LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006675

UniProt Annotations

Entry Information
Gene Nameacetoacetyl-CoA synthetase
Protein EntryAACS_HUMAN
UniProt IDQ86V21
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86V21-1; Sequence=Displayed; Name=2; IsoId=Q86V21-2; Sequence=VSP_030702; Note=No experimental confirmation available.; Name=3; IsoId=Q86V21-3; Sequence=VSP_030701; Note=No experimental confirmation available.;
Catalytic ActivityATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
FunctionActivates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).
Sequence CautionSequence=AAH41000.1; Type=Frameshift; Positions=201; Evidence= ; Sequence=BAB14793.1; Type=Frameshift; Positions=519; Evidence= ;
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family.
Subcellular LocationCytoplasm, cytosol .
Tissue SpecificityHighly expressed in kidney, heart and brain, but low in liver.