LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007012

UniProt Annotations

Entry Information
Gene Namepalmitoyl-(protein) hydrolase
Protein EntryAPTH1_YEAST
UniProt IDQ12354
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-protein + H(2)O = palmitate + protein. {ECO:0000269|PubMed:12080046}.
FunctionHydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo. {ECO:0000269|PubMed:12080046}.
MiscellaneousPresent with 1480 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the AB hydrolase superfamily. AB hydrolase 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.