Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Asthma (mmu05310)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Ccl11
KLA  ATP  ATP+KLA
 NM_011330 small chemokine (C-C motif) ligand 11 (Ccl11), mRNA [NM_011330] KLA 1.03 1.17 1.09 1.06 1.05 1.09 1.01
ATP .94 1.05 1.35 2.25 1.09 1.05 1.06
KLA/ATP 1.06 1.06 1.93 4.93 1.46 1.14 1.04
Cd40
KLA  ATP  ATP+KLA
 NM_170701 CD40 antigen (Cd40), transcript variant 3, mRNA [NM_170701] KLA 23.87 23.62 23.26 23.98 22.07 17.37 5.34
ATP 1.00 1.01 1.06 2.96 2.65 3.03 1.70
KLA/ATP 22.77 23.79 29.67 28.85 28.08 21.62 13.02
Cd40lg
KLA  ATP  ATP+KLA
 NM_011616 CD40 ligand (Cd40lg), mRNA [NM_011616] KLA 1.03 1.07 1.02 .98 1.06 1.06 1.03
ATP .95 .92 .99 1.06 1.02 1.04 1.07
KLA/ATP 1.00 1.01 .93 1.04 .94 1.01 .98
EG629860
KLA  ATP  ATP+KLA
 M17953 gb|Mouse Ig rearranged H-chain V-region mRNA VJ1 [M17953] KLA .96 1.05 1.03 1.08 1.08 1.02 .98
ATP .97 .99 1.05 1.10 .95 .94 .91
KLA/ATP .96 .94 .97 1.04 .97 1.01 .89
Epx
KLA  ATP  ATP+KLA
 NM_007946 eosinophil peroxidase (Epx), mRNA [NM_007946] KLA 1.03 .97 1.04 .99 .98 1.06 1.03
ATP 1.02 1.05 1.05 .97 1.05 .94 1.05
KLA/ATP .97 1.02 1.07 .96 1.04 .97 .98
Fcer1a
KLA  ATP  ATP+KLA
 NM_010184 Fc receptor, IgE, high affinity I, alpha polypeptide (Fcer1a), mRNA [NM_010184] KLA 1.14 .98 1.02 1.09 1.00 1.00 .96
ATP 1.04 1.03 1.07 .97 1.04 1.01 1.06
KLA/ATP .94 .98 1.09 1.04 1.06 .94 .95
Fcer1g
KLA  ATP  ATP+KLA
 J05020 gb|Mouse mast cell high affinity IgE receptor (Fc-epsilon-RI) gamma subunit mRNA, complete cds. [J05020] KLA 1.41 1.43 1.53 1.61 1.91 2.07 2.49
ATP 1.13 1.21 .88 1.25 1.06 .92 1.45
KLA/ATP 1.64 1.64 1.25 1.84 1.45 1.39 2.32
Fcer1g
KLA  ATP  ATP+KLA
 NM_010185 Fc receptor, IgE, high affinity I, gamma polypeptide (Fcer1g), mRNA [NM_010185] KLA 1.49 1.54 1.48 1.62 2.18 2.06 2.35
ATP 1.10 1.16 .78 1.00 .90 .98 1.18
KLA/ATP 1.48 1.67 1.26 1.71 1.33 1.40 2.13
H2-Aa
KLA  ATP  ATP+KLA
 NM_010378 histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA [NM_010378] KLA 1.43 1.59 1.68 1.50 1.62 1.89 1.64
ATP 1.07 1.15 1.27 1.90 1.92 1.77 1.55
KLA/ATP 1.62 1.81 1.74 2.29 1.89 1.92 2.19
H2-Ab1
KLA  ATP  ATP+KLA
 BC010322 histocompatibility 2, class II antigen A, beta 1, mRNA (cDNA clone MGC:6297 IMAGE:2651058), complete cds [BC010322] KLA 1.73 1.76 1.77 1.55 1.95 2.10 2.27
ATP 1.03 1.18 1.32 1.99 1.79 1.56 1.61
