Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Nicotine addiction (mmu05033)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Cacna1a
KLA  ATP  ATP+KLA
 NM_007578 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Cacna1a), mRNA [NM_007578] KLA .71 .66 .61 .63 .60 .71 .72
ATP 1.07 1.04 .89 1.08 .71 .56 .75
KLA/ATP .71 .72 .85 .69 .64 .63 .68
Cacna1b
KLA  ATP  ATP+KLA
 U04999 N-type calcium channel alpha1 subunit mRNA, complete cds [U04999] KLA .94 .94 .95 .88 1.09 .85 .92
ATP 1.06 1.17 1.00 1.24 1.59 1.15 1.17
KLA/ATP .91 .91 .95 .95 .90 .97 1.01
Chrna4
KLA  ATP  ATP+KLA
 NM_015730 cholinergic receptor, nicotinic, alpha polypeptide 4 (Chrna4), mRNA [NM_015730] KLA .99 .96 1.01 1.01 1.00 .98 .96
ATP 1.02 .98 .97 1.04 .94 .96 .94
KLA/ATP .97 .99 1.00 .98 1.00 .98 .98
Chrna6
KLA  ATP  ATP+KLA
 NM_021369 cholinergic receptor, nicotinic, alpha polypeptide 6 (Chrna6), mRNA [NM_021369] KLA 1.05 .98 1.00 .93 1.05 .98 .96
ATP .99 .93 .98 .99 .92 .95 1.01
KLA/ATP 1.00 1.00 1.02 .93 .96 .94 1.05
Chrna7
KLA  ATP  ATP+KLA
 NM_007390 cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7), mRNA [NM_007390] KLA 1.01 .99 1.04 .96 .99 .99 1.01
ATP .99 .97 1.00 1.00 .99 1.04 1.00
KLA/ATP .98 1.02 1.04 .99 .95 .96 1.07
Chrnb2
KLA  ATP  ATP+KLA
 NM_009602 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) (Chrnb2), mRNA [NM_009602] KLA .89 .85 .89 .88 .78 .97 .93
ATP 1.03 .99 1.36 2.35 1.30 .97 .86
KLA/ATP .86 .91 .80 1.23 1.14 1.03 1.02
Gabra1
KLA  ATP  ATP+KLA
 NM_010250 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1 (Gabra1), mRNA [NM_010250] KLA 1.01 .99 1.01 1.06 1.00 1.07 1.04
ATP 1.03 1.04 1.07 1.05 1.02 .99 .99
KLA/ATP 1.05 1.02 1.04 1.06 1.05 1.06 1.01
Gabra2
KLA  ATP  ATP+KLA
 AK048165 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130038H23 product:gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2, full insert sequence [AK048165] KLA .98 1.06 1.03 1.01 1.03 1.03 .98
ATP 1.00 1.00 1.05 1.07 .96 .92 1.04
KLA/ATP 1.02 1.09 .97 1.02 .99 .98 .80
Gabra2
KLA  ATP  ATP+KLA
 NM_008066 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 (Gabra2), mRNA [NM_008066] KLA .99 1.01 1.10 1.05 .96 .93 .98
ATP 1.09 .99 .99 .98 .97 .93 .94
KLA/ATP .99 .97 .97 .96 1.02 .97 1.04
Gabra3
KLA  ATP  ATP+KLA
 NM_008067 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3 (Gabra3), mRNA [NM_008067] KLA 1.00 1.01 1.03 .99 1.01 1.00 1.01
ATP 1.03 .97 1.03 .98 .98 .97 1.00
KLA/ATP .99 1.08 1.05 .98 1.00 1.03 .96
Gabra4
KLA  ATP  ATP+KLA
 NM_010251 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 (Gabra4), mRNA [NM_010251] KLA .98 1.01 1.02 .99 1.03 .95 1.02
ATP .98 .94 1.03 1.09 1.00 1.06 1.03
KLA/ATP 1.04 1.00 1.02 .97 1.02 1.05 .98
Gabra5
KLA  ATP  ATP+KLA
