LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP003072

UniProt Annotations

Entry Information
Gene Nameectonucleotide pyrophosphatase/phosphodiesterase 6
Protein EntryENPP6_MOUSE
UniProt IDQ8BGN3
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA lysophosphatidylcholine + H(2)O = a monoacylglycerol + phosphocholine.
Catalytic Activitysn-glycero-3-phosphocholine + H(2)O = glycerol + phosphocholine.
CofactorName=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000250};
Enzyme RegulationInhibited by EDTA and EGTA in vitro. {ECO:0000250}.
FunctionCholine-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid (By similarity). {ECO:0000250}.
SimilarityBelongs to the nucleotide pyrophosphatase/phosphodiesterase family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
SubunitHomodimer; disulfide-linked. {ECO:0000250}.
Tissue SpecificityPredominantly expressed in kidney with a lesser expression in brain and heart. {ECO:0000269|PubMed:15788404}.