LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006792

UniProt Annotations

Entry Information
Gene Namesynaptophysin
Protein EntrySYPH_HUMAN
UniProt IDP08247
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08247-1; Sequence=Displayed; Name=2; IsoId=P08247-2; Sequence=VSP_056897; Note=No experimental confirmation available;
DiseaseMental retardation, X-linked, SYP-related (MRXSYP) [MIM
DomainThe calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
FunctionPossibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
PtmUbiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
SimilarityBelongs to the synaptophysin/synaptobrevin family.
SimilarityContains 1 MARVEL domain. {ECO
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
SubunitHomohexamer or homotetramer. Interacts with SRCIN1.
Tissue SpecificityCharacteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
Web ResourceName=Wikipedia; Note=Synaptophysin entry; URL="http://en.wikipedia.org/wiki/Synaptophysin";