LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP001287

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily e, polypeptide 1
Protein EntryCP2E1_MOUSE
UniProt IDQ05421
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental StageDetectable in the female liver on day 1 and reaches steady state levels on days 16-20.
FunctionMetabolizes several precarcinogens, drugs, and solvents to reactive metabolites. {ECO:0000250}.
InductionBy ethanol and acetone in the liver and by testosterone in the kidney and adrenal tissues.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityHighest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female.