 NM_176942 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5 (Gabra5), mRNA [NM_176942] KLA .97 .92 1.00 .97 1.01 .99 .97
ATP 1.02 .99 1.03 .98 1.00 .98 1.00
KLA/ATP .97 .99 1.01 1.00 .97 .97 .92
Gabra6
KLA  ATP  ATP+KLA
 NM_008068 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6 (Gabra6), transcript variant 2, mRNA [NM_008068] KLA 1.05 1.02 .96 1.06 .96 1.02 1.07
ATP 1.01 .96 1.03 1.00 .99 .94 1.07
KLA/ATP .99 .99 1.09 1.01 1.13 .97 1.07
Gabrb1
KLA  ATP  ATP+KLA
 NM_008069 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1 (Gabrb1), mRNA [NM_008069] KLA .99 .98 .99 1.00 1.02 .99 .95
ATP 1.00 1.04 .98 1.01 1.05 1.02 1.03
KLA/ATP 1.00 .96 1.00 .96 1.05 1.03 1.04
Gabrb2
KLA  ATP  ATP+KLA
 NM_008070 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2 (Gabrb2), mRNA [NM_008070] KLA 1.04 1.04 1.03 1.04 1.00 .98 1.03
ATP .99 1.01 1.00 1.01 1.03 .99 .93
KLA/ATP 1.05 1.06 1.05 .96 .97 .94 1.00
Gabrb3
KLA  ATP  ATP+KLA
 NM_008071 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3 (Gabrb3), transcript variant 1, mRNA [NM_008071] KLA .99 .99 .99 1.01 .99 .97 1.00
ATP .98 1.02 1.00 .99 .99 .99 1.00
KLA/ATP 1.00 1.03 1.05 .97 .98 .99 .99
Gabrd
KLA  ATP  ATP+KLA
 NM_008072 gamma-aminobutyric acid (GABA-A) receptor, subunit delta (Gabrd), mRNA [NM_008072] KLA 1.36 1.25 1.30 1.25 1.16 1.42 1.07
ATP .97 .82 .91 .80 .74 1.02 .96
KLA/ATP 1.12 1.10 1.06 .87 .89 1.04 1.12
Gabre
KLA  ATP  ATP+KLA
 NM_017369 gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon (Gabre), mRNA [NM_017369] KLA .97 1.04 .98 1.01 1.03 .99 1.05
ATP .96 1.00 .96 1.04 .98 .99 1.02
KLA/ATP 1.00 1.02 1.01 .97 .93 .93 .89
Gabrg1
KLA  ATP  ATP+KLA
 AK038686 adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230055A07 product:gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1, full insert sequence. [AK038686] KLA .98 1.06 1.09 1.00 1.01 1.05 1.07
ATP .96 .99 1.03 1.03 1.03 1.00 1.08
KLA/ATP 1.04 1.04 .90 1.04 1.04 1.08 1.07
Gabrg1
KLA  ATP  ATP+KLA
 NM_010252 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1 (Gabrg1), mRNA [NM_010252] KLA 1.00 1.00 .98 .99 1.01 1.01 1.01
ATP 1.00 .99 1.00 1.03 1.01 1.02 1.01
KLA/ATP .98 .98 1.00 1.00 1.00 1.00 1.02
Gabrg2
KLA  ATP  ATP+KLA
 NM_008073 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2 (Gabrg2), transcript variant 1, mRNA [NM_008073] KLA 1.04 1.03 1.03 .97 .99 .98 1.03
ATP .97 1.00 1.05 1.00 1.01 1.01 1.01
KLA/ATP 1.01 .94 1.04 1.06 1.01 .95 1.02
Gabrg3
KLA  ATP  ATP+KLA
 NM_008074 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 3 (Gabrg3), mRNA [NM_008074] KLA .98 1.03 1.01 1.05 1.01 1.08 1.09
ATP 1.04 1.09 1.02 1.06 1.07 1.05 1.06
KLA/ATP 1.01 1.14 1.07 1.04 1.04 1.15 1.01
Gabrp
KLA  ATP  ATP+KLA
