LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001809

UniProt Annotations

Entry Information
Gene Nameoleoyl-ACP hydrolase
Protein EntrySAST_HUMAN
UniProt IDQ9NV23
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NV23-1; Sequence=Displayed; Name=2; IsoId=Q9NV23-2; Sequence=VSP_040022;
Catalytic ActivityOleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate.
FunctionIn fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).
SimilarityBelongs to the thioesterase family.
Tissue SpecificityIsoform 2 is up-regulated in bone marrow- derived mononuclear cells of rheumatoid arthritis patients.