LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP004810

Record overview

LMPD IDLMP004810
Gene ID8813
SpeciesHomo sapiens (Human)
Gene Namedolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Gene SymbolDPM1
SynonymsCDGIE; MPDS
Alternate namesdolichol-phosphate mannosyltransferase subunit 1; DPM synthase subunit 1; MPD synthase subunit 1; mannose-P-dolichol synthase subunit 1; DPM synthase complex, catalytic subunit; dolichol monophosphate mannose synthase; dolichol-phosphate mannose synthase subunit 1; dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Chromosome20
Map Location20q13.13
EC Number2.4.1.83
Summary Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DPM1

Proteins

dolichol-phosphate mannosyltransferase subunit 1
Refseq ID:NP_003850
Protein GI:4503363
UniProt ID:O60762
mRNA ID:NM_003859
Length:260
RefSeq Status:REVIEWED
MASLEVSRSPRRSRRELEVRSPRQNKYSVLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDVAEQLEKIYGSDRILLRPREKKLGLGT
AYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFLTQILLRPGASDLTGSFRLYRKEVLEKLIE
KCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT