LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP002506

UniProt Annotations

Entry Information
Gene Namephospholipid scramblase 3
Protein EntryPLS3_HUMAN
UniProt IDQ9NRY6
SpeciesHuman
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI
DomainThe N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
FunctionMay mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
InteractionO75340:PDCD6; NbExp=9; IntAct=EBI-750734, EBI-352915;
PtmPhosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.
SimilarityBelongs to the phospholipid scramblase family.
Subcellular LocationMitochondrion membrane ; Single-pass type II membrane protein .
SubunitInteracts with PDCD6 in a calcium-dependent manner.
Tissue SpecificityExpressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.