Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Thyroid cancer (mmu05216)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Braf
KLA  ATP  ATP+KLA
 NM_139294 Braf transforming gene (Braf), mRNA [NM_139294] KLA 1.52 1.57 1.55 1.33 1.83 1.52 1.60
ATP 1.08 1.17 1.02 1.37 .95 1.15 .95
KLA/ATP 1.64 1.69 1.39 1.51 1.04 1.31 1.26
Ccdc6
KLA  ATP  ATP+KLA
 NM_001111121 coiled-coil domain containing 6 (Ccdc6), mRNA [NM_001111121] KLA 1.76 1.92 2.07 1.95 1.37 1.16 1.01
ATP 1.08 1.04 .78 .74 .59 .70 .85
KLA/ATP 2.03 1.87 1.38 1.33 .95 .82 .95
Ccnd1
KLA  ATP  ATP+KLA
 S78355 gb|Cyl-1=cyclin D1 [mice, BALB/c, brain, mRNA, 3737 nt]. [S78355] KLA .24 .23 .23 .24 .29 .47 .17
ATP 1.02 1.02 .88 .80 .52 .10 .21
KLA/ATP .27 .23 .22 .24 .27 .25 .14
Cdh1
KLA  ATP  ATP+KLA
 NM_009864 cadherin 1 (Cdh1), mRNA [NM_009864] KLA 1.03 1.03 .99 .94 .95 .97 .99
ATP 1.04 1.06 1.06 .96 .99 1.07 .95
KLA/ATP 1.02 1.07 1.00 .90 .93 .94 .98
Ctnnb1
KLA  ATP  ATP+KLA
 AK020013 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830416C23 product:catenin beta, full insert sequence. [AK020013] KLA 1.06 1.15 1.00 1.06 1.27 1.14 1.03
ATP .85 .57 1.74 3.36 4.13 2.19 1.55
KLA/ATP 1.12 .87 2.47 3.61 3.79 2.21 2.06
Ctnnb1
KLA  ATP  ATP+KLA
 NM_007614 catenin (cadherin associated protein), beta 1 (Ctnnb1), mRNA [NM_007614] KLA 1.02 1.07 1.13 1.03 1.04 .93 .96
ATP 1.12 1.14 .75 .77 .73 .72 1.52
KLA/ATP 1.18 1.17 .77 .85 .60 .59 1.35
Hras1
KLA  ATP  ATP+KLA
 NM_008284 Harvey rat sarcoma virus oncogene 1 (Hras1), mRNA [NM_008284] KLA .79 .82 .77 .82 .94 1.03 1.07
ATP 1.01 .95 .69 .83 .79 1.12 1.15
KLA/ATP .84 .77 .61 .65 .82 1.00 1.05
Kras
KLA  ATP  ATP+KLA
 NM_021284 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA [NM_021284] KLA .53 .49 .40 .42 .49 .95 1.05
ATP .98 1.01 1.16 1.17 1.39 1.29 1.74
KLA/ATP .50 .47 .50 .56 1.00 1.24 1.58
Lef1
KLA  ATP  ATP+KLA
 NM_010703 lymphoid enhancer binding factor 1 (Lef1), mRNA [NM_010703] KLA 1.00 1.05 1.00 1.05 1.01 1.07 1.07
ATP .96 .98 1.03 1.09 .99 1.04 1.00
KLA/ATP 1.02 .98 .95 1.08 1.02 1.16 1.08
Map2k1
KLA  ATP  ATP+KLA
 NM_008927 mitogen-activated protein kinase kinase 1 (Map2k1), mRNA [NM_008927] KLA 1.82 2.00 2.31 2.03 2.51 2.20 1.51
ATP .99 1.14 .81 .87 .90 1.57 1.11
KLA/ATP 1.90 2.03 1.50 1.93 1.63 2.03 2.06
Map2k2
KLA  ATP  ATP+KLA
 NM_023138 mitogen-activated protein kinase kinase 2 (Map2k2), mRNA [NM_023138] KLA .96 1.01 1.09 .99 1.11 1.15 1.42
ATP 1.07 1.05 .74 .86 1.04 1.16 1.21
KLA/ATP 1.14 1.03 .68 .78 .85 1.01 1.20
Mapk1
KLA  ATP  ATP+KLA
 NM_001038663 mitogen-activated protein kinase 1 (Mapk1), transcript variant 2, mRNA [NM_001038663] KLA .97 1.03 .93 .86 .79 1.01 1.04
