide binding protein (G protein), gamma 11 (Gng11), mRNA [NM_025331] KLA 1.30 1.26 1.44 1.54 1.26 1.42 1.90
ATP .88 .78 1.26 1.14 .90 .64 1.60
KLA/ATP 1.11 1.18 1.81 1.55 1.81 1.75 3.05
Gng12
KLA  ATP  ATP+KLA
 NM_025278 guanine nucleotide binding protein (G protein), gamma 12 (Gng12), mRNA [NM_025278] KLA 2.21 2.23 2.48 2.62 2.47 2.28 1.68
ATP 1.02 1.02 1.09 1.10 1.20 1.32 1.01
KLA/ATP 2.10 2.17 2.38 2.40 1.91 1.60 1.77
Gng13
KLA  ATP  ATP+KLA
 NM_022422 guanine nucleotide binding protein (G protein), gamma 13 (Gng13), mRNA [NM_022422] KLA 1.04 1.04 .94 1.00 1.00 1.05 .96
ATP 1.07 1.05 1.02 .94 .98 1.03 1.01
KLA/ATP 1.01 .99 1.05 1.01 1.01 .98 1.02
Gng2
KLA  ATP  ATP+KLA
 NM_010315 guanine nucleotide binding protein (G protein), gamma 2 (Gng2), transcript variant 1, mRNA [NM_010315] KLA .79 .81 .81 .82 .67 .57 .75
ATP 1.02 1.01 1.13 1.35 1.48 1.01 1.31
KLA/ATP .79 .86 .97 1.05 1.29 1.00 .84
Gng3
KLA  ATP  ATP+KLA
 NM_010316 guanine nucleotide binding protein (G protein), gamma 3 (Gng3), mRNA [NM_010316] KLA 1.00 .98 1.02 .95 .99 1.00 1.06
ATP .98 1.05 .99 1.03 1.05 1.03 .97
KLA/ATP 1.01 1.00 1.07 1.01 1.04 1.04 1.05
Gng4
KLA  ATP  ATP+KLA
 NM_010317 guanine nucleotide binding protein (G protein), gamma 4 (Gng4), mRNA [NM_010317] KLA 1.27 1.26 1.47 1.30 1.15 1.13 .82
ATP 1.05 .97 1.07 1.62 3.97 3.46 1.24
KLA/ATP 1.35 1.32 1.37 1.35 1.64 2.18 1.56
Gng5
KLA  ATP  ATP+KLA
 NM_010318 guanine nucleotide binding protein (G protein), gamma 5 (Gng5), mRNA [NM_010318] KLA .94 .84 .80 1.12 .98 1.11 1.29
ATP 1.07 1.01 1.07 1.05 1.17 1.52 1.01
KLA/ATP .83 .94 1.27 1.17 1.19 1.35 1.36
Gng7
KLA  ATP  ATP+KLA
 NM_001038655 guanine nucleotide binding protein (G protein), gamma 7 (Gng7), transcript variant 1, mRNA [NM_001038655] KLA .92 .96 .87 .91 .83 .98 .98
ATP 1.04 1.06 .98 .95 .81 .77 .75
KLA/ATP .97 .95 .81 .91 .79 .77 .81
Gng8
KLA  ATP  ATP+KLA
 NM_010320 guanine nucleotide binding protein (G protein), gamma 8 (Gng8), mRNA [NM_010320] KLA .93 .93 .95 .96 .90 .88 1.09
ATP .95 .90 1.01 .92 1.04 1.01 1.05
KLA/ATP .97 1.03 .99 .90 1.10 .99 1.04
Gngt1
KLA  ATP  ATP+KLA
 NM_010314 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (Gngt1), mRNA [NM_010314] KLA 1.06 .99 .95 .98 1.03 1.10 .98
ATP .96 1.02 1.03 1.03 .94 1.06 .95
KLA/ATP .98 1.03 1.04 1.04 1.01 1.03 1.01
Grk4
KLA  ATP  ATP+KLA
 NM_019497 G protein-coupled receptor kinase 4 (Grk4), transcript variant 1, mRNA [NM_019497] KLA 1.05 1.03 .98 1.16 .96 .95 .95
ATP .95 .97 1.12 1.09 .93 .95 1.13
KLA/ATP 1.04 1.05 1.14 1.04 .95 .97 1.03
Grk5
KLA  ATP  ATP+KLA
 NM_018869 G protein-coupled receptor kinase 5 (Grk5), mRNA [NM_018869] KLA 1.38 1.35 1.36 1.01 .70 .60 1.49
ATP .96 .99 1.20 1.19 .81 2.59 1.98
