LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007025

UniProt Annotations

Entry Information
Gene NameRgd1p
Protein EntryRGD1_YEAST
UniProt IDP38339
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionGTPase activating protein of RHO3 and RHO4. Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway. Involved in various stress responses. Required at low pH for activation of the PKC pathway. Important during mating response. {ECO:0000269|PubMed:10526184, ECO:0000269|PubMed:10590461, ECO:0000269|PubMed:11779787, ECO:0000269|PubMed:15922872, ECO:0000269|PubMed:16087742}.
InductionInduced by stress including low pH, heat shock and oxidative shock. Basal and acid-stressed expression level is regulated by transcription factors MSN2 and MSN4 as well as the HOG pathway.
InteractionP46949:FYV8; NbExp=3; IntAct=EBI-15065, EBI-23450;
MiscellaneousLack of RGD1 diminishes the PKC pathway activity.
MiscellaneousPresent with 1500 molecules/cell in log phase SD medium
MiscellaneousPresent with 1500 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmPhosphorylated in vivo. In vitro, phosphorylated by IPL1
PtmPhosphorylated in vivo. In vitro, phosphorylated by IPL1. {ECO:0000269|PubMed:19779198, ECO:0000269|PubMed:23454383}.
SimilarityContains 1 FCH domain. {ECO:0000255|PROSITE- ProRule:PRU00083}.
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:23454383}. Note=Bud and bud neck. During isotropic bud growth in the G1 and S phases, detected at the bud tip. During cytokinesis, undetectable at the bud tip and localized at the bud neck only.