ATP .96 1.18 1.01 1.13 .84 1.04 1.16
KLA/ATP .99 .99 .84 .87 .63 .96 1.26
Mapk1
KLA  ATP  ATP+KLA
 NM_011949 mitogen-activated protein kinase 1 (Mapk1), transcript variant 1, mRNA [NM_011949] KLA .88 .80 .80 .73 .75 .76 .65
ATP .97 .96 1.06 .88 .90 .68 .48
KLA/ATP .82 .81 .78 .65 .64 .64 .45
Mapk3
KLA  ATP  ATP+KLA
 NM_011952 mitogen-activated protein kinase 3 (Mapk3), mRNA [NM_011952] KLA .81 .85 .88 .72 .79 .73 .90
ATP 1.13 1.30 .92 1.48 1.08 .68 1.03
KLA/ATP 1.01 1.01 .66 1.13 .77 .77 1.16
Mm.27304
9
KLA  ATP  ATP+KLA
 119672895 Unknown KLA .23 .22 .22 .22 .30 .51 .16
ATP 1.08 1.05 .88 .78 .47 .09 .20
KLA/ATP .28 .22 .21 .24 .26 .22 .12
Mm.28174
1
KLA  ATP  ATP+KLA
 94388259 Unknown KLA 1.68 1.72 2.01 1.72 1.18 1.02 .92
ATP .95 1.00 .84 .71 .53 .74 .81
KLA/ATP 1.79 1.76 1.40 1.17 .94 .74 .87
Mm.39071
7
KLA  ATP  ATP+KLA
 77404401 Unknown KLA .86 .83 .88 1.03 1.07 1.12 .85
ATP .94 .88 1.33 1.11 1.09 1.69 1.47
KLA/ATP .78 .76 1.16 .94 1.13 1.52 1.17
Mm.57199
KLA  ATP  ATP+KLA
 124256486 Unknown KLA .97 .97 .95 1.05 .96 .94 1.02
ATP .95 1.00 .96 .94 .97 1.05 .95
KLA/ATP .94 1.00 .86 1.02 .97 .96 .99
Mm.80682
KLA  ATP  ATP+KLA
 94369627 Unknown KLA .96 1.00 .97 .97 1.07 1.05 .99
ATP .97 1.02 .98 1.01 1.01 1.06 .96
KLA/ATP 1.00 .93 1.02 1.08 .98 .95 .97
Myc
KLA  ATP  ATP+KLA
 NM_010849 myelocytomatosis oncogene (Myc), mRNA [NM_010849] KLA .38 .31 .45 .45 .49 .35 .33
ATP 1.05 1.09 1.72 4.41 1.28 .45 .76
KLA/ATP .37 .30 .44 1.23 .34 .17 .19
Ncoa4
KLA  ATP  ATP+KLA
 NM_001033988 nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA [NM_001033988] KLA .60 .64 .65 .63 .80 .99 .84
ATP 1.12 1.12 1.18 1.06 1.12 1.63 1.33
KLA/ATP .63 .63 .59 .58 .79 1.68 1.98
Nras
KLA  ATP  ATP+KLA
 NM_010937 neuroblastoma ras oncogene (Nras), mRNA [NM_010937] KLA 1.20 1.22 1.27 1.20 1.09 .91 .84
ATP .98 .91 .69 .61 .59 .67 .78
KLA/ATP 1.22 1.14 .97 .79 .73 .61 .72
Ntrk1
KLA  ATP  ATP+KLA
 NM_001033124 neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA [NM_001033124] KLA .95 .96 1.03 1.03 .95 1.01 1.02
ATP 1.04 .98 .98 1.07 .99 1.01 1.02
KLA/ATP .97 1.03 1.10 1.02 1.05 1.00 .97
Pax8
KLA  ATP  ATP+KLA
 AK032920 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720473A10 product:paired box gene 8, full insert sequence [AK032920] KLA .93 .91 .92 .91 1.02 1.07 1.04
ATP .98 1.06 .98 .99 1.00 1.02 .94
KLA/ATP .92 .95 .97 1.03 .98 .91 .89
Pax8
KLA  ATP  ATP+KLA
 NM_011040 paired box gene 8 (Pax8), mRNA [NM_011040] KLA 1.06 .96 1.07 1.01 1.03 .99 1.03
ATP 1.10 .97 1.01 1.04 .97 1.00 1.00
KLA/ATP 1.09 1.06 1.03 .94 .92 .92 .99
Pparg
KLA  ATP  ATP+KLA
 NM_011146 peroxisome proliferator activated receptor gamma (Pparg), mRNA [NM_011146] KLA .32 .28 .31 .45 .38 .35 .49