KLA/ATP 1.35 1.31 1.41 1.23 .68 1.16 2.94
Grk6
KLA  ATP  ATP+KLA
 NM_001038018 G protein-coupled receptor kinase 6 (Grk6), transcript variant 1, mRNA [NM_001038018] KLA .41 .46 .43 .47 .69 .79 .75
ATP 1.03 1.09 .81 .90 .61 .65 .50
KLA/ATP .48 .45 .36 .43 .40 .54 .40
Grk6
KLA  ATP  ATP+KLA
 NM_011938 G protein-coupled receptor kinase 6 (Grk6), transcript variant 2, mRNA [NM_011938] KLA .71 .72 .69 .71 .82 .94 .80
ATP 1.04 1.15 .93 1.06 .69 .78 .65
KLA/ATP .74 .70 .65 .70 .56 .72 .55
Kcnj3
KLA  ATP  ATP+KLA
 BC068167 potassium inwardly-rectifying channel, subfamily J, member 3, mRNA (cDNA clone MGC:92970 IMAGE:30543982), complete cds [BC068167] KLA .99 .97 1.01 .94 .97 .99 .99
ATP 1.06 1.01 1.03 .82 1.01 1.00 .94
KLA/ATP .98 .91 .99 .99 1.01 1.11 .97
Kcnj3
KLA  ATP  ATP+KLA
 NM_008426 potassium inwardly-rectifying channel, subfamily J, member 3 (Kcnj3), mRNA [NM_008426] KLA 1.05 .99 1.04 1.02 1.02 1.04 .94
ATP 1.00 1.01 1.02 .99 .96 1.03 1.04
KLA/ATP 1.00 .98 1.03 1.02 1.02 .96 1.06
Kcnj5
KLA  ATP  ATP+KLA
 NM_010605 potassium inwardly-rectifying channel, subfamily J, member 5 (Kcnj5), mRNA [NM_010605] KLA 1.06 1.07 .97 .97 .99 1.05 .98
ATP .96 1.11 1.09 .98 .95 1.03 1.05
KLA/ATP .98 1.00 1.10 .98 1.07 .96 1.02
Kcnj6
KLA  ATP  ATP+KLA
 NM_001025585 potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6), transcript variant Girk2B, mRNA [NM_001025585] KLA .97 .96 .95 .96 .98 .96 .95
ATP 1.00 .98 1.02 1.00 .98 .96 .97
KLA/ATP .98 .95 .99 .96 .98 .93 .96
Kcnj6
KLA  ATP  ATP+KLA
 NM_010606 potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6), transcript variant Girk2A-1, mRNA [NM_010606] KLA .96 1.03 .97 .98 .97 .99 1.07
ATP 1.08 .99 .99 1.05 .96 1.04 .97
KLA/ATP 1.01 .92 1.03 1.03 1.04 1.03 1.08
Kcnj9
KLA  ATP  ATP+KLA
 AK007011 adult male testis cDNA, RIKEN full-length enriched library, clone:1700085N21 product:unclassifiable, full insert sequence. [AK007011] KLA 1.00 1.03 .98 1.02 .95 1.09 1.01
ATP .97 .92 1.03 1.11 1.02 .95 1.01
KLA/ATP 1.01 .98 .98 1.05 1.07 1.03 1.02
Kcnj9
KLA  ATP  ATP+KLA
 NM_008429 potassium inwardly-rectifying channel, subfamily J, member 9 (Kcnj9), mRNA [NM_008429] KLA 1.03 1.06 1.06 1.07 1.09 .95 1.00
ATP 1.02 .93 .93 1.14 1.07 .98 .95
KLA/ATP 1.03 .99 .99 1.02 1.02 .96 .96
Mm.11707
6
KLA  ATP  ATP+KLA
 124001565 Unknown KLA .78 .79 .79 .78 .79 .68 .78
ATP 1.04 1.01 1.18 .95 .89 1.00 1.32
KLA/ATP .80 .88 .95 .83 .85 .85 .83
Mm.20374
7
KLA  ATP  ATP+KLA
 146149233 Unknown KLA .34 .30 .28 .41 .80 1.31 1.29
ATP .93 .83 .82 .76 .43 .46 .88
KLA/ATP .30 .28 .27 .27 .27 .51 1.11
Mm.24661
3
KLA  ATP  ATP+KLA
 124486645 Unknown KLA 1.04 .95 1.00 .97 1.01 1.06 1.10
ATP 1.07 1.05 1.06 .98 1.04 1.08 1.01
