LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP006956

UniProt Annotations

Entry Information
Gene NameC-5 sterol desaturase
Protein EntryERG3_YEAST
UniProt IDP32353
SpeciesYeast (S288c)
Comments
Comment typeDescription
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ;
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionCatalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.
InteractionP53045:ERG25; NbExp=3; IntAct=EBI-6554, EBI-6506;
MiscellaneousPresent with 36200 molecules/cell in log phase SD medium
MiscellaneousPresent with 36200 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwaySteroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 3/5.
SimilarityBelongs to the sterol desaturase family
SimilarityBelongs to the sterol desaturase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitInteracts with ERG28
SubunitInteracts with ERG28. {ECO:0000269|PubMed:15995173}.