ATP .96 1.01 1.28 1.65 1.83 .57 .77
KLA/ATP .30 .29 .36 .53 1.23 .72 .55
Ret
KLA  ATP  ATP+KLA
 NM_009050 ret proto-oncogene (Ret), transcript variant 2, mRNA [NM_009050] KLA 1.00 1.00 1.04 1.02 1.03 1.01 1.02
ATP 1.02 .98 1.01 1.00 .99 1.01 1.01
KLA/ATP 1.01 .97 1.02 1.01 1.00 1.00 .98
Rxra
KLA  ATP  ATP+KLA
 NM_011305 retinoid X receptor alpha (Rxra), mRNA [NM_011305] KLA .53 .55 .50 .52 .54 .85 1.09
ATP .95 1.00 1.18 1.00 .82 1.20 1.65
KLA/ATP .57 .55 .58 .55 .67 1.07 1.57
Rxrb
KLA  ATP  ATP+KLA
 NM_011306 retinoid X receptor beta (Rxrb), mRNA [NM_011306] KLA .71 .75 .75 .76 .83 .81 .89
ATP 1.04 1.13 .94 1.20 1.13 .81 .75
KLA/ATP .80 .86 .72 .85 .83 .93 .92
Rxrg
KLA  ATP  ATP+KLA
 NM_009107 retinoid X receptor gamma (Rxrg), mRNA [NM_009107] KLA .98 1.07 1.07 1.00 1.00 1.00 1.07
ATP 1.02 1.03 1.06 1.06 1.11 1.01 .99
KLA/ATP .95 .97 1.05 1.05 1.09 .98 1.06
Tcf3
KLA  ATP  ATP+KLA
 NM_001079822 transcription factor 3 (Tcf3), transcript variant 1, mRNA [NM_001079822] KLA 1.03 .98 1.01 .98 .98 1.03 1.01
ATP 1.00 1.02 1.00 1.06 1.10 1.07 .99
KLA/ATP 1.07 .99 .97 1.05 1.05 1.11 .96
Tcf7
KLA  ATP  ATP+KLA
 NM_009331 transcription factor 7, T-cell specific (Tcf7), mRNA [NM_009331] KLA 1.00 1.01 1.03 1.00 .98 1.01 1.07
ATP .99 .98 1.02 1.03 1.03 1.00 1.01
KLA/ATP 1.00 1.03 1.04 1.02 1.04 1.02 1.00
Tcf7l2
KLA  ATP  ATP+KLA
 NM_009333 transcription factor 7-like 2, T-cell specific, HMG-box (Tcf7l2), mRNA [NM_009333] KLA 1.01 1.12 1.11 1.31 1.06 1.34 1.29
ATP 1.04 1.05 .94 1.06 .90 .81 .96
KLA/ATP 1.08 1.11 1.05 1.18 1.04 1.02 1.42
Tfg
KLA  ATP  ATP+KLA
 AK039139 adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230101M06 product:unclassifiable, full insert sequence [AK039139] KLA 1.12 1.11 1.12 1.05 1.12 1.04 1.02
ATP .93 .85 .91 .95 .96 1.00 .90
KLA/ATP 1.11 1.01 .92 .89 .97 1.03 .90
Tfg
KLA  ATP  ATP+KLA
 NM_019678 Trk-fused gene (Tfg), mRNA [NM_019678] KLA 1.81 1.71 2.04 2.24 1.93 1.42 1.01
ATP .94 .96 1.09 .95 .76 1.04 .84
KLA/ATP 1.56 1.62 1.71 1.63 1.45 1.49 .85
Tpm3
KLA  ATP  ATP+KLA
 NM_022314 tropomyosin 3, gamma (Tpm3), mRNA [NM_022314] KLA 1.24 1.34 1.32 1.37 1.58 1.38 1.21
ATP 1.11 1.25 .97 1.43 1.09 .80 1.10
KLA/ATP 1.43 1.65 1.10 1.73 1.02 1.06 1.55
Tpr
KLA  ATP  ATP+KLA
 NM_133780 translocated promoter region (Tpr), mRNA [NM_133780] KLA 1.86 1.70 1.73 1.84 1.35 1.12 1.05
ATP 1.03 .93 1.16 .85 .90 1.16 .66
KLA/ATP 1.64 1.73 2.44 1.50 1.27 1.00 .83
Trp53
KLA  ATP  ATP+KLA
 NM_011640 transformation related protein 53 (Trp53), mRNA [NM_011640] KLA 1.25 1.37 1.11 .86 .72 .71 .95
ATP 1.15 1.32 .90 1.85 1.26 .68 .70
KLA/ATP 1.66 1.49 .80 1.76 .81 .65 .74