 NM_146017 gamma-aminobutyric acid (GABA-A) receptor, pi (Gabrp), mRNA [NM_146017] KLA 1.03 .97 .99 1.08 .98 1.08 1.00
ATP .95 1.04 1.03 .95 .95 .95 1.05
KLA/ATP .97 .98 .98 .98 .95 .94 .86
Gabrq
KLA  ATP  ATP+KLA
 NM_020488 gamma-aminobutyric acid (GABA-A) receptor, subunit theta (Gabrq), mRNA [NM_020488] KLA 1.00 .97 1.04 1.02 1.02 .88 .96
ATP 1.03 1.03 .99 .94 1.05 .94 .90
KLA/ATP .94 1.00 1.03 .93 .98 1.01 1.01
Gabrr1
KLA  ATP  ATP+KLA
 NM_008075 gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1 (Gabrr1), mRNA [NM_008075] KLA 1.37 1.28 1.42 1.45 1.28 1.19 1.01
ATP .99 1.01 1.30 1.10 1.13 1.05 .80
KLA/ATP 1.25 1.36 1.40 1.29 1.16 1.00 .79
Gabrr2
KLA  ATP  ATP+KLA
 NM_008076 gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2 (Gabrr2), mRNA [NM_008076] KLA 1.03 1.04 .99 1.02 1.05 .98 1.12
ATP 1.07 .98 1.00 1.08 1.04 .97 1.02
KLA/ATP 1.04 1.00 .94 .99 1.05 1.05 1.05
Gria1
KLA  ATP  ATP+KLA
 NM_008165 glutamate receptor, ionotropic, AMPA1 (alpha 1) (Gria1), transcript variant 2, mRNA [NM_008165] KLA .97 1.02 1.02 1.01 1.03 1.02 1.11
ATP 1.03 .97 1.05 1.03 1.01 1.01 1.01
KLA/ATP 1.02 .99 1.01 1.06 1.15 1.06 1.05
Gria2
KLA  ATP  ATP+KLA
 BC048248 glutamate receptor, ionotropic, AMPA2 (alpha 2), mRNA (cDNA clone MGC:54603 IMAGE:6494013), complete cds. [BC048248] KLA 1.00 1.01 1.05 1.00 1.03 .97 1.06
ATP .98 1.00 1.00 .96 1.03 1.05 1.04
KLA/ATP .98 1.08 .99 1.04 1.06 1.02 1.05
Gria2
KLA  ATP  ATP+KLA
 NM_013540 glutamate receptor, ionotropic, AMPA2 (alpha 2) (Gria2), transcript variant 2, mRNA [NM_013540] KLA 1.02 1.02 .98 1.01 .98 1.02 1.01
ATP .95 1.01 .95 .99 1.09 1.02 1.09
KLA/ATP 1.06 .92 .96 .99 1.00 1.03 1.00
Gria3
KLA  ATP  ATP+KLA
 AK161163 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831401I16 product:glutamate receptor, ionotropic, AMPA3 (alpha 3), full insert sequence. [AK161163] KLA 1.01 .96 .97 .95 .99 .84 .81
ATP 1.05 1.04 1.07 .86 .88 .84 .65
KLA/ATP .94 .95 1.06 .83 .79 .75 .66
Gria3
KLA  ATP  ATP+KLA
 NM_016886 glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), mRNA [NM_016886] KLA 1.04 .95 1.05 .98 .98 .97 .95
ATP 1.00 1.08 1.01 .97 .93 .98 .97
KLA/ATP 1.03 .93 .93 .98 .96 1.03 .89
Gria4
KLA  ATP  ATP+KLA
 NM_019691 glutamate receptor, ionotropic, AMPA4 (alpha 4) (Gria4), transcript variant 1, mRNA [NM_019691] KLA 1.05 1.05 1.00 .97 1.00 1.04 1.01
ATP 1.01 1.03 1.24 .99 .95 .99 1.02
KLA/ATP .99 1.03 1.04 1.00 .98 .97 1.02
Grin1
KLA  ATP  ATP+KLA
 NM_008169 glutamate receptor, ionotropic, NMDA1 (zeta 1) (Grin1), mRNA [NM_008169] KLA .90 .97 .91 .98 .93 .94 1.01
ATP 1.04 1.04 1.02 1.08 .96 .91 .93
KLA/ATP .90 .99 .95 .95 .94 .88 .89
Grin2a
KLA  ATP  ATP+KLA
 NM_008170 glutamate receptor, ionotropic, NMDA2A (epsilon 1) (Grin2a), mRNA [NM_008170] KLA 1.00 1.08 1.00 1.03 1.09 1.02 1.04
