Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Malaria (mmu05144)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Ccl12
KLA  ATP  ATP+KLA
 NM_011331 chemokine (C-C motif) ligand 12 (Ccl12), mRNA [NM_011331] KLA 40.77 33.71 46.23 51.22 57.13 57.92 16.26
ATP 1.41 1.14 1.54 1.79 1.41 1.89 9.34
KLA/ATP 39.52 43.18 61.96 69.72 62.95 38.70 29.25
Ccl2
KLA  ATP  ATP+KLA
 NM_011333 chemokine (C-C motif) ligand 2 (Ccl2), mRNA [NM_011333] KLA 10.26 9.30 8.35 10.02 8.92 14.08 11.59
ATP 1.62 1.68 2.20 4.16 3.92 4.84 17.45
KLA/ATP 10.09 10.31 10.95 12.32 8.00 10.04 21.29
Cd36
KLA  ATP  ATP+KLA
 L23108 CD36 antigen mRNA, complete cds. [L23108] KLA .75 .74 .73 .57 .51 .40 .54
ATP .94 .93 .74 .61 .63 1.01 2.07
KLA/ATP .70 .67 .53 .47 .40 .58 1.13
Cd36
KLA  ATP  ATP+KLA
 NM_007643 CD36 antigen (Cd36), mRNA [NM_007643] KLA .70 .75 .67 .54 .45 .35 .42
ATP 1.06 1.04 .73 .58 .62 .81 1.44
KLA/ATP .83 .73 .45 .46 .35 .45 .82
Cd40
KLA  ATP  ATP+KLA
 NM_170701 CD40 antigen (Cd40), transcript variant 3, mRNA [NM_170701] KLA 23.87 23.62 23.26 23.98 22.07 17.37 5.34
ATP 1.00 1.01 1.06 2.96 2.65 3.03 1.70
KLA/ATP 22.77 23.79 29.67 28.85 28.08 21.62 13.02
Cd40lg
KLA  ATP  ATP+KLA
 NM_011616 CD40 ligand (Cd40lg), mRNA [NM_011616] KLA 1.03 1.07 1.02 .98 1.06 1.06 1.03
ATP .95 .92 .99 1.06 1.02 1.04 1.07
KLA/ATP 1.00 1.01 .93 1.04 .94 1.01 .98
Cd81
KLA  ATP  ATP+KLA
 NM_133655 CD 81 antigen (Cd81), mRNA [NM_133655] KLA .80 .79 .78 .74 .59 .45 .25
ATP .89 .74 .63 .54 .45 .57 .47
KLA/ATP .75 .67 .65 .51 .45 .39 .41
Comp
KLA  ATP  ATP+KLA
 NM_016685 cartilage oligomeric matrix protein (Comp), mRNA [NM_016685] KLA 1.02 1.09 1.18 1.08 .96 1.12 .97
ATP .89 1.02 .97 .95 1.13 2.59 1.24
KLA/ATP 1.09 1.09 1.03 .98 1.60 2.02 1.15
Csf3
KLA  ATP  ATP+KLA
 NM_009971 colony stimulating factor 3 (granulocyte) (Csf3), mRNA [NM_009971] KLA 1.44 1.56 2.06 2.25 2.97 1.58 1.55
ATP 1.04 1.05 1.14 2.18 4.85 7.52 1.83
KLA/ATP 1.54 1.93 2.57 4.75 3.85 3.95 7.39
Darc
KLA  ATP  ATP+KLA
 NM_010045 Duffy blood group, chemokine receptor (Darc), mRNA [NM_010045] KLA 1.06 1.06 1.03 1.08 1.03 1.06 1.03
ATP 1.00 .98 1.02 .97 .98 1.03 1.01
KLA/ATP 1.08 1.12 1.01 1.01 1.08 1.00 .97
Gypa
KLA  ATP  ATP+KLA
 NM_010369 glycophorin A (Gypa), mRNA [NM_010369] KLA 1.00 .98 1.01 1.06 .99 1.01 1.07
ATP 1.01 .96 1.06 1.08 1.02 1.01 1.02
KLA/ATP 1.08 .99 .94 1.03 1.09 1.08 1.02
Gypc
KLA  ATP  ATP+KLA
 NM_001048207 glycophorin C (Gypc), mRNA [NM_001048207] KLA 8.74 9.38 10.11 9.11 6.64 3.51 1.34
ATP 1.05 1.04 1.17 1.17 .66 .73 .64
KLA/ATP 9.23 9.46 10.43 10.84 7.69 3.58 2.14
Hba-a1