KLA/ATP .96 1.01 .97 1.04 1.04 1.03 1.09
Mm.41137
KLA  ATP  ATP+KLA
 148747308 Unknown KLA 1.03 1.00 .95 .92 1.04 .98 .96
ATP 1.02 .98 .98 .90 .95 .92 1.07
KLA/ATP .91 .89 1.01 .95 1.00 .96 .99
Mm.44050
5
KLA  ATP  ATP+KLA
 84579905 Unknown KLA 1.03 .96 .90 1.03 .94 1.15 1.23
ATP .88 .91 1.15 1.18 1.17 1.31 1.02
KLA/ATP .87 .97 1.19 1.18 1.36 1.34 1.25
Mm.4424
KLA  ATP  ATP+KLA
 110225367 Unknown KLA .99 .93 1.01 1.02 1.00 .92 1.00
ATP .98 1.03 3.11 1.13 1.19 1.03 1.11
KLA/ATP .95 .97 .97 .96 .93 1.01 .99
Mm.54161
KLA  ATP  ATP+KLA
 164607143 Unknown KLA .97 .99 1.00 .98 .95 .98 .94
ATP 1.01 .99 1.06 1.07 1.02 .95 .98
KLA/ATP .93 1.04 1.07 .96 .90 .95 .94
Oprm1
KLA  ATP  ATP+KLA
 NM_001039652 opioid receptor, mu 1 (Oprm1), mRNA [NM_001039652] KLA .98 1.04 .94 .96 .93 .94 1.03
ATP .89 .92 1.06 .98 1.00 1.04 1.01
KLA/ATP .94 .97 1.05 1.00 1.02 1.01 1.00
Pde10a
KLA  ATP  ATP+KLA
 NM_011866 phosphodiesterase 10A (Pde10a), mRNA [NM_011866] KLA 1.21 1.38 1.60 1.46 1.52 1.57 2.00
ATP 1.06 1.04 1.06 1.09 1.01 1.28 1.30
KLA/ATP 1.31 1.40 1.33 1.15 1.27 1.63 3.52
Pde11a
KLA  ATP  ATP+KLA
 AK018171 adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330414F14 product:unclassifiable, full insert sequence. [AK018171] KLA .95 .95 .99 .95 1.00 1.03 .96
ATP .95 .96 .97 .95 1.03 1.00 1.01
KLA/ATP .95 1.00 1.00 .97 .97 .98 .91
Pde11a
KLA  ATP  ATP+KLA
 NM_001081033 phosphodiesterase 11A (Pde11a), mRNA [NM_001081033] KLA 1.00 1.01 1.00 1.06 1.03 1.02 1.01
ATP .97 1.03 1.02 .98 .96 1.02 1.05
KLA/ATP .99 .97 1.02 .98 1.04 .96 1.05
Pde1a
KLA  ATP  ATP+KLA
 NM_001009978 phosphodiesterase 1A, calmodulin-dependent (Pde1a), transcript variant 7, mRNA [NM_001009978] KLA 1.42 1.46 1.58 1.35 1.43 1.21 1.25
ATP 1.02 1.01 1.07 1.13 1.50 1.46 1.08
KLA/ATP 1.44 1.52 1.27 1.38 1.23 1.40 1.41
Pde1a
KLA  ATP  ATP+KLA
 NM_016744 phosphodiesterase 1A, calmodulin-dependent (Pde1a), mRNA [NM_016744] KLA .98 .99 1.03 1.04 1.02 .96 1.04
ATP 1.02 1.02 1.05 1.03 1.00 .98 .98
KLA/ATP .99 1.00 1.08 1.03 1.01 1.04 1.00
Pde1b
KLA  ATP  ATP+KLA
 NM_008800 phosphodiesterase 1B, Ca2+-calmodulin dependent (Pde1b), mRNA [NM_008800] KLA 1.53 1.78 1.80 1.94 2.87 2.77 1.81
ATP 1.16 1.04 .98 1.15 1.27 1.30 .81
KLA/ATP 1.71 1.80 1.46 1.38 1.25 1.92 2.12
Pde1c
KLA  ATP  ATP+KLA
 ENSMUST00000114327 ens|Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C). [Source:Uniprot/SWISSPROT;Acc:Q64338] [ENSMUST00000114327] KLA .94 1.03 1.01 .96 1.09 1.05 1.04
ATP 1.06 1.04 1.02 1.04 1.02 1.03 .96
KLA/ATP .93 .96 .99 1.11 1.04 1.08 1.01
Pde1c
KLA  ATP  ATP+KLA
 NM_001025568 phosphodiesterase 1C (Pde1c), transcript variant 2, mRNA [NM_001025568] KLA .90 .87 .88 .83 .73 .72 .74
ATP .93 1.03 1.06 .92 .88 .78 .74