KLA/ATP 1.70 2.01 1.74 2.52 1.58 2.01 2.75
H2-Ab1
KLA  ATP  ATP+KLA
 NM_207105 histocompatibility 2, class II antigen A, beta 1 (H2-Ab1), mRNA [NM_207105] KLA 2.02 2.15 2.07 2.09 2.32 2.78 3.08
ATP 1.11 1.20 1.42 2.33 2.33 2.25 1.87
KLA/ATP 2.11 2.32 2.52 3.62 2.67 2.96 5.04
H2-DMa
KLA  ATP  ATP+KLA
 NM_010386 histocompatibility 2, class II, locus DMa (H2-DMa), mRNA [NM_010386] KLA 1.49 1.50 1.65 1.65 1.91 2.23 1.69
ATP 1.04 1.12 1.26 1.67 1.24 .99 1.32
KLA/ATP 1.58 1.68 1.70 2.02 1.37 1.35 1.90
H2-DMb1
KLA  ATP  ATP+KLA
 NM_010387 histocompatibility 2, class II, locus Mb1 (H2-DMb1), mRNA [NM_010387] KLA 1.06 1.14 1.08 1.13 1.24 1.41 1.37
ATP 1.01 1.02 1.09 1.14 .92 .73 1.36
KLA/ATP 1.13 1.05 1.21 1.17 .98 .83 1.41
H2-DMb2
KLA  ATP  ATP+KLA
 NM_010388 histocompatibility 2, class II, locus Mb2 (H2-DMb2), mRNA [NM_010388] KLA 1.00 1.04 .93 .95 .96 .95 1.03
ATP 1.06 1.04 .94 .92 .97 .95 1.00
KLA/ATP .90 .94 .99 .94 .90 .96 .92
H2-Eb1
KLA  ATP  ATP+KLA
 X52641 gb|Mouse mRNA for I-A beta NOD. [X52641] KLA 1.94 2.06 1.94 1.87 1.96 2.18 1.76
ATP 1.11 1.20 1.53 2.70 3.02 2.91 1.40
KLA/ATP 2.09 2.11 2.26 3.55 2.76 3.05 3.05
H2-Oa
KLA  ATP  ATP+KLA
 NM_008206 histocompatibility 2, O region alpha locus (H2-Oa), mRNA [NM_008206] KLA 1.22 1.32 1.37 1.33 1.31 1.26 1.53
ATP 1.02 1.05 1.16 1.21 1.12 1.07 1.16
KLA/ATP 1.32 1.34 1.31 1.34 1.25 1.35 2.78
H2-Ob
KLA  ATP  ATP+KLA
 NM_010389 histocompatibility 2, O region beta locus (H2-Ob), mRNA [NM_010389] KLA 1.05 1.07 1.01 .96 1.10 1.02 1.00
ATP 1.04 .99 1.00 1.03 .94 1.07 .94
KLA/ATP 1.02 .97 1.06 1.08 1.00 .96 1.05
Igh-VJ55
8
KLA  ATP  ATP+KLA
 AY547436 immunoglobulin heavy chain VDJ region mRNA, partial cds [AY547436] KLA 1.06 1.05 1.01 .93 1.03 .96 .93
ATP .99 1.00 1.06 .95 .96 1.06 1.05
KLA/ATP .98 .94 1.07 .95 .97 .99 1.02
Igh-VJ55
8
KLA  ATP  ATP+KLA
 CA578712 gb|K0727F04-5N NIA Mouse Hematopoietic Stem Cell (Lin- [CA578712] KLA .99 .94 1.01 1.10 .93 .97 .92
ATP .93 1.04 1.01 .98 1.05 .96 .95
KLA/ATP .99 .95 .95 .98 1.02 .98 .95
Igh-VJ55
8
KLA  ATP  ATP+KLA
 ENSMUST00000103412 ens|Immunoglobulin heavy chain C gene segment [Source:IMGT/GENE_DB;Acc:IGHA] [ENSMUST00000103412] KLA 1.01 .97 1.20 1.01 .98 1.44 1.24
ATP .99 .98 1.07 1.03 1.00 1.01 1.21
KLA/ATP .99 1.02 .96 1.03 .97 1.13 1.30
Igh-VJ55
8
KLA  ATP  ATP+KLA