KLA  ATP  ATP+KLA
 NM_008218 hemoglobin alpha, adult chain 1 (Hba-a1), mRNA [NM_008218] KLA 1.02 1.05 1.06 1.01 1.04 1.02 1.01
ATP 1.00 1.04 1.10 1.05 .98 .99 1.06
KLA/ATP 1.02 .99 1.10 .98 .95 1.00 1.02
Hba-a2
KLA  ATP  ATP+KLA
 M10466 gb|Mouse alpha-globin mRNA. [M10466] KLA 1.16 1.09 1.19 1.12 1.19 1.24 1.21
ATP .96 1.00 1.07 1.05 .97 1.07 1.18
KLA/ATP 1.09 1.08 1.16 1.14 1.14 1.09 1.27
Hbb-b1
KLA  ATP  ATP+KLA
 NM_008220 hemoglobin, beta adult major chain (Hbb-b1), mRNA [NM_008220] KLA 1.11 1.11 1.10 1.11 1.07 1.09 .99
ATP 1.01 1.01 1.01 1.04 1.03 1.07 1.02
KLA/ATP 1.06 1.12 1.15 1.09 1.09 1.45 1.45
Hgf
KLA  ATP  ATP+KLA
 AK033274 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030481P22 product:inferred: hepatocyte growth factor [AK033274] KLA 1.34 1.22 .96 .93 .82 .93 .87
ATP 1.64 2.45 3.30 1.89 .97 1.12 .90
KLA/ATP 1.49 2.50 3.96 1.88 1.07 1.00 .83
Hgf
KLA  ATP  ATP+KLA
 NM_010427 hepatocyte growth factor (Hgf), mRNA [NM_010427] KLA 1.11 1.18 1.30 1.20 1.08 .96 1.14
ATP 1.02 1.14 1.32 1.62 1.17 1.26 1.47
KLA/ATP 1.18 1.24 1.33 1.84 1.19 1.09 1.31
Icam1
KLA  ATP  ATP+KLA
 BC008626 intercellular adhesion molecule, mRNA (cDNA clone MGC:6195 IMAGE:3588949), complete cds [BC008626] KLA 36.67 32.93 28.63 27.91 14.65 8.16 4.15
ATP .96 .88 1.50 3.88 4.98 3.90 1.01
KLA/ATP 32.58 31.60 42.74 32.60 26.00 13.02 6.01
Icam1
KLA  ATP  ATP+KLA
 NM_010493 intercellular adhesion molecule 1 (Icam1), mRNA [NM_010493] KLA 15.66 15.20 12.96 12.31 9.39 6.17 3.81
ATP .96 1.06 1.21 4.19 4.33 3.16 1.06
KLA/ATP 14.31 15.46 17.84 17.60 13.77 8.36 5.42
Ifng
KLA  ATP  ATP+KLA
 NM_008337 interferon gamma (Ifng), mRNA [NM_008337] KLA 1.05 1.02 1.01 1.01 1.01 1.04 1.00
ATP 1.00 1.01 1.01 .98 .97 1.04 1.03
KLA/ATP 1.01 1.01 1.06 1.10 1.24 1.10 1.04
Il10
KLA  ATP  ATP+KLA
 NM_010548 interleukin 10 (Il10), mRNA [NM_010548] KLA 17.59 18.64 22.22 23.06 11.83 8.27 2.07
ATP 1.86 3.22 7.72 20.51 25.86 8.38 1.01
KLA/ATP 17.91 23.49 34.53 34.48 20.98 12.03 8.17
Il12a
KLA  ATP  ATP+KLA
 NM_008351 interleukin 12a (Il12a), mRNA [NM_008351] KLA 2.37 2.47 2.17 1.49 1.46 1.12 1.20
ATP 1.01 .97 1.12 1.07 1.02 1.07 1.06
KLA/ATP 2.01 2.76 2.54 1.70 1.08 1.10 1.27
Il18
KLA  ATP  ATP+KLA
 NM_008360 interleukin 18 (Il18), mRNA [NM_008360] KLA 12.14 11.96 12.28 12.96 12.23 7.84 2.40
ATP 1.06 .96 1.13 1.04 .92 1.67 2.29
KLA/ATP 11.55 11.63 13.03 9.98 9.08 6.50 6.72
Il1b
KLA  ATP  ATP+KLA
 NM_008361 interleukin 1 beta (Il1b), mRNA [NM_008361] KLA 149.78 133.59 100.91 116.58 86.48 89.37 64.72
ATP 3.49 13.96 61.44 70.91 82.12 162.79 28.18