KLA/ATP .96 .94 .95 .91 .84 .72 .72
Pde1c
KLA  ATP  ATP+KLA
 NM_011054 phosphodiesterase 1C (Pde1c), transcript variant 1, mRNA [NM_011054] KLA .96 .98 .90 .96 .91 1.01 .93
ATP .93 .95 .99 .94 .94 .92 .95
KLA/ATP 1.00 .91 .81 1.05 1.01 .88 .88
Pde2a
KLA  ATP  ATP+KLA
 NM_001008548 phosphodiesterase 2A, cGMP-stimulated (Pde2a), mRNA [NM_001008548] KLA 1.34 1.57 1.59 1.45 1.68 1.86 1.20
ATP 1.06 1.14 1.01 1.25 4.20 4.27 1.53
KLA/ATP 1.66 1.63 1.30 1.68 3.03 3.15 1.87
Pde3a
KLA  ATP  ATP+KLA
 AK004638 adult male lung cDNA, RIKEN full-length enriched library, clone:1200007J10 product:phosphodiesterase 3A, cGMP inhibited, full insert sequence. [AK004638] KLA .96 .94 .95 1.07 1.01 1.00 1.03
ATP 1.02 .95 .96 1.07 .97 .96 1.01
KLA/ATP 1.00 1.00 1.02 .94 .98 .99 1.01
Pde3a
KLA  ATP  ATP+KLA
 AK052718 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630035A07 product:inferred: phosphodiesterase 3A, cGMP inhibited, full insert sequence. [AK052718] KLA .93 1.02 .94 1.00 .98 1.03 .96
ATP 1.03 .96 1.00 .98 1.00 1.03 1.01
KLA/ATP .98 1.06 1.08 1.03 .94 .98 .89
Pde3a
KLA  ATP  ATP+KLA
 NM_018779 phosphodiesterase 3A, cGMP inhibited (Pde3a), mRNA [NM_018779] KLA 1.01 1.09 .98 .98 .93 1.03 1.09
ATP .99 .97 1.04 1.05 .96 .96 1.06
KLA/ATP 1.06 .97 .94 1.09 1.00 1.06 .96
Pde3b
KLA  ATP  ATP+KLA
 AK044183 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830097M14 product:phosphodiesterase 3B, cGMP-inhibited, full insert sequence. [AK044183] KLA .98 .99 1.04 .99 .93 1.01 .96
ATP 1.08 .96 .92 .93 .93 .90 .93
KLA/ATP .97 .94 .95 .89 .92 .89 .95
Pde3b
KLA  ATP  ATP+KLA
 NM_011055 phosphodiesterase 3B, cGMP-inhibited (Pde3b), mRNA [NM_011055] KLA 1.02 1.01 .95 1.00 .88 .75 .59
ATP 1.12 1.20 1.09 1.04 .71 .95 .81
KLA/ATP .90 .92 1.00 .94 .74 .85 .93
Pde4a
KLA  ATP  ATP+KLA
 BC044786 phosphodiesterase 4A, cAMP specific, mRNA (cDNA clone IMAGE:5062421), complete cds. [BC044786] KLA 1.03 1.01 1.05 1.12 1.06 1.10 1.05
ATP .98 1.00 .94 1.05 1.06 .99 .97
KLA/ATP 1.01 1.04 1.02 1.07 1.11 .99 1.01
Pde4a
KLA  ATP  ATP+KLA
 NM_183408 phosphodiesterase 4A, cAMP specific (Pde4a), transcript variant 5, mRNA [NM_183408] KLA 1.28 1.05 .94 .98 .78 .68 .61
ATP 1.12 .93 1.04 .81 .44 .51 .55
KLA/ATP 1.21 1.15 1.35 .88 .65 .50 .40
Pde4b
KLA  ATP  ATP+KLA
 AK171700 activated spleen cDNA, RIKEN full-length enriched library, clone:F830005J09 product:phosphodiesterase 4B, cAMP specific, full insert sequence. [AK171700] KLA 25.30 22.34 17.69 20.47 19.25 9.46 8.13
ATP 1.84 2.56 6.89 13.77 29.40 29.52 2.02
KLA/ATP 28.05 34.82 40.94 18.74 13.88 20.46 9.76
Pde4b
KLA  ATP  ATP+KLA
 NM_019840 phosphodiesterase 4B, cAMP specific (Pde4b), mRNA [NM_019840] KLA 26.82 26.37 24.04 25.17 23.52 15.22 11.94