ATP .96 .94 1.00 .98 1.03 .97 1.01
KLA/ATP .95 1.02 1.03 .95 .99 .99 .95
Grin2b
KLA  ATP  ATP+KLA
 NM_008171 glutamate receptor, ionotropic, NMDA2B (epsilon 2) (Grin2b), mRNA [NM_008171] KLA 1.03 1.02 1.10 1.09 1.02 1.03 1.08
ATP 1.15 1.07 1.05 1.07 1.08 1.04 1.02
KLA/ATP 1.10 1.04 1.07 1.13 1.09 1.08 1.06
Grin2c
KLA  ATP  ATP+KLA
 NM_010350 glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Grin2c), mRNA [NM_010350] KLA 1.09 1.13 1.19 1.24 1.14 1.15 1.09
ATP 1.05 .96 .98 .98 .94 1.01 1.10
KLA/ATP 1.08 1.14 1.09 1.05 1.05 .98 1.01
Grin2d
KLA  ATP  ATP+KLA
 NM_008172 glutamate receptor, ionotropic, NMDA2D (epsilon 4) (Grin2d), mRNA [NM_008172] KLA 1.57 1.18 1.35 1.45 1.25 1.49 .91
ATP .92 .99 1.45 1.66 1.54 2.02 1.15
KLA/ATP 1.23 1.38 2.08 2.28 1.92 2.53 1.92
Grin3a
KLA  ATP  ATP+KLA
 AK044171 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830097C19 product:similar to IONOTROPIC GLUTAMATE RECEPTOR NMDA subunit NR3A[Rattus norvegicus], full insert sequence. [AK044171] KLA 1.06 1.00 .93 .95 .97 .97 .99
ATP .96 .97 1.02 .94 1.03 1.02 1.03
KLA/ATP 1.05 .96 1.05 .98 .94 1.02 1.03
Grin3b
KLA  ATP  ATP+KLA
 NM_130455 glutamate receptor, ionotropic, NMDA3B (Grin3b), mRNA [NM_130455] KLA .90 .92 .88 .98 .91 .91 .69
ATP .96 .93 .94 .92 .93 .84 .68
KLA/ATP .92 .88 .88 .95 .96 .88 .68
Mm.32259
4
KLA  ATP  ATP+KLA
 144922605 Unknown KLA 1.02 1.03 .98 .98 .95 1.00 1.02
ATP 1.01 .98 1.08 1.01 1.04 1.01 .97
KLA/ATP .97 1.08 1.04 1.02 1.00 1.01 1.03
Mm.44009
5
KLA  ATP  ATP+KLA
 166158133 Unknown KLA .99 1.03 1.07 1.00 1.07 1.07 1.06
ATP .98 1.01 .98 .94 1.06 .96 .95
KLA/ATP 1.04 1.05 1.00 .97 1.06 .99 .95
Mm.4424
KLA  ATP  ATP+KLA
 110225367 Unknown KLA .99 .93 1.01 1.02 1.00 .92 1.00
ATP .98 1.03 3.11 1.13 1.19 1.03 1.11
KLA/ATP .95 .97 .97 .96 .93 1.01 .99
Slc17a6
KLA  ATP  ATP+KLA
 NM_080853 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 (Slc17a6), mRNA [NM_080853] KLA .97 1.03 1.05 .98 1.02 1.06 1.08
ATP .98 1.00 .97 1.05 1.01 1.01 1.02
KLA/ATP 1.01 1.01 .96 1.02 .96 .98 .97
Slc17a7
KLA  ATP  ATP+KLA
 NM_182993 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 (Slc17a7), mRNA [NM_182993] KLA .98 1.03 1.00 1.01 1.04 1.02 .96
ATP .97 .97 1.06 1.05 .96 .97 1.02
KLA/ATP .95 1.02 .90 1.05 1.04 1.03 1.01
Slc17a8
KLA  ATP  ATP+KLA
 NM_182959 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (Slc17a8), mRNA [NM_182959] KLA 1.18 1.13 1.21 1.14 1.21 1.09 1.11
ATP 1.02 .96 1.07 1.08 1.14 1.14 1.21
KLA/ATP 1.12 1.24 1.14 1.10 1.12 1.22 1.50
Slc32a1
KLA  ATP  ATP+KLA
 NM_009508 solute carrier family 32 (GABA vesicular transporter), member 1 (Slc32a1), mRNA [NM_009508] KLA 1.11 1.01 1.06 1.10 1.07 1.05 1.04
ATP 1.03 .97 1.11 1.10 1.52 1.52 1.08
KLA/ATP 1.10 1.12 1.09 1.17 1.36 1.50 1.10