KLA/ATP 130.32 139.00 219.12 148.17 165.44 172.57 146.98
Il6
KLA  ATP  ATP+KLA
 NM_031168 interleukin 6 (Il6), mRNA [NM_031168] KLA 352.99 378.70 276.81 168.47 59.99 18.66 8.27
ATP 1.04 1.08 2.28 3.69 30.40 161.93 2.11
KLA/ATP 334.28 528.66 ###.## 935.86 302.45 355.36 99.65
Itgal
KLA  ATP  ATP+KLA
 AK156251 activated spleen cDNA, RIKEN full-length enriched library, clone:F830013L17 product:integrin alpha L, full insert sequence [AK156251] KLA 5.36 5.78 4.86 5.55 7.02 8.63 11.12
ATP .99 1.17 1.22 1.57 1.35 1.95 3.79
KLA/ATP 5.42 5.89 4.95 5.91 3.96 4.93 10.15
Itgal
KLA  ATP  ATP+KLA
 NM_008400 integrin alpha L (Itgal), mRNA [NM_008400] KLA 4.48 5.17 5.28 5.82 7.82 8.09 16.96
ATP 1.03 1.06 1.24 1.44 1.34 2.02 4.59
KLA/ATP 4.71 5.63 5.49 5.60 3.66 4.65 17.76
Itgb2
KLA  ATP  ATP+KLA
 NM_008404 integrin beta 2 (Itgb2), mRNA [NM_008404] KLA .78 .78 .97 .74 1.04 .94 1.14
ATP 1.24 1.23 .79 .95 1.12 .84 1.10
KLA/ATP .99 1.01 .60 .83 .78 .73 .99
Itgb2l
KLA  ATP  ATP+KLA
 NM_008405 integrin beta 2-like (Itgb2l), mRNA [NM_008405] KLA .87 .98 .98 1.00 1.05 1.07 1.10
ATP 1.24 1.23 1.13 1.14 1.29 1.05 1.05
KLA/ATP 1.02 1.08 1.08 1.06 .98 .93 .95
Klrb1a
KLA  ATP  ATP+KLA
 NM_010737 killer cell lectin-like receptor subfamily B member 1A (Klrb1a), mRNA [NM_010737] KLA .86 .90 .93 .87 .86 .91 .88
ATP .92 1.00 .96 1.04 .91 .88 .91
KLA/ATP .91 .86 .75 .95 .84 .81 .88
Klrb1c
KLA  ATP  ATP+KLA
 NM_008527 killer cell lectin-like receptor subfamily B member 1C (Klrb1c), mRNA [NM_008527] KLA .88 .88 .85 .89 .88 .90 .98
ATP 1.01 .96 1.03 .92 .87 .94 .93
KLA/ATP .87 .93 .86 .89 .87 .87 .85
Klrb1f
KLA  ATP  ATP+KLA
 NM_153094 killer cell lectin-like receptor subfamily B member 1F (Klrb1f), mRNA [NM_153094] KLA 1.08 .99 1.07 1.02 1.04 1.02 1.01
ATP .98 1.02 1.08 .94 .99 .99 1.04
KLA/ATP .98 1.02 1.07 .97 .99 .98 .99
Klrb1f
KLA  ATP  ATP+KLA
 NM_181064 killer cell lectin-like receptor subfamily B member 1F (Klrb1f), mRNA [NM_181064] KLA 1.04 1.09 1.13 1.13 1.02 1.03 1.04
ATP 1.01 .98 .95 1.01 .99 .98 .91
KLA/ATP 1.07 1.10 1.06 .94 .97 1.01 .91
Klrk1
KLA  ATP  ATP+KLA
 NM_033078 killer cell lectin-like receptor subfamily K, member 1 (Klrk1), transcript variant 1, mRNA [NM_033078] KLA 2.39 2.96 3.81 3.16 2.96 1.97 1.34
ATP 1.12 1.05 1.13 1.17 1.06 1.14 1.08
KLA/ATP 2.56 2.79 2.32 2.12 1.68 1.43 1.15
Lrp1
KLA  ATP  ATP+KLA
 NM_008512 low density lipoprotein receptor-related protein 1 (Lrp1), mRNA [NM_008512] KLA .53 .46 .43 .39 .48 .44 .40
ATP 1.21 1.36 .96 .74 .73 .65 .65
KLA/ATP .60 .57 .47 .29 .38 .61 .99
Met
KLA  ATP  ATP+KLA