ATP .98 1.46 3.13 12.73 25.11 31.06 3.63
KLA/ATP 25.32 28.44 32.37 35.94 25.49 29.74 21.61
Pde4c
KLA  ATP  ATP+KLA
 NM_201607 phosphodiesterase 4C, cAMP specific (Pde4c), mRNA [NM_201607] KLA .84 .85 .87 .93 .98 .82 .87
ATP 1.07 1.02 1.34 1.24 1.14 .83 .90
KLA/ATP .94 .91 1.00 1.23 1.06 .87 .94
Pde7a
KLA  ATP  ATP+KLA
 NM_008802 phosphodiesterase 7A (Pde7a), transcript variant 1, mRNA [NM_008802] KLA 1.53 1.59 2.57 2.03 1.20 .99 .77
ATP 1.03 1.01 .96 .77 .98 .95 1.15
KLA/ATP 1.60 1.68 1.85 1.72 1.33 1.12 .93
Pde8a
KLA  ATP  ATP+KLA
 AK148238 B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370062O07 product:phosphodiesterase 8A, full insert sequence [AK148238] KLA .49 .45 .39 .28 .30 .59 .86
ATP 1.04 1.20 .95 1.33 .80 1.03 1.53
KLA/ATP .50 .46 .28 .48 .42 .82 1.36
Pde8b
KLA  ATP  ATP+KLA
 AK034510 adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330209J16 product:unclassifiable, full insert sequence. [AK034510] KLA .80 .82 .79 .81 .89 .89 .83
ATP 1.06 .97 .79 .80 .88 .78 .79
KLA/ATP .81 .80 .79 .78 .92 .90 .71
Pde8b
KLA  ATP  ATP+KLA
 NM_172263 phosphodiesterase 8B (Pde8b), mRNA [NM_172263] KLA .87 .86 .84 .84 .81 1.03 1.36
ATP .99 .90 .94 .77 .71 1.09 1.33
KLA/ATP .89 .93 .85 .76 .69 .94 1.37
Prkaca
KLA  ATP  ATP+KLA
 NM_008854 protein kinase, cAMP dependent, catalytic, alpha (Prkaca), mRNA [NM_008854] KLA .71 .74 .72 .70 .72 .84 .85
ATP 1.05 .98 .89 .92 .76 .60 1.02
KLA/ATP .79 .74 .55 .65 .60 .65 .93
Prkacb
KLA  ATP  ATP+KLA
 NM_011100 protein kinase, cAMP dependent, catalytic, beta (Prkacb), mRNA [NM_011100] KLA .69 .70 .66 .58 .51 .55 .59
ATP 1.02 1.19 .97 1.01 .69 .38 .56
KLA/ATP .72 .73 .57 .62 .47 .41 .45
Prkca
KLA  ATP  ATP+KLA
 NM_011101 protein kinase C, alpha (Prkca), mRNA [NM_011101] KLA 1.00 .96 .94 .95 .95 .89 .96
ATP 1.00 1.03 .91 .94 .82 .87 1.13
KLA/ATP 1.02 .95 .91 .86 .78 .84 .94
Prkcb1
KLA  ATP  ATP+KLA
 NM_008855 protein kinase C, beta 1 (Prkcb1), mRNA [NM_008855] KLA .92 .95 .93 .78 .77 1.08 1.83
ATP 1.03 1.12 1.09 1.23 .90 2.08 .96
KLA/ATP .98 .99 .82 .89 .62 1.01 1.08
Prkcc
KLA  ATP  ATP+KLA
 NM_011102 protein kinase C, gamma (Prkcc), mRNA [NM_011102] KLA 1.02 1.04 1.11 1.04 .96 1.02 1.05
ATP .98 .98 1.05 1.03 1.08 .96 .95
KLA/ATP 1.21 1.16 1.09 1.07 1.04 .98 .93
Prkx
KLA  ATP  ATP+KLA
 NM_016979 protein kinase, X-linked (Prkx), mRNA [NM_016979] KLA 3.61 3.79 4.67 4.66 4.85 4.19 1.43
ATP .98 .90 .63 .61 1.12 1.90 1.29
KLA/ATP 3.56 3.36 2.62 2.06 2.26 2.87 2.31
Slc32a1
KLA  ATP  ATP+KLA
 NM_009508 solute carrier family 32 (GABA vesicular transporter), member 1 (Slc32a1), mRNA [NM_009508] KLA 1.11 1.01 1.06 1.10 1.07 1.05 1.04
ATP 1.03 .97 1.11 1.10 1.52 1.52 1.08
KLA/ATP 1.10 1.12 1.09 1.17 1.36 1.50 1.10