 ENSMUST00000103413 ens|Immunoglobulin heavy chain C gene segment [Source:IMGT/GENE_DB;Acc:IGHE] [ENSMUST00000103413] KLA 1.00 .99 1.06 1.06 .99 1.03 1.02
ATP 1.08 1.06 1.06 1.06 1.02 1.06 .95
KLA/ATP 1.00 1.04 1.09 1.02 1.06 1.02 .95
Igh-VJ55
8
KLA  ATP  ATP+KLA
 U39781 J558+ IgM heavy chain mRNA, hybridoma clone ME2B7, partial cds. [U39781] KLA .93 .89 .98 .97 1.03 1.00 .94
ATP 1.04 1.02 1.08 .94 .93 .90 .79
KLA/ATP .88 .89 .97 .93 .88 .92 .82
Il10
KLA  ATP  ATP+KLA
 NM_010548 interleukin 10 (Il10), mRNA [NM_010548] KLA 17.59 18.64 22.22 23.06 11.83 8.27 2.07
ATP 1.86 3.22 7.72 20.51 25.86 8.38 1.01
KLA/ATP 17.91 23.49 34.53 34.48 20.98 12.03 8.17
Il13
KLA  ATP  ATP+KLA
 NM_008355 interleukin 13 (Il13), mRNA [NM_008355] KLA 1.08 1.05 .98 1.10 1.01 1.03 1.02
ATP 1.00 .98 1.08 .98 .99 1.05 .97
KLA/ATP .96 .96 1.09 1.02 1.04 1.01 .97
Il3
KLA  ATP  ATP+KLA
 NM_010556 interleukin 3 (Il3), mRNA [NM_010556] KLA 1.05 .94 1.01 .99 1.03 1.07 .95
ATP .95 1.03 1.03 .98 .98 .97 .96
KLA/ATP 1.02 1.03 1.02 .94 .97 1.02 1.04
Il4
KLA  ATP  ATP+KLA
 NM_021283 interleukin 4 (Il4), mRNA [NM_021283] KLA .94 .95 .91 .94 .91 .94 1.07
ATP 1.02 1.06 1.05 1.22 1.12 1.10 1.26
KLA/ATP .92 .96 .93 1.08 .98 1.03 1.18
Il5
KLA  ATP  ATP+KLA
 NM_010558 interleukin 5 (Il5), mRNA [NM_010558] KLA 1.10 1.11 1.10 .98 1.01 .98 .97
ATP .94 1.04 1.08 .92 .97 1.02 1.03
KLA/ATP .98 .92 1.12 1.03 1.02 1.00 1.03
Il9
KLA  ATP  ATP+KLA
 NM_008373 interleukin 9 (Il9), mRNA [NM_008373] KLA .97 1.02 1.06 1.03 1.04 1.02 1.05
ATP .98 .93 .98 1.03 1.02 1.04 .96
KLA/ATP 1.01 1.00 1.00 1.06 1.06 1.04 1.07
Mm.874
KLA  ATP  ATP+KLA
 6754317 Unknown KLA 24.98 24.87 26.43 39.61 12.88 8.64 1.63
ATP 1.97 3.50 11.05 28.47 38.30 10.44 .65
KLA/ATP 23.45 29.37 58.52 51.77 30.64 14.61 8.63
Ms4a2
KLA  ATP  ATP+KLA
 NM_013516 membrane-spanning 4-domains, subfamily A, member 2 (Ms4a2), mRNA [NM_013516] KLA 1.02 .96 1.07 1.01 1.04 1.01 .97
ATP 1.03 .97 1.10 1.01 1.00 .96 .96
KLA/ATP .99 .98 .99 .99 1.03 .99 1.00
Prg2
KLA  ATP  ATP+KLA
 NM_008920 proteoglycan 2, bone marrow (Prg2), mRNA [NM_008920] KLA 1.18 1.17 1.26 1.18 1.57 1.43 1.13
ATP .89 .93 .96 1.21 1.19 1.29 1.13
KLA/ATP 1.13 1.07 1.29 1.17 1.43 1.16 1.05
Tnf
KLA  ATP  ATP+KLA
 NM_013693 tumor necrosis factor (Tnf), mRNA [NM_013693] KLA 13.35 12.76 10.71 9.03 10.64 7.39 8.32
ATP 2.01 2.48 8.27 19.20 9.72 4.09 1.49
KLA/ATP 12.72 15.76 12.73 17.34 5.10 3.61 6.07