 NM_008591 met proto-oncogene (Met), mRNA [NM_008591] KLA 3.56 3.71 3.68 3.79 4.24 5.89 6.95
ATP .98 .96 1.16 1.21 3.32 12.98 6.60
KLA/ATP 3.75 3.80 3.58 3.28 3.69 4.27 14.22
Mm.19611
0
KLA  ATP  ATP+KLA
 145301548 Unknown KLA 1.11 1.20 1.32 1.25 1.20 1.28 1.23
ATP 1.08 1.11 1.22 1.29 1.08 1.13 1.01
KLA/ATP 1.20 1.19 1.40 1.17 1.24 1.18 1.11
Mm.27185
4
KLA  ATP  ATP+KLA
 124494255 Unknown KLA .57 .53 .47 .45 .51 .47 .35
ATP 1.02 .97 1.15 .56 .63 .72 .71
KLA/ATP .59 .50 .62 .30 .50 .63 .78
Mm.38049
KLA  ATP  ATP+KLA
 118130391 Unknown KLA .67 .65 .73 .92 .63 .81 .76
ATP .93 .92 1.08 .54 .45 1.48 1.56
KLA/ATP .57 .65 .98 .67 .44 .78 1.16
Mm.44889
KLA  ATP  ATP+KLA
 157057165 Unknown KLA 1.20 1.25 1.45 1.49 1.63 1.70 1.66
ATP 1.00 1.03 1.03 1.00 1.12 1.06 1.23
KLA/ATP 1.25 1.15 1.16 1.16 1.15 1.41 1.71
Mm.5245
KLA  ATP  ATP+KLA
 118130193 Unknown KLA 1.62 1.58 1.58 1.32 1.15 1.18 1.17
ATP .95 .99 1.18 1.78 1.34 1.15 1.03
KLA/ATP 1.66 1.70 1.66 1.59 1.28 1.23 1.01
Mm.874
KLA  ATP  ATP+KLA
 6754317 Unknown KLA 24.98 24.87 26.43 39.61 12.88 8.64 1.63
ATP 1.97 3.50 11.05 28.47 38.30 10.44 .65
KLA/ATP 23.45 29.37 58.52 51.77 30.64 14.61 8.63
Myd88
KLA  ATP  ATP+KLA
 NM_010851 myeloid differentiation primary response gene 88 (Myd88), mRNA [NM_010851] KLA 3.35 3.51 3.91 4.13 4.13 3.62 2.53
ATP .99 .96 .79 .75 .93 2.15 1.60
KLA/ATP 3.37 3.52 3.52 3.48 2.81 3.03 3.33
Pecam1
KLA  ATP  ATP+KLA
 AK031380 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030418F13 product:a disintegrin and metalloprotease domain 28, full insert sequence. [AK031380] KLA .95 1.06 1.09 1.02 1.03 .97 1.01
ATP .98 .96 1.04 1.09 1.01 1.04 .97
KLA/ATP 1.04 1.05 1.00 1.14 1.00 1.03 1.07
Pecam1
KLA  ATP  ATP+KLA
 NM_001032378 platelet/endothelial cell adhesion molecule 1 (Pecam1), transcript variant 2, mRNA [NM_001032378] KLA 1.29 1.31 1.58 1.50 1.94 2.18 1.90
ATP 1.03 1.04 1.05 1.22 1.20 1.11 1.19
KLA/ATP 1.30 1.24 1.28 1.63 1.49 1.62 2.13
Sdc1
KLA  ATP  ATP+KLA
 NM_011519 syndecan 1 (Sdc1), mRNA [NM_011519] KLA 1.40 1.34 1.52 1.50 1.64 2.31 2.39
ATP 1.20 1.20 1.28 2.62 10.61 16.35 9.95
KLA/ATP 1.61 1.71 1.60 3.94 11.52 15.28 20.29
Sdc2
KLA  ATP  ATP+KLA
 NM_008304 syndecan 2 (Sdc2), mRNA [NM_008304] KLA .93 1.00 .95 .89 .96 .93 .89
ATP 1.01 .98 .99 .99 .93 .96 .97
KLA/ATP .93 .91 1.05 .92 .92 .94 .89
Sele
KLA  ATP  ATP+KLA
 NM_011345 selectin, endothelial cell (Sele), mRNA [NM_011345] KLA 2.65 3.18 3.14 1.92 1.46 1.23 1.14
ATP .97 1.01 1.35 3.40 2.14 1.33 1.11
KLA/ATP 3.13 3.40 2.71 2.69 1.69 1.51 1.18
Selp
KLA  ATP  ATP+KLA
 NM_011347 selectin, platelet (Selp), mRNA [NM_011347] KLA 1.34 1.37 1.61 1.53 1.59 1.28 1.06
ATP .98 1.00 1.07 1.10 1.11 1.68 1.10
KLA/ATP 1.37 1.45 1.44 1.34 1.22 1.37 1.46
Tgfb1
KLA  ATP  ATP+KLA
 NM_011577 transforming growth factor, beta 1 (Tgfb1), mRNA [NM_011577] KLA .87 .89 .90 .70 .83 .77 1.12
ATP 1.20 1.41 .80 1.49 1.11 .93 .99
KLA/ATP 1.10 1.20 .53 1.05 .66 .85 .90
Tgfb2
KLA  ATP  ATP+KLA
 NM_009367 transforming growth factor, beta 2 (Tgfb2), mRNA [NM_009367] KLA 1.01 .91 .98 .98 .92 1.19 .96
ATP .99 1.03 1.00 1.02 .99 1.07 .93
KLA/ATP 1.02 .99 1.03 .98 1.04 1.06 .96
Tgfb3
KLA  ATP  ATP+KLA
 NM_009368 transforming growth factor, beta 3 (Tgfb3), mRNA [NM_009368] KLA .67 .64 .58 .56 .49 .52 .61
ATP .90 .92 1.33 1.08 .78 .65 .74
KLA/ATP .58 .60 .74 .61 .76 1.36 1.51
Thbs1
KLA  ATP  ATP+KLA
 NM_011580 thrombospondin 1 (Thbs1), mRNA [NM_011580] KLA 2.22 2.22 2.74 3.10 4.57 7.17 7.22
ATP 1.16 2.53 8.45 12.26 15.50 43.06 35.83
KLA/ATP 2.46 3.43 8.29 17.50 28.16 46.17 54.67
Thbs2
KLA  ATP  ATP+KLA
 NM_011581 thrombospondin 2 (Thbs2), mRNA [NM_011581] KLA .99 1.03 1.04 1.03 1.04 1.17 1.03
ATP 1.01 1.04 1.01 1.02 .98 1.03 .97
KLA/ATP 1.08 1.04 .95 1.05 1.15 1.14 1.04
Thbs3
KLA  ATP  ATP+KLA
 NM_013691 thrombospondin 3 (Thbs3), mRNA [NM_013691] KLA .86 .93 .86 .95 .90 .79 .79
ATP 1.06 1.02 1.11 1.10 .96 1.03 1.07
KLA/ATP .90 .88 .92 .92 .98 .96 .98
Thbs4
KLA  ATP  ATP+KLA
 NM_011582 thrombospondin 4 (Thbs4), mRNA [NM_011582] KLA 1.16 1.13 1.19 1.13 1.13 1.16 1.07
ATP 1.00 1.14 1.07 .99 1.07 1.25 1.10
KLA/ATP 1.16 1.18 1.24 1.55 1.55 1.94 1.48
Tlr2
KLA  ATP  ATP+KLA
 NM_011905 toll-like receptor 2 (Tlr2), mRNA [NM_011905] KLA 13.65 11.82 8.87 7.95 4.67 2.78 2.33
ATP 1.06 1.24 2.76 6.28 11.55 13.82 .67
KLA/ATP 13.11 12.91 14.48 13.84 14.18 11.14 2.78
Tlr4
KLA  ATP  ATP+KLA
 NM_021297 toll-like receptor 4 (Tlr4), mRNA [NM_021297] KLA .69 .61 .75 .94 .64 .81 .73
ATP .95 .90 1.12 .56 .47 1.51 1.53
KLA/ATP .57 .62 1.01 .64 .39 .73 1.13
Tlr9
KLA  ATP  ATP+KLA
 NM_031178 toll-like receptor 9 (Tlr9), mRNA [NM_031178] KLA 1.08 1.09 1.18 1.15 1.34 1.25 1.16
ATP 1.04 1.05 1.23 1.85 1.41 1.06 1.21
KLA/ATP 1.16 1.17 1.45 1.88 1.67 1.32 1.46
Tnf
KLA  ATP  ATP+KLA
 NM_013693 tumor necrosis factor (Tnf), mRNA [NM_013693] KLA 13.35 12.76 10.71 9.03 10.64 7.39 8.32
ATP 2.01 2.48 8.27 19.20 9.72 4.09 1.49
KLA/ATP 12.72 15.76 12.73 17.34 5.10 3.61 6.07
Vcam1
KLA  ATP  ATP+KLA
 NM_011693 vascular cell adhesion molecule 1 (Vcam1), mRNA [NM_011693] KLA 18.71 22.30 20.87 18.09 13.61 6.09 2.09
ATP 1.08 1.00 1.56 4.23 5.09 5.04 1.50
KLA/ATP 19.09 25.02 26.43 25.42 20.08 11.45 6.67